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Article ; Online: Calcimimetics treatment strategy for serum calcium and phosphate management in patients with secondary hyperparathyroidism undergoing dialysis: A systematic review and meta-analysis of randomized studies.

Nakai, Kentaro / Kono, Keiji / Yamada, Shunsuke / Taniguchi, Masatomo / Hamano, Takayuki / Fukagawa, Masafumi

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2024

Abstract: Introduction: Several calcimimetics, other than cinacalcet, are commercially available; however, their effects on calcium and phosphate levels have not yet been fully studied. We conducted a systematic review and meta-analysis of randomized controlled ... ...

Abstract	Introduction: Several calcimimetics, other than cinacalcet, are commercially available; however, their effects on calcium and phosphate levels have not yet been fully studied. We conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the impact of calcimimetics on the management of serum calcium and phosphate levels in patients with secondary hyperparathyroidism undergoing dialysis. Methods: A systematic literature search through October 2023 and a meta-analysis were conducted on the effects of upacicalcet, etelcalcetide, evocalcet, and cinacalcet on serum calcium and phosphate levels in patients with secondary hyperparathyroidism undergoing dialysis; we searched PubMed, Ovid MEDLINE, and the Cochrane Central Register of Controlled Trials, and 21 studies comprising 6371 patients undergoing dialysis were included. Results: Participants treated with calcimimetics had lower serum calcium and phosphate levels than placebo. Conclusion: Calcimimetics significantly reduced serum calcium and phosphate levels compared to placebo in patients with secondary hyperparathyroidism undergoing dialysis, independent of therapeutic strategy or concomitant vitamin D treatment.
Language	English
Publishing date	2024-03-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.14125
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Article ; Online: Unveiling controlling factors of the S0/S1 minimum-energy conical intersection (3): Frozen orbital analysis based on the spin-flip theory.

Yoshikawa, Takeshi / Ikabata, Yasuhiro / Nakai, Hiromi / Ogawa, Kentaro / Sakata, Ken

The Journal of chemical physics

2023 Volume 158, Issue 20

Abstract: ... the systematic interpretation of the minimum energy CI (MECI) geometries is unclear. A previous study [Nakai et ...

Abstract	Conical intersections (CIs), which indicate the crossing of two or more adiabatic electronic states, are crucial in the mechanisms of photophysical, photochemical, and photobiological processes. Although various geometries and energy levels have been reported using quantum chemical calculations, the systematic interpretation of the minimum energy CI (MECI) geometries is unclear. A previous study [Nakai et al., J. Phys. Chem. A 122, 8905 (2018)] performed frozen orbital analysis (FZOA) based on time-dependent density functional theory (TDDFT) at the MECI formed between the ground and first electronic excited states (S0/S1 MECI), thereby inductively clarifying two controlling factors. However, one of the factors that the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy gap became close to the HOMO-LUMO Coulomb integral was not valid in the case of spin-flip TDDFT (SF-TDDFT), which is frequently used as a means of the geometry optimization of MECI [Inamori et al., J. Chem. Phys. 152, 144108 (2020)]. This study revisited the controlling factors using FZOA for the SF-TDDFT method. Based on spin-adopted configurations within a minimum active space, the S0-S1 excitation energy is approximately represented by the HOMO and LUMO energy gap ΔεHL, a contribution from Coulomb integrals JHL″ and that from the HOMO-LUMO exchange integral KHL″. Furthermore, numerical applications of the revised formula at the SF-TDDFT method confirmed the control factors of S0/S1 MECI.
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0151492
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Article: [Efficacy and safety of selective estrogen receptor modulators in patients with advanced chronic kidney disease].

Nakai, Kentaro

Clinical calcium

2016 Volume 26, Issue 9, Page(s) 1325–1332

Abstract: Selective estrogen receptor modulators(SERMs)have beneficial effects on the improvement of bone mineral density of the spine and hip, and decrease the vertebral fracture in postmenopausal women. Similar to patients with advanced chronic kidney disease, ... ...

Abstract	Selective estrogen receptor modulators(SERMs)have beneficial effects on the improvement of bone mineral density of the spine and hip, and decrease the vertebral fracture in postmenopausal women. Similar to patients with advanced chronic kidney disease, including dialysis patients, however, SERMs cannot decrease the risk of hip fracture, which is extremely high in Japanese dialysis patients. One of the most important disadvantages of SERMs is an increase in the risk of venous thromboembolic events and fatal stroke in high-risk groups of the Framingham Stroke Risk Score. On the other hand, SERMs may be used in unique osteoporosis drugs for reducing the incidence and progression of breast cancer. Moreover, SERMs attenuate oxidative stress and may lessen the deterioration of kidney function in patients with chronic kidney disease. The evidences for the efficacy and safety of SERMs in patients with advanced chronic kidney disease are insufficient, and knowledge concerning the selection and indication of osteoporosis drugs for those patients need to be developed.
MeSH term(s)	Animals ; Bone Density/drug effects ; Bone Diseases/drug therapy ; Bone Diseases/etiology ; Creatinine/blood ; Humans ; Renal Insufficiency, Chronic/complications ; Selective Estrogen Receptor Modulators/adverse effects ; Selective Estrogen Receptor Modulators/therapeutic use
Chemical Substances	Selective Estrogen Receptor Modulators ; Creatinine (AYI8EX34EU)
Language	Japanese
Publishing date	2016-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa160913251332
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Article ; Online: Making adaptive governance work in biodiversity conservation

Kentaro Miyanaga / Katsuki Nakai

Ecology and Society, Vol 26, Iss 2, p

lessons in invasive alien aquatic plant management in Lake Biwa, Japan

2021 Volume 11

Abstract: Invasive alien species are a serious threat to freshwater ecosystems and overall biodiversity. Although invasive alien species management in the form of environmental governance has often been practiced under an adaptive governance scheme, prevailing ... ...

Abstract	Invasive alien species are a serious threat to freshwater ecosystems and overall biodiversity. Although invasive alien species management in the form of environmental governance has often been practiced under an adaptive governance scheme, prevailing theoretical and practical difficulties must be solved to enhance policy effectiveness and outcomes. Our objective was to clarify how it is possible to make adaptive governance work in biodiversity conservation, especially invasive alien species management in freshwater ecosystems. To fulfill this objective, we investigated two analytical concepts - invasion management and adaptive governance - and studied a case of invasive alien aquatic plant management in Lake Biwa, Japan. The conclusion of our analysis and the lessons learned can be summarized as the following three points: First, whether learning processes are properly equipped by local environmental governance is critical for adaptive governance. We provide insights into three aspects of learning: the system where scientific knowledge is produced and shared for policy preparation, implementation, and evaluation; where social learning and processes that support social learning occur; and where a process of organizational learning occurs. Second, we discuss the role and function of government in adaptive governance, which indicates that interactive governance is possible even when a government initiates a governing process, and that an interactive governing structure would be fundamental for addressing social-ecological complexities and uncertainties. Third, the transition from symptomatic treatments toward precautionary actions for invasive alien species, which is essential for policy effectiveness and outcomes, can be fostered by an interactive governing structure. In addition, organizational learning can induce the transition, through which the competency trap caused by conformity bias in invasive alien species management could be avoided.
Keywords	adaptive governance ; biodiversity conservation ; environmental governance ; invasive alien species ; lake biwa ; ludwigia grandiflora ; Biology (General) ; QH301-705.5 ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Resilience Alliance
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Statin Use Influence on the Occurrence of Acute Kidney Injury in Patients with Peripheral Arterial Disease.

Kanai, Daisuke / Fujii, Hideki / Nakai, Kentaro / Kono, Keiji / Watanabe, Kentaro / Goto, Shunsuke / Nishi, Shinichi

Journal of atherosclerosis and thrombosis

2022 Volume 29, Issue 11, Page(s) 1646–1654

Abstract: Aim: Acute kidney injury (AKI) is an important clinical issue in the diagnosis and treatment of cardiovascular diseases. The association between pretreatment by statins and the occurrence of AKI in patients with peripheral arterial diseases (PAD) ... ...

Abstract	Aim: Acute kidney injury (AKI) is an important clinical issue in the diagnosis and treatment of cardiovascular diseases. The association between pretreatment by statins and the occurrence of AKI in patients with peripheral arterial diseases (PAD) remains unclear. Therefore, we examined the association between statin therapy and the occurrence of AKI in patients with PAD. Methods: We retrospectively analyzed data from the endovascular treatment (EVT) database in our hospital. A total of 295 patients who underwent angiography and/or intervention for PAD between October 2011 and March 2016 were enrolled and divided into two groups: those without statins (control group; N=157) and those with statins (statin group; N=138) for at least 1 month before admission. We examined the occurrence of AKI and its related factors in these patients. Results: The serum creatinine levels, dose of contrast medium, use of a renin-angiotensin system inhibitor, smoking habit, and blood pressure were similar in both groups. The statin group had more diabetes patients, had patients who were significantly younger, had patients with a higher body mass index (BMI), and had patients with lower low-density lipoprotein cholesterol than the control group. With regard to the occurrence of AKI, there was a significantly lower incidence in the statin group compared with the control group (5% vs. 16%, p＜0.05). The result of the multivariate analysis indicated that statin therapy was significantly correlated with lower occurrence rates of AKI (p＜0.05). Conclusions: Our study suggests that statin therapy might prevent the occurrence of AKI after angiography and/or intervention for PAD.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Retrospective Studies ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Contrast Media ; Peripheral Arterial Disease/epidemiology ; Risk Factors
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Contrast Media
Language	English
Publishing date	2022-01-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.63265
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Article: Impact of physician interpretation of at-home ECG on clinically-detected AF.

Senoo, Keitaro / Yukawa, Arito / Iwakoshi, Hibiki / Nishimura, Tetsuro / Shimoo, Satoshi / Inoue, Keiji / Sakatani, Tomohiko / Kakita, Ken / Hattori, Tetsuhisa / Kitajima, Hiroki / Nakai, Kentaro / Nishiuchi, Suguru / Nakata, Mitsuko / Teramukai, Satoshi / Shiraishi, Hirokazu / Matoba, Satoaki

International journal of cardiology. Heart & vasculature

2024 Volume 51, Page(s) 101378

Language	English
Publishing date	2024-03-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2024.101378
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Article ; Online: Methyl-

Niitsu, Hikaru / Fukumitsu, Nobuyoshi / Tanaka, Keiichi / Mizumoto, Masashi / Nakai, Kei / Matsuda, Masahide / Ishikawa, Eiichi / Hatano, Kentaro / Hashimoto, Tsuyoshi / Kamizawa, Satoshi / Sakurai, Hideyuki

Annals of nuclear medicine

2024 Volume 38, Issue 4, Page(s) 305–314

Abstract: Objective: To investigate differences in uptake regions between methyl-: Methods: Twenty consecutive patients with grade 3 or 4 glioma who had recurrence after postoperative radiotherapy (RT) between April 2016 and October 2017 were examined. The ... ...

Abstract	Objective: To investigate differences in uptake regions between methyl- Methods: Twenty consecutive patients with grade 3 or 4 glioma who had recurrence after postoperative radiotherapy (RT) between April 2016 and October 2017 were examined. The study was performed using simulation with the assumption that all patients received RT. The clinical target volume (CTV) was contoured using the Gd-enhanced region (CTV(Gd)), the tumor/normal tissue (T/N) ratios of Results: The Jaccard index (JI) for concordance of CTV (Gd) with CTVs using Conclusions: The region of
MeSH term(s)	Humans ; Methionine ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/pathology ; Glioma/diagnostic imaging ; Glioma/radiotherapy ; Glioma/pathology ; Positron-Emission Tomography/methods ; Racemethionine ; Magnetic Resonance Imaging/methods
Chemical Substances	Methionine (AE28F7PNPL) ; Racemethionine (73JWT2K6T3)
Language	English
Publishing date	2024-02-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1146984-5
ISSN	1864-6433 ; 0914-7187
ISSN (online)	1864-6433
ISSN	0914-7187
DOI	10.1007/s12149-024-01901-z
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Article ; Online: Clostridium paraputrificum Bacteremia in a Patient with Rectal Cancer after Receiving Antibiotic Therapy for Acute Pharyngolaryngitis.

Maeda, Yasunori / Miura, Ryo / Echizenya, Takuma / Hoshi, Kentaro / Kubo, Norihito / Nakai, Hajime / Matsumoto, Kazuhito / Ikejima, Shin / Kudo, Naomi / Matsubara, Atsushi

Internal medicine (Tokyo, Japan)

2023

Abstract: Clostridium paraputrificum bacteremia is very rare, and its clinical importance is poorly understood. An 86-year-old man was receiving lascufloxacin therapy for acute pharyngolaryngitis before presenting to our emergency department with a recurrent fever. ...

Abstract	Clostridium paraputrificum bacteremia is very rare, and its clinical importance is poorly understood. An 86-year-old man was receiving lascufloxacin therapy for acute pharyngolaryngitis before presenting to our emergency department with a recurrent fever. Two sets of blood cultures on admission revealed C. paraputrificum. A stool culture showed a reduced presence of intestinal commensal bacteria. After admission, the patient's fever resolved without antibiotics. Colonoscopy revealed a rectal tumor. Rectal tumor and microbial substitutions caused by antibiotics may have led to bacteremia. When treating C. paraputrificum bacteremia, physicians should be mindful of coexisting gastrointestinal disorders and a history of antibiotic administration.
Language	English
Publishing date	2023-10-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2192-23
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Article: [Magnesium homeostasis and its disturbances].

Nakai, Kentaro

Clinical calcium

2012 Volume 22, Issue 8, Page(s) 1167–1172

Abstract: Magnesium homeostasis is maintained through normal functions of the kidney, intestine, and bone. In the kidney, approximately 80% magnesium is filtered by the glomeruli. In general, 95% filtered magnesium is collectively reabsorbed in the proximal tubule ...

Abstract	Magnesium homeostasis is maintained through normal functions of the kidney, intestine, and bone. In the kidney, approximately 80% magnesium is filtered by the glomeruli. In general, 95% filtered magnesium is collectively reabsorbed in the proximal tubule (15%-20%) , thick ascending limb of Henle (TAL, 65%-75%) , and the distal convoluted tubule (DCT, 5%-10%) . In the TAL, magnesium reabsorption regulated by the paracellular pathway via claudin-16 is driven by electrochemical voltage. Chloride channel Kb and renal outer medullary potassium channels control this lumen-positive voltage. In the DCT, the transcellular pathway via transient receptor potential melastatin 6 (TRPM6) plays a fundamental role in the final 5%-10% magnesium reabsorption. The functions of TRPM6 depend on Na-Cl co-transporters and Na( + )-K( + )-ATPase. Defects in these regulatory proteins may cause inherited or drug-induced disorders of magnesium metabolism. Recently, some proteins have been confirmed to be responsible for magnesium homeostasis however, further research is required to elucidate the mechanisms underlying the maintenance of magnesium homeostasis.
MeSH term(s)	Chloride Channels/physiology ; Claudins/physiology ; Homeostasis/physiology ; Humans ; Intestinal Absorption ; Kidney Tubules, Distal/physiology ; Loop of Henle/physiology ; Magnesium/metabolism ; Potassium Channels/physiology ; Sodium Chloride/metabolism ; Sodium Chloride Symporters/physiology ; Sodium-Potassium-Exchanging ATPase/physiology ; TRPM Cation Channels/physiology ; Tissue Distribution
Chemical Substances	Chloride Channels ; Claudins ; Potassium Channels ; Sodium Chloride Symporters ; TRPM Cation Channels ; TRPM6 protein, human ; claudin 16 ; Sodium Chloride (451W47IQ8X) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Magnesium (I38ZP9992A)
Language	Japanese
Publishing date	2012-08
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa120811671172
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Article ; Online: Conduction gap mapping of linear ablation lesions with high-density mapping.

Nakai, Kentaro / Kashiwa, Asami / Kunitomi, Akira / Matsuoka, Shunzo

Journal of cardiovascular electrophysiology

2020 Volume 31, Issue 8, Page(s) 1953–1963

Abstract: Introduction: When performing linear ablation, creating contiguous and transmural lesions are technically challenging due to the difficulty in finding electrical conduction gaps. We hypothesized that high-density mapping could identify the gaps.: ... ...

Abstract	Introduction: When performing linear ablation, creating contiguous and transmural lesions are technically challenging due to the difficulty in finding electrical conduction gaps. We hypothesized that high-density mapping could identify the gaps. Methods and results: This study included consecutive patients who underwent conduction gap mapping of de novo lesions (41 patients, 55 lines) and previous lesions (25 patients, 34 lines). We analyzed the utility of bipolar and unipolar conduction gap mapping and retrospectively assessed the voltage and morphology of the bipolar electrograms at the gap sites. Bipolar and unipolar propagation maps were classified into three types: the propagation wavefront traveled through the linear ablation lesions (direct leak), the wavefront jumped to an opposite site across the line and returned to the line (jump and return leak), and others (indefinite leak). In the jump and return leak maps, the site where it returned suggested a conduction gap site. Bipolar propagation maps identified 30 (54.5%) conduction gaps and unipolar maps identified 40 (72.7%) gaps at de novo linear ablation lesions (P = .01), and 32 (94.1%) gaps and 33 (97.1%) gaps, respectively, at previous lesions (P = .56). Bipolar voltage mapping did not add any further efficacy in detecting conduction gaps, and the morphology of the electrograms recorded at the gap sites was not related to the types of propagation maps. Conclusion: Conduction gaps of linear ablation lesions can be visualized by high-density mapping with a high probability. Unipolar propagation, when used with bipolar mapping, may help detect conduction gap sites.
MeSH term(s)	Atrial Fibrillation/surgery ; Body Surface Potential Mapping ; Catheter Ablation ; Heart Atria/surgery ; Heart Conduction System/surgery ; Humans ; Retrospective Studies
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.14604
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