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  1. Article ; Online: Rechallenge in Immune Checkpoint Inhibitors Associated Renal Tubular Acidosis.

    Shah, Chintan V / Weiner, I David

    Kidney international reports

    2023  Volume 8, Issue 7, Page(s) 1476–1477

    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.05.013
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  2. Article ; Online: A Novel Form of Renal Tubular Acidosis Associated With Immune Checkpoint Inhibitors.

    Shah, Chintan V / Lee, Hyun-Wook / Clapp, William L / Weiner, I David

    Kidney international reports

    2022  Volume 8, Issue 1, Page(s) 197–201

    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.10.019
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  3. Article ; Online: New insights into the molecular regulation of urine concentration.

    Weiner, I David

    American journal of physiology. Renal physiology

    2016  Volume 311, Issue 1, Page(s) F184–5

    MeSH term(s) Urinary Tract Physiological Phenomena ; Urine
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00161.2016
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    Uc I Zs.89: Show issues Location:
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  4. Article ; Online: Sex differences in renal ammonia metabolism.

    Harris, Autumn N / Weiner, I David

    American journal of physiology. Renal physiology

    2020  Volume 320, Issue 1, Page(s) F55–F60

    Abstract: Sexual dimorphic variations are present in many aspects of biology and involve the structure and/or function of nearly every organ system. Acid-base homeostasis is critical for optimal health, and renal ammonia metabolism has a major role in the ... ...

    Abstract Sexual dimorphic variations are present in many aspects of biology and involve the structure and/or function of nearly every organ system. Acid-base homeostasis is critical for optimal health, and renal ammonia metabolism has a major role in the maintenance of acid-base homeostasis. Recent studies have shown sex-dependent differences in renal ammonia metabolism with regard to both basal ammonia excretion and the response to an exogenous acid load. These sexual dimorphisms are associated with structural changes in the proximal tubule and the collecting duct and variations in the expression of multiple proteins involved in ammonia metabolism and transport. Studies using orchiectomy-induced testosterone deficiency and physiological testosterone replacement have shown that testosterone underlies much of the sex-dependent differences in the proximal tubule. This parallels the finding that the canonical testosterone target receptor, androgen receptor (AR), is present exclusively in the proximal tubule. Thus testosterone, possibly acting through AR activation, regulates multiple components of renal structure and ammonia metabolism. The lack of detectable AR in the remainder of the nephron and collecting duct suggests that some dimorphisms in renal structure and ammonia transporter expression are mediated through mechanisms other than direct testosterone-dependent AR activation. A better understanding of the mechanism and biological implications of sex's effect on renal structure and ammonia metabolism is critical for optimizing our ability to care for both men and women with acid-base disturbances.
    MeSH term(s) Acid-Base Equilibrium ; Ammonia/metabolism ; Animals ; Female ; Humans ; Hydrogen-Ion Concentration ; Kidney Tubules, Proximal/metabolism ; Male ; Membrane Transport Proteins/metabolism ; Receptors, Androgen/metabolism ; Renal Elimination ; Renal Reabsorption ; Sex Characteristics ; Sex Factors ; Testosterone/metabolism
    Chemical Substances Membrane Transport Proteins ; Receptors, Androgen ; Testosterone (3XMK78S47O) ; Ammonia (7664-41-7)
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00531.2020
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  5. Article ; Online: Untangling the complex relationship between dietary acid load and glucocorticoid metabolism.

    Weiner, I David

    Kidney international

    2016  Volume 90, Issue 2, Page(s) 247–249

    Abstract: The kidney's maintenance of the metabolic component of acid-base homeostasis is critical for normal health. The study by Esche and colleagues in this issue of Kidney International shows that normal children with higher levels of renal net acid excretion ... ...

    Abstract The kidney's maintenance of the metabolic component of acid-base homeostasis is critical for normal health. The study by Esche and colleagues in this issue of Kidney International shows that normal children with higher levels of renal net acid excretion and of dietary acid loads have stimulation of glucocorticoid hormone metabolism. Thus, normal variations in dietary acid intake and renal net acid excretion have important biological correlates.
    MeSH term(s) Acid-Base Equilibrium ; Acids ; Diet ; Glucocorticoids ; Humans ; Kidney
    Chemical Substances Acids ; Glucocorticoids
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2016.04.011
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    Zs.A 797: Show issues Location:
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  6. Article ; Online: Roles of renal ammonia metabolism other than in acid-base homeostasis.

    Weiner, I David

    Pediatric nephrology (Berlin, Germany)

    2016  Volume 32, Issue 6, Page(s) 933–942

    Abstract: The importance of renal ammonia metabolism in acid-base homeostasis is well known. However, the effects of renal ammonia metabolism other than in acid-base homeostasis are not as widely recognized. First, ammonia differs from almost all other solutes in ... ...

    Abstract The importance of renal ammonia metabolism in acid-base homeostasis is well known. However, the effects of renal ammonia metabolism other than in acid-base homeostasis are not as widely recognized. First, ammonia differs from almost all other solutes in the urine in that it does not result from arterial delivery. Instead, ammonia is produced by the kidney, and only a portion of the ammonia produced is excreted in the urine, with the remainder returned to the systemic circulation through the renal veins. In normal individuals, systemic ammonia addition is metabolized efficiently by the liver, but in patients with either acute or chronic liver disease, conditions that increase the addition of ammonia of renal origin to the systemic circulation can result in precipitation and/or worsening of hyperammonemia. Second, ammonia appears to serve as an intrarenal paracrine signaling molecule. Hypokalemia increases proximal tubule ammonia production and secretion as well as reabsorption in the thick ascending limb of the loop of Henle, thereby increasing delivery to the renal interstitium and the collecting duct. In the collecting duct, ammonia decreases potassium secretion and stimulates potassium reabsorption, thereby decreasing urinary potassium excretion and enabling feedback correction of the initiating hypokalemia. Finally, the stimulation of renal ammonia metabolism by hypokalemia may contribute to the development of metabolic alkalosis, which in turn can stimulate NaCl reabsorption and contribute to the intravascular volume expansion, increased blood pressure and diuretic resistance that can develop with hypokalemia. The evidence supporting these novel non-acid-base roles of renal ammonia metabolism is discussed in this review.
    MeSH term(s) Acid-Base Equilibrium ; Ammonia/blood ; Ammonia/metabolism ; Humans ; Hyperammonemia/blood ; Hyperammonemia/complications ; Hypokalemia/blood ; Hypokalemia/complications ; Kidney Tubules, Collecting/metabolism ; Kidney Tubules, Proximal/metabolism ; Liver/metabolism ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/metabolism ; Potassium/blood ; Potassium/metabolism ; Renal Elimination ; Sodium Chloride/metabolism
    Chemical Substances Sodium Chloride (451W47IQ8X) ; Ammonia (7664-41-7) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2016-05-12
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-016-3401-x
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    Zs.A 2196: Show issues Location:
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  7. Article ; Online: Cardiac Xenotransplantation: Clinical Impact of Science and Discovery.

    Garry, Daniel J / Weiner, Joshua I / Greising, Sarah M / Garry, Mary G / Sachs, David H

    Circulation

    2022  Volume 146, Issue 13, Page(s) 961–963

    MeSH term(s) Heart ; Heart Transplantation ; Humans ; Transplantation, Heterologous
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.059191
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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.

    Weiner, I David / Verlander, Jill W

    Seminars in nephrology

    2019  Volume 39, Issue 4, Page(s) 394–405

    Abstract: Ammonia metabolism has a critical role in acid-base homeostasis and in other cellular functions. Kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion; ammonia metabolism is the quantitatively ... ...

    Abstract Ammonia metabolism has a critical role in acid-base homeostasis and in other cellular functions. Kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion; ammonia metabolism is the quantitatively greatest component of net acid excretion, both under basal conditions and in response to acid-base disturbances. Several recent studies have advanced our understanding substantially of the molecular mechanisms and regulation of ammonia metabolism. First, the previous paradigm that ammonia transport could be explained by passive NH
    MeSH term(s) Acid-Base Equilibrium/physiology ; Acidosis/metabolism ; Ammonia/metabolism ; Animals ; Biological Transport ; Homeostasis/physiology ; Humans ; Hyperkalemia/metabolism ; Kidney/metabolism
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2019-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2019.04.008
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    Se 784: Show issues Location:
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  9. Article ; Online: The clinical significance of cervical tears' anatomical location - A retrospective study.

    Gluck, Ohad / David, Maayan / Kovo, Michal / Mor, Liat / Kleiner, Ilia / Weiner, Eran / Ginath, Shimon

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 295, Page(s) 215–218

    Abstract: Objective: Up to 4.8% of all vaginal deliveries are complicated by significant cervical tears related to maternal compromise, yet the location of the cervical tear and its impact on the attributed risk have not been studied to date. This study aimed to ... ...

    Abstract Objective: Up to 4.8% of all vaginal deliveries are complicated by significant cervical tears related to maternal compromise, yet the location of the cervical tear and its impact on the attributed risk have not been studied to date. This study aimed to determine the associations between the location and characteristics of cervical tears with short-term maternal complications and outcomes.
    Methods: This is a retrospective cohort study. Included were all patients that delivered vaginally at our institute between the years 2009-2020 and were diagnosed with a cervical tear. Maternal complications were compared between cases with posterior cervical tears and cases with anterior or lateral cervical tears. Exclusion criteria included patients who delivered by cesarean delivery and preterm labor below 37.0 weeks of gestation.
    Results: Overall, 96 patients were diagnosed with posterior cervical tears, while 117 patients were diagnosed with anterior or lateral tears. Maternal demographics and pregnancy characteristics were similar between the groups. There were also no differences in delivery outcomes between the groups. Patients with posterior cervical tears had a higher rate of disseminated intravascular coagulation (DIC) (6.25 % vs. 0.9 %, p = 0.04) and prolonged hospitalization (35.4 % vs. 23.1 %, p = 0.05), as compared to patients with anterior or lateral tears. There were no differences in other maternal complications.
    Conclusions: Cases of posterior cervical tears are at higher risk for maternal adverse outcomes (DIC and prolonged hospitalization), as compared to cases of anterior or lateral tears.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Retrospective Studies ; Clinical Relevance ; Delivery, Obstetric/adverse effects ; Cesarean Section
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.02.022
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  10. Article: Human muscle in gene edited pigs for treatment of volumetric muscle loss.

    Greising, Sarah M / Weiner, Joshua I / Garry, Daniel J / Sachs, David H / Garry, Mary G

    Frontiers in genetics

    2022  Volume 13, Page(s) 948496

    Abstract: Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment ... ...

    Abstract Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.948496
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