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Article ; Online: Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.

Hsieh, Ching-Lin / Leist, Sarah R / Miller, Emily Happy / Zhou, Ling / Powers, John M / Tse, Alexandra L / Wang, Albert / West, Ande / Zweigart, Mark R / Schisler, Jonathan C / Jangra, Rohit K / Chandran, Kartik / Baric, Ralph S / McLellan, Jason S

Nature communications

2024 Volume 15, Issue 1, Page(s) 1553

Abstract: ... neutralizing responses against several sarbecoviruses and protects female BALB/c mice from mouse-adapted SARS ... CoV-2 lethal challenge and partially protects female BALB/c mice from mouse-adapted SARS-CoV lethal ...

Abstract	Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that offers a greater breadth of protection against current and future VOCs would eliminate the need to reformulate COVID-19 vaccines. Here, we rationally engineer the sequence-conserved S2 subunit of the SARS-CoV-2 spike protein and characterize the resulting S2-only antigens. Structural studies demonstrate that the introduction of interprotomer disulfide bonds can lock S2 in prefusion trimers, although the apex samples a continuum of conformations between open and closed states. Immunization with prefusion-stabilized S2 constructs elicits broadly neutralizing responses against several sarbecoviruses and protects female BALB/c mice from mouse-adapted SARS-CoV-2 lethal challenge and partially protects female BALB/c mice from mouse-adapted SARS-CoV lethal challenge. These engineering and immunogenicity results should inform the development of next-generation pan-coronavirus therapeutics and vaccines.
MeSH term(s)	Female ; Animals ; Humans ; Mice ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/prevention & control ; Antigens, Viral/genetics ; Mice, Inbred BALB C ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Neutralizing ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; spike protein, SARS-CoV-2 ; Antigens, Viral ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45404-x
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Article ; Online: Secondary syphilis of the oropharynx and cervical lymph nodes: a case report.

Han, Albert Y / Wang, Jennifer N / Yu, Alice C / Shiba, Travis L

Ear, nose, & throat journal

2022 , Page(s) 1455613221095605

Abstract: Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be ... ...

Abstract	Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be mistaken for head and neck cancer. We report a case of an enlarging throat and painless cystic neck mass in a transgender woman in her forties who was initially suspected to have oropharyngeal squamous cell carcinoma. A subsequent workup revealed the presence of spirochetes without cellular atypia consistent with secondary syphilis. We include the ultrasonography images as well as an endoscopic photograph of the oropharyngeal manifestation in this report.
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221095605
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Article ; Online: Synthesis and Surface Attachment of Molecular Re(I) Complexes Supported by Functionalized Bipyridyl Ligands.

Jia, Xiaofan / Nedzbala, Hannah S / Bottum, Samuel R / Cahoon, James F / Concepcion, Javier J / Donley, Carrie L / Gang, Albert / Han, Qi / Hazari, Nilay / Kessinger, Matthew C / Lockett, Matthew R / Mayer, James M / Mercado, Brandon Q / Meyer, Gerald J / Pearce, Adam J / Rooney, Conor L / Sampaio, Renato N / Shang, Bo / Wang, Hailiang

Inorganic chemistry

2023 Volume 62, Issue 5, Page(s) 2359–2375

Abstract: Eleven 2,2'-bipyridine (bpy) ligands functionalized with attachment groups for covalent immobilization on silicon surfaces were prepared. Five of the ligands feature silatrane functional groups for attachment to metal oxide coatings on the silicon ... ...

Abstract	Eleven 2,2'-bipyridine (bpy) ligands functionalized with attachment groups for covalent immobilization on silicon surfaces were prepared. Five of the ligands feature silatrane functional groups for attachment to metal oxide coatings on the silicon surfaces, while six contain either alkene or alkyne functional groups for attachment to hydrogen-terminated silicon surfaces. The bpy ligands were coordinated to Re(CO)
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c04137
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Article ; Online: Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.

Alzheimer's research & therapy

2023 Volume 15, Issue 1, Page(s) 66

Abstract: Background: Both Alzheimer's disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the ... ...

Abstract	Background: Both Alzheimer's disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition. Methods: Analyses used data from the Preclinical AD Consortium, including harmonized data from 5 longitudinal cohort studies. Participants were cognitively normal at baseline (M baseline age = 64 years, 59% female) and underwent 10 years of follow-up, on average. AD genetic risk was measured by (i) apolipoprotein-E (APOE) genetic status (APOE-ε2 and APOE-ε4 vs. APOE-ε3; N = 1819) and (ii) AD polygenic risk scores (AD-PRS; N = 1175). A CR index was calculated by combining years of education and literacy scores. Longitudinal cognitive performance was measured by harmonized factor scores for global cognition, episodic memory, and executive function. Results: In mixed-effects models, higher CR index scores were associated with better baseline cognitive performance for all cognitive outcomes. APOE-ε4 genotype and AD-PRS that included the APOE region (AD-PRS Conclusions: These results suggest that APOE-ε4 and non-APOE-ε4 AD polygenic risk are independently associated with global cognitive and executive function declines among individuals with normal cognition at baseline, but only APOE-ε4 is associated with declines in episodic memory. Importantly, higher levels of CR may mitigate APOE-ε4-related declines in some cognitive domains. Future research is needed to address study limitations, including generalizability due to cohort demographic characteristics.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Alzheimer Disease/genetics ; Alzheimer Disease/psychology ; Cognitive Reserve ; Apolipoprotein E2/genetics ; Longitudinal Studies ; Apolipoproteins E/genetics ; Genotype ; Apolipoprotein E4/genetics ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/psychology ; Cognition
Chemical Substances	Apolipoprotein E2 ; Apolipoproteins E ; Apolipoprotein E4
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-023-01206-9
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Article ; Online: A hepatitis B virus core antigen-based virus-like particle vaccine expressing SARS-CoV-2 B and T cell epitopes induces epitope-specific humoral and cell-mediated immune responses but confers limited protection against SARS-CoV-2 infection.

Hassebroek, Anna M / Sooryanarain, Harini / Heffron, Connie L / Hawks, Seth A / LeRoith, Tanya / Cecere, Thomas E / Stone, William B / Walter, Debra / Mahsoub, Hassan M / Wang, Bo / Tian, Debin / Ivester, Hannah M / Allen, Irving C / Auguste, Albert J / Duggal, Nisha K / Zhang, Chenming / Meng, Xiang-Jin

Journal of medical virology

2023 Volume 95, Issue 2, Page(s) e28503

Abstract: The hepatitis B virus core antigen (HBcAg) tolerates insertion of foreign epitopes and maintains its ability to self-assemble into virus-like particles (VLPs). We constructed a ∆HBcAg-based VLP vaccine expressing three predicted severe acute respiratory ... ...

Abstract	The hepatitis B virus core antigen (HBcAg) tolerates insertion of foreign epitopes and maintains its ability to self-assemble into virus-like particles (VLPs). We constructed a ∆HBcAg-based VLP vaccine expressing three predicted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B and T cell epitopes and determined its immunogenicity and protective efficacy. The recombinant ∆HBcAg-SARS-CoV-2 protein was expressed in Escherichia coli, purified, and shown to form VLPs. K18-hACE2 transgenic C57BL/6 mice were immunized intramuscularly with ∆HBcAg VLP control (n = 15) or ∆HBcAg-SARS-CoV-2 VLP vaccine (n = 15). One week after the 2nd booster and before virus challenge, five ∆HBcAg-SARS-CoV-2 vaccinated mice were euthanized to evaluate epitope-specific immune responses. There is a statistically significant increase in epitope-specific Immunoglobulin G (IgG) response, and statistically higher interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) expression levels in ∆HBcAg-SARS-CoV-2 VLP-vaccinated mice compared to ∆HBcAg VLP controls. While not statistically significant, the ∆HBcAg-SARS-CoV-2 VLP mice had numerically more memory CD8+ T-cells, and 3/5 mice also had numerically higher levels of interferon gamma (IFN-γ) and tumor necrosis factor (TNF). After challenge with SARS-CoV-2, ∆HBcAg-SARS-CoV-2 immunized mice had numerically lower viral RNA loads in the lung, and slightly higher survival, but the differences are not statistically significant. These results indicate that the ∆HBcAg-SARS-CoV-2 VLP vaccine elicits epitope-specific humoral and cell-mediated immune responses but they were insufficient against SARS-CoV-2 infection.
MeSH term(s)	Mice ; Animals ; Hepatitis B Core Antigens/genetics ; Hepatitis B virus/genetics ; Epitopes, T-Lymphocyte ; SARS-CoV-2 ; Vaccines, Virus-Like Particle ; COVID-19 ; Mice, Inbred C57BL ; Immunity, Cellular ; Recombinant Proteins
Chemical Substances	Hepatitis B Core Antigens ; Epitopes, T-Lymphocyte ; Vaccines, Virus-Like Particle ; Recombinant Proteins
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28503
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Article ; Online: Whole tumor analysis reveals early origin of the TERT promoter mutation and intercellular heterogeneity in TERT expression.

Appin, Christina L / Hong, Chibo / Suwala, Abigail K / Hilz, Stephanie / Mathur, Radhika / Solomon, David A / Smirnov, Ivan V / Stevers, Nicholas O / Shai, Anny / Wang, Albert / Berger, Mitchel S / Chang, Susan M / Phillips, Joanna J / Costello, Joseph F

Neuro-oncology

2023 Volume 26, Issue 4, Page(s) 640–652

Abstract: Background: The TERT promoter mutation (TPM) is acquired in most IDH-wildtype glioblastomas (GBM) and IDH-mutant oligodendrogliomas (OD) enabling tumor cell immortality. Previous studies on TPM clonality show conflicting results. This study was ... ...

Abstract	Background: The TERT promoter mutation (TPM) is acquired in most IDH-wildtype glioblastomas (GBM) and IDH-mutant oligodendrogliomas (OD) enabling tumor cell immortality. Previous studies on TPM clonality show conflicting results. This study was performed to determine whether TPM is clonal on a tumor-wide scale. Methods: We investigated TPM clonality in relation to presumed early events in 19 IDH-wildtype GBM and 10 IDH-mutant OD using 3-dimensional comprehensive tumor sampling. We performed Sanger sequencing on 264 tumor samples and deep amplicon sequencing on 187 tumor samples. We obtained tumor purity and copy number estimates from whole exome sequencing. TERT expression was assessed by RNA-seq and RNAscope. Results: We detected TPM in 100% of tumor samples with quantifiable tumor purity (219 samples). Variant allele frequencies (VAF) of TPM correlate positively with chromosome 10 loss in GBM (R = 0.85), IDH1 mutation in OD (R = 0.87), and with tumor purity (R = 0.91 for GBM; R = 0.90 for OD). In comparison, oncogene amplification was tumor-wide for MDM4- and most EGFR-amplified cases but heterogeneous for MYCN and PDGFRA, and strikingly high in low-purity samples. TPM VAF was moderately correlated with TERT expression (R = 0.52 for GBM; R = 0.65 for OD). TERT expression was detected in a subset of cells, solely in TPM-positive samples, including samples equivocal for tumor. Conclusions: On a tumor-wide scale, TPM is among the earliest events in glioma evolution. Intercellular heterogeneity of TERT expression, however, suggests dynamic regulation during tumor growth. TERT expression may be a tumor cell-specific biomarker.
MeSH term(s)	Humans ; Brain Neoplasms/pathology ; Glioma/pathology ; Glioblastoma/genetics ; Glioblastoma/pathology ; Oligodendroglioma/genetics ; Mutation ; Biomarkers, Tumor/genetics ; Isocitrate Dehydrogenase/genetics ; Telomerase/genetics ; Proto-Oncogene Proteins/genetics ; Cell Cycle Proteins/genetics
Chemical Substances	Biomarkers, Tumor ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; Telomerase (EC 2.7.7.49) ; TERT protein, human (EC 2.7.7.49) ; MDM4 protein, human ; Proto-Oncogene Proteins ; Cell Cycle Proteins
Language	English
Publishing date	2023-12-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noad231
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Article ; Online: Author Correction: Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.

Nature medicine

2024 Volume 30, Issue 3, Page(s) 909–910

Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02778-7
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Article: Caldesmon and the regulation of cytoskeletal functions.

Wang, C L Albert

Advances in experimental medicine and biology

2009 Volume 644, Page(s) 250–272

Abstract: Caldesmon (CaD) is an extraordinary actin-binding protein, because in addition to actin, it also bindsmyosin, calmodulin and tropomyosin. As a component of the smoothmuscle and nonmuscle contractile apparatus CaD inhibits the actomyosin ATPase activity ... ...

Abstract	Caldesmon (CaD) is an extraordinary actin-binding protein, because in addition to actin, it also bindsmyosin, calmodulin and tropomyosin. As a component of the smoothmuscle and nonmuscle contractile apparatus CaD inhibits the actomyosin ATPase activity and its inhibitory action is modulated by both Ca2+ and phosphorylation. The multiplicity of binding partners and diverse biochemical properties suggest CaD is a potent and versatile regulatory protein both in contractility and cell motility. However, after decades ofinvestigation in numerous laboratories, hard evidence is still lacking to unequivocally identify its in vivo functions, although indirect evidence is mounting to support an important role in connection with the actin cytoskeleton. This chapter reviews the highlights of the past findings and summarizes the current views on this protein, with emphasis of its interaction with tropomyosin.
MeSH term(s)	Actomyosin/chemistry ; Animals ; Aorta/metabolism ; Biochemistry/methods ; Calmodulin/chemistry ; Calmodulin-Binding Proteins/metabolism ; Calmodulin-Binding Proteins/physiology ; Cell Movement ; Cytoskeleton/metabolism ; Humans ; Models, Biological ; Myocytes, Smooth Muscle/metabolism ; Phosphorylation ; Protein Structure, Tertiary ; Tropomyosin/chemistry ; Urinary Bladder/metabolism
Chemical Substances	Calmodulin ; Calmodulin-Binding Proteins ; Tropomyosin ; Actomyosin (9013-26-7)
Language	English
Publishing date	2009-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-0-387-85766-4_19
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Article ; Online: Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan.

Luo, Jingqin / Agboola, Folasade / Grant, Elizabeth / Morris, John C / Masters, Colin L / Albert, Marilyn S / Johnson, Sterling C / McDade, Eric M / Fagan, Anne M / Benzinger, Tammie L S / Hassenstab, Jason / Bateman, Randall J / Perrin, Richard J / Wang, Guoqiao / Li, Yan / Gordon, Brian / Cruchaga, Carlos / Day, Gregory S / Levin, Johannes /

Vöglein, Jonathan / Ikeuchi, Takeshi / Suzuki, Kazushi / Allegri, Ricardo F / Xiong, Chengjie

Brain : a journal of neurology

2022 Volume 145, Issue 12, Page(s) 4459–4473

Abstract: The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the molecular imaging of cerebral ... ...

Abstract	The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the molecular imaging of cerebral fibrillar amyloid-β with PET using the 11C-Pittsburgh Compound-B (PiB), MRI-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. By leveraging a large harmonized database from 8 biomarker studies with longitudinal data from 2609 participants in cognition, 873 in MRI biomarkers, 519 in PET PiB imaging and 475 in CSF biomarkers for a median follow-up of 5-6 years, we estimated the longitudinal trajectories of all major Alzheimer disease biomarkers as functions of baseline age that spanned from 18 to 103 years, located the baseline age window at which the longitudinal rates of change accelerated and further examined possible modifying effects of apolipoprotein E (APOE) genotype. We observed that participants 18-45 years at baseline exhibited learning effects on cognition and unexpected directions of change on CSF and PiB biomarkers. The earliest acceleration of longitudinal change occurred for CSF Aβ42 and Aβ42/Aβ40 ratio (with an increase) and for Tau, and pTau181 (with a decrease) at the next baseline age interval of 45-50 years, followed by an accelerated increase for PiB SUVR at the baseline age of 50-55 years and an accelerated decrease for hippocampal volume at the baseline age of 55-60 years and finally by an accelerated decline for cortical thickness and cognition at the baseline age of 65-70 years. Another acceleration in the rate of change occurred at the baseline age of 65-70 years for Aβ42/Aβ40 ratio, Tau, pTau181, PiB SUVR and hippocampal volume. Accelerated declines in hippocampal volume and cognition continued after 70 years. For participants 18-45 years at baseline, significant increases in Aβ42 and Aβ42/Aβ40 ratio and decreases in PiB SUVR occurred in APOE ɛ4 non-carriers but not carriers. After age 45 years, APOE ɛ4 carriers had greater magnitudes than non-carriers in the rates of change for all CSF biomarkers, PiB SUVR and cognition. Our results characterize the temporal evolutions and relative orderings of Alzheimer disease biomarkers across the adult lifespan and the modification effect of APOE ɛ4. These findings may better inform the design of prevention trials on Alzheimer disease.
MeSH term(s)	Humans ; Adult ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Longevity ; tau Proteins ; Positron-Emission Tomography ; Amyloid beta-Peptides ; Biomarkers ; Apolipoproteins E/genetics ; Peptide Fragments ; Longitudinal Studies
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Biomarkers ; Apolipoproteins E ; Peptide Fragments
Language	English
Publishing date	2022-07-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awac238
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Article ; Online: Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.

Bahrani, Ahmed A / Abner, Erin L / DeCarli, Charles S / Barber, Justin M / Sutton, Abigail C / Maillard, Pauline / Sandoval, Francisco / Arfanakis, Konstantinos / Yang, Yung-Chuan / Evia, Arnold M / Schneider, Julie A / Habes, Mohamad / Franklin, Crystal G / Seshadri, Sudha / Satizabal, Claudia L / Caprihan, Arvind / Thompson, Jeffrey F / Rosenberg, Gary A / Wang, Danny J J /

Jann, Kay / Zhao, Chenyang / Lu, Hanzhang / Rosenberg, Paul B / Albert, Marilyn S / Ali, Doaa G / Singh, Herpreet / Schwab, Kristin / Greenberg, Steven M / Helmer, Karl G / Powel, David K / Gold, Brian T / Goldstein, Larry B / Wilcock, Donna M / Jicha, Gregory A

Journal of Alzheimer's disease : JAD

2023 Volume 96, Issue 2, Page(s) 683–693

Abstract: Background: White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker ... ...

Abstract	Background: White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker for clinical trials designed to address vascular cognitive-impairment and dementia and Alzheimer's Disease. Objective: Conducting multi-site cross-site inter-rater and test-retest reliability of the MarkVCID white matter hyperintensity growth and regression protocol. Methods: The NINDS-supported MarkVCID Consortium evaluated a neuroimaging biomarker developed to track WMH change. Test-retest and cross-site inter-rater reliability of the protocol were assessed. Cognitive test scores were analyzed in relation to WMH changes to explore its construct validity. Results: ICC values for test-retest reliability of WMH growth and regression were 0.969 and 0.937 respectively, while for cross-site inter-rater ICC values for WMH growth and regression were 0.995 and 0.990 respectively. Word list long-delay free-recall was negatively associated with WMH growth (p < 0.028) but was not associated with WMH regression. Conclusions: The present data demonstrate robust ICC validity of a WMH growth/regression protocol over a one-year period as measured by cross-site inter-rater and test-retest reliability. These data suggest that this approach may serve an important role in clinical trials of disease-modifying agents for VCID that may preferentially affect WMH growth, stability, or regression.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; Reproducibility of Results ; Magnetic Resonance Imaging ; Alzheimer Disease/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Dementia, Vascular ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-10-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230629
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