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  1. Article: Chronic obstructive pulmonary disease: moving from symptom relief to mortality reduction.

    Celi, Alessandro / Latorre, Manuela / Paggiaro, Pierluigi / Pistelli, Riccardo

    Therapeutic advances in chronic disease

    2021  Volume 14, Page(s) 20406223211014028

    Abstract: Chronic obstructive pulmonary disease (COPD) has a 3-year mortality rate up to 37%, 2-6 times higher than the general population. We present evidence supporting pharmacological therapies to improve patient life expectancy, focusing on inhaled ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) has a 3-year mortality rate up to 37%, 2-6 times higher than the general population. We present evidence supporting pharmacological therapies to improve patient life expectancy, focusing on inhaled corticosteroids (ICSs) combined with long-acting bronchodilators (LABDs). A reduction in 3-year all-cause mortality (ACM) has been shown in patients with severe COPD treated with fluticasone propionate (an ICS) and salmeterol [long-acting beta-agonist (LABA)], compared with placebo. An observational study of elderly patients with severe COPD and multiple comorbidities suggested ICS+LABD reduce ACM compared with LABD monotherapy. Patients with symptomatic COPD at risk of exacerbations saw a mortality benefit with the ICS/long-acting muscarinic antagonist (LAMA)/LABA combinations fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) or budesonide/glycopyrrolate/formoterol (BUD/GLY/FOR)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223211014028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Patient and physician perspectives on biological treatment in severe asthma: a Severe Asthma Network Italy survey.

    Crimi, Claudia / Calabrese, Cecilia / D'Amato, Maria / Blasi, Francesco / Canonica, Giorgio Walter / Guida, Giuseppe / Heffler, Enrico / Paggiaro, Pierluigi / Carpagnano, Giovanna Elisiana

    ERJ open research

    2023  Volume 9, Issue 6

    Abstract: Patients with severe asthma perceive beneficial effects of biologics and good self-reported adherence to treatment, even when self-administered at ... ...

    Abstract Patients with severe asthma perceive beneficial effects of biologics and good self-reported adherence to treatment, even when self-administered at home
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00560-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma.

    Sposato, Bruno / Scalese, Marco / Ricci, Alberto / Rogliani, Paola / Paggiaro, Pierluigi

    The clinical respiratory journal

    2021  Volume 15, Issue 2, Page(s) 237–243

    Abstract: Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics.: Methods: About 202 ...

    Abstract Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics.
    Methods: About 202 severe asthmatics were studied after 12-120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV
    Results: Pre-/post-treatment bronchodilator FEV
    Conclusion: Persistent SABA-induced FEV
    MeSH term(s) Airway Obstruction/drug therapy ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Eosinophils ; Forced Expiratory Volume ; Humans ; Lung
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13325
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  4. Article ; Online: Is adherence to treatment influenced by the ability to use inhaled devices in patients with COPD correctly?

    Latorre, Manuela / Parri, Giulia / Paggiaro, Pierluigi

    Pulmonology

    2020  Volume 26, Issue 2, Page(s) 63–65

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Aptitude/physiology ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/therapeutic use ; Disease Progression ; Humans ; Nebulizers and Vaporizers/classification ; Nebulizers and Vaporizers/statistics & numerical data ; Observational Studies as Topic ; Patient Education as Topic ; Portugal/epidemiology ; Psychometrics/methods ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Treatment Adherence and Compliance/statistics & numerical data
    Chemical Substances Adrenal Cortex Hormones ; Bronchodilator Agents
    Language English
    Publishing date 2020-02-06
    Publishing country Spain
    Document type Editorial
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2020.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply.

    Paggiaro, Pierluigi / Latorre, Manuela

    The journal of allergy and clinical immunology. In practice

    2016  Volume 4, Issue 4, Page(s) 793

    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2016.04.025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  6. Article: Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry.

    Caminati, Marco / Guarnieri, Gabriella / Paggiaro, Pierluigi / Vianello, Andrea / Crisafulli, Ernesto / Vaia, Rachele / Senna, Gianenrico

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: Smoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, ... ...

    Abstract Smoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, and the impact of smoke on asthma outcomes. The Severe Asthma Network in Italy (SANI) registry was analyzed. Demographic, clinical, and functional features of smokers, never and former smokers were compared. Data from 1194 patients were explored. Smokers were younger, with a lower asthma onset age. Atopy, BMI and respiratory/systemic comorbidities were equally distributed. In former smokers pre- and post-FEV1/FVC was significantly lower; no other significant differences were detected. Similar findings were confirmed when stratifying the former smokers by pack-years and length of smoking cessation. Among former smokers, lymphocytes and neutrophils were higher in the <15 years of smoking cessation group. Blood eosinophils were comparable in never and former smokers. When clustering the population by blood eosinophils, no significant differences in pulmonary function and exacerbations were observed. Our data suggest that a personal smoking history has a relatively low impact on disease burden. It remarks the importance of smoking cessation as a main intervention, particularly in severe asthma.
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247465
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  7. Article ; Online: Symptom

    Latorre, Manuela / Pistelli, Riccardo / Carpagnano, Giovanna Elisiana / Celi, Alessandro / Puxeddu, Ilaria / Scichilone, Nicola / Spanevello, Antonio / Canonica, Giorgio Walter / Paggiaro, Pierluigi

    Therapeutic advances in respiratory disease

    2023  Volume 17, Page(s) 17534666231159261

    Abstract: The article traces the concept of asthma control within GINA guidelines over the past 25 years. In the first 15 years after 1995, the main objective of asthma management was to obtain the control of all clinical and functional characteristics of asthma. ... ...

    Abstract The article traces the concept of asthma control within GINA guidelines over the past 25 years. In the first 15 years after 1995, the main objective of asthma management was to obtain the control of all clinical and functional characteristics of asthma. A landmark study (GOAL) showed for the first time that a good control of asthma is a reasonable outcome that can be achieved in a large proportion of asthmatics with a regular appropriate treatment. In the following years, more emphasis was placed on the role of exacerbations as critical manifestations of poor asthma control, whose frequency is associated with excessive FEV1 decline and increased risk of death. Accordingly, the 2014 GINA report makes a clear distinction between the control of the day-by-day symptoms and the reduction in the risk of severe exacerbations, stating that both conditions should be obtained. The 2019 update included a significant change in the management of mild asthma, prioritizing the prevention of exacerbations to that of mild symptoms. This view was repeated in the 2021 update, where the prevention of exacerbations, together with an acceptable symptom control with a minimal use of rescue medication, appeared to be the real main goal of asthma management. While a discrepancy between current symptoms and exacerbations may be present in mild asthma, a significant relationship between these two features is observed in moderate-severe asthma: a persistent poor symptom control is a major risk factor for exacerbations, whereas achieving symptom control through regular treatment is associated with a reduction in exacerbation rate. Thus, the opinion that frequent symptoms are not important in the absence of acute exacerbations should be discouraged, whereas education of patients to a good symptom perception and to improve adherence to regular treatment should be implemented. Furthermore, the persistence of risk factors, such as increased airway inflammation, even in a patient with minor daily symptoms, should be considered for optimizing treatment.
    MeSH term(s) Humans ; Asthma/diagnosis ; Asthma/drug therapy ; Risk Factors ; Anti-Asthmatic Agents/therapeutic use ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Anti-Asthmatic Agents ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/17534666231159261
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6753: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: New pharmacologic perspectives in pneumology: beclomethasone-formoterol extrafine.

    Paggiaro, Pierluigi

    The open respiratory medicine journal

    2009  Volume 3, Page(s) 38–42

    Abstract: International asthma guidelines have recently focused on the concept of ... >, which is the main outcome to reach and maintain in the long term management. Asthma control is associated with several positive consequences, both in terms of quality of ...

    Abstract International asthma guidelines have recently focused on the concept of <<control>>, which is the main outcome to reach and maintain in the long term management. Asthma control is associated with several positive consequences, both in terms of quality of life and pathophysiological findings. Combination therapy with inhaled corticosteroids (ICS) and long-acting-beta2-agonists (LABA) is recommended in a large part of asthmatic subjects (those who are not controlled with low-dose ICS alone).Recently, a new beclomethasone/formoterol combination in an extrafine HFA formulation has been developed. This new technology allows to obtain a very high fine particle fraction which reaches lower airways, while the dose which remain in the upper airways and possibly responsible for systemic side effects is very low. Therefore, this combination allows a different dose ratio between BDP and the other ICS (budesonide, fluticasone), in favour of a lower dose of BDP. Recent studies have demonstrated the equivalence of this new combination with the other ICS/LABA combination, as regards all asthma outcomes. Then, this new BDP/formoterol combination may increase the possibility to manage adequately patients with moderate-to-severe asthma.
    Language English
    Publishing date 2009-03-12
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395996-4
    ISSN 1874-3064 ; 1874-3064
    ISSN (online) 1874-3064
    ISSN 1874-3064
    DOI 10.2174/1874306400903010038
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  9. Article ; Online: Dupilumab-induced hypereosinophilia: review of the literature and algorithm proposal for clinical management.

    Caminati, Marco / Olivieri, Bianca / Dama, Annarita / Micheletto, Claudio / Paggiaro, Pierluigi / Pinter, Patrick / Senna, Gianenrico / Schiappoli, Michele

    Expert review of respiratory medicine

    2022  Volume 16, Issue 7, Page(s) 713–721

    Abstract: Introduction: Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, moderate-to-severe atopic dermatitis, and chronic rhinosinusitis with nasal polyps (CRSwNP). ... ...

    Abstract Introduction: Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, moderate-to-severe atopic dermatitis, and chronic rhinosinusitis with nasal polyps (CRSwNP). Eosinophilia has been reported as a potential adverse event in treated patients.
    Areas covered: A selective search on PubMed and Medline up to January 2022 was performed, by focusing on dupilumab-induced hypereosinophilia described in clinical trials, real-life studies, and case reports. The possible mechanisms underlying dupilumab-induced hypereosinophilia and the eosinophil-related morbidity have also been explored.
    Expert opinion: Dealing with dupilumab-induced hypereosinophilia represents a clinical challenge for clinicians managing patients on dupilumab therapy. An algorithm for the practical management of dupilumab-induced hypereosinophilia has been proposed, in order to properly investigate potential eosinophil-related morbidity and avoid unnecessary drug discontinuation.
    MeSH term(s) Algorithms ; Antibodies, Monoclonal, Humanized ; Eosinophilia ; Humans ; Nasal Polyps ; Sinusitis
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2090342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6963: Show issues Location:
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  10. Article ; Online: Patient and physician perspectives on biological treatment in severe asthma

    Claudia Crimi / Cecilia Calabrese / Maria D'Amato / Francesco Blasi / Giorgio Walter Canonica / Giuseppe Guida / Enrico Heffler / Pierluigi Paggiaro / Giovanna Elisiana Carpagnano

    ERJ Open Research, Vol 9, Iss

    a Severe Asthma Network Italy survey

    2023  Volume 6

    Keywords Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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