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  1. Article: After SARS-CoV-2 Pandemics: New Insights into ICU-Acquired Pneumonia.

    Timsit, Jean-Francois

    Journal of clinical medicine

    2023  Volume 12, Issue 6

    Abstract: SARS-CoV-2 pandemics profoundly modified the process of hospital care [ ... ]. ...

    Abstract SARS-CoV-2 pandemics profoundly modified the process of hospital care [...].
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12062160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impact of Multiplex PCR in the Therapeutic Management of Severe Bacterial Pneumonia.

    Dessajan, Julien / Timsit, Jean-François

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: Pneumonia is a common and severe illness that requires prompt and effective management. Advanced, rapid, and accurate tools are needed to diagnose patients with severe bacterial pneumonia, and to rapidly select appropriate antimicrobial therapy, which ... ...

    Abstract Pneumonia is a common and severe illness that requires prompt and effective management. Advanced, rapid, and accurate tools are needed to diagnose patients with severe bacterial pneumonia, and to rapidly select appropriate antimicrobial therapy, which must be initiated within the first few hours of care. Two multiplex molecular tests, Unyvero HPN and FilmArray Pneumonia+ Panel, have been developed using the multiplex polymerase chain reaction (mPCR) technique to rapidly identify pathogens and their main antibiotic resistance mechanisms from patient respiratory specimens. Performance evaluation of these tests showed strong correlations with reference techniques. However, good knowledge of their indications, targets, and limitations is essential. Collaboration with microbiologists is, therefore, crucial for their appropriate use. Under these conditions, and with standardized management, these rapid tests can improve the therapeutic management of severe pneumonia faster, more precisely, and with narrow-spectrum antibiotic therapy. Further randomized controlled trials are needed to address the many unanswered questions about multiplex rapid molecular testing during the diagnosis and the management of severe pneumonia. This narrative review will address the current knowledge, advantages, and disadvantages of these tests, and propose solutions for their routine use.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13010095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: After SARS-CoV-2 Pandemics

    Jean-Francois Timsit

    Journal of Clinical Medicine, Vol 12, Iss 2160, p

    New Insights into ICU-Acquired Pneumonia

    2023  Volume 2160

    Abstract: SARS-CoV-2 pandemics profoundly modified the process of hospital care [.] ...

    Abstract SARS-CoV-2 pandemics profoundly modified the process of hospital care [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Should initial ICU admission become a standard of care for acute bacterial meningitis ?

    Thy, Michael / Dupuis, Claire / Timsit, Jean-François / Sonneville, Romain

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 48

    Language English
    Publishing date 2024-04-01
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-024-01277-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid diagnostics for skin and soft tissue infections: the current landscape and future potential.

    Barbier, François / Woerther, Paul-Louis / Timsit, Jean-François

    Current opinion in infectious diseases

    2023  Volume 36, Issue 2, Page(s) 57–66

    Abstract: Purpose of review: Managing antimicrobial therapy in patients with complicated skin and soft tissue infections (SSTI) constitutes a growing challenge due to the wide spectrum of potential pathogens and resistance phenotypes. Today, microbiological ... ...

    Abstract Purpose of review: Managing antimicrobial therapy in patients with complicated skin and soft tissue infections (SSTI) constitutes a growing challenge due to the wide spectrum of potential pathogens and resistance phenotypes. Today, microbiological documentation relies on cultural methods. This review summarizes the available evidence regarding the clinical input of rapid microbiological diagnostic tools (RMDT) and their impact on the management of antimicrobial therapy in SSTI.
    Recent findings: Accurate tools are already available for the early detection of methicillin-resistant Staphylococcus aureus (MRSA) in SSTI samples and may help avoiding or shortening empirical anti-MRSA coverage. Further research is necessary to develop and evaluate RMDT detecting group A streptococci (e.g., antigenic test) and Gram-negative pathogens (e.g., multiplex PCR assays), including through point-of-care utilization. Next-generation sequencing (NGS) methods could provide pivotal information for the stewardship of antimicrobial therapy, especially in case of polymicrobial or fungal SSTI and in the immunocompromised host; however, a shortening in the turnaround time and prospective data regarding their therapeutic input are needed to better appraise the clinical positioning of these promising approaches.
    Summary: The clinical input of RMDT in SSTI is currently limited due to the scarcity of available dedicated assays and the polymicrobial feature of certain cases. NGS appears as a relevant tool but requires further developments before its implementation in routine clinical practice.
    MeSH term(s) Humans ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/microbiology ; Methicillin-Resistant Staphylococcus aureus/genetics ; Prospective Studies ; Rapid Diagnostic Tests ; Skin ; Staphylococcal Skin Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option.

    Helms, Julie / Poissy, Julien / Dequin, Pierre-François / Timsit, Jean-François

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 58

    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01158-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens.

    Thy, Michaël / Timsit, Jean-François / de Montmollin, Etienne

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to their renal and ... ...

    Abstract Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to their renal and cochleovestibular toxicity, their indications in the treatment of sepsis and septic shock have been gradually reduced. This article reviews the spectrum of activity, mode of action, and methods for optimizing the efficacy of aminoglycosides. We discuss the current indications for aminoglycosides, with an emphasis on multidrug-resistant Gram-negative bacteria, such as extended-spectrum β-lactamase-producing
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Preventing healthcare-acquired infections in cancer patients with febrile neutropenia in intensive care units: The role of granulocyte-colony stimulating factor prophylaxis.

    Blot, Stijn / Timsit, Jean-Francois / Zahar, Jean-Ralph

    Intensive & critical care nursing

    2023  Volume 78, Page(s) 103466

    MeSH term(s) Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Intensive Care Units ; Febrile Neutropenia/complications ; Febrile Neutropenia/drug therapy ; Delivery of Health Care ; Granulocytes
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2023-06-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2023.103466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2818: Show issues Location:
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  9. Article ; Online: Management strategies for severe Pseudomonas aeruginosa infections.

    Do Rego, Hermann / Timsit, Jean-François

    Current opinion in infectious diseases

    2023  Volume 36, Issue 6, Page(s) 585–595

    Abstract: Purpose of review: This review focuses on the management of severe Pseudomonas aeruginosa infections in critically ill patients.: Recent findings: Pseudomonas aeruginosa is the most common pathogen in intensive care; the main related infections are ... ...

    Abstract Purpose of review: This review focuses on the management of severe Pseudomonas aeruginosa infections in critically ill patients.
    Recent findings: Pseudomonas aeruginosa is the most common pathogen in intensive care; the main related infections are nosocomial pneumonias, then bloodstream infections. Antimicrobial resistance is common; despite new antibiotics, it is associated with increased mortality, and can lead to a therapeutic deadlock.
    Summary: Carbapenem resistance in difficult-to-treat P. aeruginosa (DTR-PA) strains is primarily mediated by loss or reduction of the OprD porin, overexpression of the cephalosporinase AmpC, and/or overexpression of efflux pumps. However, the role of carbapenemases, particularly metallo-β-lactamases, has become more important. Ceftolozane-tazobactam, ceftazidime-avibactam and imipenem-relebactam are useful against DTR phenotypes (noncarbapenemase producers). Other new agents, such as aztreonam-ceftazidime-avibactam or cefiderocol, or colistin, might be effective for carbapenemase producers. Regarding nonantibiotic agents, only phages might be considered, pending further clinical trials. Combination therapy does not reduce mortality, but may be necessary for empirical treatment. Short-term treatment of severe P. aeruginosa infections should be preferred when it is expected that the clinical situation resolves rapidly.
    MeSH term(s) Humans ; Pseudomonas Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Aztreonam/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Aztreonam (G2B4VE5GH8)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Risk stratification for selecting empiric antibiotherapy during and after COVID-19.

    Zahar, Jean-Ralph / Timsit, Jean-Francois

    Current opinion in infectious diseases

    2022  Volume 35, Issue 6, Page(s) 605–613

    Abstract: Purpose of review: SARS-CoV-2 deeply modified the risk of bacterial infection, bacterial resistance, and antibiotic strategies. This review summarized what we have learned.: Recent findings: During the COVID-19 pandemic, we observed an increase in ... ...

    Abstract Purpose of review: SARS-CoV-2 deeply modified the risk of bacterial infection, bacterial resistance, and antibiotic strategies. This review summarized what we have learned.
    Recent findings: During the COVID-19 pandemic, we observed an increase in healthcare-acquired infection and multidrug-resistant organism-related infection, triggered by several factors: structural factors, such as increased workload and ongoing outbreaks, underlying illnesses, invasive procedures, and treatment-induced immunosuppression. The two most frequently healthcare-acquired infections described in patients hospitalized with COVID-19 were bloodstream infection, related or not to catheters, health-acquired pneumonia (in ventilated or nonventilated patients). The most frequent species involved in bacteremia were Gram-positive cocci and Gram-negative bacilli in health-acquired pneumonia. The rate of Gram-negative bacilli is particularly high in late-onset ventilator-associated pneumonia, and the specific risk of Pseudomonas aeruginosa- related pneumonia increased when the duration of ventilation was longer than 7 days. A specificity that remains unexplained so far is the increase in enterococci bacteremia.
    Summary: The choice of empiric antibiotimicrobials depends on several factors such as the site of the infection, time of onset and previous length of stay, previous antibiotic therapy, and known multidrug-resistant organism colonization. Pharmacokinetics of antimicrobials could be markedly altered during SARS-CoV-2 acute respiratory failure, which should encourage to perform therapeutic drug monitoring.
    MeSH term(s) Humans ; Gram-Negative Bacterial Infections/drug therapy ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Pandemics ; SARS-CoV-2 ; Gram-Negative Bacteria ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Risk Assessment ; COVID-19 Drug Treatment
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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