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  1. Book: How to set up an acute stroke service

    Grunwald, Iris Q. / Faßbender, Klaus / Wakhloo, Ajay K.

    2012  

    Author's details Iris Q. Grunwald ; Klaus Fassbender ; Ajay K. Wakhloo
    Keywords Schlaganfall ; Klinischer Behandlungspfad
    Subject Clinical Pathway ; Klinischer Pfad ; Standard Operating Procedure ; SOP ; Standardvorgehensweise ; Standardarbeitsanweisung ; Verfahrensvorschrift ; Standardisierter Ablaufplan ; Geplanter Behandlungsablauf ; Standardablauf ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Language English
    Size XXII, 198 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017104451
    ISBN 978-3-642-21404-2 ; 3-642-21404-5 ; 9783642214059 ; 3642214053
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 462 order for loan Magazin

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  2. Book ; Thesis: Vergleichende Untersuchungen zu graduierten Oberflächenstrukturen zementfreier Endoprothesen im mechanischen Modell

    Grunwald, Iris Q.

    1997  

    Author's details vorgelegt von Iris Quasar Grunwald
    Language German
    Size 75 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lübeck, Med. Univ., Diss., 1999
    HBZ-ID HT012848240
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Impact of mobile stroke units.

    Fassbender, Klaus / Merzou, Fatma / Lesmeister, Martin / Walter, Silke / Grunwald, Iris Quasar / Ragoschke-Schumm, Andreas / Bertsch, Thomas / Grotta, James

    Journal of neurology, neurosurgery, and psychiatry

    2021  

    Abstract: Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit enabling prehospital stroke treatment has rapidly expanded worldwide. This review summarises current knowledge in this young field of stroke research, discussing ...

    Abstract Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit enabling prehospital stroke treatment has rapidly expanded worldwide. This review summarises current knowledge in this young field of stroke research, discussing topics such as benefits in reduction of delay before treatment, vascular imaging-based triage of patients with large-vessel occlusion in the field, differential blood pressure management or prehospital antagonisation of anticoagulants. However, before mobile stroke units can become routine, several questions remain to be answered. Current research, therefore, focuses on safety, long-term medical benefit, best setting and cost-efficiency as crucial determinants for the sustainability of this novel strategy of acute stroke management.
    Language English
    Publishing date 2021-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2020-324005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Progressive Cerebral Small Vessel Disease Caused by an Autoimmune Response to Intravesical Bacille-Calmette-Guérin Treatment.

    Becker, Anouck / Grunwald, Iris Quasar / Unger, Marcus M / Behnke, Stefanie / Spiegel, Joerg / Yilmaz, Umut / Walter, Silke / Faßbender, Klaus

    Frontiers in neurology

    2020  Volume 11, Page(s) 484282

    Abstract: Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms ... ...

    Abstract Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms of dementia up to mutism as well as tonic seizures. Immune-mediated cerebral small vessel disease was diagnosed and retraced to former instillations of BCG. Intense immunosuppressive treatment was performed and clinical restoration was achieved within several months. While cerebral vasculitis due to BCGitis has already been described before, this is to our knowledge the first case report to illustrate an immune-mediated small vessel disease after BCG-instillations. This should be considered in patients with rapidly progressive dementia-like symptoms treated with BCG, as an immunosuppressive treatment can be highly effective even at severe clinical stages.
    Language English
    Publishing date 2020-10-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.484282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current pediatric stroke treatment.

    Grunwald, Iris Quasar / Kühn, Anna Luisa

    World neurosurgery

    2011  Volume 76, Issue 6 Suppl, Page(s) S80–4

    Abstract: Background: The treatment of stroke in children and infants is essential, but unfortunately is not supported by factual and substantiated data.: Methods: This is a comprehensive review of the currently published data on acute ischemic stroke ... ...

    Abstract Background: The treatment of stroke in children and infants is essential, but unfortunately is not supported by factual and substantiated data.
    Methods: This is a comprehensive review of the currently published data on acute ischemic stroke treatment in children and highlights recent advances and possibilities with mechanical devices in the treatment of stroke in this vulnerable age population.
    Results: The current treatment for most children with acute ischemic stroke is limited to the management of the symptoms. Mechanical recanalization may improve recanalization rates and clinical outcomes.
    Conclusions: Although clinical trials will be difficult to establish in children, continued research and additional experience are imperative to treat this often devastating condition.
    MeSH term(s) Brain Ischemia/complications ; Brain Ischemia/therapy ; Child ; Cost of Illness ; Fibrinolytic Agents/therapeutic use ; Humans ; Neurosurgical Procedures ; Pediatrics/trends ; Stroke/drug therapy ; Stroke/economics ; Stroke/etiology ; Stroke/therapy ; Thrombolytic Therapy/economics ; Vascular Surgical Procedures
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2011.06.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Current management and treatment of cerebral vasospasm complicating SAH.

    Kühn, Anna Luisa / Balami, Joyce Saleh / Grunwald, Iris Quasar

    CNS & neurological disorders drug targets

    2012  Volume 12, Issue 2, Page(s) 233–241

    Abstract: Cerebral vasospasm is a common and serious complication of aneurysmal subarachnoid haemorrhage. Despite the improvements in treatment of aneurysmal subarachnoid haemorrhage (aSAH), cerebral vasospasm complicating aSAH has remained the main cause of ... ...

    Abstract Cerebral vasospasm is a common and serious complication of aneurysmal subarachnoid haemorrhage. Despite the improvements in treatment of aneurysmal subarachnoid haemorrhage (aSAH), cerebral vasospasm complicating aSAH has remained the main cause of morbidity and mortality. Subarachnoid haemorrhage (SAH)-induced vasospasm is a complex entity caused by vasculopathy, impaired autoregulation, and hypovolaemia, causing a regional reduction of cerebral brain perfusion which can then induce ischaemia. Cerebral vasospasm can present either asymptomatically detected only radiologically or symptomatically (delayed ischaemic neurologic deficit). The various diagnostic approaches include the use of transcranial doppler, digital subtraction angiography and multimodal computed tomography (CT) and magnetic resonance (MR) techniques. Although digital subtraction angiography is usually the gold standard for the diagnosis of cerebral vasospam, transcranial doppler is commonly the first-screening method for the detection of cerebral vasospam. The treatment of subarachnoid haemorrhage -induced vasospasm include the use of both medical and endovascular therapy. The aim of this review is to discuss the various current therapeutic options and future perspective measures for reducing cerebral vasospasm induced stroke after SAH.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Subarachnoid Hemorrhage/complications ; Tomography, X-Ray Computed ; Vasospasm, Intracranial/diagnosis ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/therapy
    Language English
    Publishing date 2012-09-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/1871527311312020010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Influence of coil geometry on intra-aneurysmal packing density: evaluation of a new primary wind technology.

    Quasar Grunwald, Iris / Molyneux, Andrew / Kühn, Anna Luisa / Watson, Dave / Byrne, James V

    Vascular and endovascular surgery

    2010  Volume 44, Issue 4, Page(s) 289–293

    Abstract: Introduction: This prospective randomized double-blinded in-vitro study was conducted to determine the relative Packing Density (PD) of the new Deltapaq coil (Micrus Endovascular) as compared to Micrus's conventional filling CHE (Helipaq) and finishing ... ...

    Abstract Introduction: This prospective randomized double-blinded in-vitro study was conducted to determine the relative Packing Density (PD) of the new Deltapaq coil (Micrus Endovascular) as compared to Micrus's conventional filling CHE (Helipaq) and finishing CFS (Ultipaq) coils.
    Methods: Two physicians independently deployed the coils under fluoroscopy into a 4mm berry shaped glass aneurysm. Each coil tested was a 4mm x 35cm coil specially made for this study. Physicians and observer were blinded as to the type of coil. Five samples per group, per operator, were deployed.
    Results: mean PD were 36.6% (Helipaq), 37.9% (Ultipaq) and 40.4% (Deltapaq). Two-sample T-test showed a significantly higher PD of Deltapaq versus Helipaq (p < 0.022).
    Discussion: Higher coil PD and better neck coverage may provide an increased biomechanical stability and may potentially reduce the recanalization rate of aneurysms.
    Conclusion: The new Deltapaq coil may have the potential to achieve higher packing densities in the treatment of aneurysms.
    MeSH term(s) Embolization, Therapeutic/instrumentation ; Equipment Design ; Fluoroscopy ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Materials Testing ; Models, Anatomic ; Models, Cardiovascular ; Prospective Studies
    Language English
    Publishing date 2010-05
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/1538574410363916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 622: Show issues Location:
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  8. Book ; Thesis: Vergleichende Untersuchungen zu graduierten Oberflächenstrukturen zementfreier Endoprothesen im mechanischen Modell

    Grunwald, Iris Quasar

    1997  

    Author's details vorgelegt von Iris Quasar Grunwald
    Language German
    Size 75 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Lübeck, 1999
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Prehospital Computed Tomography Angiography in Acute Stroke Management.

    Kettner, Michael / Helwig, Stefan Alexander / Ragoschke-Schumm, Andreas / Schwindling, Lenka / Roumia, Safwan / Keller, Isabel / Martens, Daniel / Kulikovski, Johann / Manitz, Matthias / Lesmeister, Martin / Walter, Silke / Grunwald, Iris Quasar / Schlechtriemen, Thomas / Reith, Wolfgang / Fassbender, Klaus

    Cerebrovascular diseases (Basel, Switzerland)

    2017  Volume 44, Issue 5-6, Page(s) 338–343

    Abstract: Background: An ambulance equipped with a computed tomography (CT) scanner, a point-of-care laboratory, and telemedicine capabilities (mobile stroke unit [MSU]) has been shown to enable the delivery of thrombolysis to stroke patients directly at the ... ...

    Abstract Background: An ambulance equipped with a computed tomography (CT) scanner, a point-of-care laboratory, and telemedicine capabilities (mobile stroke unit [MSU]) has been shown to enable the delivery of thrombolysis to stroke patients directly at the emergency site, thereby significantly decreasing time to treatment. However, work-up in an MSU that includes CT angiography (CTA) may also potentially facilitate triage of patients directly to the appropriate target hospital and specialized treatment, according to their individual vascular pathology.
    Methods: Our institution manages a program investigating the prehospital management of patients with suspicion of acute stroke. Here, we report a range of scenarios in which prehospital CTA could be relevant in triaging patients to the appropriate target hospital and to the individually required treatment.
    Results: Prehospital CTA by use of an MSU allowed to detect large vessel occlusion of the middle cerebral artery in one patient with ischemic stroke and occlusion of the basilar artery in another, thereby allowing rational triage to comprehensive stroke centers for immediate intra-arterial treatment. In complementary cases, prehospital imaging not only allowed diagnosis of parenchymal hemorrhage with a spot sign indicating ongoing bleeding in one patient and of subarachnoid hemorrhage in another but also clarified the underlying vascular pathology, which was relevant for subsequent triage decisions.
    Conclusion: Defining the vascular pathology by CTA directly at the emergency site may be beneficial in triaging patients with various cerebrovascular diseases to the most appropriate target hospital and specialized treatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Cerebral Angiography/methods ; Clinical Decision-Making ; Computed Tomography Angiography ; Emergency Medical Services/methods ; Feasibility Studies ; Female ; Humans ; Male ; Predictive Value of Tests ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/therapy ; Time-to-Treatment ; Treatment Outcome ; Triage
    Language English
    Publishing date 2017-10-31
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1069462-6
    ISSN 1421-9786 ; 1015-9770
    ISSN (online) 1421-9786
    ISSN 1015-9770
    DOI 10.1159/000484097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 226: Show issues

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  10. Article ; Online: Cerebral abscess due to sinusitis.

    Papanagiotou, Panagiotis / Grunwald, Iris Quasar / Politi, Maria / Reith, Wolfgang J

    Archives of neurology

    2008  Volume 65, Issue 5, Page(s) 668–669

    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Brain Abscess/drug therapy ; Brain Abscess/etiology ; Brain Abscess/pathology ; Child ; Clindamycin/administration & dosage ; Headache/etiology ; Humans ; Injections, Intravenous ; Magnetic Resonance Imaging ; Male ; Neurosurgical Procedures/methods ; Paranasal Sinuses/drug effects ; Paranasal Sinuses/pathology ; Paranasal Sinuses/surgery ; Penicillins/administration & dosage ; Seizures/etiology ; Sinusitis/complications ; Sinusitis/pathology ; Sinusitis/therapy ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; Clindamycin (3U02EL437C)
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80049-1
    ISSN 1538-3687 ; 0003-9942
    ISSN (online) 1538-3687
    ISSN 0003-9942
    DOI 10.1001/archneur.65.5.668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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