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  1. Article ; Online: First Report of Pinnatoxin-G (PnTX-G) in a Marine-Coastal Area of the Adriatic Sea Associated with the Presence of the Dinoflagellate

    Cangini, Monica / Dall'Ara, Sonia / Rubini, Silva / Bertasi, Barbara / Rizzi, Paolo / Dell'Orfano, Giovanni / Milandri, Stefania / Manfredini, Stefano / Baldini, Erika / Vertuani, Silvia

    Marine drugs

    2024  Volume 22, Issue 3

    Abstract: This study reports the first detection of the marine neurotoxin pinnatoxin-G (PnTX-G) in clams ...

    Abstract This study reports the first detection of the marine neurotoxin pinnatoxin-G (PnTX-G) in clams collected in the northwestern Adriatic Sea (Italy). It also represents the first report of the potential toxin-producing dinoflagellate,
    MeSH term(s) Humans ; Alkaloids ; Dinoflagellida ; France ; Italy ; Spiro Compounds
    Chemical Substances pinnatoxin G ; Alkaloids ; Spiro Compounds
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22030122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Developing Benign Ni/g-C

    Pieta, Izabela S / Gieroba, Barbara / Kalisz, Grzegorz / Pieta, Piotr / Nowakowski, Robert / Naushad, Mu / Rathi, Anuj / Gawande, Manoj B / Sroka-Bartnicka, Anna / Zboril, Radek

    Industrial & engineering chemistry research

    2022  Volume 61, Issue 29, Page(s) 10496–10510

    Abstract: This research discusses the ... ...

    Abstract This research discusses the CO
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484436-9
    ISSN 1520-5045 ; 0888-5885
    ISSN (online) 1520-5045
    ISSN 0888-5885
    DOI 10.1021/acs.iecr.2c00452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Les G-quadruplex favorisent la réplication du virus de l’hépatite B en activant la transcription de l’ADNccc et sa séparation de phase dans les hépatocytes.

    Giraud, Guillaume / Testoni, Barbara

    Medecine sciences : M/S

    2024  Volume 40, Issue 4, Page(s) 338–341

    Title translation cccDNA phase separates in a G-quadruplex-dependent manner to facilitate its transcription and HBV replication.
    MeSH term(s) Humans ; Virus Replication/physiology ; Virus Replication/genetics ; G-Quadruplexes ; Hepatitis B virus/genetics ; Hepatitis B virus/physiology ; Transcription, Genetic/genetics ; DNA, Viral/genetics ; DNA, Circular/genetics
    Chemical Substances DNA, Viral ; DNA, Circular
    Language French
    Publishing date 2024-04-23
    Publishing country France
    Document type News ; Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2024035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Neonatal Platelets: Lower G

    Schlagenhauf, Axel / Bohler, Sheila / Kunze, Mirjam / Strini, Tanja / Haidl, Harald / Erlacher, Miriam / Zieger, Barbara

    Cells

    2022  Volume 11, Issue 16

    Abstract: ... peculiarities are lower receptor densities, reduced calcium mobilization, and functional impairments of G ... studies with adult platelets have shown a regulating effect of the G ...

    Abstract Despite fully functional primary hemostasis, platelets of healthy neonates exhibit hypoaggregability and secretion defects, which may be adaptations to specific requirements in this developmental stage. The etiologies for reduced signal transduction vary with the type of agonist. The discovered peculiarities are lower receptor densities, reduced calcium mobilization, and functional impairments of G proteins. Reduced secretion of dense granules has been attributed to lower numbers of granules. Signaling studies with adult platelets have shown a regulating effect of the G
    MeSH term(s) Blood Platelets/metabolism ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; GTP-Binding Proteins/metabolism ; Hemostasis ; Humans ; Infant, Newborn ; Signal Transduction ; Thrombin/pharmacology
    Chemical Substances Thrombin (EC 3.4.21.5) ; GTP-Binding Proteins (EC 3.6.1.-) ; GTP-Binding Protein alpha Subunits, G12-G13 (EC 3.6.5.1)
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11162563
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  5. Book ; Thesis: Therapie der fortgeschrittenen, rezidivierten chronischen lymphatischen Leukämie mit einer Kombination aus Fludarabin, Mitoxantron und Cyclophosphamid mit oder ohne G-CSF

    Simon, Florian / Eichhorst, Barbara / Hellmich, Martin

    Langzeitbeobachtung von Sicherheit und Wirksamkeit der CLL6-Studie der deutschen CLL Studiengruppe

    2020  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von Florian Simon ; 1. Gutachterin: Professorin Dr. med. B. Eichhorst, 2. Gutachter: Professor Dr. rer. medic. M. Hellmich ; aus dem Zentrum für Innere Meidzin I der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I
    Subject code 610
    Language German
    Size 90 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    HBZ-ID HT020667328
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 836 order for loan Magazin

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  6. Article ; Online: Role of HLA-G in tumors and upon COVID-19 infection.

    Seliger, Barbara

    Human immunology

    2024  , Page(s) 110792

    Abstract: HLA-G expression of tumors and upon viral infections is involved in their immune escape leading ... to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression ... relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components ...

    Abstract HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2024.110792
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors.

    Pettinella, Francesca / Mariotti, Barbara / Lattanzi, Chiara / Bruderek, Kirsten / Donini, Marta / Costa, Sara / Marini, Olivia / Iannoto, Giulia / Gasperini, Sara / Caveggion, Elena / Castellucci, Monica / Calzetti, Federica / Bianchetto-Aguilera, Francisco / Gardiman, Elisa / Giani, Matteo / Dusi, Stefano / Cantini, Maurizio / Vassanelli, Aurora / Pavone, Denise /
    Milella, Michele / Pilotto, Sara / Biondani, Pamela / Höing, Benedikt / Schleupner, Marie Carolin / Hussain, Timon / Hadaschik, Boris / Kaspar, Cordelia / Visco, Carlo / Tecchio, Cristina / Koenderman, Leo / Bazzoni, Flavia / Tamassia, Nicola / Brandau, Sven / Cassatella, Marco A / Scapini, Patrizia

    Cell reports. Medicine

    2024  Volume 5, Issue 2, Page(s) 101380

    Abstract: Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature ... ...

    Abstract Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature CD66b
    MeSH term(s) Humans ; Neutrophils ; Myeloid-Derived Suppressor Cells/metabolism ; Myeloid-Derived Suppressor Cells/pathology ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/metabolism ; Neoplasms/pathology ; CD52 Antigen/metabolism ; Signaling Lymphocytic Activation Molecule Family/metabolism
    Chemical Substances Receptors, Prostaglandin E, EP2 Subtype ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; CD52 protein, human ; CD52 Antigen ; CD84 protein, human ; Signaling Lymphocytic Activation Molecule Family ; PTGER2 protein, human
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101380
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  8. Article ; Online: Role of HLA-G in Viral Infections.

    Jasinski-Bergner, Simon / Schmiedel, Dominik / Mandelboim, Ofer / Seliger, Barbara

    Frontiers in immunology

    2022  Volume 13, Page(s) 826074

    Abstract: The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct ... restricted, tightly regulated expression and immune modulatory properties. HLA-G expression in tumor cells ... and virus-infected cells, as well as the release of soluble HLA-G leads to escape from host immune ...

    Abstract The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and immune modulatory properties. HLA-G expression in tumor cells and virus-infected cells, as well as the release of soluble HLA-G leads to escape from host immune surveillance. Increased knowledge of the link between HLA-G expression, viral infection and disease progression is urgently required, which highlights the possible use of HLA-G as novel diagnostic and prognostic biomarker for viral infections, but also as therapeutic target. Therefore, this review aims to summarize the expression, regulation, function and impact of HLA-G in the context of different viral infections including virus-associated cancers. The characterization of HLA-G-driven immune escape mechanisms involved in the interactions between host cells and viruses might result in the design of novel immunotherapeutic strategies targeting HLA-G and/or its interaction with its receptors on immune effector cells.
    MeSH term(s) HLA-A Antigens ; HLA-G Antigens/genetics ; Humans ; Immunologic Surveillance ; Polymorphism, Genetic ; Virus Diseases
    Chemical Substances HLA-A Antigens ; HLA-G Antigens
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.826074
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  9. Article ; Online: Affinity Resins for the Isolation of Immunoglobulins G Obtained Using Biocatalytic Technology.

    Tereshin, Mikhail N / Melikhova, Tatiana D / Eletskaya, Barbara Z / Ksenofontova, Olga B / Pantyushenko, Pavel V / Berzina, Maria Ya / Ivanov, Igor / Myagkikh, Igor V / Stepanenko, Vasiliy N

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Affinity chromatography resins that are obtained by conjugation of matrices with proteins of bacterial origin, like protein A, are frequently used for the purification of numerous therapeutic monoclonal antibodies. This article presents the development ... ...

    Abstract Affinity chromatography resins that are obtained by conjugation of matrices with proteins of bacterial origin, like protein A, are frequently used for the purification of numerous therapeutic monoclonal antibodies. This article presents the development of a biocatalytic method for the production of novel affinity resins with an immobilized mutant form of protein A via sortase A mediated reaction. The conditions for activation of the agarose Seplife 6FF matrix, selection of different types of linkers with free amino groups and conditions for immobilization of recombinant protein A on the surface of the activated matrix were studied. Finally, the basic operational properties, like dynamic binding capacity (DBC), temperature dependance of DBC and stability during the cleaning-in-place process of the affinity resin with the Gly-Gly-EDA-Gly-Gly linker, were assessed using recombinant hyperchimeric monoclonal antibodies. The main characteristics show comparable results with the widely used commercial samples.
    MeSH term(s) Immunoglobulin G ; Antibodies, Monoclonal/chemistry ; Technology ; Chromatography, Affinity/methods
    Chemical Substances Immunoglobulin G ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031367
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  10. Article: Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients.

    Kljaković-Gašpić Batinjan, Marina / Petrović, Tea / Vučković, Frano / Hadžibegović, Irzal / Radovani, Barbara / Jurin, Ivana / Đerek, Lovorka / Huljev, Eva / Markotić, Alemka / Lukšić, Ivica / Trbojević-Akmačić, Irena / Lauc, Gordan / Gudelj, Ivan / Čivljak, Rok

    Engineering (Beijing, China)

    2022  

    Abstract: The essential role of immunoglobulin G (IgG) in immune system regulation and combatting ...

    Abstract The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its
    Language English
    Publishing date 2022-09-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2886869-9
    ISSN 2095-8099
    ISSN 2095-8099
    DOI 10.1016/j.eng.2022.08.007
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