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  1. Article ; Online: New methods for diagnosis and treatment of vestibular diseases.

    Hegemann, Stefan Ca / Palla, Antonella

    F1000 medicine reports

    2010  Volume 2, Page(s) 60

    Abstract: Dizziness and vertigo are common complaints, with a lifetime prevalence of over 30%. This review provides a brief summary of the recent diagnostic and therapeutic advances in the field of neuro-otology. A special focus is placed on the clinical ... ...

    Abstract Dizziness and vertigo are common complaints, with a lifetime prevalence of over 30%. This review provides a brief summary of the recent diagnostic and therapeutic advances in the field of neuro-otology. A special focus is placed on the clinical usefulness of vestibular tests. While these have markedly improved over the years, treatment options for vestibular disorders still remain limited. Available therapies for selected vestibular diseases are discussed.
    Language English
    Publishing date 2010-08-09
    Publishing country England
    Document type Journal Article
    ISSN 1757-5931
    ISSN (online) 1757-5931
    DOI 10.3410/M2-60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute onset of tinnitus in patients with sudden deafness

    Ljiljana Cvorovic / Nenad Arsovic / Nemanja Radivojevic / Ivan Soldatovic / Stefan C.A Hegemann

    Noise and Health, Vol 23, Iss 110, Pp 81-

    2021  Volume 86

    Abstract: Objective: We made hypotheses that tinnitus will appear more likely in patients with sudden deafness with superior hearing in unaffected ear or with more severe acute hearing loss. Methods: A retrospective cohort study was performed. Five hundred forty- ... ...

    Abstract Objective: We made hypotheses that tinnitus will appear more likely in patients with sudden deafness with superior hearing in unaffected ear or with more severe acute hearing loss. Methods: A retrospective cohort study was performed. Five hundred forty-one patients were identified with idiopathic sudden sensorineural hearing loss (ISSHL) from January 1995 to August 2006. The exclusion criteria for this study were as follows: bilateral sudden hearing loss and Meniere disease, previous tinnitus or bilateral tinnitus at initial evaluation, and onset of hearing loss less than 7 days. The cohort enrolled 454 patients. The enrolled patients were classified into two groups: patient with acute onset tinnitus in the affected ear and patients without tinnitus at initial visit. Main outcome measures were patient age, the presence or absence of vertigo and tinnitus, audiometric patterns, the severity of hearing loss, and hearing in the unaffected ear. Results: Better contralateral hearing (n = 220 versus n = 72, P < 0.001) and younger age (48 versus 55 years, P < 0.001) were independently associated with the acute onset of tinnitus in patients with ISSHL. The degree of asymmetry between the ears did not differ significantly between patients with and without tinnitus. The sex, presence of vertigo, shape of audiogram, and severity of hearing loss were not correlated with tinnitus occurrence. Conclusions: Tinnitus triggered by ISSHL was more frequent in patients with better contralateral hearing and of a younger age, irrespective of the severity of hearing loss on the affected side or the asymmetry between the ears.
    Keywords acute hearing loss ; acute tinnitus ; audiogram ; cohort ; idiopathic sudden sensorineural hearing loss ; sudden deafness ; tinnitus ; Otorhinolaryngology ; RF1-547 ; Industrial medicine. Industrial hygiene ; RC963-969
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Effectiveness of Systemic High-Dose Dexamethasone Therapy for Idiopathic Sudden Sensorineural Hearing Loss

    Egli Gallo, Doris / Khojasteh, Elham / Gloor, Martina / Hegemann, Stefan C.A.

    Audiology and Neurotology

    2013  Volume 18, Issue 3, Page(s) 161–170

    Abstract: Objective: To evaluate the effectiveness of systemic high-dose dexamethasone therapy for sudden sensorineural hearing loss in comparison to the previous treatment regimen at our clinic with systemic prednisone 100 mg daily for 7 days analyzed in a ... ...

    Institution Department of Otorhinolaryngology, University Hospital Zurich, Zurich, Switzerland
    Abstract Objective: To evaluate the effectiveness of systemic high-dose dexamethasone therapy for sudden sensorineural hearing loss in comparison to the previous treatment regimen at our clinic with systemic prednisone 100 mg daily for 7 days analyzed in a previous study. Methods: We conducted a retrospective review of an electronic patient data base of 79 patients with idiopathic sudden sensorineural hearing loss. The standard treatment was orally applied dexamethasone (1st to 3rd day: 40 mg daily, 4th to 6th day: 10 mg daily) in an ambulant setting. The primary endpoint was change in hearing threshold from the initial audiogram to an audiogram at least 4 weeks later. Factors that were analyzed included patient's age, interval between onset of symptoms and start of treatment, presence or absence of dizziness and tinnitus, the audiogram pattern, severity of hearing loss and hearing in the opposite ear. Hearing gain was expressed either as absolute or relative hearing gain. Functionally relevant recovery of hearing was defined as the final pure-tone average (PTA) of 30 dB or less (or the same as the PTA of the opposite ear ± 10 dB). Furthermore, we calculated the percentage of patients with complete, partial and no recovery as defined in the recently published Clinical Practice Guideline of the American Academy of Otolaryngology - Head and Neck Surgery Foundation. We then compared our results with the previous treatment regimen carried out at our clinic. Results: The average initial PTA hearing loss in the affected ear compared to baseline PTA of the unaffected ear was 51.5 ± 20.9 dB (mean ± SD). The mean absolute hearing gain was 44.4 ± 18.1 dB. The mean relative hearing gain was 86 ± 19%. Of the total, 87% had functionally relevant recovery of hearing. All of our patients showed partial (24%) or complete recovery (76%). No difference in recovery rate could be detected between patients with start of therapy within 24 h and patients with beginning of therapy within 7 days. We found a correlation between the severity of hearing loss and functionally relevant recovery. A mild hearing loss was noted in 34% of patients, with an average relative hearing gain of 89% and a functionally relevant recovery in 96% of them; the 9% of patients with initial deafness showed a mean relative hearing gain of 69% and a functionally relevant recovery in 43%. The audiogram pattern with low- or high-frequency hearing loss showed the best recovery rate; the poorest recovery rate was found in patients with initial deafness. Con-clusion: Application of high-dose orally applied dexamethasone seems to improve the recovery outcomes in comparison to prednisone 100 mg p.o. for 7 days.
    Keywords Steroids ; Idiopathic sudden sensorineural hearing loss ; High-dose dexamethasone therapy ; Glucocorticoids
    Language English
    Publishing date 2013-02-27
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 2188925-9
    ISSN 1421-9700 ; 1420-3030
    ISSN (online) 1421-9700
    ISSN 1420-3030
    DOI 10.1159/000346938
    Database Karger publisher's database

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  4. Article: Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.

    Akerboom, Jasper / Carreras Calderón, Nicole / Tian, Lin / Wabnig, Sebastian / Prigge, Matthias / Tolö, Johan / Gordus, Andrew / Orger, Michael B / Severi, Kristen E / Macklin, John J / Patel, Ronak / Pulver, Stefan R / Wardill, Trevor J / Fischer, Elisabeth / Schüler, Christina / Chen, Tsai-Wen / Sarkisyan, Karen S / Marvin, Jonathan S / Bargmann, Cornelia I /
    Kim, Douglas S / Kügler, Sebastian / Lagnado, Leon / Hegemann, Peter / Gottschalk, Alexander / Schreiter, Eric R / Looger, Loren L

    Frontiers in molecular neuroscience

    2013  Volume 6, Page(s) 2

    Abstract: ... the recently published red GECI R-GECO1 give insight into the chromophore environments of the Ca(2+)-bound ... both within the same cell (registering mitochondrial and somatic [Ca(2+)]) and between two populations of cells ... higher Ca(2+) affinity and larger dynamic range than RCaMP, but exhibits significant photoactivation ...

    Abstract Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, "RCaMPs," engineered from circular permutation of the thermostable red fluorescent protein mRuby. High-resolution crystal structures of mRuby, the red sensor RCaMP, and the recently published red GECI R-GECO1 give insight into the chromophore environments of the Ca(2+)-bound state of the sensors and the engineered protein domain interfaces of the different indicators. We characterized the biophysical properties and performance of RCaMP sensors in vitro and in vivo in Caenorhabditis elegans, Drosophila larvae, and larval zebrafish. Further, we demonstrate 2-color calcium imaging both within the same cell (registering mitochondrial and somatic [Ca(2+)]) and between two populations of cells: neurons and astrocytes. Finally, we perform integrated optogenetics experiments, wherein neural activation via channelrhodopsin-2 (ChR2) or a red-shifted variant, and activity imaging via RCaMP or GCaMP, are conducted simultaneously, with the ChR2/RCaMP pair providing independently addressable spectral channels. Using this paradigm, we measure calcium responses of naturalistic and ChR2-evoked muscle contractions in vivo in crawling C. elegans. We systematically compare the RCaMP sensors to R-GECO1, in terms of action potential-evoked fluorescence increases in neurons, photobleaching, and photoswitching. R-GECO1 displays higher Ca(2+) affinity and larger dynamic range than RCaMP, but exhibits significant photoactivation with blue and green light, suggesting that integrated channelrhodopsin-based optogenetics using R-GECO1 may be subject to artifact. Finally, we create and test blue, cyan, and yellow variants engineered from GCaMP by rational design. This engineered set of chromatic variants facilitates new experiments in functional imaging and optogenetics.
    Language English
    Publishing date 2013-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2013.00002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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