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  1. Article ; Online: New international guidance on quality, safety and efficacy of DNA vaccines.

    Beasley, David W C

    NPJ vaccines

    2020  Volume 5, Issue 1, Page(s) 53

    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-020-0199-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Erratum: Publisher Correction: New international guidance on quality, safety and efficacy of DNA vaccines.

    Beasley, David W C

    NPJ vaccines

    2020  Volume 5, Page(s) 62

    Abstract: This corrects the article DOI: 10.1038/s41541-020-0199-0.]. ...

    Abstract [This corrects the article DOI: 10.1038/s41541-020-0199-0.].
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Published Erratum
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-020-00217-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complete genome sequence of Koutango virus strain DakAnD5443 isolated from

    Haila, Gabriel J / Plante, Jessica A / Widen, Steven G / Beasley, David W C

    Microbiology resource announcements

    2023  Volume 12, Issue 11, Page(s) e0042323

    Abstract: Koutango virus (KOUV), a close relative of West Nile virus, is highly neuroinvasive in animal models and has been associated with human disease. The complete genome of the KOUV prototype strain DakAnD5443 is reported here and may facilitate development ... ...

    Abstract Koutango virus (KOUV), a close relative of West Nile virus, is highly neuroinvasive in animal models and has been associated with human disease. The complete genome of the KOUV prototype strain DakAnD5443 is reported here and may facilitate development of infectious clones for further characterization of this novel flavivirus.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00423-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2.

    Thursz, Mark / Sadiq, Fouzia / Tree, Julia A / Karayiannis, Peter / Beasley, David W C / Dejnirattisai, Wanwissa / Mongkolsapaya, Juthathip / Screaton, Gavin / Wand, Matthew / Elmore, Michael J / Carroll, Miles W / Matthews, Ian / Thomas, Howard

    The Journal of general virology

    2023  Volume 104, Issue 7

    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
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  5. Article ; Online: Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development.

    Files, Megan A / Hansen, Clairissa A / Herrera, Vanessa C / Schindewolf, Craig / Barrett, Alan D T / Beasley, David W C / Bourne, Nigel / Milligan, Gregg N

    NPJ vaccines

    2022  Volume 7, Issue 1, Page(s) 38

    Abstract: Oropouche virus (OROV) is an arthropod-borne orthobunyavirus found in South America and causes Oropouche fever, a febrile infection similar to dengue. It is the second most prevalent arthropod-borne viral disease in South America after dengue. Over 500, ... ...

    Abstract Oropouche virus (OROV) is an arthropod-borne orthobunyavirus found in South America and causes Oropouche fever, a febrile infection similar to dengue. It is the second most prevalent arthropod-borne viral disease in South America after dengue. Over 500,000 cases have been diagnosed since the virus was first discovered in 1955; however, this is likely a significant underestimate given the limited availability of diagnostics. No fatalities have been reported to date, however, up to 60% of cases have a recurrent phase of disease within one month of recovery from the primary disease course. The main arthropod vector is the biting midge Culicoides paraensis, which has a geographic range as far north as the United States and demonstrates the potential for OROV to geographically expand. The transmission cycle is incompletely understood and vertebrate hosts include both non-human primates and birds further supporting the potential ability of the virus to spread. A number of candidate antivirals have been evaluated against OROV in vitro but none showed antiviral activity. Surprisingly, there is only one report in the literature on candidate vaccines. We suggest that OROV is an undervalued pathogen much like chikungunya, Schmallenberg, and Zika viruses were before they emerged. Overall, OROV is an important emerging disease that has been under-investigated and has the potential to cause large epidemics in the future. Further research, in particular candidate vaccines, is needed for this important pathogen.
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-022-00456-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2.

    Thursz, Mark / Sadiq, Fouzia / Tree, Julia A / Karayiannis, Peter / Beasley, David W C / Dejnirattisai, Wanwissa / Mongkolsapaya, Juthathip / Screaton, Gavin / Wand, Matthew / Elmore, Michael J / Carroll, Miles W / Matthews, Ian / Thomas, Howard

    The Journal of general virology

    2023  Volume 104, Issue 7

    Abstract: ... tested in cell-based antiviral assays using encephalomyocarditis virus (EMCV), hepatitis C virus (HCV ...

    Abstract The 2',5'- oligoadenylate synthetase (OAS) - ribonuclease L (RNAseL) - phosphodiesterase 12 (PDE12) pathway is an essential interferon-induced effector mechanism against RNA virus infection. Inhibition of PDE12 leads to selective amplification of RNAseL activity in infected cells. We aimed to investigate PDE12 as a potential pan-RNA virus antiviral drug target and develop PDE12 inhibitors that elicit antiviral activity against a range of viruses. A library of 18 000 small molecules was screened for PDE12 inhibitor activity using a fluorescent probe specific for PDE12. The lead compounds (CO-17 or CO-63) were tested in cell-based antiviral assays using encephalomyocarditis virus (EMCV), hepatitis C virus (HCV), dengue virus (DENV), West Nile virus (WNV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
    MeSH term(s) Humans ; Mice ; Animals ; Rats ; Antiviral Agents/pharmacology ; SARS-CoV-2 ; COVID-19 ; RNA Viruses ; Interferon-alpha ; Encephalomyocarditis virus ; Phosphoric Diester Hydrolases
    Chemical Substances Antiviral Agents ; diethylstilbestrol monophosphate (47341-71-9) ; Interferon-alpha ; Phosphoric Diester Hydrolases (EC 3.1.4.-)
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
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  7. Article ; Online: Impacts of a perinatal exposure to manganese coupled with maternal stress in rats: Tests of untrained behaviors.

    McDaniel, Katherine L / Beasley, Tracey E / Oshiro, Wendy M / Huffstickler, Mitchell / Moser, Virginia C / Herr, David W

    Neurotoxicology and teratology

    2022  Volume 91, Page(s) 107088

    Abstract: Manganese (Mn), an element that naturally occurs in the environment, has been shown to produce neurotoxic effects on the developing young when levels exceed physiological requirements. To evaluate the effects of this chemical in combination with non- ... ...

    Abstract Manganese (Mn), an element that naturally occurs in the environment, has been shown to produce neurotoxic effects on the developing young when levels exceed physiological requirements. To evaluate the effects of this chemical in combination with non-chemical factors pregnant Long-Evans rats were treated with 0, 2, or 4 mg/mL Mn in their drinking water from gestational day (GD) 7 to postnatal day (PND) 22. Half of the dams received a variable stress protocol from GD13 to PND9, that included restraint, small cage with reduced bedding, exposure to predator odor, intermittent intervals of white noise, lights on for 24 h, intermittent intervals of lights on during dark cycle and cages with grid floors and reduced bedding. One male and one female offspring from each litter were tested to assess untrained behavior. Ultrasonic vocalizations (USV) were recorded from PND13 pups while they were isolated from the litter. Locomotor activity (MA) was measured in figure-eight mazes at PND 17, 29, and 79 (different set of rats at each time point). Social approach (SA) was tested at PND48. Acoustic startle response (ASR) and pre-pulse inhibition (PPI) were measured starting at PND58. At PND53 a sweetness preference for a chocolate flavored milk solution was assessed. There were sex related differences on several parameters for the USVs. There was also a Mn by stress by sex interaction with the females from the 4 mg/mL stressed dams having more frequency modulated (FM) call elements than the 4 mg/mL non-stressed group. There was an effect of Mn on motor activity but only at PND29 with the 2 mg/mL group having higher counts than the 0 mg/mL group. The social approach test showed sex differences for both the habituation and test phase. There was an effect of Mn, with the 4 mg/mL males having a greater preference for the stimulus rat than did the 0 mg/mL males. There was also a stress by sex interaction. The ASR and PPI had only a sex effect. Thus, with only the FM call elements having a Mn by stress effect, and the PND29 MA and SA preference index having a Mn effect but at different doses requires further investigation.
    MeSH term(s) Animals ; Behavior, Animal ; Female ; Humans ; Male ; Manganese/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prepulse Inhibition ; Rats ; Rats, Long-Evans ; Reflex, Startle
    Chemical Substances Manganese (42Z2K6ZL8P)
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639165-5
    ISSN 1872-9738 ; 0892-0362
    ISSN (online) 1872-9738
    ISSN 0892-0362
    DOI 10.1016/j.ntt.2022.107088
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    Zs.A 1626: Show issues Location:
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  8. Article ; Online: Long-term, West Nile virus-induced neurological changes: A comparison of patients and rodent models.

    Fulton, Corey D M / Beasley, David W C / Bente, Dennis A / Dineley, Kelly T

    Brain, behavior, & immunity - health

    2020  Volume 7, Page(s) 100105

    Abstract: West Nile virus (WNV) is a mosquito-borne virus that can cause severe neurological disease in those infected. Those surviving infection often present with long-lasting neurological changes that can severely impede their lives. The most common reported ... ...

    Abstract West Nile virus (WNV) is a mosquito-borne virus that can cause severe neurological disease in those infected. Those surviving infection often present with long-lasting neurological changes that can severely impede their lives. The most common reported symptoms are depression, memory loss, and motor dysfunction. These sequelae can persist for the rest of the patients' lives. The pathogenesis behind these changes is still being determined. Here, we summarize current findings in human cases and rodent models, and discuss how these findings indicate that WNV induces a state in the brain similar neurodegenerative diseases. Rodent models have shown that infection leads to persistent virus and inflammation. Initial infection in the hippocampus leads to neuronal dysfunction, synapse elimination, and astrocytosis, all of which contribute to memory loss, mimicking findings in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). WNV infection acts on pathways, such as ubiquitin-signaled protein degradation, and induces the production of molecules, including IL-1β, IFN-γ, and α-synuclein, that are associated with neurodegenerative diseases. These findings indicate that WNV induces neurological damage through similar mechanisms as neurodegenerative diseases, and that pursuing research into the similarities will help advance our understanding of the pathogenesis of WNV-induced neurological sequelae.
    Language English
    Publishing date 2020-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2020.100105
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  9. Article ; Online: Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.

    Koga, Shunsuke / Metrick, Michael A / Golbe, Lawrence I / Santambrogio, Alessia / Kim, Minji / Soto-Beasley, Alexandra I / Walton, Ronald L / Baker, Matthew C / De Castro, Cristhoper Fernandez / DeTure, Michael / Russell, David / Navia, Bradford A / Sandiego, Christine / Ross, Owen A / Vendruscolo, Michele / Caughey, Byron / Dickson, Dennis W

    Acta neuropathologica communications

    2023  Volume 11, Issue 1, Page(s) 88

    Abstract: Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical parkinsonism, and they usually have distinct clinical features. The most ... ...

    Abstract Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical parkinsonism, and they usually have distinct clinical features. The most common clinical presentation of PSP is Richardson syndrome, and the most common presentation of CBD is corticobasal syndrome. In this report, we describe a patient with a five-year history of Richardson syndrome and a family history of PSP in her mother and sister. A tau PET scan (
    MeSH term(s) Humans ; Female ; Supranuclear Palsy, Progressive/diagnostic imaging ; Supranuclear Palsy, Progressive/genetics ; Corticobasal Degeneration ; Tauopathies/diagnostic imaging ; Tauopathies/pathology ; tau Proteins/genetics ; tau Proteins/metabolism ; Neurofibrillary Tangles/pathology ; Neocortex/pathology
    Chemical Substances tau Proteins
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-023-01584-z
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  10. Article ; Online: Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjects.

    Beasley, David W C

    Expert review of vaccines

    2011  Volume 10, Issue 5, Page(s) 601–604

    Abstract: A recent Phase II clinical trial has demonstrated comparable safety and immunogenicity of ChimeriVax-WN02, a chimeric West Nile virus (WNV) vaccine candidate based on yellow fever 17D, in small cohorts of healthy adults aged 18-40, 41-64 and 65-80 years. ...

    Abstract A recent Phase II clinical trial has demonstrated comparable safety and immunogenicity of ChimeriVax-WN02, a chimeric West Nile virus (WNV) vaccine candidate based on yellow fever 17D, in small cohorts of healthy adults aged 18-40, 41-64 and 65-80 years. Adults ≥65 years of age are an important target population for candidate WNV vaccines as they have a high risk for severe WNV neuroinvasive disease. The apparent safety and immunogenicity of ChimeriVax-WN02 in this population indicates that further development and clinical testing are justified.
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.11.47
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