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  1. Article: Targeting calcium signaling in Alzheimer's disease: challenges and promising therapeutic avenues.

    Song, LinLin / Tang, YongPei / Law, Betty Yuen Kwan

    Neural regeneration research

    2023  Volume 19, Issue 3, Page(s) 501–502

    Language English
    Publishing date 2023-09-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.380898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.

    Ma, Xiu Mei / Geng, Kang / Wang, Peng / Jiang, Zongzhe / Law, Betty Yuen-Kwan / Xu, Yong

    Cardiovascular diabetology

    2024  Volume 23, Issue 1, Page(s) 96

    Abstract: Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate, a byproduct of glycolysis, is known to be significantly elevated in type ... ...

    Abstract Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate, a byproduct of glycolysis, is known to be significantly elevated in type 2 diabetes, its specific role in DCM remains uncertain. This study reveals an abnormal upregulation of monocarboxylate transporter 4 (MCT4) on the plasma membrane of cardiomyocytes in type 2 diabetes, leading to excessive lactate efflux from these cells. The disruption in lactate transport homeostasis perturbs the intracellular lactate-pyruvate balance in cardiomyocytes, resulting in oxidative stress and inflammatory responses that exacerbate myocardial damage. Additionally, our findings suggest increased lactate efflux augments histone H4K12 lactylation in macrophages, facilitating inflammatory infiltration within the microenvironment. In vivo experiments have demonstrated that inhibiting MCT4 effectively alleviates myocardial oxidative stress and pathological damage, reduces inflammatory macrophage infiltration, and enhances cardiac function in type 2 diabetic mice. Furthermore, a clinical prediction model has been established, demonstrating a notable association between peripheral blood lactate levels and diastolic dysfunction in individuals with type 2 diabetes. This underscores the potential of lactate as a prognostic biomarker for DCM. Ultimately, our findings highlight the pivotal involvement of MCT4 in the dysregulation of cardiac energy metabolism and macrophage-mediated inflammation in type 2 diabetes. These insights offer novel perspectives on the pathogenesis of DCM and pave the way for the development of targeted therapeutic strategies against this debilitating condition.
    MeSH term(s) Animals ; Humans ; Mice ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Cardiomyopathies/etiology ; Energy Metabolism ; Inflammation ; Lactic Acid/metabolism ; Models, Statistical ; Prognosis
    Chemical Substances Lactic Acid (33X04XA5AT) ; Slc16a4 protein, mouse
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-024-02178-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway.

    Liu, Ting / Li, Kangdi / Zhang, Zhenxing / Peng, Jinghui / Yang, Jingzhao / Law, Betty Yuen Kwan / Liu, Xin / Li, Wenhua

    The American journal of Chinese medicine

    2023  Volume 51, Issue 2, Page(s) 425–444

    Abstract: Targeting the stemness of triple-negative breast cancer (TNBC) is a potential therapeutic approach for treating TNBC. Tetrandrine, a natural plant alkaloid, has several anticancer effects. Here, we aimed to evaluate the efficacy of tetrandrine in cancer ... ...

    Abstract Targeting the stemness of triple-negative breast cancer (TNBC) is a potential therapeutic approach for treating TNBC. Tetrandrine, a natural plant alkaloid, has several anticancer effects. Here, we aimed to evaluate the efficacy of tetrandrine in cancer stemness and epithelial to mesenchymal transition (EMT) in TNBC, and to explore the underlying mechanisms. The effects of tetrandrine on cell growth, cell viability, cell stemness capacity, cell migration, and cell invasion, as well as the molecules involved in these processes, were investigated in a cell culture system. An
    MeSH term(s) Mice ; Animals ; Humans ; Epithelial-Mesenchymal Transition ; Superoxide Dismutase-1/metabolism ; Reactive Oxygen Species/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Mice, Nude ; Cell Line, Tumor ; Signal Transduction ; Cell Proliferation ; Neoplastic Stem Cells/pathology ; Cell Movement
    Chemical Substances Superoxide Dismutase-1 (EC 1.15.1.1) ; tetrandrine (29EX23D5AJ) ; Reactive Oxygen Species ; SOD1 protein, human
    Language English
    Publishing date 2023-01-20
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 193085-0
    ISSN 1793-6853 ; 0090-2942 ; 0192-415X
    ISSN (online) 1793-6853
    ISSN 0090-2942 ; 0192-415X
    DOI 10.1142/S0192415X23500222
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations.

    Qiu, Congling / Chan, Joyce Tsz Wai / Zhang, David Wei / Wong, Io Nam / Zeng, Yaling / Law, Betty Yuen Kwan / Mok, Simon Wing Fai / De Seabra Rodrigues Dias, Ivo Ricardo / Liu, Wenfeng / Liu, Liang / Wong, Vincent Kam Wai

    Genes & diseases

    2023  Volume 10, Issue 6, Page(s) 2252–2255

    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.02.007
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  5. Article ; Online: Two 18-norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease.

    Qiu, Wen-Qiao / Yu, Lu / He, Chang-Long / Wu, Jian-Ming / Law, Betty Yuen-Kwan / Yu, Chong-Lin / Qin, Da-Lian / Zhou, Xiao-Gang / Wu, An-Guo

    Clinical and translational medicine

    2023  Volume 13, Issue 9, Page(s) e1390

    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Mitophagy
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1390
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  6. Article: Licochalcone B, a Natural Autophagic Agent for Alleviating Oxidative Stress-Induced Cell Death in Neuronal Cells and

    Qu, Liqun / Wu, Jianhui / Tang, Yong / Yun, Xiaoyun / Lo, Hang Hong / Yu, Lu / Li, Wenhua / Wu, Anguo / Law, Betty Yuen Kwan

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 9

    Abstract: Autophagy has been implicated in the regulation of neuroinflammation and neurodegenerative disorders. Licochalcone B (LCB), a chalcone ... ...

    Abstract Autophagy has been implicated in the regulation of neuroinflammation and neurodegenerative disorders. Licochalcone B (LCB), a chalcone from
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15091052
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  7. Article: Development of Serum Lactate Level-Based Nomograms for Predicting Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients.

    Jiang, Chunxia / Ma, Xiumei / Chen, Jiao / Zeng, Yan / Guo, Man / Tan, Xiaozhen / Wang, Yuping / Wang, Peng / Yan, Pijun / Lei, Yi / Long, Yang / Law, Betty Yuen Kwan / Xu, Yong

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2024  Volume 17, Page(s) 1051–1068

    Abstract: Purpose: To establish nomograms integrating serum lactate levels and traditional risk factors for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients.: Patients and methods: A total of 570 T2DM patients and 100 ... ...

    Abstract Purpose: To establish nomograms integrating serum lactate levels and traditional risk factors for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients.
    Patients and methods: A total of 570 T2DM patients and 100 healthy subjects were enrolled. T2DM patients were categorized into normal and high lactate groups. Univariate and multivariate logistic regression analyses were employed to identify independent predictors for DKD. Then, nomograms for predicting DKD were established, and the model performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration, and decision curve analysis (DCA).
    Results: T2DM patients exhibited higher lactate levels compared to those in healthy subjects. Glucose, platelet, uric acid, creatinine, and hypertension were independent factors for DKD in T2DM patients with normal lactate levels, while diabetes duration, creatinine, total cholesterol, and hypertension were indicators in high lactate levels group (
    Conclusion: The serum lactate level-based nomogram models, combined with traditional risk factors, offer an effective tool for predicting DKD probability in T2DM patients. This approach holds promise for early risk assessment and tailored intervention strategies.
    Language English
    Publishing date 2024-03-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S453543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease

    Wen‐Qiao Qiu / Lu Yu / Chang‐Long He / Jian‐Ming Wu / Betty Yuen‐Kwan Law / Chong‐Lin Yu / Da‐Lian Qin / Xiao‐Gang Zhou / An‐Guo Wu

    Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)

    2023  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer's disease.

    Tang, Yong / Wei, Jing / Wang, Xiao-Fang / Long, Tao / Xiang, Xiaohong / Qu, Liqun / Wang, Xingxia / Yu, Chonglin / Xiao, Xingli / Hu, Xueyuan / Zeng, Jing / Xu, Qin / Wu, Anguo / Wu, Jianming / Qin, Dalian / Zhou, Xiaogang / Law, Betty Yuen-Kwan

    Neural regeneration research

    2024  Volume 19, Issue 11, Page(s) 2467–2479

    Abstract: JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on ... ...

    Abstract JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson's and Huntington's diseases, however, the effect of Citri Reticulatae Semen on Alzheimer's disease remains unelucidated. In the current study, the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated. Citri Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of autophagy. In addition, Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro, and suppress amyloid-beta-induced pathology such as paralysis, in a transgenic Caenorhabditis elegans in vivo model. Moreover, genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was autophagy-dependent. Most importantly, Citri Reticulatae Semen extract was confirmed to improve cognitive impairment, neuronal injury and amyloid-beta burden in 3×Tg Alzheimer's disease mice. As revealed by both in vitro and in vivo models, these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer's disease via its neuroprotective autophagic effects.
    Language English
    Publishing date 2024-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/NRR.NRR-D-23-00954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

    Congling Qiu / Joyce Tsz Wai Chan / David Wei Zhang / Io Nam Wong / Yaling Zeng / Betty Yuen Kwan Law / Simon Wing Fai Mok / Ivo Ricardo De Seabra Rodrigues Dias / Wenfeng Liu / Liang Liu / Vincent Kam Wai Wong

    Genes and Diseases, Vol 10, Iss 6, Pp 2252-

    2023  Volume 2255

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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