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Article: Presence of WT1 in nuclear messenger RNP particles in the human acute myeloid leukemia cell lines HL60 and K562.

Morrison, Avril A / Ladomery, Michael R

2006 Volume 244, Issue 1, Page(s) 136–141

Abstract: The WT1 gene is a key player in acute myeloid leukaemia, in which it is frequently over-expressed. WT1 encodes a multifunctional zinc finger protein transcription factor, which also binds mRNA. Thus increasing evidence suggests that WT1 works both at the ...

Abstract	The WT1 gene is a key player in acute myeloid leukaemia, in which it is frequently over-expressed. WT1 encodes a multifunctional zinc finger protein transcription factor, which also binds mRNA. Thus increasing evidence suggests that WT1 works both at the DNA and mRNA level, not only in the urogenital system but also in other contexts. Nuclear poly(A)(+) mRNP particles were isolated by oligo(dT) chromatography from the human acute myeloid leukemia cell lines HL60 and K562, and analysed by Western blotting and 2D minigels. MALDI-TOF demonstrated the presence of hnRNP proteins, splice factors, and unexpectedly vimentin in the mRNP fraction. WT1 was also shown to be present in nuclear mRNP particles suggesting that in leukaemia, and by extension in all cancers in which it is involved, WT1 works both at the DNA and mRNA target level.
MeSH term(s)	Acute Disease ; Cell Nucleus/metabolism ; DNA/genetics ; DNA/metabolism ; Electrophoresis, Gel, Two-Dimensional ; HL-60 Cells ; Humans ; K562 Cells ; Leukemia, Myeloid/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleoproteins/analysis ; Ribonucleoproteins/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; WT1 Proteins/analysis ; WT1 Proteins/metabolism
Chemical Substances	RNA, Messenger ; Ribonucleoproteins ; WT1 Proteins ; messenger ribonucleoprotein ; DNA (9007-49-2)
Language	English
Publishing date	2006-11-28
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2005.12.018
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Article: The post-transcriptional roles of WT1, a multifunctional zinc-finger protein.

Morrison, Avril A / Viney, Rebecca L / Ladomery, Michael R

Biochimica et biophysica acta

2008 Volume 1785, Issue 1, Page(s) 55–62

Abstract: WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C(2)-H(2) zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple ... ...

Abstract	WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C(2)-H(2) zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple levels: it is involved in the development of several organ systems; and is both a tumour suppressor and oncogene. Here we review evidence that has accumulated over the past decade to suggest that as well as binding DNA, WT1 also binds mRNA targets via its zinc fingers and interacts with several splice factors. WT1's first reported post-transcriptional function is also reviewed. WT1's complex roles in development and disease now need to be understood in terms of both DNA and mRNA targets.
MeSH term(s)	Alternative Splicing ; Animals ; Gene Expression Regulation ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Mice ; Models, Biological ; Protein Binding ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism ; Ribonucleoproteins/chemistry ; WT1 Proteins/physiology ; Zinc Fingers/physiology
Chemical Substances	RNA, Messenger ; Ribonucleoproteins ; WT1 Proteins ; messenger ribonucleoprotein
Language	English
Publishing date	2008-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbcan.2007.10.002
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Article: New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.

Morrison, Avril A / Viney, Rebecca L / Saleem, Moin A / Ladomery, Michael R

American journal of physiology. Renal physiology

2008 Volume 295, Issue 1, Page(s) F12–7

Abstract: The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to the ... ...

Abstract	The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to the glomerular podocytes. Several human nephrotic diseases arise from mutations of the WT1 gene, including mutations that affect its zinc-fingers and alternative splicing of +/- KTS isoforms. These include WAGR (for Wilms tumor, aniridia, genitourinary anomalies, and mental retardation), and Frasier and Denys-Drash syndromes. Recent advances including the development of transgenic mouse models and conditionally immortalized podocyte cell lines are beginning to shed light on WT1's crucial role in podocyte function.
MeSH term(s)	Animals ; Cell Line ; DNA/metabolism ; Denys-Drash Syndrome/genetics ; Denys-Drash Syndrome/physiopathology ; Frasier Syndrome/genetics ; Genes, Wilms Tumor/physiology ; Humans ; PAX2 Transcription Factor/genetics ; Podocytes/physiology ; RNA, Messenger/metabolism ; WT1 Proteins/genetics ; WT1 Proteins/physiology ; Zinc Fingers/genetics
Chemical Substances	PAX2 Transcription Factor ; PAX2 protein, human ; RNA, Messenger ; WT1 Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603837-2
ISSN	1522-1466 ; 1931-857X ; 0363-6127
ISSN (online)	1522-1466
ISSN	1931-857X ; 0363-6127
DOI	10.1152/ajprenal.00597.2007
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Article: The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.

Bor, Yeou-cherng / Swartz, Jennifer / Morrison, Avril / Rekosh, David / Ladomery, Michael / Hammarskjöld, Marie-Louise

Genes & development

2006 Volume 20, Issue 12, Page(s) 1597–1608

Abstract: The Wilms' tumor 1 (WT1) gene plays an important role in mammalian urogenital development, and dysregulation of this gene is observed in many human cancers. Alternative splicing of WT1 RNA leads to the expression of two major protein isoforms, WT1(+KTS) ... ...

Abstract	The Wilms' tumor 1 (WT1) gene plays an important role in mammalian urogenital development, and dysregulation of this gene is observed in many human cancers. Alternative splicing of WT1 RNA leads to the expression of two major protein isoforms, WT1(+KTS) and WT1(-KTS). Whereas WT1(-KTS) acts as a transcriptional regulator, no clear function has been ascribed to WT1(+KTS), despite the fact that this protein is crucial for normal development. Here we show that WT1(+KTS) functions to enhance expression from RNA possessing a retained intron and containing either a cellular or viral constitutive transport element (CTE). WT1(+KTS) expression increases the levels of unspliced RNA containing a CTE and specifically promotes the association of this RNA with polyribosomes. These studies provide further support for links between different steps in RNA metabolism and for the existence of post-transcriptional operons.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Cytoplasm ; Exons/genetics ; Gene Expression Regulation ; Humans ; Introns/genetics ; Mice ; Molecular Sequence Data ; Mutagenesis, Insertional ; Polyribosomes/metabolism ; Protein Biosynthesis/genetics ; Protein Isoforms ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splicing ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Viral/metabolism ; Regulatory Sequences, Nucleic Acid/genetics ; Viral Proteins/metabolism ; WT1 Proteins/chemistry ; WT1 Proteins/genetics ; WT1 Proteins/metabolism
Chemical Substances	Protein Isoforms ; RNA Precursors ; RNA, Messenger ; RNA, Viral ; Viral Proteins ; WT1 Proteins
Language	English
Publishing date	2006-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.1402306
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Article: A proteomic investigation of glomerular podocytes from a Denys-Drash syndrome patient with a mutation in the Wilms tumour suppressor gene WT1.

Viney, Rebecca L / Morrison, Avril A / van den Heuvel, Lambert P / Ni, Lan / Mathieson, Peter W / Saleem, Moin A / Ladomery, Michael R

Proteomics

2007 Volume 7, Issue 5, Page(s) 804–815

Abstract: Glomerular podocytes are essential for blood filtration in the kidney underpinned by their unique cytoskeletal morphology. An increasing number of kidney diseases are being associated with key podocyte abnormalities. The Wilms tumour suppressor gene (WT1) ...

Abstract	Glomerular podocytes are essential for blood filtration in the kidney underpinned by their unique cytoskeletal morphology. An increasing number of kidney diseases are being associated with key podocyte abnormalities. The Wilms tumour suppressor gene (WT1) encodes a zinc finger protein with a crucial role in normal kidney development; and in the adult, WT1 is required for normal podocyte function. Denys-Drash Syndrome (DDS) results from mutations affecting the zinc finger domain of WT1. The aim of this study was to undertake, for the first time, a proteomic analysis of cultured human podocytes; and to analyse the molecular changes in DDS podocytes. The morphology of DDS podocytes was highly irregular, reminiscent of a fibroblastic appearance. A reference 2-D gel was generated, and 75 proteins were identified of which 43% involved in cytoskeletal architecture. The DDS and wild-type proteomes were compared by 2-D DIGE. The level of 95.6% of proteins was unaltered; but 4.4% were altered more than two-fold. A sample of proteins involved in cytoskeletal architecture appeared to be misexpressed in DDS podocytes. Consistent with this finding, overall levels of filamentous actin also appeared reduced in DDS podocytes. We conclude that one of WT1 functions in podocytes is to regulate the expression of key components and regulators of the cytoskeleton.
MeSH term(s)	Amino Acid Substitution ; Cells, Cultured ; Child ; Denys-Drash Syndrome/genetics ; Denys-Drash Syndrome/metabolism ; Humans ; Podocytes/metabolism ; Proteome/metabolism ; Proteomics ; WT1 Proteins/genetics
Chemical Substances	Proteome ; WT1 Proteins
Language	English
Publishing date	2007-02-13
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2032093-0
ISSN	1615-9861 ; 1615-9853
ISSN (online)	1615-9861
ISSN	1615-9853
DOI	10.1002/pmic.200600666
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Article: Sudden rise in uptake of hepatitis B vaccination among injecting drug users associated with a universal vaccine programme in prisons.

Hutchinson, Sharon J / Wadd, Sarah / Taylor, Avril / Bird, Sheila M / Mitchell, Alan / Morrison, David S / Ahmed, Syed / Goldberg, David J

Vaccine

2004 Volume 23, Issue 2, Page(s) 210–214

Abstract: Hitherto, services have failed to deliver the UK Government's 1988 recommendation to vaccinate injecting drug users (IDUs) against hepatitis B virus (HBV). In April 1999, the Scottish Prison Service implemented an initiative to offer HBV vaccination to ... ...

Abstract	Hitherto, services have failed to deliver the UK Government's 1988 recommendation to vaccinate injecting drug users (IDUs) against hepatitis B virus (HBV). In April 1999, the Scottish Prison Service implemented an initiative to offer HBV vaccination to all inmates; we sought to determine the impact of this initiative on the IDU population. Among community-recruited IDUs (who had injected for < or =5 years) in Glasgow, vaccine uptake was significantly higher among those surveyed in 2001-2002 (52% of 387) than in 1993 (16% of 166), 1994 (19% of 138) or January-March 1999 (15% of 128); of the 2001-2002 vaccinees, 56% had been vaccinated in prison. Our results indicate that the universal offer of vaccination to all prisoners, within two years of the initiative's implementation, has had a dramatic impact on uptake among IDUs.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Female ; Hepatitis B/epidemiology ; Hepatitis B/transmission ; Hepatitis B Vaccines/administration & dosage ; Hepatitis B Vaccines/immunology ; Humans ; Male ; Prisoners ; Substance Abuse, Intravenous/epidemiology ; Surveys and Questionnaires ; Vaccination
Chemical Substances	Hepatitis B Vaccines
Language	English
Publishing date	2004-11-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2004.05.019
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Zs.MO 458: Show issues

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Article ; Online: Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial.

Newby, David E / Williams, Michelle C / Flapan, Andrew D / Forbes, John F / Hargreaves, Allister D / Leslie, Stephen J / Lewis, Steff C / McKillop, Graham / McLean, Scott / Reid, John H / Sprat, James C / Uren, Neal G / van Beek, Edwin J / Boon, Nicholas A / Clark, Liz / Craig, Peter / Flather, Marcus D / McCormack, Chiara / Roditi, Giles /

Timmis, Adam D / Krishan, Ashma / Donaldson, Gillian / Fotheringham, Marlene / Hall, Fiona J / Neary, Paul / Cram, Louisa / Perkins, Sarah / Taylor, Fiona / Eteiba, Hany / Rae, Alan P / Robb, Kate / Barrie, Dawn / Bissett, Kim / Dawson, Adelle / Dundas, Scot / Fogarty, Yvonne / Ramkumar, Prasad Guntur / Houston, Graeme J / Letham, Deborah / O'Neill, Linda / Pringle, Stuart D / Ritchie, Valerie / Sudarshan, Thiru / Weir-McCall, Jonathan / Cormack, Alistair / Findlay, Iain N / Hood, Stuart / Murphy, Clare / Peat, Eileen / Allen, Barbara / Baird, Andrew / Bertram, Danielle / Brian, David / Cowan, Amy / Cruden, Nicholas L / Dweck, Marc R / Flint, Laura / Fyfe, Samantha / Keanie, Collette / MacGillivray, Tom J / Maclachlan, David S / MacLeod, Margaret / Mirsadraee, Saeed / Morrison, Avril / Mills, Nicholas L / Minns, Fiona C / Phillips, Alyson / Queripel, Laura J / Weir, Nicholas W / Bett, Fiona / Divers, Frances / Fairley, Katie / Jacob, Ashok J / Keegan, Edith / White, Tricia / Gemmill, John / Henry, Margo / McGowan, James / Dinnel, Lorraine / Francis, C Mark / Sandeman, Dennis / Yerramasu, Ajay / Berry, Colin / Boylan, Heather / Brown, Ammani / Duffy, Karen / Frood, Alison / Johnstone, Janet / Lanaghan, Kirsten / MacDuff, Ross / MacLeod, Martin / McGlynn, Deborah / McMillan, Nigel / Murdoch, Laura / Noble, Colin / Paterson, Victoria / Steedman, Tracey / Tzemos, Nikolaos

Trials

2012 Volume 13, Page(s) 184

Abstract: Background: Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues to be under-diagnosed and many ... ...

Abstract	Background: Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues to be under-diagnosed and many patients are left untreated and at risk. Recent advances in imaging technology have now led to the widespread use of noninvasive computed tomography, which can be used to measure coronary artery calcium scores and perform coronary angiography in one examination. However, this technology has not been robustly evaluated in its application to the clinic. Methods/design: The SCOT-HEART study is an open parallel group prospective multicentre randomized controlled trial of 4,138 patients attending the rapid access chest pain clinic for evaluation of suspected cardiac chest pain. Following clinical consultation, participants will be approached and randomized 1:1 to receive standard care or standard care plus ≥64-multidetector computed tomography coronary angiography and coronary calcium score. Randomization will be conducted using a web-based system to ensure allocation concealment and will incorporate minimization. The primary endpoint of the study will be the proportion of patients diagnosed with angina pectoris secondary to coronary heart disease at 6 weeks. Secondary endpoints will include the assessment of subsequent symptoms, diagnosis, investigation and treatment. In addition, long-term health outcomes, safety endpoints, such as radiation dose, and health economic endpoints will be assessed. Assuming a clinic rate of 27.0% for the diagnosis of angina pectoris due to coronary heart disease, we will need to recruit 2,069 patients per group to detect an absolute increase of 4.0% in the rate of diagnosis at 80% power and a two-sided P value of 0.05. The SCOT-HEART study is currently recruiting participants and expects to report in 2014. Discussion: This is the first study to look at the implementation of computed tomography in the patient care pathway that is outcome focused. This study will have major implications for the management of patients with cardiovascular disease. Trial registration: ClinicalTrials.gov Identifier: NCT01149590.
MeSH term(s)	Angina Pectoris/diagnostic imaging ; Angina Pectoris/etiology ; Angina Pectoris/therapy ; Cardiology Service, Hospital ; Clinical Protocols ; Coronary Angiography/methods ; Coronary Disease/complications ; Coronary Disease/diagnostic imaging ; Coronary Disease/therapy ; Decision Support Techniques ; Emergency Service, Hospital ; Health Services Accessibility ; Humans ; Multidetector Computed Tomography ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Research Design ; Risk Factors ; Scotland ; Time Factors ; Time-to-Treatment
Language	English
Publishing date	2012-10-04
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/1745-6215-13-184
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Article ; Online: Developing human capital for successful implementation of international marine scientific research projects.

Morrison, R J / Zhang, J / Urban, E R / Hall, J / Ittekkot, V / Avril, B / Hu, L / Hong, G H / Kidwai, S / Lange, C B / Lobanov, V / Machiwa, J / San Diego-McGlone, M L / Oguz, T / Plumley, F G / Yeemin, T / Zhu, W / Zuo, F

Marine pollution bulletin

2013 Volume 77, Issue 1-2, Page(s) 11–22

Abstract: The oceans play a crucial role in the global environment and the sustainability of human populations, because of their involvement in climate regulation and provision of living and non-living resources to humans. Maintenance of healthy oceans in an era ... ...

Abstract	The oceans play a crucial role in the global environment and the sustainability of human populations, because of their involvement in climate regulation and provision of living and non-living resources to humans. Maintenance of healthy oceans in an era of increasing human pressure requires a high-level understanding of the processes occurring in the marine environment and the impacts of anthropogenic activities. Effective protection and sustainable resource management must be based, in part, on knowledge derived from successful research. Current marine research activities are being limited by a need for high-quality researchers capable of addressing critical issues in broad multidisciplinary research activities. This is particularly true for developing countries which will require the building of capacity for marine scientific research. This paper reviews the current activities aimed at increasing marine research capacity in developing and emerging countries and analyses the challenges faced, including: appropriate alignment of the research goals and societal and policy-relevant needs; training in multidisciplinary research; increasing capacity for overall synthesis of scientific data; building the capacity of technical staff; keeping highly qualified personnel in marine scientific research roles; cross-cultural issues in training; minimising duplication in training activities; improving linkages among human capital, project resources and infrastructure. Potential solutions to these challenges are provided, along with some priorities for action aimed at improving the overall research effort.
MeSH term(s)	Community Participation ; Conservation of Natural Resources/methods ; Developing Countries ; Environment ; Humans ; Oceans and Seas ; Research
Language	English
Publishing date	2013-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2013.09.001
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Article: Developing human capital for successful implementation of international marine scientific research projects

Morrison, R.J / B. Avril / C.B. Lange / E.R. Urban / F. Zuo / F.G. Plumley / G.H. Hong / J. Hall / J. Machiwa / J. Zhang / L. Hu / M.L. San Diego-McGlone / S. Kidwai / T. Oguz / T. Yeemin / V. Ittekkot / V. Lobanov / W. Zhu

Marine pollution bulletin. 2013 Dec. 15, v. 77, no. 1-2

2013

Abstract	The oceans play a crucial role in the global environment and the sustainability of human populations, because of their involvement in climate regulation and provision of living and non-living resources to humans. Maintenance of healthy oceans in an era of increasing human pressure requires a high-level understanding of the processes occurring in the marine environment and the impacts of anthropogenic activities. Effective protection and sustainable resource management must be based, in part, on knowledge derived from successful research. Current marine research activities are being limited by a need for high-quality researchers capable of addressing critical issues in broad multidisciplinary research activities. This is particularly true for developing countries which will require the building of capacity for marine scientific research. This paper reviews the current activities aimed at increasing marine research capacity in developing and emerging countries and analyses the challenges faced, including: appropriate alignment of the research goals and societal and policy-relevant needs; training in multidisciplinary research; increasing capacity for overall synthesis of scientific data; building the capacity of technical staff; keeping highly qualified personnel in marine scientific research roles; cross-cultural issues in training; minimising duplication in training activities; improving linkages among human capital, project resources and infrastructure. Potential solutions to these challenges are provided, along with some priorities for action aimed at improving the overall research effort.
Keywords	anthropogenic activities ; climate ; developing countries ; environmental impact ; environmental sustainability ; human capital ; human population ; human resources ; humans ; infrastructure ; marine environment ; oceans ; research projects ; resource management ; water pollution
Language	English
Dates of publication	2013-1215
Size	p. 11-22.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2013.09.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Developing human capital for successful implementation of international marine scientific research projects

Morrison, R.J. / Zhang, J. / Urban, E.R., Jr. / Hall, J. / Ittekkot, V. / Avril, B. / Hu, L. / Hong, G.H. / Kidwai, S. / Lange, C.B. / Lobanov, V. / Machiwa, J. / San Diego-McGlone, M.L. / Oguz, T. / Plumley, F.G. / Yeemin, T. / Zhu, W. / Zuo, F.

Marine pollution bulletin

Volume v. 77,, Issue no. 1

Abstract	The oceans play a crucial role in the global environment and the sustainability of human populations, because of their involvement in climate regulation and provision of living and non-living resources to humans. Maintenance of healthy oceans in an era of increasing human pressure requires a high-level understanding of the processes occurring in the marine environment and the impacts of anthropogenic activities. Effective protection and sustainable resource management must be based, in part, on knowledge derived from successful research. Current marine research activities are being limited by a need for high-quality researchers capable of addressing critical issues in broad multidisciplinary research activities. This is particularly true for developing countries which will require the building of capacity for marine scientific research. This paper reviews the current activities aimed at increasing marine research capacity in developing and emerging countries and analyses the challenges faced, including: appropriate alignment of the research goals and societal and policy-relevant needs; training in multidisciplinary research; increasing capacity for overall synthesis of scientific data; building the capacity of technical staff; keeping highly qualified personnel in marine scientific research roles; cross-cultural issues in training; minimising duplication in training activities; improving linkages among human capital, project resources and infrastructure. Potential solutions to these challenges are provided, along with some priorities for action aimed at improving the overall research effort.
Keywords	developing countries ; anthropogenic activities ; environmental impact ; human capital ; oceans ; humans ; environmental sustainability ; human resources ; marine environment ; human population ; research projects ; water pollution ; infrastructure ; climate ; resource management
Language	English
Document type	Article
ISSN	0025-326X
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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