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  1. Article ; Online: The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive.

    Amaral, David G / Augustinack, Jean / Barbas, Helen / Frosch, Matthew / Gabrieli, John / Luebke, Jennifer / Rakic, Pasko / Rosene, Douglas / Rushmore, Richard J

    Hippocampus

    2024  Volume 34, Issue 2, Page(s) 52–57

    Abstract: The famous amnesic patient Henry Molaison (H.M.) died on December 2, 2008. After extensive in situ ... analysis of the state of H.M.'s brain at the time of his death has not yet been published. The brain tissue ... of a freely accessible H.M. website. Research publications on the microscopic anatomy and neuropathology of H ...

    Abstract The famous amnesic patient Henry Molaison (H.M.) died on December 2, 2008. After extensive in situ magnetic resonance imaging in Boston, his brain was removed at autopsy and transported to the University of California San Diego. There the brain was prepared for frozen sectioning and cut into 2401, 70 μm coronal slices. While preliminary analyses of the brain sections have been reported, a comprehensive microscopic neuroanatomical analysis of the state of H.M.'s brain at the time of his death has not yet been published. The brain tissue and slides were subsequently moved to the University of California Davis and the slides digitized at high resolution. Initial stages of producing a website for the public viewing of the images were also carried out. Recently, the slides, digital images, and tissue have been transferred to Boston University for permanent archiving. A new steering committee has been established and plans are in place for completion of a freely accessible H.M. website. Research publications on the microscopic anatomy and neuropathology of H.M.'s brain at the time of his death are also planned. We write this commentary to provide the hippocampus and memory neuroscience communities with a brief summary of what has transpired following H.M.'s death and outline plans for future publications and a tissue archive.
    MeSH term(s) Humans ; Brain/diagnostic imaging ; Brain/pathology ; Hippocampus ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.23597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Conference proceedings: 84. Ordentlicher Medizinischer Fakultätentag am 8. und 9. Juni 2023 in Jena

    Frosch, Matthias

    Tagungsbericht

    2023  

    Institution Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Event/congress Ordentlicher Medizinischer Fakultätentag (84., 2023, Jena)
    Author's details Herausgeber: Prof. Dr. Matthias Frosch ; MFT Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Subject code 610
    Language German
    Size 1 Online-Ressource (168 Seiten), Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher MFT Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; Conference proceedings
    Note Open Access
    HBZ-ID HT030622418
    ISBN 9783982500416 ; 3982500419
    DOI 10.4126/FRL01-006472884
    Database Repository for Life Sciences

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  3. Book ; Online ; Conference proceedings: 83. Ordentlicher Medizinischer Fakultätentag am 16. und 17. Juni 2022 in Essen

    Frosch, Matthias

    Tagungsbericht

    2022  

    Institution Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Event/congress Ordentlicher Medizinischer Fakultätentag (83., 2022, Essen)
    Author's details Herausgeber: Prof. Dr. Matthias Frosch ; MFT Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Subject code 610
    Language German
    Size 1 Online-Ressource (163 Seiten), Illustrationen
    Edition 1. Auflage
    Publisher MFT Medizinischer Fakultätentag der Bundesrepublik Deutschland e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; Conference proceedings
    Note Open Access
    HBZ-ID HT030622403
    ISBN 9783982500409 ; 3982500400
    DOI 10.4126/FRL01-006453782
    Database Repository for Life Sciences

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  4. Book ; Thesis: Die Histondeacetylasen 1 und 2 und das Mikrobiom beeinflussen die Epigenetik der Mikroglia im Verlauf ihrer Entwicklung und der Neurodegeneration

    Frosch, Maximilian

    2020  

    Author's details vorgelegt 2020 von Maximilian Benedict Matthias Frosch
    Language German
    Size IX, 123 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2020
    HBZ-ID HT020806124
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 E 209 order for loan Magazin

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  5. Article ; Online: Postmortem examination of patient H.M.'s brain based on histological sectioning and digital 3D reconstruction.

    Annese, Jacopo / Schenker-Ahmed, Natalie M / Bartsch, Hauke / Maechler, Paul / Sheh, Colleen / Thomas, Natasha / Kayano, Junya / Ghatan, Alexander / Bresler, Noah / Frosch, Matthew P / Klaming, Ruth / Corkin, Suzanne

    Nature communications

    2014  Volume 5, Page(s) 3122

    Abstract: ... from the case of Henry G. Molaison (H.M.), an epileptic patient whose amnesia ensued unexpectedly following ... The neuroanatomical extent of the 1953 operation could not be assessed definitively during H.M.'s life. Here ... new evidence that may help elucidate the consequences of H.M.'s operation in the context ...

    Abstract Modern scientific knowledge of how memory functions are organized in the human brain originated from the case of Henry G. Molaison (H.M.), an epileptic patient whose amnesia ensued unexpectedly following a bilateral surgical ablation of medial temporal lobe structures, including the hippocampus. The neuroanatomical extent of the 1953 operation could not be assessed definitively during H.M.'s life. Here we describe the results of a procedure designed to reconstruct a microscopic anatomical model of the whole brain and conduct detailed 3D measurements in the medial temporal lobe region. This approach, combined with cellular-level imaging of stained histological slices, demonstrates a significant amount of residual hippocampal tissue with distinctive cytoarchitecture. Our study also reveals diffuse pathology in the deep white matter and a small, circumscribed lesion in the left orbitofrontal cortex. The findings constitute new evidence that may help elucidate the consequences of H.M.'s operation in the context of the brain's overall pathology.
    MeSH term(s) Adult ; Autopsy ; Brain/diagnostic imaging ; Brain/pathology ; Dissection ; Frontal Lobe/pathology ; Hippocampus/pathology ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Staining and Labeling ; Temporal Lobe/pathology ; Tomography, X-Ray Computed ; White Matter/pathology
    Language English
    Publishing date 2014-01-29
    Publishing country England
    Document type Journal Article ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/ncomms4122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: H.M.'s contributions to neuroscience: a review and autopsy studies.

    Augustinack, Jean C / van der Kouwe, André J W / Salat, David H / Benner, Thomas / Stevens, Allison A / Annese, Jacopo / Fischl, Bruce / Frosch, Matthew P / Corkin, Suzanne

    Hippocampus

    2014  Volume 24, Issue 11, Page(s) 1267–1286

    Abstract: H.M., Henry Molaison, was one of the world's most famous amnesic patients. His amnesia was caused ... M.'s body was transported to the Mass General Morgue for autopsy. The photographs taken at that time ... provided the first documentation of H.M.'s lesions in his physical brain. After tissue fixation ...

    Abstract H.M., Henry Molaison, was one of the world's most famous amnesic patients. His amnesia was caused by an experimental brain operation, bilateral medial temporal lobe resection, carried out in 1953 to relieve intractable epilepsy. He died on December 2, 2008, and that night we conducted a wide variety of in situ MRI scans in a 3 T scanner at the Massachusetts General Hospital (Mass General) Athinoula A. Martinos Center for Biomedical Imaging. For the in situ experiments, we acquired a full set of standard clinical scans, 1 mm isotropic anatomical scans, and multiple averages of 440 μm isotropic anatomical scans. The next morning, H.M.'s body was transported to the Mass General Morgue for autopsy. The photographs taken at that time provided the first documentation of H.M.'s lesions in his physical brain. After tissue fixation, we obtained ex vivo structural data at ultra-high resolution using 3 T and 7 T magnets. For the ex vivo acquisitions, the highest resolution images were 210 μm isotropic. Based on the MRI data, the anatomical areas removed during H.M.'s experimental operation were the medial temporopolar cortex, piriform cortex, virtually all of the entorhinal cortex, most of the perirhinal cortex and subiculum, the amygdala (except parts of the dorsal-most nuclei-central and medial), anterior half of the hippocampus, and the dentate gyrus (posterior head and body). The posterior parahippocampal gyrus and medial temporal stem were partially damaged. Spared medial temporal lobe tissue included the dorsal-most amygdala, the hippocampal-amygdalo-transition-area, ∼2 cm of the tail of the hippocampus, a small part of perirhinal cortex, a small portion of medial hippocampal tissue, and ∼2 cm of posterior parahippocampal gyrus. H.M.'s impact on the field of memory has been remarkable, and his contributions to neuroscience continue with a unique dataset that includes in vivo, in situ, and ex vivo high-resolution MRI.
    MeSH term(s) Amnesia/history ; Amnesia/pathology ; Autopsy ; Brain/pathology ; Epilepsy/history ; Epilepsy/pathology ; Epilepsy/surgery ; History, 20th Century ; Humans ; Magnetic Resonance Imaging ; Male ; Memory
    Language English
    Publishing date 2014-09-23
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22354
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  7. Article ; Online: Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature.

    Vodopivec, Ivana / Cho, Tracey A / Rizzo, Joseph F / Frosch, Matthew P / Sims, Katherine B

    The neurologist

    2016  Volume 21, Issue 4, Page(s) 61–65

    Abstract: ... stroke-like episodes (MELAS) in an adult patient who carries m.10158T>C mutation in complex ... compared with all previously reported ND3 disease cases.: Conclusions: ND3 disease due to m.10158T>C ...

    Abstract Introduction: Establishing a diagnosis of mitochondrial disease in adults remains a clinician's challenge. We report a case of syndrome reminiscent of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) in an adult patient who carries m.10158T>C mutation in complex I respiratory chain gene MT-ND3 (mitochondrially encoded NADH dehydrogenase 3).
    Case report: This 26-year-old man from Thailand presented with new-onset headaches, seizures, stroke-like episodes, and poor vision due to optic neuropathy and cortical blindness. Instead of expected mutations in the mitochondrial tRNA gene that are frequently associated with MELAS, the mutation in MT-ND3 with variable tissue heteroplasmy (blood 5.3%, muscle 89.5%) was demonstrated. The patient's clinical features, blood biomarkers, neuroimaging findings, muscle biopsy with histochemical and functional in vitro analysis, and genetic studies were analyzed and compared with all previously reported ND3 disease cases.
    Conclusions: ND3 disease due to m.10158T>C mutation was previously described only in patients with Leigh or Leigh-like syndrome. Our findings thus indicate that ND3 disease can manifest with atypical phenotype in adults. The diagnosis of mitochondrial disease caused by other than typical MELAS-associated mutations in adults with stroke-like episodes, headaches, and seizures should be considered. An analysis of tissue other than blood, which is more likely to harbor a tissue-specific mitochondrial DNA mutation at a measurable level, may be necessary for diagnosis.
    MeSH term(s) Adult ; Electron Transport Complex I/genetics ; Humans ; MELAS Syndrome/diagnosis ; MELAS Syndrome/genetics ; Male ; Mutation/genetics ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/genetics
    Chemical Substances Electron Transport Complex I (EC 1.6.5.3) ; MT-ND3 protein, human (EC 7.1.1.2)
    Language English
    Publishing date 2016-06-27
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000084
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  8. Article: Pliny Earle, M.D., 1809-1892.

    Frosch, William A / Richardson, Diane

    The American journal of psychiatry

    2004  Volume 161, Issue 11, Page(s) 1989

    MeSH term(s) History, 19th Century ; Psychiatry/history ; United States
    Language English
    Publishing date 2004-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.161.11.1989
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  9. Article: Precision measurement of the pion mass difference m pi --m pi 0.

    Crawford / Daum / Frosch / Jost / Kettle / Marshall / Wright / Ziock

    Physical review. D, Particles and fields

    1991  Volume 43, Issue 1, Page(s) 46–58

    Language English
    Publishing date 1991-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209772-2
    ISSN 0556-2821 ; 2470-0010 ; 1550-7998
    ISSN 0556-2821 ; 2470-0010 ; 1550-7998
    DOI 10.1103/physrevd.43.46
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    Z 71/751: Show issues

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  10. Article: Pannikulitis, Nekrosen und Exanthem nach Interferon-beta-1b s. c. - Toleranz gegenüber Interferon-beta-1a i. m.

    Reischl, K. / Winer, M. / Lincke, H.-O. / Frosch, P. J.

    H+G

    2001  Volume 76, Issue 4, Page(s) 224

    Language German
    Document type Article
    ZDB-ID 124647-1
    ISSN 0301-0481
    Database Current Contents Medicine

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