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  1. Article: Editorial: Targeting metabolism of cancer cells and host to overcome drug resistance: Preclinical and clinical studies.

    Wang, Lishun / Xu, Hanchen / Wu, Yadi

    Frontiers in oncology

    2023  Volume 13, Page(s) 1154661

    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1154661
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  2. Article ; Online: Epigenetic Regulation and Post-Translational Modifications of SNAI1 in Cancer Metastasis

    Bo Dong / Yadi Wu

    International Journal of Molecular Sciences, Vol 22, Iss 11062, p

    2021  Volume 11062

    Abstract: SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, ... ...

    Abstract SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.
    Keywords SNAI1 ; metastasis ; post-translational modifications ; epigenetic ; EMT ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: [Cloning and functional analysis of

    Wu, Wenhui / Xu, Yang / Zhang, Yadi / Yu, Zhengjiao / Pang, Yumeng / Qin, Lei / Wang, Yong

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2024  Volume 40, Issue 4, Page(s) 1076–1088

    Abstract: Flavin-containing monooxygenase (FMO) is the key enzyme in the biosynthesis pathway of CSOs with sulfur oxidation. In order to explore the molecular regulatory mechanism of FMO in the synthesis of onion CSOs, based on transcriptome database and ... ...

    Abstract Flavin-containing monooxygenase (FMO) is the key enzyme in the biosynthesis pathway of CSOs with sulfur oxidation. In order to explore the molecular regulatory mechanism of FMO in the synthesis of onion CSOs, based on transcriptome database and phylogenetic analysis, one AcFMO gene that may be involved in alliin synthesis was obtained, the AcFMO had a cDNA of 1 374 bp and encoded 457 amino acids, which was evolutionarily closest to the AsFMO of garlic. Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) indicated that AcFMO was the highest in the flowers and the lowest in the leaf sheaths. The results of subcellular localization showed that the AcFMO gene product was widely distributed throughout the cell A yeast expression vector was constructed, and the
    MeSH term(s) Onions/genetics ; Onions/metabolism ; Cloning, Molecular ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Cysteine/biosynthesis ; Cysteine/metabolism ; Cysteine/analogs & derivatives ; Oxygenases/genetics ; Oxygenases/metabolism ; Amino Acid Sequence ; Phylogeny ; Disulfides/metabolism ; Molecular Sequence Data ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances alliin (7I4L2D0E9G) ; Plant Proteins ; Cysteine (K848JZ4886) ; Oxygenases (EC 1.13.-) ; Disulfides
    Language Chinese
    Publishing date 2024-04-24
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; English Abstract
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.230527
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    Zs.A 3505: Show issues Location:
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  4. Article ; Online: Epigenetic Regulation and Post-Translational Modifications of SNAI1 in Cancer Metastasis.

    Dong, Bo / Wu, Yadi

    International journal of molecular sciences

    2021  Volume 22, Issue 20

    Abstract: SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, ... ...

    Abstract SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.
    MeSH term(s) Epigenesis, Genetic ; Epithelial-Mesenchymal Transition ; Histones/metabolism ; Humans ; Neoplasm Metastasis ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Processing, Post-Translational ; Snail Family Transcription Factors/chemistry ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism
    Chemical Substances Histones ; SNAI1 protein, human ; Snail Family Transcription Factors
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222011062
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  5. Article ; Online: HD-Zip proteins modify floral structures for self-pollination in tomato.

    Wu, Minliang / Bian, Xinxin / Huang, Benben / Du, Yadi / Hu, Shourong / Wang, Yanli / Shen, Jingyuan / Wu, Shuang

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6691, Page(s) 124–130

    Abstract: Cleistogamy is a type of self-pollination that relies on the formation of a stigma-enclosing floral structure. We identify three homeodomain-leucine zipper IV (HD-Zip IV) genes that coordinately promote the formation of interlocking trichomes at the ... ...

    Abstract Cleistogamy is a type of self-pollination that relies on the formation of a stigma-enclosing floral structure. We identify three homeodomain-leucine zipper IV (HD-Zip IV) genes that coordinately promote the formation of interlocking trichomes at the anther margin to unite neighboring anthers, generating a closed anther cone and cleistogamy (flower morphology necessitating strict self-pollination). These HD-Zip IV genes also control style length by regulating the transition from cell division to endoreduplication. The expression of these HD-Zip IV genes and their downstream gene,
    MeSH term(s) Crops, Agricultural/genetics ; Crops, Agricultural/physiology ; Flowers/cytology ; Flowers/genetics ; Flowers/physiology ; Gene Expression Regulation, Plant ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified/cytology ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/physiology ; Pollination ; Solanum lycopersicum/cytology ; Solanum lycopersicum/genetics ; Solanum lycopersicum/physiology ; Self-Fertilization ; Leucine Zippers ; Trichomes/cytology ; Trichomes/physiology
    Chemical Substances Homeodomain Proteins ; Plant Proteins
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adl1982
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    Zs.A 27: Show issues Location:
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  6. Article: Visible-light-induced selective defluoroalkylations of polyfluoroarenes with alcohols.

    Xu, Wengang / Shao, Qi / Xia, Congjian / Zhang, Qiao / Xu, Yadi / Liu, Yingguo / Wu, Mingbo

    Chemical science

    2022  Volume 14, Issue 4, Page(s) 916–922

    Abstract: To provide α-polyfluoroarylalcohols, a novel protocol for the selective defluoroalkylation of polyfluoroarenes with easily accessible alcohols was ... ...

    Abstract To provide α-polyfluoroarylalcohols, a novel protocol for the selective defluoroalkylation of polyfluoroarenes with easily accessible alcohols was reported
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc06290a
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  7. Article ; Online: Retraction: CircNF1-419 improves the gut microbiome structure and function in AD-like mice.

    Diling, Chen / Longkai, Qi / Yinrui, Guo / Yadi, Liu / Xiaocui, Tang / Xiangxiang, Zhu / Miao, Zeng / Ran, Li / Ou, Shuai / Dongdong, Wang / Yizhen, Xie / Xujiang, Yuan / Yang, Burton B / Qingping, Wu

    Aging

    2023  Volume 15, Issue 14, Page(s) 7333

    Language English
    Publishing date 2023-07-30
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204905
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  8. Article ; Online: Construction of Cyclopentanes Consisting of Five Stereocenters via NHC-Catalyzed Cascade Reactions of Enals with Oxindole-Dienones.

    Niu, Yadi / Yao, Laiping / Zhao, Hongli / Tang, Xue / Zhao, Qian / Wu, Yuling / Han, Bo / Huang, Wei / Zhan, Gu

    Organic letters

    2023  Volume 25, Issue 47, Page(s) 8445–8450

    Abstract: Despite the widespread presence of the chiral cyclopentane motif, the asymmetric synthesis of cyclopentanes containing five stereocenters remains a formidable challenge. Here, we present ... ...

    Abstract Despite the widespread presence of the chiral cyclopentane motif, the asymmetric synthesis of cyclopentanes containing five stereocenters remains a formidable challenge. Here, we present an
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03341
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  9. Article ; Online: Diverse Structural Design Strategies of MXene-Based Macrostructure for High-Performance Electromagnetic Interference Shielding.

    Liu, Yue / Wang, Yadi / Wu, Na / Han, Mingrui / Liu, Wei / Liu, Jiurong / Zeng, Zhihui

    Nano-micro letters

    2023  Volume 15, Issue 1, Page(s) 240

    Abstract: There is an urgent demand for flexible, lightweight, mechanically robust, excellent electromagnetic interference (EMI) shielding materials. Two-dimensional (2D) transition metal carbides/nitrides (MXenes) have been potential candidates for the ... ...

    Abstract There is an urgent demand for flexible, lightweight, mechanically robust, excellent electromagnetic interference (EMI) shielding materials. Two-dimensional (2D) transition metal carbides/nitrides (MXenes) have been potential candidates for the construction of excellent EMI shielding materials due to their great electrical electroconductibility, favorable mechanical nature such as flexibility, large aspect ratios, and simple processability in aqueous media. The applicability of MXenes for EMI shielding has been intensively explored; thus, reviewing the relevant research is beneficial for advancing the design of high-performance MXene-based EMI shields. Herein, recent progress in MXene-based macrostructure development is reviewed, including the associated EMI shielding mechanisms. In particular, various structural design strategies for MXene-based EMI shielding materials are highlighted and explored. In the end, the difficulties and views for the future growth of MXene-based EMI shields are proposed. This review aims to drive the growth of high-performance MXene-based EMI shielding macrostructures on basis of rational structural design and the future high-efficiency utilization of MXene.
    Language English
    Publishing date 2023-11-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2642093-4
    ISSN 2150-5551 ; 2150-5551
    ISSN (online) 2150-5551
    ISSN 2150-5551
    DOI 10.1007/s40820-023-01203-5
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  10. Article ; Online: RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization.

    Dong, Bo / Wang, Xinzhao / Song, Xiang / Wang, Jianlin / Liu, Xia / Yu, Zhiyong / Zhou, Yongkun / Deng, Jiong / Wu, Yadi

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 7, Page(s) e2307150121

    Abstract: Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 increases sensitivity to immunotherapy, but the underlying mechanism remains ... ...

    Abstract Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 increases sensitivity to immunotherapy, but the underlying mechanism remains unclear. We now report that RNF20 stabilizes LSD1 via K29-mediated ubiquitination, which is dependent on CDK9-mediated phosphorylation. This CDK9- and RNF20-dependent LSD1 stabilization is necessary for the demethylation of histone H3K4, then subsequent repression of endogenous retrovirus, and an interferon response, leading to epigenetic immunosuppression. Moreover, we found that loss of RNF20 sensitizes cancer cells to the immune checkpoint inhibitor anti-PD-1 in vivo and that this effect can be rescued by the expression of ectopic LSD1. Our findings are supported by the observation that RNF20 levels correlate with LSD1 levels in human breast cancer specimens. This study sheds light on the role of RNF20 in CDK9-dependent LSD1 stabilization, which is crucial for epigenetic silencing and immunosuppression. Our findings explore the potential importance of targeting the CDK9-RNF20-LSD1 axis in the development of new cancer therapies.
    MeSH term(s) Humans ; Cyclin-Dependent Kinase 9/genetics ; Cyclin-Dependent Kinase 9/metabolism ; Epigenesis, Genetic ; Histone Demethylases/metabolism ; Histones/metabolism ; Immune Tolerance ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances CDK9 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 9 (EC 2.7.11.22) ; Histone Demethylases (EC 1.14.11.-) ; Histones ; KDM1A protein, human (EC 1.5.-) ; RNF20 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2307150121
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    Zs.A 1148: Show issues Location:
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