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  1. Article: New insights into therapeutic activity and anticancer properties of curcumin.

    Panda, Abir Kumar / Chakraborty, Dwaipayan / Sarkar, Irene / Khan, Tila / Sa, Gaurisankar

    Journal of experimental pharmacology

    2017  Volume 9, Page(s) 31–45

    Abstract: Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to ... ...

    Abstract Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause compared to chemotherapeutic drugs. Furthermore, such natural products perform even better when given as an adjuvant along with traditional chemotherapeutic drugs, thereby enhancing the potential of chemotherapeutics and simultaneously reducing their undesired side effects. Curcumin, a naturally occurring polyphenol compound found in the plant
    Language English
    Publishing date 2017-03-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2587465-2
    ISSN 1179-1454
    ISSN 1179-1454
    DOI 10.2147/JEP.S70568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Curcumin and tumor immune-editing: resurrecting the immune system.

    Bose, Sayantan / Panda, Abir Kumar / Mukherjee, Shravanti / Sa, Gaurisankar

    Cell division

    2015  Volume 10, Page(s) 6

    Abstract: Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies continue on its molecular mechanism of action. ...

    Abstract Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies continue on its molecular mechanism of action. Curcumin has been shown to act in a multi-faceted manner by targeting the classical hallmarks of cancer like sustained proliferation, evasion of apoptosis, sustained angiogenesis, insensitivity to growth inhibitors, tissue invasion and metastasis etc. However, one of the emerging hallmarks of cancer is the avoidance of immune system by tumors. Growing tumors adopt several strategies to escape immune surveillance and successfully develop in the body. In this review we highlight the recent studies that show that curcumin also targets this process and helps restore the immune activity against cancer. Curcumin mediates several processes like restoration of CD4(+)/CD8(+) T cell populations, reversal of type-2 cytokine bias, reduction of Treg cell population and suppression of T cell apoptosis; all these help to resurrect tumor immune surveillance that leads to tumor regression. Thus interaction of curcumin with the immune system is also an important feature of its multi-faceted modes of action against cancer. Finally, we also point out the drawbacks of and difficulties in curcumin administration and indicate the use of nano-formulations of curcumin for better therapeutic efficacy.
    Language English
    Publishing date 2015-10-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1747-1028
    ISSN 1747-1028
    DOI 10.1186/s13008-015-0012-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.

    Saha, Taniya / Guha, Deblina / Manna, Argha / Panda, Abir Kumar / Bhat, Jyotsna / Chatterjee, Subhrangsu / Sa, Gaurisankar

    Scientific reports

    2016  Volume 6, Page(s) 32626

    Abstract: p53 preserves genomic integrity by restricting anomaly at the gene level. Till date, limited information is available for cytosol to nuclear shuttling of p53; except microtubule-based trafficking route, which utilizes minus-end directed motor dynein. The ...

    Abstract p53 preserves genomic integrity by restricting anomaly at the gene level. Till date, limited information is available for cytosol to nuclear shuttling of p53; except microtubule-based trafficking route, which utilizes minus-end directed motor dynein. The present study suggests that monomeric actin (G-actin) guides p53 traffic towards the nucleus. Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin. Co-immunoprecipitation data supports the same. Confocal imaging explores intense perinuclear colocalization between p53 and G-actin. To address atomistic details of the complex, constraint-based docked model of p53:G-actin complex was generated based on crystal structures. MD simulation reveals that p53 DNA-binding domain arrests very well the G-actin protein. Docking benchmark studies have been carried out for a known crystal structure, 1YCS (complex between p53DBD and BP2), which validates the docking protocol we adopted. Co-immunoprecipitation study using "hot-spot" p53 mutants suggested reduced G-actin association with cancer-associated p53 conformational mutants (R175H and R249S). Considering these findings, we hypothesized that point mutation in p53 structure, which diminishes p53:G-actin complexation results in mutant p53 altered subcellular localization. Our model suggests p53Arg249 form polar-contact with Arg357 of G-actin, which upon mutation, destabilizes p53:G-actin interaction and results in cytoplasmic retention of p53R249S.
    Language English
    Publishing date 2016-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep32626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alarming India-wide phenomenon of antifungal resistance in dermatophytes: A multicentre study.

    Ebert, Andreas / Monod, Michel / Salamin, Karine / Burmester, Anke / Uhrlaß, Silke / Wiegand, Cornelia / Hipler, Uta-Christina / Krüger, Constanze / Koch, Daniela / Wittig, Franziska / Verma, Shyam B / Singal, Archana / Gupta, Sanjeev / Vasani, Resham / Saraswat, Abir / Madhu, Rengarajan / Panda, Saumya / Das, Anupam / Kura, Mahendra M /
    Kumar, Akshy / Poojary, Shital / Schirm, Sibylle / Gräser, Yvonne / Paasch, Uwe / Nenoff, Pietro

    Mycoses

    2020  Volume 63, Issue 7, Page(s) 717–728

    Abstract: Background: An alarming increase in recalcitrant dermatophytosis has been witnessed in India over the past decade. Drug resistance may play a major role in this scenario.: Objectives: The aim of the present study was to determine the prevalence of in ...

    Abstract Background: An alarming increase in recalcitrant dermatophytosis has been witnessed in India over the past decade. Drug resistance may play a major role in this scenario.
    Objectives: The aim of the present study was to determine the prevalence of in vitro resistance to terbinafine, itraconazole and voriconazole in dermatophytes, and to identify underlying mutations in the fungal squalene epoxidase (SQLE) gene.
    Patients/methods: We analysed skin samples from 402 patients originating from eight locations in India. Fungi were identified by microbiological and molecular methods, tested for antifungal susceptibility (terbinafine, itraconazole, voriconazole), and investigated for missense mutations in SQLE.
    Results: Trichophyton (T.) mentagrophytes internal transcribed spacer (ITS) Type VIII was found in 314 (78%) samples. Eighteen (5%) samples harboured species identified up to the T interdigitale/mentagrophytes complex, and T rubrum was detected in 19 (5%) samples. 71% of isolates were resistant to terbinafine. The amino acid substitution Phe397Leu in the squalene epoxidase of resistant T mentagrophytes was highly prevalent (91%). Two novel substitutions in resistant Trichophyton strains, Ser395Pro and Ser443Pro, were discovered. The substitution Ala448Thr was found in terbinafine-sensitive and terbinafine-resistant isolates but was associated with increased MICs of itraconazole and voriconazole.
    Conclusions: The high frequencies of terbinafine resistance in dermatophytes are worrisome and demand monitoring and further research. Squalene epoxidase substitutions between Leu393 and Ser443 could serve as markers of resistance in the future.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antifungal Agents/therapeutic use ; Arthrodermataceae/classification ; Arthrodermataceae/drug effects ; Arthrodermataceae/enzymology ; Child ; Drug Resistance, Multiple, Fungal/genetics ; Female ; Fungal Proteins/genetics ; Humans ; India ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mutation, Missense ; Squalene Monooxygenase/genetics ; Young Adult
    Chemical Substances Antifungal Agents ; Fungal Proteins ; Squalene Monooxygenase (EC 1.14.14.17)
    Language English
    Publishing date 2020-05-04
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Biogenic synthesis of silver nanoparticles from

    Mohanta, Yugal Kishore / Panda, Sujogya Kumar / Biswas, Kunal / Tamang, Abiral / Bandyopadhyay, Jaya / De, Debashis / Mohanta, Dambarudhar / Bastia, Akshaya Kumar

    IET nanobiotechnology

    2016  Volume 10, Issue 6, Page(s) 438–444

    Abstract: The present study reports on biogenic-synthesised silver nanoparticles (AgNPs) derived by treating Ag ions with an extract ... ...

    Abstract The present study reports on biogenic-synthesised silver nanoparticles (AgNPs) derived by treating Ag ions with an extract of
    MeSH term(s) Anti-Infective Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Cassia/chemistry ; Cell Line, Tumor ; Humans ; Metal Nanoparticles ; Plant Extracts/pharmacology ; Silver
    Chemical Substances Anti-Infective Agents ; Antineoplastic Agents ; Antioxidants ; Plant Extracts ; Silver (3M4G523W1G)
    Language English
    Publishing date 2016-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2264529-9
    ISSN 1751-875X ; 1751-8741
    ISSN (online) 1751-875X
    ISSN 1751-8741
    DOI 10.1049/iet-nbt.2015.0104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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