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Article ; Online: Theoretical study of the bonding in M(n+)-RG complexes and the transport of M(n+) through rare gas (M=Ca, Sr, and Ra; n=1 and 2; and RG=He-Rn).

Gardner, Adrian M / Withers, Carolyn D / Wright, Timothy G / Kaplan, Kimberly I / Chapman, Chivone Y N / Viehland, Larry A / Lee, Edmond P F / Breckenridge, W H

The Journal of chemical physics

2010 Volume 132, Issue 5, Page(s) 54302

Abstract: We present high level ab initio potential energy curves for the M(n+)-RG complexes, where n=1 and 2 ... to calculate transport coefficients for M(n+) moving through a bath of rare gas (RG) atoms. ... RG=He-Rn; and M=Ca, Sr, and Ra. Spectroscopic constants have been derived from these potentials and ...

Abstract	We present high level ab initio potential energy curves for the M(n+)-RG complexes, where n=1 and 2; RG=He-Rn; and M=Ca, Sr, and Ra. Spectroscopic constants have been derived from these potentials and are compared with a wide range of experimental and previous theoretical data, and good agreement is generally seen. Large changes in binding energy, D(e), and bond length, R(e), between M(+)-He, M(+)-Ne, and M(+)-Ar, also found previously in the analogous Ba(+)-RG complexes [M. F. McGuirk et al., J. Chem. Phys. 130, 194305 (2009)], are identified and the cause investigated; the results shed light on the previous Ba(+)-RG results. These unusual trends are not observed for the dicationic complexes, which behave in a fashion similar to the isoelectronic alkali metal ion complexes. The potentials have also been employed to calculate transport coefficients for M(n+) moving through a bath of rare gas (RG) atoms.
Language	English
Publishing date	2010-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.3297891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Octapeptide segments from the amino terminus of glycophorin A contain the antigenic determinants of the M and N blood groups systems.

Pedersen, J T / Kaplan, H / Wedeck, L / Murphy, R B / LoBue, J / Pincus, M R

The Journal of laboratory and clinical medicine

1990 Volume 116, Issue 4, Page(s) 527–534

Abstract: Human red blood cells with phenotype N/N and M/M were tested in an agglutination assay with anti-N ... however, of the agglutination of M-positive cells with anti-M antibodies by the N-amino terminal octapeptide. Likewise, the M ... Because the synthesized octapeptides contained no carbohydrate, the anti-N and anti-M specificity appears to be determined ...

Abstract	Human red blood cells with phenotype N/N and M/M were tested in an agglutination assay with anti-N and anti-M antibodies, respectively. After incubation of the synthesized octapeptide (Leu-Ser-Thr-Thr-Glu-Val-Ala-Met) from the N-amino terminus of glycophorin A, with anti-N antibody, there was significant inhibition of the agglutination of the N-positive cells. There was also inhibition of the agglutination of the M-positive cells with anti-M antibody by the synthesized octapeptide (Ser-Ser-Thr-Thr-Gly-Val-Ala-Met) from the M-amino terminus of glycophorin A. There was no inhibition, however, of the agglutination of M-positive cells with anti-M antibodies by the N-amino terminal octapeptide. Likewise, the M-amino terminal octapeptide did not inhibit agglutination of N-positive cells with anti-N. Because the synthesized octapeptides contained no carbohydrate, the anti-N and anti-M specificity appears to be determined principally by the peptides themselves. Further studies with the use of chimeric peptides indicate that the amino terminal amino acid leucine of N-glycophorin A is a primary determinant of the N antigen, whereas the amino terminal serine of M-glycophorin A is a primary determinant for the M antigen.
MeSH term(s)	Amino Acid Sequence ; Antibodies ; Epitopes/analysis ; Erythrocytes/immunology ; Ficain ; Glycophorin/immunology ; Hemagglutination Inhibition Tests ; Humans ; MNSs Blood-Group System/immunology ; Molecular Sequence Data ; Neuraminidase ; Oligopeptides/chemical synthesis
Chemical Substances	Antibodies ; Epitopes ; Glycophorin ; MNSs Blood-Group System ; Oligopeptides ; Neuraminidase (EC 3.2.1.18) ; Ficain (EC 3.4.22.3)
Language	English
Publishing date	1990-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80208-6
ISSN	1532-6543 ; 0022-2143
ISSN (online)	1532-6543
ISSN	0022-2143
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Article ; Online: Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes.

Jackson, Courtney M / Kaplan, Alexandra N / Järvinen, Kirsi M

Current allergy and asthma reports

2023 Volume 23, Issue 2, Page(s) 77–91

Abstract: Purpose of review: There has been an increased prevalence of allergy. Due to this relatively rapid rise, changes in environmental exposures are likely the main contributor. In this review, we highlight literature from the last 3 years pertaining to the ... ...

Abstract	Purpose of review: There has been an increased prevalence of allergy. Due to this relatively rapid rise, changes in environmental exposures are likely the main contributor. In this review, we highlight literature from the last 3 years pertaining to the role of air pollution, greenness, and the rural/farm lifestyle and their association with the development of allergic sensitization, atopic dermatitis, food allergy, and allergic rhinitis in infancy and childhood. Because asthma has a more complex pathophysiology, it was excluded from this review. Recent findings: Recent studies support a role for air pollution, greenness, and rural/farming lifestyle influencing atopic outcomes that continue to be defined. While many studies have examined singular environmental exposures, the interconnectedness of these exposures and others points to a need for future work to consider an individual's whole exposure. Environmental exposures' influence on atopic disease development remains an ongoing and important area of study.
MeSH term(s)	Humans ; Child ; Farms ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/etiology ; Air Pollution/adverse effects ; Rhinitis, Allergic/epidemiology ; Environmental Exposure/adverse effects
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057370-4
ISSN	1534-6315 ; 1529-7322
ISSN (online)	1534-6315
ISSN	1529-7322
DOI	10.1007/s11882-022-01061-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5548: Show issues

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Article ; Online: An Isolated Perfused Rat Liver Model: Simultaneous LC-MS Quantification of Pitavastatin, Coproporphyrin I, and Coproporphyrin III Levels in the Rat Liver and Bile.

Izat, Nihan / Kaplan, Ozan / Çelebier, Mustafa / Sahin, Selma

ACS omega

2024 Volume 9, Issue 17, Page(s) 19250–19260

Abstract: The isolated perfused rat liver (IPRL) model provides a mechanistic understanding of the organic-anion-transporting polypeptide (OATP/Oatp)-mediated pharmacokinetics in the preclinical evaluation, which often requires the use of control substrates (i.e., ...

Abstract	The isolated perfused rat liver (IPRL) model provides a mechanistic understanding of the organic-anion-transporting polypeptide (OATP/Oatp)-mediated pharmacokinetics in the preclinical evaluation, which often requires the use of control substrates (i.e., pitavastatin) and monitoring endogenous biomarkers (coproporphyrin I and III). This study aimed to develop and validate an LC-MS method allowing the simultaneous quantification of pitavastatin, coproporphyrin I (CPI), and coproporphyrin III (CPIII) in rat liver perfusion matrices (perfusate, liver homogenate, bile). The analysis was performed on a C18 column at 60 °C with 20 μL of sample injection. The mobile phases consisted of water with 0.1% formic acid and acetonitrile with 0.1% formic acid with a gradient flow of 0.5 mL/min. The assay was validated according to the ICH M10 Bioanalytical Method Validation Guideline (2022) for selectivity, calibration curve and range, matrix effect, carryover, accuracy, precision, and reinjection reproducibility. The method allowing the simultaneous quantification of pitavastatin, CPI, and CPIII was selective without having carryover and matrix effects. The linear calibration curves were obtained within various calibration ranges for three analytes in different matrices. Accuracy and precision values fulfilled the required limits. After 60 min perfusion with pitavastatin (1 μM), the cumulative amounts of pitavastatin in the liver and bile were 5.770 ± 1.504 and 0.852 ± 0.430 nmol/g liver, respectively. CPIII was a more dominant marker than CPI in both liver (0.028 ± 0.017 vs 0.013 ± 0.008 nmol/g liver) and bile (0.016 ± 0.011 vs 0.009 ± 0.007 nmol/g liver). The novel and validated bioanalytical method can be applied in further IPRL preparations investigating Oatp-mediated pharmacokinetics and DDIs.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeting tumor microenvironment and metastasis in children with solid tumors.

Wessel, Kristin M / Kaplan, Rosandra N

Current opinion in pediatrics

2021 Volume 34, Issue 1, Page(s) 53–60

Abstract: Purpose of review: The prognosis of pediatric patients with metastatic solid tumors remains poor, necessitating development of novel therapeutic strategies. The biology of the pediatric tumor microenvironment (TME) presents obstacles for the efficacy of ...

Abstract	Purpose of review: The prognosis of pediatric patients with metastatic solid tumors remains poor, necessitating development of novel therapeutic strategies. The biology of the pediatric tumor microenvironment (TME) presents obstacles for the efficacy of current therapeutic approaches including immunotherapies. Targeting various aspects of the TME in pediatric patients with solid tumors represents a therapeutic opportunity that may improve outcomes. Here we will discuss recent advances in characterization of the TME, and clinical advances in targeting the immune, vascular, and stromal aspects of the TME. Recent findings: Although immunotherapies have shown limited success in the treatment of pediatric solid tumor patients thus far, optimization of these approaches to overcome the TME shows promise. In addition, there is increasing focus on the myeloid compartment as a therapeutic target. Vascular endothelial growth factor (VEGF) targeting has resulted in responses in some refractory pediatric solid tumors. There has been relatively little focus on stromal targeting; however, emerging preclinical data are improving our understanding of underlying biology, paving the way for future therapies. Summary: Although translation of TME-targeting therapies for pediatric solid tumors is in the early stages, we are optimistic that continued exploration of approaches aimed at rebalancing the TME will lead to improved outcomes for this population.
MeSH term(s)	Child ; Humans ; Immunotherapy/methods ; Neoplasms/drug therapy ; Prognosis ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A/therapeutic use
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2021-11-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000001082
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Zs.A 3049: Show issues

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Book: Treatment of hypertension in general practice

Kaplan, Norman M.

2001

Author's details	Norman M. Kaplan
Keywords	Hypertension/Treatment
Subject code	616.13206
Language	English
Size	79 S. : graph. Darst., 19 cm.
Publisher	Dunitz
Publishing place	London
Publishing country	Great Britain
Document type	Book
Note	Includes index
HBZ-ID	HT013355385
ISBN	1-85317-906-X ; 978-1-85317-906-8
Database	Catalogue ZB MED Medicine, Health

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2002 A 2973	order for loan	Magazin

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Article ; Online: A theoretical framework for upscaling species distribution models

Christine N. Meynard / Cyril Piou / David M. Kaplan

Methods in Ecology and Evolution, Vol 14, Iss 11, Pp 2888-

2023 Volume 2899

Abstract: Abstract Species distribution models (SDM) have become one of the most popular predictive tools in ecology. With the advent of new computation and remote sensing technology, high‐resolution environmental data sets are becoming more and more common ... ...

Abstract	Abstract Species distribution models (SDM) have become one of the most popular predictive tools in ecology. With the advent of new computation and remote sensing technology, high‐resolution environmental data sets are becoming more and more common predictors in these modelling efforts. Understanding how scaling affects their outputs is therefore fundamental to understand their applicability. Here, we develop a theoretical basis to understand the consequences of aggregating occurrence and environmental data at different resolutions. We provide a theoretical framework, along with numerical simulations and a real‐world case study, to show how these scaling rules influence predictive outputs. We show that the properties of the environment–occurrence relationships change when the data are aggregated: the mean probability of occurrence and species prevalence increases, the optimal environmental values shift and classification rates increase at coarser resolutions up to a certain level. Furthermore, and contrary to the widespread expectation that high‐resolution data would produce better predictions, we show here that model performance may increase using coarser resolution data sets rather than the inverse. Finally, we also show that model performance depends not only on the environment–occurrence relationship but also on the interaction between this and the geography and distribution of the available environment. This theoretical framework helps understanding previously incoherent results regarding SDM upscaling and model performance, and illustrates how theoretical and empirical results can provide important feedbacks to advance in understanding scaling issues in macroecology. The interaction between the shape of the environment–occurrence relationship and the rates of change of the environment is fundamental to understand the effects of upscaling in model performance, and may explain why some models are more difficult to transfer to different regions. Most importantly, we argue that there are conceptual choices ...
Keywords	AUC ; ENM ; prediction ; resolution ; scaling ; SDM ; Ecology ; QH540-549.5 ; Evolution ; QH359-425
Subject code	612
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sexual dysfunction and commonly used drugs in neurology.

Behn, Maya / Kielhofner, Jane / Panicker, Jalesh N / Kaplan, Tamara B

Practical neurology

2024

Abstract: Sexual dysfunction is common in men and women with neurological diseases. Medications used in neurology can cause sexual dysfunction independently of the disease process and this may adversely affect patients' quality of life. This review focuses on ... ...

Abstract	Sexual dysfunction is common in men and women with neurological diseases. Medications used in neurology can cause sexual dysfunction independently of the disease process and this may adversely affect patients' quality of life. This review focuses on medications commonly prescribed to neurological patients that may contribute to altered sexual function, and discusses how they may differ in men and women.
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/pn-2023-003760
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Zs.A 6001: Show issues

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Article ; Online: Evaluation of intestinal necrosis with laser Doppler in experimental mesenteric ischemia model.

Aksoy, Nurullah / Kaplan, Davut Sinan / Orkmez, Mustafa / Eronat, Ömer

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2024 Volume 30, Issue 1, Page(s) 1–8

Abstract: Background: Acute mesenteric ischemia (AMI) is responsible for one in a thousand emergency hospital admissions in America and Europe and is associated with high morbidity and mortality rates. Current diagnostic and treatment methods fall short of ... ...

Title translation	Deneysel mezenter iskemi modelinde bağırsak nekrozunun lazer Doppler ile değerlendirilmesi.
Abstract	Background: Acute mesenteric ischemia (AMI) is responsible for one in a thousand emergency hospital admissions in America and Europe and is associated with high morbidity and mortality rates. Current diagnostic and treatment methods fall short of desired outcomes, often resulting in delayed diagnoses and difficulties in detecting ischemic bowel tissue during treatment. This study evaluates the diagnostic value of commonly used biochemical markers in clinical practice-creatine kinase, C-reactive protein (CRP), and lactate dehydrogenase (LDH)-alongside blood flow measurements using laser Doppler in a rat model of experimental mesenteric ischemia. We also compare these markers with pathological ischemia scoring. Methods: Rats were divided into five groups: control, 1 hour, 2 hours, 3 hours, and 4 hours. Mesenteric ischemia was induced for the respective durations in each group. After these periods, we measured blood flow using laser Doppler. We also collected blood samples and intestinal biopsies for biochemical parameter analysis. These values were assessed in relation to intestinal viability using the Chiu ischemia scoring system. Results: Blood flow measurement with laser Doppler correlated with both the duration and severity of bowel ischemia. No significant relationship was found between CRP levels and the duration of ischemia. However, creatine kinase and lactate dehydrogenase (LDH) levels were significantly higher in ischemia lasting into the third and fourth hours. Conclusion: Creatine kinase and lactate dehydrogenase (LDH) levels may be useful biomarkers in patients with suspected acute mesenteric ischemia (AMI). Blood flow measurements using laser Doppler can accurately identify intestinal loops for resection during surgery.
MeSH term(s)	Humans ; Rats ; Animals ; Mesenteric Ischemia/diagnosis ; Ischemia/diagnostic imaging ; Biomarkers ; Creatine Kinase ; Lactate Dehydrogenases ; Necrosis ; Lasers
Chemical Substances	Biomarkers ; Creatine Kinase (EC 2.7.3.2) ; Lactate Dehydrogenases (EC 1.1.-)
Language	English
Publishing date	2024-01-15
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2024.38399
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Zs.A 6718: Show issues

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Book ; Conference proceedings: The challenge to treat hypertensive patients with type 2 diabetes: blood pressure control and target organ protection

Kaplan, Norman M.

based on a satellite symposium to the ISH/ESH annual meeting, June 23, 2002, Prague

(Journal of hypertension ; 21, Suppl. 1)

2003

Author's details	ed.: Norman Kaplan
Series title	Journal of hypertension ; 21, Suppl. 1
Collection
Language	English
Size	S31 : graph. Darst.
Publisher	Lippincott Williams & Wilkins
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT013725171
Database	Catalogue ZB MED Medicine, Health

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Zs A 1885 -21,Suppl.1-	not available for loan	Zeitschriften-Lesesaal

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