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Article ; Online: Evidence of a novel galectin-9-binding membrane glycoprotein ligand on T helper cells.

Cedeno-Laurent, Filiberto / Dimitroff, Charles J

2012 Volume 143, Issue 1, Page(s) 6–7

MeSH term(s)	Animals ; Female ; Galectins/immunology ; Hepatitis A Virus Cellular Receptor 2 ; Interleukin-2/immunology ; Male ; Receptors, Virus/immunology ; Th17 Cells/immunology
Chemical Substances	Galectins ; Havcr2 protein, mouse ; Hepatitis A Virus Cellular Receptor 2 ; Interleukin-2 ; Receptors, Virus ; galectin 9, mouse
Language	English
Publishing date	2012-01-24
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2012.01.010
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Article: Polydactylous Longitudinal Melanonychia Acquired following Total Skin Electron Beam Radiation Therapy for Sézary Syndrome.

Cedeno-Laurent, Filiberto / Kim, Ellen J / Rook, Alain H / Vittorio, Carmela C / Rubin, Adam I

Skin appendage disorders

2015 Volume 1, Issue 2, Page(s) 60–61

Language	English
Publishing date	2015-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806972-9
ISSN	2296-9160 ; 2296-9195
ISSN (online)	2296-9160
ISSN	2296-9195
DOI	10.1159/000398817
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Article ; Online: Galectins and their ligands: negative regulators of anti-tumor immunity.

Cedeno-Laurent, Filiberto / Dimitroff, Charles J

Glycoconjugate journal

2012 Volume 29, Issue 8-9, Page(s) 619–625

Abstract: Cytotoxic CD8(+) T cells are major players of anti-tumor immune responses, as their functional activity can limit tumor growth and progression. Data show that cytotoxic T cells efficiently control the proliferation of tumor cells through major ... ...

Abstract	Cytotoxic CD8(+) T cells are major players of anti-tumor immune responses, as their functional activity can limit tumor growth and progression. Data show that cytotoxic T cells efficiently control the proliferation of tumor cells through major histocompatibility complex class I-mediated mechanisms; nevertheless, the presence of tumor-infiltrating CD8(+) T cells in lesional tissue does not always correlate with better prognosis and increased survival of cancer patients. Similarly, adoptive transfer of tumor-specific cytotoxic T cells has only shown marginal improvement in life spans of patients with metastatic disease. In this report, we discuss experimental evidence showing that expression of tumor-derived galectins, galectin (Gal)-1, Gal-3 and Gal-9, and concomitant presence of their ligands on the surface of anti-tumor immunocytes directly compromise anti-tumor CD8(+) T cell immune responses and, perhaps, undermine the promise of adoptive CD8(+) T cell immunotherapy. Furthermore, we describe novel strategies designed to counteract Gal-1-, Gal-3- and Gal-9-mediated effects and highlight their targeting potential for creating more effective anti-tumor immune responses. We believe that Gal and their ligands represent an efficacious targeted molecular paradigm that warrants clinical evaluation.
MeSH term(s)	Animals ; Cytotoxicity, Immunologic ; Galectins/metabolism ; Humans ; Ligands ; Neoplasms/immunology ; Neoplasms/metabolism ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Escape
Chemical Substances	Galectins ; Ligands
Language	English
Publishing date	2012-04-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	283770-5
ISSN	1573-4986 ; 0282-0080
ISSN (online)	1573-4986
ISSN	0282-0080
DOI	10.1007/s10719-012-9379-0
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Article: Cryptococcal cellulitis in a heart transplant recipient.

Ashchyan, Hovik J / Blumberg, Emily / Cedeno-Laurent, Filiberto / Olson, Taylor / Xu, Xiaowei / Taylor, Laura A / Micheletti, Robert G / Rosenbach, Misha

JAAD case reports

2016 Volume 2, Issue 5, Page(s) 403–405

Language	English
Publishing date	2016-10-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2016.08.005
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Article ; Online: Galectin-1 research in T cell immunity: past, present and future.

Cedeno-Laurent, Filiberto / Dimitroff, Charles J

Clinical immunology (Orlando, Fla.)

2011 Volume 142, Issue 2, Page(s) 107–116

Abstract: Galectin-1 (Gal-1) is one of 15 evolutionarily conserved ß-galactoside-binding proteins that display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is variably expressed on immune cells and endothelial cells, though is ... ...

Abstract	Galectin-1 (Gal-1) is one of 15 evolutionarily conserved ß-galactoside-binding proteins that display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is variably expressed on immune cells and endothelial cells, though is commonly found and secreted at high levels in cancer cells. It induces apoptosis in effector T cells through homodimeric binding of N-acetyllactosamines on membrane glycoproteins (Gal-1 ligands). There is also compelling evidence in models of cancer and autoimmunity that recombinant Gal-1 (rGal-1) can potentiate immunoregulatory function of T cells. Here, we review Gal-1's structural and functional features, while analyzing potential drawbacks and technical difficulties inherent to rGal-1's nature. We also describe new Gal-1 preparations that exhibit dimeric stability and functional activity on T cells, providing renewed excitement for studying Gal-1 efficacy and/or use as anti-inflammatory therapeutics. We lastly summarize strategies targeting the Gal-1-Gal-1 ligand axis to circumvent Gal-1-driven immune escape in cancer and boost anti-tumor immunity.
MeSH term(s)	Amino Sugars/immunology ; Amino Sugars/metabolism ; Animals ; Apoptosis/immunology ; Cell Survival/immunology ; Galectin 1/chemistry ; Galectin 1/history ; Galectin 1/immunology ; Galectin 1/metabolism ; History, 21st Century ; Humans ; Immunomodulation/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/therapy ; Ligands ; Lymphocyte Activation/immunology ; Mice ; Mice, Knockout ; Models, Immunological ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Chemical Substances	Amino Sugars ; Galectin 1 ; Ligands ; Recombinant Proteins ; N-acetyllactosamine (3Y5B2K5OOK)
Language	English
Publishing date	2011-10-06
Publishing country	United States
Document type	Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2011.09.011
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Article ; Online: Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides.

Cedeno-Laurent, Filiberto / Wysocka, Maria / Obstfeld, Amrom E / Novoa, Roberto A / Vittorio, Carmela C / Kim, Ellen J / Weng, Wen-Kai / Rook, Alain H

Journal of cutaneous pathology

2017 Volume 44, Issue 5, Page(s) 462–466

Abstract: Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual ... ...

Abstract	Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T-cells with high CD26 expression. Polymerase chain reaction studies and high-throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T-cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.
MeSH term(s)	Aged ; Biomarkers, Tumor ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; Dermatitis, Exfoliative/metabolism ; Dermatitis, Exfoliative/pathology ; Dipeptidyl Peptidase 4/biosynthesis ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Leukemic ; Humans ; Leukemia, T-Cell/metabolism ; Leukemia, T-Cell/pathology ; Mycosis Fungoides/metabolism ; Mycosis Fungoides/pathology ; Neoplasm Proteins/biosynthesis ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; Neoplasm Proteins ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.12899
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Zs.A 1043: Show issues

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Article ; Online: Gliomas and brain lymphomas in HIV-1/AIDS patients

Filiberto Cedeno-Laurent / J. Roberto Trujillo

Microbiology Research , Vol 2, Iss 1, Pp e11-e

reflections from a 20-year follow up in Mexico and Brazil

2011 Volume 11

Abstract: Opportunistic infections and invasive primary tumors represent major causes of morbidity and mortality in HIV-1-infected individuals. HIV-1 involvement of the central nervous system (CNS) affects nearly half of seropositive patients, being the primary ... ...

Abstract	Opportunistic infections and invasive primary tumors represent major causes of morbidity and mortality in HIV-1-infected individuals. HIV-1 involvement of the central nervous system (CNS) affects nearly half of seropositive patients, being the primary CNS lymphoma (PCNSL) a hallmark neoplasia of this population. Interestingly, the incidence of other brain tumors (e.g. gliomas) is exceedingly rare in AIDS patients, and their co-morbidity has been limited to case reports. Here, we share our 20-year experience following brain tumors in HIV-1/AIDS patients from major referral hospitals in Mexico and Brazil. Additionally, we provide the most updated compilation of reported glioma cases in AIDS patients, with a thorough epidemiological analysis. Furthermore, we discuss HIV-1-driven mechanisms that would theoretically increase malignant transformation of glial cells; while offering newly reported explanations as to why protease inhibitors, key components of multi-drug anti-retroviral schemes, may be responsible for such a low co-incidence of gliomas in HIV-1 infected individuals.
Keywords	Lymphomas ; gliomas ; HIV-1 ; AIDS. ; Microbiology ; QR1-502 ; Science ; Q
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Polydactylous Longitudinal Melanonychia Acquired following Total Skin Electron Beam Radiation Therapy for Sézary Syndrome

Cedeno-Laurent, Filiberto / Kim, Ellen J. / Rook, Alain H. / Vittorio, Carmela C. / Rubin, Adam I.

Skin Appendage Disorders

2015 Volume 1, Issue 2, Page(s) 60–61

Institution	Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa., USA
Keywords	Lymphoma ; Melanonychia ; Radiation therapy
Language	English
Publishing date	2015-06-03
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Letter to the Editor
ZDB-ID	2806972-9
ISSN	2296-9160 ; 2296-9195
ISSN (online)	2296-9160
ISSN	2296-9195
DOI	10.1159/000398817
Database	Karger publisher's database

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Article ; Online: Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities.

Cedeno-Laurent, Filiberto / Singer, Elisha M / Wysocka, Maria / Benoit, Bernice M / Vittorio, Carmela C / Kim, Ellen J / Yosipovitch, Gil / Rook, Alain H

Clinical immunology (Orlando, Fla.)

2015 Volume 158, Issue 1, Page(s) 1–7

Abstract: Pruritus is one of the cardinal symptoms found in patients with leukemic cutaneous T cell lymphoma (CTCL). The nature of the pruritus experienced by CTCL patients is complex, involving different pathways and cell mediators, thus making it poorly ... ...

Abstract	Pruritus is one of the cardinal symptoms found in patients with leukemic cutaneous T cell lymphoma (CTCL). The nature of the pruritus experienced by CTCL patients is complex, involving different pathways and cell mediators, thus making it poorly responsive to conventional anti-itch therapies. Recent reports highlight the role of interleukin 31 (IL-31) as a novel cytokine involved in the pathogenesis of pruritus in atopic dermatitis and CTCL. Here we provide both in vivo and in vitro evidence suggesting that histone deacetylase (HDAC) inhibitors may mitigate itch through lowering of levels of IL-31-expressing T cells. Furthermore, we demonstrate that chemokine receptor type-4 (CCR4)-bearing T cells are a main source of IL-31 in CTCL, and that neutralizing the IL-31 pathway through targeting of the CCR4-expressing T cells may represent a promising therapeutic strategy for symptomatic relief in CTCL.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Depsipeptides/pharmacology ; Depsipeptides/therapeutic use ; Dexamethasone/pharmacology ; Dexamethasone/therapeutic use ; Female ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/therapeutic use ; In Vitro Techniques ; Interleukins/immunology ; Lymphoma, T-Cell, Cutaneous/complications ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/immunology ; Male ; Middle Aged ; Pruritus/drug therapy ; Pruritus/etiology ; Pruritus/immunology ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Skin Neoplasms/complications ; Skin Neoplasms/drug therapy ; Skin Neoplasms/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Treatment Outcome
Chemical Substances	Depsipeptides ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; IL31 protein, human ; Interleukins ; RNA, Messenger ; vorinostat (58IFB293JI) ; Dexamethasone (7S5I7G3JQL) ; romidepsin (CX3T89XQBK)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2015.02.014
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Article ; Online: Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.

Cedeno-Laurent, Filiberto / Opperman, Matthew / Barthel, Steven R / Kuchroo, Vijay K / Dimitroff, Charles J

Journal of immunology (Baltimore, Md. : 1950)

2012 Volume 188, Issue 7, Page(s) 3127–3137

Abstract: Galectin-1 (Gal-1), a β-galactoside-binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound ... ...

Abstract	Galectin-1 (Gal-1), a β-galactoside-binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10 synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor pathway, independent of APCs. Gal-1-induced IL-10(+) T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation, and tumor immunity.
MeSH term(s)	Adoptive Transfer ; Animals ; Antibodies, Monoclonal/pharmacology ; Cytokines/biosynthesis ; Cytokines/genetics ; Dermatitis, Allergic Contact/immunology ; Dermatitis, Allergic Contact/therapy ; Dimerization ; Galectin 1/antagonists & inhibitors ; Galectin 1/genetics ; Galectin 1/immunology ; Galectin 1/pharmacology ; Gene Expression Regulation/immunology ; Humans ; Immune Tolerance ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Interleukin-10/deficiency ; Interleukin-10/metabolism ; Melanoma, Experimental/immunology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Recombinant Fusion Proteins/pharmacology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/transplantation ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Helper-Inducer/transplantation ; Transcription Factors/physiology ; Tumor Escape/immunology
Chemical Substances	Antibodies, Monoclonal ; Cytokines ; Galectin 1 ; Immunoglobulin Fc Fragments ; Recombinant Fusion Proteins ; Transcription Factors ; Interleukin-10 (130068-27-8)
Keywords	covid19
Language	English
Publishing date	2012-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1103433
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