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  1. Article ; Online: Commentary on: Renin-angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure.

    Ferrario, Carlos M

    Clinical science (London, England : 1979)

    2021  Volume 135, Issue 5, Page(s) 683–686

    Abstract: We comment on the publication of a paper in which Brazilian investigators evaluate the anticontractile response of perivascular adipose tissue (PVAT) in experimental heart failure (HF) induced in rats by occlusion of a coronary artery. ...

    Abstract We comment on the publication of a paper in which Brazilian investigators evaluate the anticontractile response of perivascular adipose tissue (PVAT) in experimental heart failure (HF) induced in rats by occlusion of a coronary artery.
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Heart Failure/metabolism ; Rats ; Renin-Angiotensin System ; Vascular Diseases/metabolism ; Vasoconstriction
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20210017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Oscar A. Carretero, MD (1936-2024).

    Schiffrin, Ernesto L / Navar, Luis Gabriel / Ferrario, Carlos M

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) e47–e48

    MeSH term(s) Receptors, Cell Surface
    Chemical Substances Receptors, Cell Surface
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.124.22855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Commentary on "angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic".

    Ferrario, Carlos M

    Diabetes & metabolic syndrome

    2020  Volume 14, Issue 5, Page(s) 1401–1402

    MeSH term(s) Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.07.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: New approaches to hypertension management: always reasonable but now necessary

    Ferrario, Carlos M.

    (American journal of hypertension ; 18,2, Pt. 2 = Suppl.)

    2005  

    Author's details ed. Carlos M. Ferrario
    Series title American journal of hypertension ; 18,2, Pt. 2 = Suppl.
    Collection
    Language English
    Size 91S S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014336143
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2329 -18,2,Pt.2- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Alternative Renin-Angiotensin System.

    Bader, Michael / Steckelings, U Muscha / Alenina, Natalia / Santos, Robson A S / Ferrario, Carlos M

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 964–976

    Abstract: The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, ...

    Abstract The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT
    MeSH term(s) Renin-Angiotensin System/physiology ; Angiotensin II ; Peptidyl-Dipeptidase A/metabolism ; Peptides ; Angiotensin I/metabolism ; Peptide Fragments/metabolism ; Renin ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Peptides ; Angiotensin I (9041-90-1) ; Peptide Fragments ; Renin (EC 3.4.23.15) ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Commentary on "angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic"

    Ferrario, Carlos M

    Diabetes Metab Syndr

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #670339
    Database COVID19

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  7. Article ; Online: Commentary on “angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic”

    Ferrario, Carlos M.

    Diabetes & Metabolic Syndrome: Clinical Research & Reviews

    2020  Volume 14, Issue 5, Page(s) 1401–1402

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.07.041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Is chymase 1 a therapeutic target in cardiovascular disease?

    Ferrario, Carlos M / Ahmad, Sarfaraz / Speth, Robert / Dell'Italia, Louis J

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 8, Page(s) 645–656

    Abstract: Introduction: Non-angiotensin converting enzyme mechanisms of angiotensin II production remain underappreciated in part due to the success of current therapies to ameliorate the impact of primary hypertension and atherosclerotic diseases of the heart ... ...

    Abstract Introduction: Non-angiotensin converting enzyme mechanisms of angiotensin II production remain underappreciated in part due to the success of current therapies to ameliorate the impact of primary hypertension and atherosclerotic diseases of the heart and the blood vessels. This review scrutinize the current literature to highlight chymase role as a critical participant in the pathogenesis of cardiovascular disease and heart failure.
    Areas covered: We review the contemporaneous understanding of circulating and tissue biotransformation mechanisms of the angiotensins focusing on the role of chymase as an alternate tissue generating pathway for angiotensin II pathological mechanisms of action.
    Expert opinion: While robust literature documents the singularity of chymase as an angiotensin II-forming enzyme, particularly when angiotensin converting enzyme is inhibited, this knowledge has not been fully recognized to clinical medicine. This review discusses the limitations of clinical trials' that explored the benefits of chymase inhibition in accounting for the failure to duplicate in humans what has been demonstrated in experimental animals.
    MeSH term(s) Animals ; Humans ; Chymases/metabolism ; Chymases/therapeutic use ; Cardiovascular Diseases/drug therapy ; Angiotensin II/metabolism ; Angiotensin II/therapeutic use ; Heart Failure
    Chemical Substances Chymases (EC 3.4.21.39) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2247561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
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  9. Book: Efecto "de clase" de los medicamentos

    Ferrario, Carlos M.

    (Medicina clinica ; 114, Supl. 1)

    2000  

    Title variant The "class effect" of drugs
    Author's details ed. invitados: C. M. Ferrario
    Series title Medicina clinica ; 114, Supl. 1
    Medicina clínica
    Collection Medicina clínica
    Language Spanish
    Size 45 S. : graph. Darst.
    Publisher Ed. Doyma
    Publishing place Barcelona
    Publishing country Spain
    Document type Book
    HBZ-ID HT012775199
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 279 -114,Supl.1- verfügbar in Königswinter Königswinter

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  10. Article ; Online: Cardiac remodelling and RAS inhibition.

    Ferrario, Carlos M

    Therapeutic advances in cardiovascular disease

    2016  Volume 10, Issue 3, Page(s) 162–171

    Abstract: Risk factors such as hypertension and diabetes are known to augment the activity and tissue expression of angiotensin II (Ang II), the major effector peptide of the renin-angiotensin system (RAS). Overstimulation of the RAS has been implicated in a chain ...

    Abstract Risk factors such as hypertension and diabetes are known to augment the activity and tissue expression of angiotensin II (Ang II), the major effector peptide of the renin-angiotensin system (RAS). Overstimulation of the RAS has been implicated in a chain of events that contribute to the pathogenesis of cardiovascular (CV) disease, including the development of cardiac remodelling. This chain of events has been termed the CV continuum. The concept of CV disease existing as a continuum was first proposed in 1991 and it is believed that intervention at any point within the continuum can modify disease progression. Treatment with antihypertensive agents may result in regression of left ventricular hypertrophy, with different drug classes exhibiting different degrees of efficacy. The greatest decrease in left ventricular mass is observed following treatment with angiotensin converting enzyme inhibitors (ACE-Is), which inhibit Ang II formation. Although ACE-Is and angiotensin receptor blockers (ARBs) provide significant benefits in terms of CV events and stroke, mortality remains high. This is partly due to a failure to completely suppress the RAS, and, as our knowledge has increased, an escape phenomenon has been proposed whereby the human sequence of the 12 amino acid substrate angiotensin-(1-12) is converted to Ang II by the mast cell protease, chymase. Angiotensin-(1-12) is abundant in a wide range of organs and has been shown to increase blood pressure in animal models, an effect abolished by the presence of ACE-Is or ARBs. This review explores the CV continuum, in addition to examining the influence of the RAS. We also consider novel pathways within the RAS and how new therapeutic approaches that target this are required to further reduce Ang II formation, and so provide patients with additional benefits from a more complete blockade of the RAS.
    MeSH term(s) Angiotensin II/biosynthesis ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Humans ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Ventricular Remodeling/drug effects ; Ventricular Remodeling/physiology
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2485062-7
    ISSN 1753-9455 ; 1753-9447
    ISSN (online) 1753-9455
    ISSN 1753-9447
    DOI 10.1177/1753944716642677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6798: Show issues Location:
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