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Article ; Online: Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy.

Scarabel, Lucia / Garziera, Marica / Fortuna, Sara / Asaro, Fioretta / Toffoli, Giuseppe / Geremia, Silvano

2020 Volume 10, Issue 1, Page(s) 8773

Abstract: We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical ... biomarker in metastatic colorectal cancer (mCRC). To this aim the sHLA-G protein was measured in plasma ... and leucovorin (LV)) regimen. The results suggest a link between HLA-G levels and irinotecan (CPT-11 ...

Abstract	We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical biomarker in metastatic colorectal cancer (mCRC). To this aim the sHLA-G protein was measured in plasma samples of 40 patients with mCRC treated with the FOLFIRI (irinotecan (CPT-11) plus 5-fluorouracil (5-FU) and leucovorin (LV)) regimen. The results suggest a link between HLA-G levels and irinotecan (CPT-11) pharmacokinetic, leading to hypothesize a molecular interaction between sHLA-G and CPT-11. This interaction was confirmed experimentally by fluorescence spectroscopy. HLA-G is known to exist in a number of polymorphs that affect both the protein expression levels and its peptide-binding cleft. The interaction between HLA-G polymorphs and CPT-11 was explored by means of computational modelling, confirming the hypothesis that CPT-11 could actually target the peptide binding cleft of the most common HLA-G polymorphs.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/secondary ; Aged ; Antigens, Neoplasm/blood ; Antigens, Neoplasm/chemistry ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Binding Sites ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Colorectal Neoplasms/drug therapy ; Female ; Fluorouracil/administration & dosage ; HLA-G Antigens/blood ; HLA-G Antigens/chemistry ; Humans ; Irinotecan/administration & dosage ; Irinotecan/blood ; Irinotecan/pharmacokinetics ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Isoforms/blood ; Protein Isoforms/chemistry ; Solubility ; Spectrometry, Fluorescence
Chemical Substances	Antigens, Neoplasm ; HLA-G Antigens ; Protein Isoforms ; Irinotecan (7673326042) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-65424-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Short \& intermediate distance HVP contributions to muon g-2

Alexandrou, Constantia / Bacchio, Simone / Dimopoulos, Petros / Finkenrath, Jacob / Frezzotti, Roberto / Gagliardi, Giuseppe / Garofalo, Marco / Hadjiyiannakou, Kyriakos / Kostrzewa, Bartosz / Jansen, Karl / Lubicz, Vittorio / Petschlies, Marcus / Sanfilippo, Francesco / Simula, Silvano / Urbach, Carsten / Wenger, Urs

SM (lattice) prediction versus $e^+e^-$ annihilation data

2022

Abstract: We present new lattice results of the ETM Collaboration, obtained from extensive simulations of lattice QCD with dynamical up, down, strange and charm quarks at physical mass values, different volumes and lattice spacings, concerning the SM prediction ... ...

Abstract	We present new lattice results of the ETM Collaboration, obtained from extensive simulations of lattice QCD with dynamical up, down, strange and charm quarks at physical mass values, different volumes and lattice spacings, concerning the SM prediction for the so-called intermediate window (W) and short-distance (SD) contributions to the leading order hadronic vacuum polarization (LO-HVP) term of the muon anomalous magnetic moment, $a_\mu$. Results for $a_{\mu}^{\rm LO-HVP,W}$ and $a_{\mu}^{\rm LO-HVP,SD}$, besides representing a step forward to a complete lattice computation of $a_{\mu}^{\rm LO-HVP}$ and a useful benchmark among lattice groups, are compared here with their dispersive counterparts based on experimental data for $e^+e^-$ into hadrons. The comparison confirms the tension in $a_{\mu}^{\rm LO-HVP,W}$, already noted in 2020 by the BMW Collaboration, while showing no tension in $a_{\mu}^{\rm LO-HVP,SD}$. Comment: Talk given at ICHEP 2022 (6-13 July 2022, Bologna - Italy) - Results here are almost final - Contribution accepted for publication on PoS
Keywords	High Energy Physics - Phenomenology ; High Energy Physics - Lattice
Subject code	530 ; 612
Publishing date	2022-12-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

Lucia Scarabel / Marica Garziera / Sara Fortuna / Fioretta Asaro / Giuseppe Toffoli / Silvano Geremia

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level ... as clinical biomarker in metastatic colorectal cancer (mCRC). To this aim the sHLA-G protein was measured ... 5-FU) and leucovorin (LV)) regimen. The results suggest a link between HLA-G levels and irinotecan ...

Abstract	Abstract We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical biomarker in metastatic colorectal cancer (mCRC). To this aim the sHLA-G protein was measured in plasma samples of 40 patients with mCRC treated with the FOLFIRI (irinotecan (CPT-11) plus 5-fluorouracil (5-FU) and leucovorin (LV)) regimen. The results suggest a link between HLA-G levels and irinotecan (CPT-11) pharmacokinetic, leading to hypothesize a molecular interaction between sHLA-G and CPT-11. This interaction was confirmed experimentally by fluorescence spectroscopy. HLA-G is known to exist in a number of polymorphs that affect both the protein expression levels and its peptide-binding cleft. The interaction between HLA-G polymorphs and CPT-11 was explored by means of computational modelling, confirming the hypothesis that CPT-11 could actually target the peptide binding cleft of the most common HLA-G polymorphs.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electrical Spin Driving by g-Matrix Modulation in Spin-Orbit Qubits.

Crippa, Alessandro / Maurand, Romain / Bourdet, Léo / Kotekar-Patil, Dharmraj / Amisse, Anthony / Jehl, Xavier / Sanquer, Marc / Laviéville, Romain / Bohuslavskyi, Heorhii / Hutin, Louis / Barraud, Sylvain / Vinet, Maud / Niquet, Yann-Michel / De Franceschi, Silvano

Physical review letters

2018 Volume 120, Issue 13, Page(s) 137702

Abstract: ... voltage dependence and anisotropy of the hole g factor. We show that a g-matrix formalism ... in the literature: one associated with the modulation of the g factor, and measurable by Zeeman energy spectroscopy ...

Abstract	In a semiconductor spin qubit with sizable spin-orbit coupling, coherent spin rotations can be driven by a resonant gate-voltage modulation. Recently, we have exploited this opportunity in the experimental demonstration of a hole spin qubit in a silicon device. Here we investigate the underlying physical mechanisms by measuring the full angular dependence of the Rabi frequency, as well as the gate-voltage dependence and anisotropy of the hole g factor. We show that a g-matrix formalism can simultaneously capture and discriminate the contributions of two mechanisms so far independently discussed in the literature: one associated with the modulation of the g factor, and measurable by Zeeman energy spectroscopy, the other not. Our approach has a general validity and can be applied to the analysis of other types of spin-orbit qubits.
Language	English
Publishing date	2018-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.137702
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Article ; Online: Maternal and fetal HLA-G 14 bp gene polymorphism in pregnancy-induced hypertension, preeclampsia, intrauterine growth restricted and normal pregnancies.

Mandò, Chiara / Pileri, Paola / Mazzocco, Martina I / Lattuada, Debora / Zolin, Anna / Plebani, Maddalena / Massari, Maddalena / Calabrese, Stefania / Milani, Silvano / Cetin, Irene

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2016 Volume 29, Issue 9, Page(s) 1509–1514

Abstract: Objective: Trophoblast expression of Human Leukocyte Antigene-G (HLA-G) is essential for feto ... between HLA-G polymorphisms and preeclampsia (PE), intrauterine growth restriction (IUGR) and ... pregnancy-induced hypertension (PIH). Here, we investigate the association between both maternal and fetal HLA-G 14 bp insertion ...

Abstract	Objective: Trophoblast expression of Human Leukocyte Antigene-G (HLA-G) is essential for feto-maternal immune tolerance and successful placentation. There is contradicting evidence on the relationship between HLA-G polymorphisms and preeclampsia (PE), intrauterine growth restriction (IUGR) and pregnancy-induced hypertension (PIH). Here, we investigate the association between both maternal and fetal HLA-G 14 bp insertion/deletion polymorphism and obstetrical complications. Methods: Clinical and genetic data of 282 women/fetuses (31 severe PE, 8 mild PE, 46 IUGR, 42 PIH and 155 controls) were analyzed both individually and jointly under a codominant, a dominant and a recessive model. Results: HLA-G 14 bp polymorphism was not associated with obstetrical complications, considering the mother and fetus genotypes both jointly and individually. Conclusions: With this study we filled several gaps occurring in previous studies: we analyzed a very well-defined population of PE, PIH and IUGR pregnancies, considering both fetal and maternal HLA-G 14 bp polymorphism, individually and jointly. Our findings showed that fetal and maternal HLA-G 14 bp genotypes are not associated with increased risk for the development of obstetrical complications, suggesting that this polymorphism has no immuno-modulatory role in the development of PE, PIH or IUGR.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Fetal Growth Retardation/genetics ; Genetic Predisposition to Disease ; HLA-G Antigens/genetics ; Humans ; Polymorphism, Genetic ; Pre-Eclampsia/genetics ; Pregnancy
Chemical Substances	HLA-G Antigens
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.3109/14767058.2015.1052398
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Book ; Online: Gastrointestinal Hormones

Paternoster, Silvano / Keating, Damien / Falasca, Marco

2019

Keywords	Medicine ; Endocrinology ; glucagon-like peptides ; gastrointestinal hormone ; G protein coupled receptor (GPCR) ; NAFLD ; enteroendocrine cell
Size	1 electronic resource (123 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230734
ISBN	9782889631674 ; 2889631672
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: A brief history of Western medicine

Silvano, Giovanni

Beijing University of Chinese Medicine Journal of traditional Chinese medical sciences. 2021 Nov., v. 8

2021

Abstract: A concise history of Western medicine is here outlined focusing on major breakthroughs that occurred in such civilization from the ancient world to the present. Anatomy, physiology, pathology and therapy, both medical and surgical, are the main areas ... ...

Abstract	A concise history of Western medicine is here outlined focusing on major breakthroughs that occurred in such civilization from the ancient world to the present. Anatomy, physiology, pathology and therapy, both medical and surgical, are the main areas that witnessed dramatic advancements of science and medicine. The new knowledge of the body, of its functioning and pathology, first organically described by Morgagni and then by Virchow, made it possible to produce effective therapies. Microbiology and virology have played a very important role in defeating diseases that for millennia had been torturing humanity. Today's medicine is a planetary enterprise, as research and collaboration among scientists all over the world is widely accepted.
Keywords	business enterprises ; medicine ; physiology ; therapeutics ; virology
Language	English
Dates of publication	2021-11
Size	p. S10-S16.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834228-8
ISSN	2095-7548 ; 2589-0395
ISSN	2095-7548 ; 2589-0395
DOI	10.1016/j.jtcms.2020.06.002
Database	NAL-Catalogue (AGRICOLA)

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Article: High prevalence of GB virus C/hepatitis G virus RNA among Brazilian blood donors.

Levi, José Eduardo / Contri, Daniela Gazoto / Lima, Liliam Pereira / Takaoka, Deise Tihe / Garrini, Regina Helena / Santos, Wellingtom / Fachini, Roberta / Wendel, Silvano

Revista do Instituto de Medicina Tropical de Sao Paulo

2003 Volume 45, Issue 2, Page(s) 75–78

Abstract: The aim of this study was to investigate the presence of the Hepatitis G Virus on a population ...

Abstract	The aim of this study was to investigate the presence of the Hepatitis G Virus on a population of blood donors from S o Paulo, Brazil and to evaluate its association to sociodemographic variables. Two RT-PCR systems targeting the putative 5'NCR and NS3 regions were employed and the former has shown a higher sensitivity. The observed prevalence of HGV-RNA on 545 blood donors was 9.7% (CI 95% 7.4;12.5). Statistical analysis depicted an association with race/ethnicity, black and mulatto donors being more frequently infected; and also with years of education, less educated donors presenting higher prevalences. No association was observed with other sociodemographic parameters as age, gender, place of birth and of residence. DNA sequencing of nine randomly chosen isolates demonstrated the presence of genotypes 1, 2 and 3 among our population but clustering of these Brazilian isolates was not detected upon phylogenetic analysis.
MeSH term(s)	Adolescent ; Adult ; Blood Donors ; Brazil ; Chi-Square Distribution ; Confidence Intervals ; DNA, Viral/analysis ; Female ; Flaviviridae Infections/virology ; GB virus C/genetics ; GB virus C/immunology ; Hepatitis Antibodies/blood ; Hepatitis, Viral, Human/virology ; Humans ; Male ; Middle Aged ; RNA, Viral/analysis ; Socioeconomic Factors
Chemical Substances	DNA, Viral ; Hepatitis Antibodies ; RNA, Viral
Language	English
Publishing date	2003-05-14
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/s0036-46652003000200004
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Article ; Online: High prevalence of GB Virus C/Hepatitis G Virus RNA among Brazilian blood donors Alta prevalência do RNA do vírus da hepatite G (HGV) em doadores de sangue brasileiros

José Eduardo Levi / Daniela Gazoto Contri / Liliam Pereira Lima / Deise Tihe Takaoka / Regina Helena Garrini / Wellingtom Santos / Roberta Fachini / Silvano Wendel

Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 2, Pp 75-

2003 Volume 78

Abstract: The aim of this study was to investigate the presence of the Hepatitis G Virus on a population ... deste estudo foi investigar a presença do vírus da hepatite G e sua associação com variáveis ...

Abstract	The aim of this study was to investigate the presence of the Hepatitis G Virus on a population of blood donors from São Paulo, Brazil and to evaluate its association to sociodemographic variables. Two RT-PCR systems targeting the putative 5'NCR and NS3 regions were employed and the former has shown a higher sensitivity. The observed prevalence of HGV-RNA on 545 blood donors was 9.7% (CI 95% 7.4;12.5). Statistical analysis depicted an association with race/ethnicity, black and mulatto donors being more frequently infected; and also with years of education, less educated donors presenting higher prevalences. No association was observed with other sociodemographic parameters as age, gender, place of birth and of residence. DNA sequencing of nine randomly chosen isolates demonstrated the presence of genotypes 1, 2 and 3 among our population but clustering of these Brazilian isolates was not detected upon phylogenetic analysis. O objetivo deste estudo foi investigar a presença do vírus da hepatite G e sua associação com variáveis sóciodemográficas em uma população de doadores de sangue da cidade de São Paulo, Brasil. Dois sistemas de PCR foram empregados, um focando a região 5' não-codificadora e outro a região não-estrutural 3, apresentando o primeiro maior sensibilidade. A prevalência detectada do HGV-RNA em 545 doadores foi de 9,7% (IC 95% 7,4;12,5). A prevalência do HGV-RNA foi significativamente maior em doadores da raça negra/mulata (26,5%) quando comparados aos doadores caucasianos (7,5%), (OR = 4,5). Também foi observada uma tendência de maiores prevalências em doadores de menor escolaridade. Não se observou associação significativa com outros parâmetros estudados como idade, sexo, origem geográfica e local de residência. O sequenciamento do DNA de nove isolados selecionados ao acaso demonstrou a presença dos genótipos 1, 2 e 3, mas não houve um agrupamento das amostras brasileiras quando submetidas à análise filogenética
Keywords	Hepatitis G Virus ; HGV ; Blood donors ; PCR ; Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2003-04-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Medical Challenges of a Common Variable Immunodeficiency With a TNFRSF13B Gene Mutation in a Simultaneous Kidney and Pancreas Transplant Recipient.

Coimbra, Miguel T / Silvano, José / Martins, La Salete

Cureus

2023 Volume 15, Issue 8, Page(s) e44211

Abstract: ... infections, low immunoglobulin G (IgG) and A (IgA) serum levels, a slightly decreased population of memory ...

Abstract	Common variable immune deficiency (CVID) is a primary immunodeficiency disorder, with hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmune disorders, granulomatous diseases and malignancy. Among the solid organ transplant (SOT) recipient population, those with primary immunodeficiency disorders under chronic immunosuppression therapy can theoretically be at higher risk of atypical infections, autoimmune complications and disease recurrence with suboptimal long term graft survival, but literature is scarce. Here, we report a 27-year-old female with type 1 diabetes mellitus, complicated with nephropathy that progressed to end-stage renal disease (ESRD), who had a history of a chronic inflammatory response dysregulation, with chronic monoarthritis, persistent elevation of inflammation markers, recurrent infections, low immunoglobulin G (IgG) and A (IgA) serum levels, a slightly decreased population of memory B cells at flow cytometric immunophenotyping, and a confirmed pathological heterozygous mutation in the tumor necrosis factor receptor superfamily 13B (TNFRSF13B), with a suspected diagnosis of CVID. Whilst on hemodialysis, she received a simultaneous kidney and pancreas transplant from a standard criteria donor (SCD), and our induction and maintenance immunosuppression protocol and prophylaxis regimen allowed for a successful transplant with immediate pancreatic function, with no evidence of renal graft rejection upon biopsy in the early post-transplant period, and no novel episodes of serious infectious complications were recorded during a follow-up period of six months.
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44211
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