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Article ; Online: Dopamine D

Matuskey, David / Angarita, Gustavo A / Worhunsky, Patrick / Koohsari, Sheida / Gravel, Paul / Pittman, Brian / Gaiser, Edward C / Gallezot, Jean-Dominque / Nabulsi, Nabeel / Huang, Yiyun / Carson, Richard E / Potenza, Marc N / Malison, Robert T

Drug and alcohol dependence

2021 Volume 220, Page(s) 108514

Abstract: Background: Positron emission tomography (PET) work with the dopamine D3 receptor (D: Methods ... suggest that obesity in CUD was not associated with significant differences in D ...

Abstract	Background: Positron emission tomography (PET) work with the dopamine D3 receptor (D Methods: Non-obese CUD subjects (N = 12) were compared to age-matched obese CUD subjects (N = 14). All subjects underwent [ Results: In between-group analyses, D2/3R availability in non-obese and obese CUD groups was not significantly different overall. BMI was inversely correlated withBP Conclusion: These data suggest that obesity in CUD was not associated with significant differences in D
MeSH term(s)	Adult ; Body Mass Index ; Cocaine-Related Disorders/pathology ; Globus Pallidus/diagnostic imaging ; Humans ; Ligands ; Middle Aged ; Obesity/pathology ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism ; Substantia Nigra/diagnostic imaging ; Ventral Tegmental Area/diagnostic imaging
Chemical Substances	Ligands ; Receptors, Dopamine D2 ; Receptors, Dopamine D3
Language	English
Publishing date	2021-01-08
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2021.108514
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Article ; Online: Multimodal investigation of dopamine D

Worhunsky, Patrick D / Angarita, Gustavo A / Zhai, Zu Wei / Matuskey, David / Gallezot, Jean-Dominique / Malison, Robert T / Carson, Richard E / Potenza, Marc N

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2020 Volume 46, Issue 2, Page(s) 316–324

Abstract: Stimulant-use disorders have been associated with lower availability of dopamine type-2 receptors (D2R) and greater availability of type-3 receptors (D3R). Links between D2R levels, cognitive performance, and suppression of the default mode network (DMN) ...

Abstract	Stimulant-use disorders have been associated with lower availability of dopamine type-2 receptors (D2R) and greater availability of type-3 receptors (D3R). Links between D2R levels, cognitive performance, and suppression of the default mode network (DMN) during executive functioning have been observed in healthy and addicted populations; however, there is limited evidence regarding a potential role of elevated D3R in influencing cognitive control processes in groups with and without addictions. Sixteen individuals with cocaine-use disorder (CUD) and 16 healthy comparison (HC) participants completed [
MeSH term(s)	Cocaine ; Cognition ; Default Mode Network ; Dopamine ; Humans ; Receptors, Dopamine D2 ; Receptors, Dopamine D3
Chemical Substances	Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; Cocaine (I5Y540LHVR) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-020-00874-7
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Article ; Online: PET Imaging of Pancreatic Dopamine D

Bini, Jason / Sanchez-Rangel, Elizabeth / Gallezot, Jean-Dominique / Naganawa, Mika / Nabulsi, Nabeel / Lim, Keunpoong / Najafzadeh, Soheila / Shirali, Anupama / Ropchan, Jim / Matuskey, David / Huang, Yiyun / Herold, Kevan C / Harris, Paul E / Sherwin, Robert S / Carson, Richard E / Cline, Gary W

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2019 Volume 61, Issue 4, Page(s) 570–576

Abstract: ... with the dopamine D ...

Abstract	Type 1 diabetes mellitus (T1DM) has traditionally been characterized by a complete destruction of β-cell mass (BCM); however, there is growing evidence of possible residual BCM present in T1DM. Given the absence of in vivo tools to measure BCM, routine clinical measures of β-cell function (e.g., C-peptide release) may not reflect BCM. We previously demonstrated the potential utility of PET imaging with the dopamine D
MeSH term(s)	Adult ; Diabetes Mellitus, Type 1/diagnostic imaging ; Diabetes Mellitus, Type 1/metabolism ; Female ; Humans ; Ligands ; Male ; Middle Aged ; Oxazines ; Pancreas/diagnostic imaging ; Pancreas/metabolism ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism ; Young Adult
Chemical Substances	Ligands ; Oxazines ; Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; naxagolide (22Z7E0X6OF)
Language	English
Publishing date	2019-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.119.234013
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Article ; Online: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

Chaikovsky, Andrea C / Li, Chuan / Jeng, Edwin E / Loebell, Samuel / Lee, Myung Chang / Murray, Christopher W / Cheng, Ran / Demeter, Janos / Swaney, Danielle L / Chen, Si-Han / Newton, Billy W / Johnson, Jeffrey R / Drainas, Alexandros P / Shue, Yan Ting / Seoane, Jose A / Srinivasan, Preethi / He, Andy / Yoshida, Akihiro / Hipkins, Susan Q /

McCrea, Edel / Poltorack, Carson D / Krogan, Nevan J / Diehl, J Alan / Kong, Christina / Jackson, Peter K / Curtis, Christina / Petrov, Dmitri A / Bassik, Michael C / Winslow, Monte M / Sage, Julien

Nature

2021 Volume 592, Issue 7856, Page(s) 794–798

Abstract: The initiation of cell division integrates a large number of intra- and extracellular inputs. D ... type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication ...

Abstract	The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Adenocarcinoma of Lung/genetics ; Animals ; Cell Division ; Cyclin D/metabolism ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/metabolism ; Genes, Tumor Suppressor ; Humans ; Lung Neoplasms/genetics ; Mice ; Piperazines/pharmacology ; Pyridines/pharmacology ; U937 Cells ; Ubiquitination
Chemical Substances	AMBRA1 protein, human ; Adaptor Proteins, Signal Transducing ; Ambra1 protein, mouse ; Cyclin D ; Piperazines ; Pyridines ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22) ; palbociclib (G9ZF61LE7G)
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-03474-7
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Zs.MO 244: Show issues

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Article ; Online: Elevated Dopamine D

Gaiser, Edward C / Gallezot, Jean-Dominique / Worhunsky, Patrick D / Jastreboff, Ania M / Pittman, Brian / Kantrovitz, Lauren / Angarita, Gustavo A / Cosgrove, Kelly P / Potenza, Marc N / Malison, Robert T / Carson, Richard E / Matuskey, David

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2016 Volume 41, Issue 13, Page(s) 3042–3050

Abstract: Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D ...

Abstract	Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D
MeSH term(s)	Adult ; Body Mass Index ; Brain/diagnostic imaging ; Brain/drug effects ; Case-Control Studies ; Cohort Studies ; Dopamine Agonists/pharmacokinetics ; Female ; Humans ; Male ; Middle Aged ; Obesity/diagnostic imaging ; Oxazines/pharmacokinetics ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism ; Young Adult
Chemical Substances	DRD2 protein, human ; Dopamine Agonists ; Oxazines ; Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; naxagolide (22Z7E0X6OF)
Language	English
Publishing date	2016-07-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/npp.2016.115
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Article ; Online: Separating dopamine D

Smart, Kelly / Gallezot, Jean-Dominique / Nabulsi, Nabeel / Labaree, David / Zheng, Ming-Qiang / Huang, Yiyun / Carson, Richard E / Hillmer, Ansel T / Worhunsky, Patrick D

NeuroImage

2020 Volume 214, Page(s) 116762

Abstract: Development of medications selective for dopamine D ...

Abstract	Development of medications selective for dopamine D
MeSH term(s)	Adult ; Binding, Competitive ; Brain/metabolism ; Carbon Radioisotopes/pharmacokinetics ; Dopamine Antagonists/pharmacology ; Humans ; Image Processing, Computer-Assisted/methods ; Male ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacokinetics ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism
Chemical Substances	Carbon Radioisotopes ; Dopamine Antagonists ; Radiopharmaceuticals ; Receptors, Dopamine D2 ; Receptors, Dopamine D3
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2020.116762
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Zs.MO 7: Show issues

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Article ; Online: In vivo imaging of D

Lattin, Christine R / Merullo, Devin P / Riters, Lauren V / Carson, Richard E

Scientific reports

2019 Volume 9, Issue 1, Page(s) 10407

Abstract: ... and higher stress-induced corticosteroid titres at capture. Birds with higher striatal D ...

Abstract	Individual physiological variation may underlie individual differences in behaviour in response to stressors. This study tested the hypothesis that individual variation in dopamine and corticosteroid physiology in wild house sparrows (Passer domesticus, n = 15) would significantly predict behaviour and weight loss in response to a long-term stressor, captivity. We found that individuals that coped better with captivity (fewer anxiety-related behaviours, more time spent feeding, higher body mass) had lower baseline and higher stress-induced corticosteroid titres at capture. Birds with higher striatal D
MeSH term(s)	Adrenal Cortex Hormones/metabolism ; Animals ; Animals, Wild/metabolism ; Animals, Wild/physiology ; Anxiety/metabolism ; Anxiety/physiopathology ; Female ; Humans ; Male ; Positron-Emission Tomography/methods ; Raclopride/metabolism ; Receptors, Dopamine D2/metabolism ; Sparrows/metabolism ; Sparrows/physiology ; Stress, Physiological/physiology
Chemical Substances	Adrenal Cortex Hormones ; Receptors, Dopamine D2 ; Raclopride (430K3SOZ7G)
Language	English
Publishing date	2019-07-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-46845-x
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Article ; Online: Living the Dream: Working with Rod J. Rohrich, M.D., Editor-in-Chief of Plastic and Reconstructive Surgery.

Burch, Angela / Carson, Christina / Miner, Darienne / Moore, Isiah Donnell / Ramos, Madeline / Stokes, Mike / Tynan, Edward / Weinstein, Aaron

Plastic and reconstructive surgery

2021 Volume 148, Issue 6, Page(s) 1439–1444

MeSH term(s)	Humans ; Leadership ; Publishing/organization & administration ; Reconstructive Surgical Procedures/methods ; Surgeons/organization & administration ; Surgeons/psychology
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Editorial
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000008701
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Article ; Online: Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study.

Meng, Lingqiong / Wang, Xiangbing / Carson, Jeffrey L / Schlussel, Yvette / Shapses, Sue A

The Journal of clinical endocrinology and metabolism

2023 Volume 109, Issue 1, Page(s) e18–e24

Abstract: ... Vitamin D binding protein (DBP) is a potential prognostic indicator of outcomes since it is important ... DBP tertile (<28.0 mg/dL). Total 25-hydroxyvitamin-D did not differ between tertiles (22.0 ± 9.5 ng/mL ...

Abstract	Context: Hip fracture is a serious injury that can lead to increased morbidity and mortality. Vitamin D binding protein (DBP) is a potential prognostic indicator of outcomes since it is important for actin scavenging and inflammation after tissue injury. Objective: To determine whether circulating DBP is associated with mobility or mortality after hip fracture and its association with acute tissue injury markers. Methods: Post hoc analysis of a multisite North American prospective study of 260 patients with hip fracture; mobility assessed at 30 and 60 days and mortality at 60 days after repair surgery. Biochemical markers were measured before, and 2 to 4 days after surgery. Tissue injury markers were measured in 100 randomly selected patients and controls. The primary outcome was mobility and mortality by DBP tertiles. Secondary outcomes were assessment of pre- and postoperative biomarkers. Results: Among all patients (81 ± 9 years, BMI 25 ± 4 kg/m2; 72% female), the highest DBP tertile had greater mobility at 30 (OR: 2.66; 95% CI: 1.43, 4.92; P = .002) and 60 days (OR: 2.31; 95% CI: 1.17, 4.54; P = .014) and reduced mortality (OR: 0.18; 95% CI: 0.04, 0.86; P = .032) compared with the lowest DBP tertile (<28.0 mg/dL). Total 25-hydroxyvitamin-D did not differ between tertiles (22.0 ± 9.5 ng/mL). Circulating DBP and gelsolin were lower and interleukin-6, C-reactive protein, and F-actin were higher (P < .01) in patients vs controls, and worsened (P < .01) after surgery. Conclusion: High circulating DBP concentrations are associated with better mobility and reduced mortality after hip fracture surgery. The role of DBP as an acute phase reactant to tissue injury and clinical outcomes should be addressed in future study.
MeSH term(s)	Female ; Humans ; Male ; Biomarkers ; Hip Fractures/surgery ; Prospective Studies ; Vitamin D ; Vitamin D Deficiency ; Vitamin D-Binding Protein/metabolism
Chemical Substances	Biomarkers ; Vitamin D (1406-16-2) ; Vitamin D-Binding Protein
Language	English
Publishing date	2023-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad502
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Article ; Online: In patients hospitalized for COVID-19, tocilizumab reduces mortality at 28 d.

Lo, Carson K L / Chagla, Zain

Annals of internal medicine

2021 Volume 174, Issue 11, Page(s) JC125

Abstract: Source citation: WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group; Shankar-Hari M, Vale CL, Godolphin PJ, et al. ...

Abstract	Source citation: WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group; Shankar-Hari M, Vale CL, Godolphin PJ, et al.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
Chemical Substances	Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/ACPJ202111160-125
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