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  1. Article ; Online: Successful management of the delayed leaflet perforation after transcatheter edge-to-edge repair procedure using transcatheter occlusion.

    Zhu, Da / Xie, Chun-Mei / Wang, Shou-Zheng / Pan, Xiang-Bin

    European heart journal. Case reports

    2024  Volume 8, Issue 3, Page(s) ytae103

    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae103
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  2. Article ; Online: Successful treatment of severe primary mitral regurgitation due to rheumatic aetiology using a novel-designed transcatheter edge-to-edge repair system.

    Xie, Chun-Mei / Zhu, Da / Wang, Shou-Zheng / Pan, Xiang-Bin

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2024  

    Abstract: The transcatheter edge-to-edge mitral valve repair (TEER) has been recommended as a reliable treatment option for selected patients with severe degenerative and functional mitral regurgitation (MR). Although MR patients with rheumatic etiology were ... ...

    Abstract The transcatheter edge-to-edge mitral valve repair (TEER) has been recommended as a reliable treatment option for selected patients with severe degenerative and functional mitral regurgitation (MR). Although MR patients with rheumatic etiology were excluded from two significant trials (EVEREST II and COAPT) that established a role for the TEER in degenerative and functional MR. However, it has been reported that the TEER procedure could be safely and effectively performed in carefully selected rheumatic MR patients. Therefore, we share a case report of successfully treating severe rheumatic MR using a novel-designed TEER system (JensClip
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.31058
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  3. Article ; Online: The current practice of transcatheter aortic valve replacement in China.

    Xie, Chun-Mei / Yao, Yun-Tai

    Journal of cardiac surgery

    2022  Volume 37, Issue 10, Page(s) 3168–3177

    Abstract: Objective: The purpose of this study is to summarize the current practice and experience of transcatheter aortic valve replacement in China.: Methods: The relevant articles were identified through computerized searches of the CNKI, WANFANG, VIP, and ... ...

    Abstract Objective: The purpose of this study is to summarize the current practice and experience of transcatheter aortic valve replacement in China.
    Methods: The relevant articles were identified through computerized searches of the CNKI, WANFANG, VIP, and PubMed databases through February 1, 2022, using the search terms: "transcatheter aortic valve replacement," "transcatheter aortic valve implantation," "China."
    Results: The database searches identified 22 articles, 2092 patients, 57.65% were male, with a mean age of 74.2 ± 6.0 years, 71.51% of patients were classified by New York Heart Association as class Ⅲ/Ⅳ, Society of Thoracic Surgeons score 8.4 ± 4.1, mean left ventricular ejection fraction 52.8 ± 14.2%, mean transvalvular aortic pressure gradient 59.9 ± 18.9 mmHg. The overall procedural success rate was 97.85%, and 2.15% of patients were converted to sternotomy, mainly due to transcatheter aortic bioprosthesis dislocation. The most common vascular access approach was transfemoral (1071 patients, 51.20%). General anesthesia (48.90%) was the commonly used anesthesia technique. The incidence of postprocedural complications was as follows: permanent pacemaker implantation (10.47%), bleeding events (8.60%), mild paravalvular leakage (17.73%), moderate and severe paravalvular leakage (4.16%), vascular complications (3.30%), stroke (1.43%), respectively. The overall periprocedural period and postprocedural 30-day mortality was 2.72%.
    Conclusions: Among patients undergoing transcatheter aortic valve replacement in China, device implantation success was achieved in 97.85% of cases. The most common vascular access approach was transfemoral. General anesthesia was the most commonly used anesthetic technique. Paravalvular leakage (458 patients, 21.89%) was the most common complication.
    MeSH term(s) Aged ; Aged, 80 and over ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Female ; Heart Valve Prosthesis ; Humans ; Male ; Prosthesis Design ; Risk Factors ; Stroke Volume ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome ; Ventricular Function, Left
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16815
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  4. Article ; Online: Anesthesia Management for Pediatrics with Congenital Heart Diseases Who Undergo Cardiac Catheterization in China.

    Xie, Chun-Mei / Yao, Yun-Tai

    Journal of interventional cardiology

    2021  Volume 2021, Page(s) 8861461

    Abstract: Objectives: The goal of this study was to summarize anesthesia management for pediatrics with congenital heart diseases who undergo cardiac catheterization procedure in China.: Methods: The relevant articles were identified through computerized ... ...

    Abstract Objectives: The goal of this study was to summarize anesthesia management for pediatrics with congenital heart diseases who undergo cardiac catheterization procedure in China.
    Methods: The relevant articles were identified through computerized searches in the CNKI, Wanfang, VIP, and PubMed databases through May 2020, using different combinations of keywords: "congenital heart diseases," "pediatric," "children," "anesthesia," "cardiac catheterization," "interventional therapy," "interventional treatment," "interventional examination," and "computed tomography."
    Results: The database searches identified 48 potentially qualified articles, of which 25 (9,738 patients in total) were determined to be eligible and included. The authors collect data from the article information. Anesthesia methods included endotracheal intubation or laryngeal mask ventilation general anesthesia, monitored anesthesia care, and combined with sacral canal block. Anesthesia-related complications occurred in 7.41% of the patients and included dysphoria, respiratory depression, nausea, vomiting, cough, increased respiratory secretion, and airway obstruction. The incidence of procedure-related complications was 12.14%, of which the most common were arrhythmia and hypotension.
    Conclusions: For pediatric patients with congenital heart diseases who undergo cardiac catheterization procedures in China, arrhythmia and hypotension are the most common procedure-related complications. Monitored anesthesia care is the commonly used anesthesia methods, and dysphoria, cough, nausea, vomiting, and respiratory depression are frequent complications associated with anesthesia.
    MeSH term(s) Anesthesia, General/adverse effects ; Anesthesia, General/methods ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Child ; China/epidemiology ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/surgery ; Humans ; Hypotension/diagnosis ; Hypotension/epidemiology ; Hypotension/etiology ; Incidence ; Pediatrics/methods ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2021-01-30
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 1036325-7
    ISSN 1540-8183 ; 0896-4327
    ISSN (online) 1540-8183
    ISSN 0896-4327
    DOI 10.1155/2021/8861461
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  5. Article ; Online: Successful management of the leaflet perforation after the transcatheter edge-to-edge repair procedure using transcatheter occlusion.

    Xie, Chun-Mei / Zhu, Da / Wang, Shou-Zheng / Luo, Zhi-Ling / Pan, Xiang-Bin

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 9, Page(s) e269

    MeSH term(s) Humans ; Mitral Valve/surgery ; Mitral Valve Insufficiency/surgery ; Vascular Diseases ; Heart Valve Prosthesis Implantation/methods ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Treatment Outcome
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead116
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  6. Article ; Online: The effects of continuous renal replacement therapy with different anticoagulation methods on the expression of cytokines in severe acute pancreatitis.

    Chen, Zhi-Feng / Gui, Chun-Mei / Xie, Zhi-Hui

    Transplant immunology

    2022  Volume 73, Page(s) 101603

    Abstract: Objective: Severe acute pancreatitis (SAP) is a highly morbid condition in general population as well as in solid organ transplant (SOT) recipients. The present study aimed to investigate the effect of continuous renal replacement therapy (CRRT) with ... ...

    Abstract Objective: Severe acute pancreatitis (SAP) is a highly morbid condition in general population as well as in solid organ transplant (SOT) recipients. The present study aimed to investigate the effect of continuous renal replacement therapy (CRRT) with different anticoagulation methods on the expression levels of cytokines in SAP.
    Methods: A total of 120 patients with SAP, admitted into our hospital between September 2017 and July 2020, were enrolled as the research subjects and randomly divided into a control group (60 cases) and a study group (60 cases). CRRT with low molecular weight (LMW) heparin‑calcium anticoagulation was conducted on patients in the control group, and CRRT with topical citrate + low-dose LMW heparin‑calcium anticoagulation was conducted on patients in the study group. The expressions of cytokines in the two groups were compared after treatment.
    Results: There was no significant difference in white blood cells (WBC), C-reactive proteins (CRP), and procalcitonin (PCT) before treatment between the two groups (P > 0.05). After treatment, the levels of WBC (P = 0.006), CRP (P < 0.001), and PCT (P < 0.001) were significantly lower in the study group when compared with those in the control group. There was no significant difference in the concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) between the two groups before treatment (P > 0.05). After treatment, the concentrations of IL-6, IL-8, and TNF-α were significantly lower in the study group when compared with those in the control group. The APACHEII, SOFA and Ranson scores of the two groups were analyzed, and there was no difference between the two groups before treatment (P > 0.05). After treatment, the score of the study group was lower than that of the control group (P < 0.05).
    Conclusion: CRRT with topical citrate + low-dose LMW heparin‑calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-α. This inhibits the release of inflammatory mediators in patients with SAP and reduces damage to the body caused by the inflammatory response, thus effectively improving the patients' condition.
    MeSH term(s) Acute Disease ; Anticoagulants/therapeutic use ; C-Reactive Protein ; Citrates ; Continuous Renal Replacement Therapy ; Cytokines ; Humans ; Interleukin-6 ; Interleukin-8 ; Pancreatitis/drug therapy ; Renal Replacement Therapy/methods ; Tumor Necrosis Factor-alpha
    Chemical Substances Anticoagulants ; Citrates ; Cytokines ; Interleukin-6 ; Interleukin-8 ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2022.101603
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  7. Article ; Online: Identification and expression analysis of invertase family genes during grape (Vitis vinifera L.) berry development under CPPU and GA treatment.

    Du, Chen-Lu / Cai, Chun-Liu / Lu, Yi / Li, You-Mei / Xie, Zhao-Sen

    Molecular genetics and genomics : MGG

    2023  Volume 298, Issue 3, Page(s) 777–789

    Abstract: Sugar is crucial for grape berry, whether used for fresh food or wine. However, berry enlargement treatment with forchlorfenuron (N-(2-chloro4-pyridyl)-N'-phenylurea) (CPPU, a synthetic cytokinin) and gibberellin (GA) always had adverse effects on sugar ... ...

    Abstract Sugar is crucial for grape berry, whether used for fresh food or wine. However, berry enlargement treatment with forchlorfenuron (N-(2-chloro4-pyridyl)-N'-phenylurea) (CPPU, a synthetic cytokinin) and gibberellin (GA) always had adverse effects on sugar accumulation in some grape varieties, especially CPPU. Therefore exploring the molecular mechanisms behind these adverse effects could provide a foundation for improving or developing technology to mitigate the effects of CPPU/GA treatments for grape growers. In the present study, invertase (INV) family, the key gene controlling sugar accumulation, was identified and characterized on the latest annotated grape genome. Their express pattern, as well as invertase activity and sugar content, were analyzed during grape berry development under CPPU and GA
    MeSH term(s) Humans ; Vitis ; beta-Fructofuranosidase/genetics ; Fruit ; Sugars/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances beta-Fructofuranosidase (EC 3.2.1.26) ; co(polyether)polyurethane ; Sugars
    Language English
    Publishing date 2023-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2044817-X
    ISSN 1617-4623 ; 1617-4615
    ISSN (online) 1617-4623
    ISSN 1617-4615
    DOI 10.1007/s00438-023-02015-3
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  8. Article: Computer-modified paramedian approach technique reduces failures and alleviates pain in lumbar puncture: a prospective comparative study.

    Zhuang, Yuan-Dong / Xie, Hai-Shu / Chen, Jing / Wu, Guo-Hua / Wu, Jian-Feng / Chen, Chun-Mei

    Frontiers in medicine

    2024  Volume 10, Page(s) 1293689

    Abstract: Background: The conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study ... ...

    Abstract Background: The conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study evaluated a computer-modified paramedian approach technique (CMPAT) to optimize lumbar puncture using computational techniques.
    Methods: In this prospective study, 120 patients underwent CMPAT-LP (
    Results: No significant demographic differences existed between groups. Failure rates were 3.3% for CMPAT vs. 13.3% for MAT. Puncture attempts averaged 2.0 vs. 3.5 and pain scores were 2.7 vs. 4.1 for CMPAT and MAT, respectively. All outcomes were significantly improved with CMPAT, especially in elderly patients. No significant difference in complications was observed.
    Conclusion: Compared to MAT, CMPAT-LP demonstrated lower failure rates, fewer puncture attempts, and less pain, without compromising safety. CMPAT may be superior and should be more widely implemented in clinical practice.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1293689
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  9. Article ; Online: Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry.

    Sang, Xudong / Gan, Tian / Ge, Gai / Li, Dan / Mei, Youming / Pan, Chun / Long, Siyu / Xie, Bibo / Yu, Xiaobing / Chen, Zhiming / Wang, Hongsheng

    Journal of immunology research

    2024  Volume 2024, Page(s) 9927964

    Abstract: Background: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite ... ...

    Abstract Background: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, the cellular and molecular mechanisms underlying this progression remain unclear.
    Methods: We performed high-dimensional, in-depth immunophenotyping of peripheral blood mononuclear cells (PBMCs) in patients with PsA and psoriasis vulgaris (PsV) by mass cytometry. Blood samples were collected before and after therapy for a longitudinal study. Then three sets of comparisons were made here: active PsA
    Results: Marked differences were observed in multiple lymphocyte subsets of PsA related to PsV, with expansion of CD4
    Conclusion: In the circulation of PsA patients, the T
    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Longitudinal Studies ; Leukocytes, Mononuclear ; CD28 Antigens ; Psoriasis/diagnosis
    Chemical Substances CD28 Antigens
    Language English
    Publishing date 2024-04-01
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2024/9927964
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  10. Article ; Online: Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB.

    Xie, Chun-Lan / Xiao, Hong-Xiu / Song, Pei-Fang / Liu, Qing-Mei / Wei, Haoxiang / Wu, Liang / Zhu, Guang-Hao / Liu, Guang-Ming / Zhang, Yandong / Wang, Ping / Yang, Xian-Wen

    Journal of medicinal chemistry

    2024  

    Abstract: Food allergy (FA) poses a growing global food safety concern, yet no effective cure exists in clinics. Previously, we discovered a potent antifood allergy compound, butyrolactone I (BTL-I, ...

    Abstract Food allergy (FA) poses a growing global food safety concern, yet no effective cure exists in clinics. Previously, we discovered a potent antifood allergy compound, butyrolactone I (BTL-I,
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00354
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