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  1. Book ; Online ; E-Book: Situation specific theories

    Im, Eun-Ok / Meleis, Afaf Ibrahim

    development, utilization, and evaluation in nursing

    2021  

    Abstract: This book fills the gap in the literature on nursing theories by presenting the background information on situation specific theories such as philosophical bases and current status of situation specific theories and providing a collection of situation ... ...

    Author's details Eun-Ok Im, Afaf I. Meleis, editors
    Abstract This book fills the gap in the literature on nursing theories by presenting the background information on situation specific theories such as philosophical bases and current status of situation specific theories and providing a collection of situation specific theories that have been developed. It provides specific guidelines for nursing research and practice, essentials for PhD and DNP students to complete the requirements for their degrees (e.g., dissertation, QI project). In addition, this book can be used in theory courses in other graduate nursing programs that require theoretical bases for their comprehensive exam or scholarly project (e.g., MSN, NP). Throughout nursing history, nursing theories have evolved within the contexts of changing and emerging theoretical needs of nursing discipline. Subsequently, several different types of nursing theories have been proposed, developed, and used in nursing education, research, and practice. Situation specific theories could be easily adopted and used in nursing practice and research due to their foci on specific populations or particular fields. Since situation specific theories were firstly proposed in 1990s, they became a major part of nursing theories in the past two decades, making this book appeals to all levels of nursing students.
    Keywords Nursing
    Subject code 610.73
    Language English
    Size 1 online resource (XIII, 355 p. 41 illus., 20 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-63223-7 ; 3-030-63222-9 ; 978-3-030-63223-6 ; 978-3-030-63222-9
    DOI 10.1007/978-3-030-63223-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Therapeutic Potential of Bioactive Components from

    Jang, Jung Yoon / Im, Eunok / Kim, Nam Deuk

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Scutellaria ... ...

    Abstract Scutellaria baicalensis
    MeSH term(s) Humans ; Scutellaria baicalensis ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Flavonoids ; Plants, Medicinal ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Colorectal Neoplasms/drug therapy
    Chemical Substances Plant Extracts ; Flavonoids
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer

    Jung Yoon Jang / Eunok Im / Nam Deuk Kim

    International Journal of Molecular Sciences, Vol 24, Iss 1954, p

    A Review

    2023  Volume 1954

    Abstract: Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is effective in treatment of colitis, hepatitis, pneumonia, ... ...

    Abstract Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is effective in treatment of colitis, hepatitis, pneumonia, respiratory infections, and allergic diseases. This herbal medicine consists of major active substances, such as baicalin, baicalein, wogonoside, and wogonin. Inflammatory bowel disease (IBD) comprises a group of inflammatory conditions of the colon and small intestine, with Crohn’s disease and ulcerative colitis being the main types. IBD can lead to serious complications, such as increased risk of colorectal cancer (CRC), one of the most common cancers worldwide. Currently, there is no cure for IBD, and its incidence has been increasing over the past few decades. This review comprehensively summarizes the efficacy of SBG in IBD and CRC and may serve as a reference for future research and development of drugs for IBD and cancer treatment.
    Keywords inflammatory bowel disease ; Scutellaria baicalensis Georgi ; anti-inflammatory ; colorectal cancer ; molecular mechanisms ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review.

    Jang, Jung Yoon / Im, Eunok / Kim, Nam Deuk

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: Resveratrol (3,5,4'-trihydroxy- ...

    Abstract Resveratrol (3,5,4'-trihydroxy-
    MeSH term(s) Humans ; Resveratrol/pharmacology ; Neoplasms/drug therapy ; Apoptosis ; Stilbenes/pharmacology ; Stilbenes/therapeutic use ; Stilbenes/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Drug Discovery
    Chemical Substances Resveratrol (Q369O8926L) ; Stilbenes ; Antineoplastic Agents
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232213689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS.

    Lee, Yunna / Im, Eunok

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert ... ...

    Abstract Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert cardioprotective effects by reducing oxidative stress, increasing vasodilation, and normalizing endothelial dysfunction. Recently, considerable evidence has highlighted an important role played by the synergistic interaction between endothelial nitric oxide synthase (eNOS) and sirtuin 1 (SIRT1) in the maintenance of endothelial function. To provide a new perspective on the role of natural antioxidants against CVDs, we focused on microRNAs (miRNAs), which are important posttranscriptional modulators in human diseases. Several miRNAs are regulated via the consumption of natural antioxidants and are related to the regulation of oxidative stress by targeting eNOS and/or SIRT1. In this review, we have discussed the specific molecular regulation of eNOS/SIRT1-related endothelial dysfunction and its contribution to CVD pathologies; furthermore, we selected nine different miRNAs that target the expression of eNOS and SIRT1 in CVDs. Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.
    Language English
    Publishing date 2021-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lactobacillus plantarum

    Jeong, Sihyun / Kim, Yuju / Park, Soyeong / Lee, Doyeon / Lee, Juho / Hlaing, Shwe Phyu / Yoo, Jin-Wook / Rhee, Sang Hoon / Im, Eunok

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: Lactobacillus ... ...

    Abstract Lactobacillus plantarum
    MeSH term(s) Humans ; Lactobacillus plantarum/metabolism ; Caco-2 Cells ; Antineoplastic Agents/pharmacology ; Probiotics/pharmacology ; Autophagy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p.

    Lee, Yunna / Kim, Yuju / Park, Soyeong / Heo, Gwangbeom / Chung, Hae Young / Im, Eunok

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1241097

    Abstract: Background: Aging is associated with a broad loss of function throughout the body, and gastrointestinal (GI) dysfunction can occur with aging. The endocannabinoid (eCB) system plays a pivotal role in various GI diseases, and alterations in the eCB ... ...

    Abstract Background: Aging is associated with a broad loss of function throughout the body, and gastrointestinal (GI) dysfunction can occur with aging. The endocannabinoid (eCB) system plays a pivotal role in various GI diseases, and alterations in the eCB system have been observed during brain and skin aging. Therefore, we investigated the putative role of the eCB system in aging-related changes in the intestine.
    Methods: The expression of cannabinoid receptor type 1 (CB
    Results and discussion: The expression of CB
    MeSH term(s) Animals ; Humans ; Rats ; Endocannabinoids ; Hydrogen Peroxide ; Hydroxyurea ; MicroRNAs/genetics ; NF-kappa B ; Permeability ; Receptor, Cannabinoid, CB1/genetics
    Chemical Substances Endocannabinoids ; Hydrogen Peroxide (BBX060AN9V) ; Hydroxyurea (X6Q56QN5QC) ; MicroRNAs ; MIRN191 microRNA, human ; NF-kappa B ; CNR1 protein, human ; Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1241097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Interplay between the Gut Microbiota and Inflammatory Mediators in the Development of Colorectal Cancer.

    Heo, Gwangbeom / Lee, Yunna / Im, Eunok

    Cancers

    2021  Volume 13, Issue 4

    Abstract: Inflammatory mediators modulate inflammatory pathways during the development of colorectal cancer. Inflammatory mediators secreted by both immune and tumor cells can influence carcinogenesis, progression, and tumor metastasis. The gut microbiota, which ... ...

    Abstract Inflammatory mediators modulate inflammatory pathways during the development of colorectal cancer. Inflammatory mediators secreted by both immune and tumor cells can influence carcinogenesis, progression, and tumor metastasis. The gut microbiota, which colonize the entire intestinal tract, especially the colon, are closely linked to colorectal cancer through an association with inflammatory mediators such as tumor necrosis factor, nuclear factor kappa B, interleukins, and interferons. This association may be a potential therapeutic target, since therapeutic interventions targeting the gut microbiota have been actively investigated in both the laboratory and in clinics and include fecal microbiota transplantation and probiotics.
    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

    Lee, Yunna / Im, Eunok

    Antioxidants. 2021 Mar. 03, v. 10, no. 3

    2021  

    Abstract: Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert ... ...

    Abstract Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert cardioprotective effects by reducing oxidative stress, increasing vasodilation, and normalizing endothelial dysfunction. Recently, considerable evidence has highlighted an important role played by the synergistic interaction between endothelial nitric oxide synthase (eNOS) and sirtuin 1 (SIRT1) in the maintenance of endothelial function. To provide a new perspective on the role of natural antioxidants against CVDs, we focused on microRNAs (miRNAs), which are important posttranscriptional modulators in human diseases. Several miRNAs are regulated via the consumption of natural antioxidants and are related to the regulation of oxidative stress by targeting eNOS and/or SIRT1. In this review, we have discussed the specific molecular regulation of eNOS/SIRT1-related endothelial dysfunction and its contribution to CVD pathologies; furthermore, we selected nine different miRNAs that target the expression of eNOS and SIRT1 in CVDs. Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.
    Keywords antioxidants ; endothelial nitric oxide synthase ; humans ; microRNA ; morbidity ; mortality ; oxidative stress ; sirtuins ; synergism ; vasodilation
    Language English
    Dates of publication 2021-0303
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030377
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review.

    Jang, Jung Yoon / Im, Eunok / Choi, Yung Hyun / Kim, Nam Deuk

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Bile acids are major signaling molecules that play a significant role as emulsifiers in the digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by the reaction of enzymes with cholesterol as a substrate, and they are ...

    Abstract Bile acids are major signaling molecules that play a significant role as emulsifiers in the digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by the reaction of enzymes with cholesterol as a substrate, and they are the primary metabolites of cholesterol in the body. Bile acids were initially considered as tumor promoters, but many studies have deemed them to be tumor suppressors. The tumor-suppressive effect of bile acids is associated with programmed cell death. Moreover, based on this fact, several synthetic bile acid derivatives have also been used to induce programmed cell death in several types of human cancers. This review comprehensively summarizes the literature related to bile acid-induced programmed cell death, such as apoptosis, autophagy, and necroptosis, and the status of drug development using synthetic bile acid derivatives against human cancers. We hope that this review will provide a reference for the future research and development of drugs against cancer.
    MeSH term(s) Apoptosis ; Bile Acids and Salts/pharmacology ; Cholesterol/metabolism ; Drug Discovery ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology
    Chemical Substances Bile Acids and Salts ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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