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Book ; Thesis: Operationstechniken beim Vollwandrektumprolaps

Lau, Arthur

Vergleich der transanalen Muskularisraffung nach Rehn-Delorme mit der Resektionsrektopexie im Rahmen der DeloRes-Studie

2018

Author's details	vorgelegt von Arthur Lau
Language	German
Size	102 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2018
HBZ-ID	HT019893867
Database	Catalogue ZB MED Medicine, Health

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2018 E 1527	order for loan	Magazin

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Article ; Online: An in silico study of the effects of cardiovascular aging on carotid flow waveforms and indexes in a virtual population.

Suriani, Irene / Bouwman, R Arthur / Mischi, Massimo / Lau, Kevin D

American journal of physiology. Heart and circulatory physiology

2024 Volume 326, Issue 4, Page(s) H877–H899

Abstract: Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond ... ...

Abstract	Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond chronological age, making the clinical assessment of cardiovascular aging an important prompt for preventative action. Carotid flow waveforms contain information about age-dependent cardiovascular properties, and their ease of measurement via noninvasive Doppler ultrasound (US) makes their analysis a promising tool for the routine assessment of cardiovascular aging. In this work, the impact of different aging processes on carotid waveform morphology and derived indexes is studied in silico, with the aim of establishing the clinical potential of a carotid US-based assessment of cardiovascular aging. One-dimensional (1-D) hemodynamic modeling was employed to generate an age-specific virtual population (VP) of
MeSH term(s)	Humans ; Aged ; Aging ; Carotid Arteries/diagnostic imaging ; Hemodynamics ; Cardiovascular Diseases ; Ultrasonography
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00304.2023
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Article ; Online: Re: First do no harm.

Yao, Jinna / Lau, Howard / Allen, Richard D M / Vass, Justin / Vasilaras, Arthur / Pleass, Henry C

ANZ journal of surgery

2022 Volume 92, Issue 11, Page(s) 3115

MeSH term(s)	Humans ; Self-Injurious Behavior ; Emergency Service, Hospital
Language	English
Publishing date	2022-11-17
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.17986
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Zs.A 180: Show issues

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Article ; Online: Effectiveness and Safety of Endoanchors in Abdominal and Thoracic Endovascular Aneurysm Repair: A Systematic Review and Meta-analysis.

Tang, Esther Wai Chi / Lau, Arthur Chak Kai / Cheng, Joshua Cheuk Hei / Wong, Joseph Chi-Yeung / Chan, Yiu Che

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2024 , Page(s) 15266028241245911

Abstract: Purpose: This systematic review aimed to summarize the effectiveness and safety of endoanchor, a stabilizing device for the proximal endograft designed to prevent endoleak and stent migration in endovascular aneurysm repair (EVAR) and thoracic ... ...

Abstract	Purpose: This systematic review aimed to summarize the effectiveness and safety of endoanchor, a stabilizing device for the proximal endograft designed to prevent endoleak and stent migration in endovascular aneurysm repair (EVAR) and thoracic endovascular aneurysm repair (TEVAR). Materials and methods: A systematic review and meta-analysis was conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. Literature up to May 31, 2023 was searched and independently screened from 4 databases. Data were pooled for meta-analysis. Primary outcomes included intraoperative and follow-up endoleak, stent migration, and reintervention rates; sac regression; and 30-day all-cause mortality. Results: Sixteen EVAR (n=1145) and 6 TEVAR studies (n=163) using the Heli-Fx EndoAnchor system were included from 2225 retrieved records. For EVAR patients (mean follow-up=11.9 months), the endoleak, graft migration, and reintervention rates were 3.97% (95% confidence interval [CI]=0.36%-1.99%), 0.004% (95% CI=0.00%-0.76%), and 5.43% (95% CI=0.86%-12.54%), respectively. The endoleak rates for primary and revision EVAR were 0.16% (95% CI=0.00%-1.65%) and 3.60% (95% CI=0.14%-9.72%), respectively. Only 4 cases of 30-day mortality (n=4) were reported in the literature. For TEVAR patients, the endoleak, stent migration, and reintervention rates were 7.4% (95% CI=0.03%-0.13%), 0.2% (95% CI=0.00%-0.06%), and 17.1% (95% CI=0.01%-0.45%), respectively. The 30-day mortality was 0.9% (95% CI=0%-0.12%). Conclusions: Endoanchor fixation in EVAR and TEVAR is effective and safe in preventing and treating endoleak and stent migration. The mortality is minimal in EVAR but higher in TEVAR. Clinical impact: Endoleak, graft migration, and reintervention in EVAR and TEVAR with endoanchor use were rare. Mortality in EVAR was low. The adjunctive deployment of endoanchors is an effective and safe means to prevent and treat endoleak and stent migration in EVAR and TEVAR. Yet, long-term efficacy and safety data and randomized controlled trials would be required to definitively recommend endoanchor use in routine clinical practice.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028241245911
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Zs.A 4547: Show issues

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Article ; Online: Comparison of Five Commercial Molecular Assays for

Totten, Arthur H / Adams, Anna Julia / Halas, Hyunmi K / Gebo, James E T / East, Amanda D / Lau, Anna F

Journal of clinical microbiology

2023 Volume 61, Issue 2, Page(s) e0149822

Abstract: Testing of cellular therapy products ... ...

Abstract	Testing of cellular therapy products for
MeSH term(s)	Humans ; Mycoplasma ; Limit of Detection ; Cell Culture Techniques ; Reference Standards ; Cell- and Tissue-Based Therapy
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01498-22
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Zs.A 1188: Show issues

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Article ; Online: Simulation of vertical dispersion and pollution impact of artificial light at night in urban environment.

Tong, Jimmy C K / Wun, Anthonio H L / Chan, Thomas T H / Lau, Edmond S L / Lau, Edwin C F / Chu, Hahn H K / Lau, Arthur P S

The Science of the total environment

2023 Volume 902, Page(s) 166101

Abstract: The use of artificial light at night (ALAN) enables social and commercial activities for urban living. However, the excessive usage of lighting causes nuisance and waste of energy. Light is provided to illuminate target areas on the street level where ... ...

Abstract	The use of artificial light at night (ALAN) enables social and commercial activities for urban living. However, the excessive usage of lighting causes nuisance and waste of energy. Light is provided to illuminate target areas on the street level where activities take place, yet light can also cause trespass to residents at the floors above. While regulations are beginning to cover light design, simulation tools for the outdoor environment have also become more popular for assessing the design condition. Simulation tools allow visualisation of the impact of the selected light sources on those who are affected. However, this cause-and-effect relationship is not easy to determine in the complex urban environment. The current work offers a simple methodology that takes site survey results and correlates them with the simulation model to determine lighting impact on the investigated area in 3D. Four buildings in two mixed commercial and residential streets in Hong Kong were studied. Data collection from each residential building requires lengthy work and permission from each household. Therefore, a valid lighting simulation model could help determine the light pollution impact in the area. A light model using DIALux is developed and calibrated by correlating the simulated data with the actual measured data. The correlation value R
Language	English
Publishing date	2023-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.166101
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Zs.A 949: Show issues

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Article ; Online: Measurement of Vertical Dispersion and Pollution Impact of Artificial Light at Night in Urban Environment

Jimmy C.K. Tong / Edmond S.L. Lau / Cindy W.Y. Chan / Stevie M.W. Law / Patrick C.H. Yeung / Hahn H.K. Chu / Arthur P.S. Lau

Sustainable Futures, Vol 7, Iss , Pp 100145- (2024)

1481

Abstract: Excessive artificial light disrupts our lives and poses health risks. In mixed-use urban areas, commercial lighting conflicts with residential activities. Vertical towers exacerbate the issue, as lower-level lighting affects higher-level occupants, and ... ...

Abstract	Excessive artificial light disrupts our lives and poses health risks. In mixed-use urban areas, commercial lighting conflicts with residential activities. Vertical towers exacerbate the issue, as lower-level lighting affects higher-level occupants, and more research is needed to understand the vertical dispersion of light and its impact on sleep disturbance. This work offers a simple mathematical model for height dependence of illuminance in an urban building. It correlates basic measurements to reduce the values of the Exponent (n) and Linear (Coeff2) coefficients in a standard power-law curve. The collection of only a few data points can help to investigate the extent of the lighting spread at various floors of the building. Even with the complex lighting environment in Hong Kong, the methodology is exercised in 8 sample buildings from 4 different neighbourhoods to show the insights from the testing results. The heights of the studied buildings range from 3 to 18 stories, and they are for residential and mixed use. While the average measured illuminance at the street level was between 37 lx and 303 lx for the 4 neighbourhoods, the average illuminance across building heights was 14 lx to 247 lx. The existence of multiple light sources on building facades disrupts the simple inverse-square relationship with a single light source. The power n values range from approximately -1.7 to -0.8, while the Coeff2 values range from 61 to 7603 for the measured buildings. These variations indicate deviations from the assumption of a single source and suggest higher luminance and the presence of light sources at higher heights. With the simple inverse-square relationship, the proposed methodology can help to determine the height where the recommended limit can be met given the light situation at the street level.
Keywords	Street level light illuminance ; On-site testing ; Spatial distribution ; Urban residential and commercial zones ; Building design ; Light pollution ; Environmental sciences ; GE1-350 ; Technology ; T
Subject code	720
Language	English
Publishing date	2024-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation of an aging virtual population for the study of carotid hemodynamics.

Suriani, Irene / Bouwman, R Arthur / Mischi, Massimo / Lau, Kevin D

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 4249–4252

Abstract: The analysis of carotid ultrasound (US) flow, velocity, and diameter waveforms provides important information about cardiovascular and circulatory health. These can be used to derive clinical indices of atherosclerosis, vascular aging, and hemodynamic ... ...

Abstract	The analysis of carotid ultrasound (US) flow, velocity, and diameter waveforms provides important information about cardiovascular and circulatory health. These can be used to derive clinical indices of atherosclerosis, vascular aging, and hemodynamic status. To derive clinical insight from carotid waveforms, it is essential to understand the relationship of the observed variability in morphology with the underlying hemodynamic status and cardiovascular properties. For this purpose, using a one-dimensional modeling approach, we have developed and validated a virtual population that is able to realistically simulate carotid waveforms of healthy subjects aged between 10 and 80 years old.Clinical Relevance-Our virtual population of carotid waveforms can support the interpretation of US patient data. It can be used, e.g., to investigate how waveform morphology and derived indices relate to individual arterial and cardiac properties.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Carotid Arteries/diagnostic imaging ; Child ; Hemodynamics ; Humans ; Middle Aged ; Ultrasonography ; Young Adult
Language	English
Publishing date	2021-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zoster Sine Herpete Masquerading as Central Nervous System Vasculitis.

Lau, Arthur / Essien, Eno-Obong / Tan, Irene J

Cureus

2020 Volume 12, Issue 3, Page(s) e7231

Abstract: Central nervous system (CNS) vasculopathy caused by varicella zoster virus (VZV) is a rare condition. Rarer still is the development of CNS vasculopathy in the absence of a typical zoster rash, a phenomenon known as zoster sine herpete. We report a case ... ...

Abstract	Central nervous system (CNS) vasculopathy caused by varicella zoster virus (VZV) is a rare condition. Rarer still is the development of CNS vasculopathy in the absence of a typical zoster rash, a phenomenon known as zoster sine herpete. We report a case of a 34-year-old male with HIV, non-compliant with highly active antiretroviral therapy (HAART), who presented with left-sided temporal headaches and numbness without rash. The patient had a complicated one-month hospital stay when he was initially diagnosed with mycobacterium avium complex (MAC) tuberculosis infection and treated with isoniazid, rifabutin, ethambutol, and azithromycin. Additionally, he was thought to have immune reconstitution inflammatory syndrome (IRIS) and was given steroids. Unfortunately, he presented one day post-discharge with lethargy, aphasia, and dysphagia and was found to have acute/subacute infarcts affecting multiple areas of the brain. CT angiogram (CTA) of the brain showed evidence of multifocal areas of mild to moderate stenosis throughout the intracranial arterial circulation. The patient underwent conventional angiography, which showed segmental arterial constrictions with post-stenotic dilatation consistent with vasculitis. Cerebrospinal fluid (CSF) studies eventually returned positive for VZV by polymerase chain reaction (PCR), confirming a diagnosis of VZV-induced CNS vasculopathy, or more specifically, CNS vasculopathy due to zoster sine herpete. The patient was treated with high-dose steroids as well as IV acyclovir with improvement in his symptoms. He was discharged with advice for a close follow-up with the infectious disease (ID) department. Our case highlights the importance of maintaining a high index of suspicion for varicella infection masquerading as CNS vasculitis, particularly in the absence of classic blistering shingles rash. Early detection may prevent neurological sequelae of the infection, including stroke, dissection, or neuropathy.
Language	English
Publishing date	2020-03-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.7231
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Case of Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in a Patient with an Underlying Rheumatic Disease.

Lau, Arthur / Youn, Hayoung / Caricchio, Roberto / Brent, Lawrence

Cureus

2020 Volume 12, Issue 5, Page(s) e8130

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition caused by overproduction of inflammatory cytokines and overactivation of macrophages that can progress to multiorgan dysfunction and failure. Although there are guidelines that ... ...

Abstract	Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition caused by overproduction of inflammatory cytokines and overactivation of macrophages that can progress to multiorgan dysfunction and failure. Although there are guidelines that attempt to recognize the condition in its early stage, diagnosis can be very challenging due to heterogeneous presentations of HLH. Symptoms and clinical findings include fever, neurologic complaints, respiratory issues, liver dysfunction, cytopenias, amongst others most of which are not specific to HLH. In addition, response to treatment can be highly variable, necessitating an individualized treatment plan based on the presentation. We present a case of a 21-year-old female with a history of biopsy-proven inflammatory myositis on azathioprine and prednisone who presented with fever, hypotension, and pancytopenia. Additional imaging studies showed multiorgan involvement, including pneumonia, pyelonephritis, and splenomegaly. A bone marrow biopsy of her iliac crest showed hemophagocytosis and the infectious workup confirmed cytomegalovirus (CMV) infection, which led to the diagnosis of CMV-induced HLH. She was treated initially with anakinra for macrophage activation syndrome (MAS) in addition to dexamethasone and ganciclovir. Unfortunately, she did not respond to anakinra and was subsequently switched to etoposide with dexamethasone and valganciclovir, which subsequently helped our patient to recover clinically. Our case highlights the challenging nature of HLH and the importance of early detection and a personalized treatment plan in achieving optimal outcomes in patients with HLH.
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.8130
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