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Article ; Online: Are cryptocurrencies currencies? Bitcoin as legal tender in El Salvador.

Alvarez, Fernando / Argente, David / Van Patten, Diana

2023 Volume 382, Issue 6677, Page(s) eadd2844

Abstract: A currency's essential feature is to be a medium of exchange. This study explores the potential of cryptocurrencies to be used in daily transactions in El Salvador, the first country to make bitcoin legal tender. The government's "big push" introduced " ... ...

Abstract	A currency's essential feature is to be a medium of exchange. This study explores the potential of cryptocurrencies to be used in daily transactions in El Salvador, the first country to make bitcoin legal tender. The government's "big push" introduced "Chivo Wallet," a digital wallet sharing features with Central Bank Digital Currencies (CBDCs), with perks to use it for trading bitcoins and US dollars. Through a nationally representative, face-to-face survey of 1800 households and blockchain data encompassing all Chivo Wallet transactions, we document a pattern of low and decreasing usage of digital payments and bitcoin. Privacy and security concerns are key adoption barriers, which speaks to a policy debate on crypto and CBDCs with anonymity at its core. Additionally, we estimate Chivo Wallet's adoption cost and complementarities among adopters.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.add2844
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Article: Microbial Colonization of Capsular Traction Sutures in Hip Arthroscopic Surgery.

Patten, Ian S / Sun, Yuhang / Maldonado, David R / Lee, Michael S / Banffy, Michael B

Orthopaedic journal of sports medicine

2023 Volume 11, Issue 5, Page(s) 23259671231166705

Abstract: Background: A common practice in hip arthroscopic surgery is the utilization of capsular traction sutures that can be incorporated into the capsular repair site at the end of the procedure, potentially seeding the hip joint with colonized suture ... ...

Abstract	Background: A common practice in hip arthroscopic surgery is the utilization of capsular traction sutures that can be incorporated into the capsular repair site at the end of the procedure, potentially seeding the hip joint with colonized suture material. Purpose: To investigate the rate of the microbial colonization of capsular traction sutures used during hip arthroscopic surgery and to identify patient-associated risk factors for this microbial colonization. Study design: Cross-sectional study; Level of evidence, 3. Methods: A total of 50 consecutive patients who underwent hip arthroscopic surgery with a single surgeon were enrolled. There were 4 braided nonabsorbable sutures utilized for capsular traction during each hip arthroscopic procedure. These 4 traction sutures and 1 control suture were submitted for aerobic and nonaerobic cultures. Cultures were held for 21 days. Demographic information was collected, such as age, sex, and body mass index. All variables underwent bivariate analysis, and variables with a Results: One of 200 experimental traction sutures and 1 of 50 control sutures had a positive culture. Conclusion: The rate of the microbial colonization of capsular traction sutures used in hip arthroscopic surgery was low, and no patient-associated risk factors were identified for microbial colonization. Capsular traction sutures used in hip arthroscopic surgery were not a significant potential source of microbial contamination. Based on these results, capsular traction sutures can be incorporated in capsular closure with a low risk of seeding the hip joint with microbial contaminants.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671231166705
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Article ; Online: Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation.

Parmar, Gaganvir / Fong-McMaster, Claire / Pileggi, Chantal A / Patten, David A / Cuillerier, Alexanne / Myers, Stephanie / Wang, Ying / Hekimi, Siegfried / Cuperlovic-Culf, Miroslava / Harper, Mary-Ellen

The Journal of biological chemistry

2024 Volume 300, Issue 2, Page(s) 105626

Abstract: Mitochondrial electron transport chain complexes organize into supramolecular structures called respiratory supercomplexes (SCs). The role of respiratory SCs remains largely unconfirmed despite evidence supporting their necessity for mitochondrial ... ...

Abstract	Mitochondrial electron transport chain complexes organize into supramolecular structures called respiratory supercomplexes (SCs). The role of respiratory SCs remains largely unconfirmed despite evidence supporting their necessity for mitochondrial respiratory function. The mechanisms underlying the formation of the I
MeSH term(s)	Electron Transport ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Electron Transport Complex III/genetics ; Electron Transport Complex III/metabolism ; Energy Metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Humans ; HEK293 Cells
Chemical Substances	Electron Transport Complex I (EC 7.1.1.2) ; Electron Transport Complex III (EC 7.1.1.8)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.105626
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Article ; Online: The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration.

Wilkinson, Alex L / Hulme, Samuel / Kennedy, James I / Mann, Emily R / Horn, Paul / Shepherd, Emma L / Yin, Kelvin / Zaki, Marco Y W / Hardisty, Gareth / Lu, Wei-Yu / Rantakari, Pia / Adams, David H / Salmi, Marko / Hoare, Matthew / Patten, Daniel A / Shetty, Shishir

iScience

2023 Volume 26, Issue 10, Page(s) 107966

Abstract: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment ... ...

Abstract	Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment are poorly understood. Plasmalemma-vesicle-associated protein (PLVAP) has been characterized as a marker of LSEC in CLD; notably we found that PLVAP upregulation strongly correlated with markers of tissue senescence. Furthermore, exposure of human LSEC to the senescence-associated secretory phenotype (SASP) led to a significant upregulation of PLVAP. Flow-based assays demonstrated that SASP-driven leukocyte recruitment was characterized by paracellular transmigration of monocytes while the majority of lymphocytes migrated transcellularly. Knockdown studies confirmed that PLVAP selectively supported monocyte transmigration mediated through PLVAP's impact on LSEC permeability by regulating phospho-VE-cadherin expression and endothelial gap formation. PLVAP may therefore represent an endothelial target that selectively shapes the senescence-mediated immune microenvironment in liver disease.
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107966
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Article ; Online: The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

Alex L. Wilkinson / Samuel Hulme / James I. Kennedy / Emily R. Mann / Paul Horn / Emma L. Shepherd / Kelvin Yin / Marco Y.W. Zaki / Gareth Hardisty / Wei-Yu Lu / Pia Rantakari / David H. Adams / Marko Salmi / Matthew Hoare / Daniel A. Patten / Shishir Shetty

iScience, Vol 26, Iss 10, Pp 107966- (2023)

2023

Abstract: Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell ... ...

Abstract	Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment are poorly understood. Plasmalemma-vesicle-associated protein (PLVAP) has been characterized as a marker of LSEC in CLD; notably we found that PLVAP upregulation strongly correlated with markers of tissue senescence. Furthermore, exposure of human LSEC to the senescence-associated secretory phenotype (SASP) led to a significant upregulation of PLVAP. Flow-based assays demonstrated that SASP-driven leukocyte recruitment was characterized by paracellular transmigration of monocytes while the majority of lymphocytes migrated transcellularly. Knockdown studies confirmed that PLVAP selectively supported monocyte transmigration mediated through PLVAP’s impact on LSEC permeability by regulating phospho-VE-cadherin expression and endothelial gap formation. PLVAP may therefore represent an endothelial target that selectively shapes the senescence-mediated immune microenvironment in liver disease.
Keywords	Microenvironment ; Molecular biology ; Cell biology ; Omics ; Transcriptomics ; Science ; Q
Subject code	570
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New therapeutic agents for castration-refractory prostate cancer.

Patten, David Y / Sartor, Oliver

Clinical genitourinary cancer

2009 Volume 7, Issue 2, Page(s) E4–6

MeSH term(s)	Androstenes ; Androstenols/therapeutic use ; Endothelins/antagonists & inhibitors ; Humans ; Male ; Orchiectomy ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/therapeutic use ; Prostatic Neoplasms/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Receptors, Androgen/physiology ; Thalidomide/therapeutic use ; Tissue Extracts/therapeutic use
Chemical Substances	Androstenes ; Androstenols ; Endothelins ; Protein Kinase Inhibitors ; Receptors, Androgen ; Tissue Extracts ; Phenylthiohydantoin (2010-15-3) ; Thalidomide (4Z8R6ORS6L) ; sipuleucel-T (8Q622VDR18) ; enzalutamide (93T0T9GKNU) ; abiraterone (G819A456D0)
Language	English
Publishing date	2009-04-15
Publishing country	United States
Document type	Editorial ; Review
ZDB-ID	2225121-2
ISSN	1938-0682 ; 1558-7673
ISSN (online)	1938-0682
ISSN	1558-7673
DOI	10.3816/CGC.2009.n.013
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Article: Grx2

Liaghati, Ava / Pileggi, Chantal A / Parmar, Gaganvir / Patten, David A / Hadzimustafic, Nina / Cuillerier, Alexanne / Menzies, Keir J / Burelle, Yan / Harper, Mary-Ellen

Frontiers in physiology

2021 Volume 12, Page(s) 604210

Abstract: Glutathione is an important antioxidant that regulates cellular redox status and is disordered in many disease states. Glutaredoxin 2 ( ...

Abstract	Glutathione is an important antioxidant that regulates cellular redox status and is disordered in many disease states. Glutaredoxin 2 (
Language	English
Publishing date	2021-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.604210
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Article ; Online: Prohibitin 1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers.

Kong, Bao / Han, Chae Young / Kim, Se Ik / Patten, David A / Han, Youngjin / Carmona, Euridice / Shieh, Dar-Bin / Cheung, Annie C / Mes-Masson, Anne-Marie / Harper, Mary-Ellen / Song, Yong Sang / Tsang, Benjamin K

Journal of ovarian research

2022 Volume 15, Issue 1, Page(s) 70

Abstract: Background: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive ... ...

Abstract	Background: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive character of mitochondrial fragmentation, associated with chemosensitivity. Here, we examined the role of prohibitin (Phb)1 in increasing L-Opa1 processing via the regulating mitochondrial protease, Oma1 and its direct interaction with p-p53 (ser15) and pro-apoptotic Bcl-2 antagonist/killer (Bak) 1 in the signaling axis and if this phenomenon is associated with prognosis of patients. Methods: We compared Cisplatin (CDDP)-induced response of mitochondrial dynamics, molecular interaction among p-p53 (ser15)-Phb1-Bak, and chemoresponsiveness in paired chemosensitive and chemoresistant gynecologic cancer cells (ovarian and cervical cancer cell lines) using western blot, immunoprecipitation, sea horse, and immunofluorescence. Translational strategy with proximity ligation assessment in phb1-p-p53 (ser15) in human ovarian tumor sections further confirmed in vitro finding, associated with clinical outcome. Results: We report that: (1) Knock-down of Phb1 prevents Cisplatin (cis-diamine-dichloroplatinum; CDDP) -induced changes in mitochondrial fragmentation and Oma1 mediated cleavage, and Opa1 processing; (2) In response to CDDP, Phb1 facilitates the p-p53 (ser15)-Phb1-Bak interaction in mitochondria in chemosensitive gynecologic cancer cells but not in chemoresistant cells; (3) Akt overexpression results in suppressed p-p53(Ser15)-Phb1 interaction and dysregulated mitochondrial dynamics, and (4) Consistent with in vitro findings, proximity ligation assessment (PLA) in human ovarian tumor sections demonstrated that p-p53(ser15)-Phb1-Bak interaction in mitochondria is associated with better chemoresponsiveness and clinical outcome of patients. Determining the molecular mechanisms by which Phb1 facilitates mitochondrial fragmentation and interacts with p53 may advance the current understanding of chemoresistance and pathogenesis of gynecologic cancer. Conclusion: Determining the key molecular mechanisms by which Phb1 facilitates the formation of p-p53 (ser15)-Bak-Phb1 and its involvement in the regulation of mitochondrial dynamics and apoptosis may ultimately contribute to the current understanding of molecular and cellular basis of chemoresistance in this gynecologic cancer.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Cell Line, Tumor ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Female ; Genital Neoplasms, Female ; Humans ; Mitochondrial Dynamics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Prohibitins ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms
Chemical Substances	Antineoplastic Agents ; Prohibitins ; Tumor Suppressor Protein p53 ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2455679-8
ISSN	1757-2215 ; 1757-2215
ISSN (online)	1757-2215
ISSN	1757-2215
DOI	10.1186/s13048-022-00999-x
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Article: Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer.

Cancers

2021 Volume 13, Issue 14

Abstract: In epithelial ovarian cancer (EOC), carboplatin/cisplatin-induced chemoresistance is a major hurdle to successful treatment. Aerobic glycolysis is a common characteristic of cancer. However, the role of glycolytic metabolism in chemoresistance and its ... ...

Abstract	In epithelial ovarian cancer (EOC), carboplatin/cisplatin-induced chemoresistance is a major hurdle to successful treatment. Aerobic glycolysis is a common characteristic of cancer. However, the role of glycolytic metabolism in chemoresistance and its impact on clinical outcomes in EOC are not clear. Here, we show a functional interaction between the key glycolytic enzyme hexokinase II (HKII) and activated P-p53 (Ser15) in the regulation of bioenergetics and chemosensitivity. Using translational approaches with proximity ligation assessment in cancer cells and human EOC tumor sections, we showed that nuclear HKII-P-p53 (Ser15) interaction is increased after chemotherapy, and functions as a determinant of chemoresponsiveness as a prognostic biomarker. We also demonstrated that p53 is required for the intracellular nuclear HKII trafficking in the control of glycolysis in EOC, associated with chemosensitivity. Mechanistically, cisplatin-induced P-p53 (Ser15) recruits HKII and apoptosis-inducing factor (AIF) in chemosensitive EOC cells, enabling their translocation from the mitochondria to the nucleus, eliciting AIF-induced apoptosis. Conversely, in p53-defective chemoresistant EOC cells, HKII and AIF are strongly bound in the mitochondria and, therefore, apoptosis is suppressed. Collectively, our findings implicate nuclear HKII-P-p53(Ser15) interaction in chemosensitivity and could provide an effective clinical strategy as a promising biomarker during platinum-based therapy.
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13143399
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Article ; Online: Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity.

Whytock, Katie L / Pino, Maria F / Sun, Yifei / Yu, GongXin / De Carvalho, Flavia G / Yeo, Reichelle X / Vega, Rick B / Parmar, Gaganvir / Divoux, Adeline / Kapoor, Nidhi / Yi, Fancaho / Cornnell, Heather / Patten, David A / Harper, Mary-Ellen / Gardell, Stephen J / Smith, Steven R / Walsh, Martin J / Sparks, Lauren M

American journal of physiology. Endocrinology and metabolism

2023 Volume 325, Issue 4, Page(s) E291–E302

Abstract: Insulin resistance and blunted mitochondrial capacity in skeletal muscle are often synonymous, however, this association remains controversial. The aim of this study was to perform an in-depth multifactorial comparison of skeletal muscle mitochondrial ... ...

Abstract	Insulin resistance and blunted mitochondrial capacity in skeletal muscle are often synonymous, however, this association remains controversial. The aim of this study was to perform an in-depth multifactorial comparison of skeletal muscle mitochondrial capacity between individuals who were lean and active (Active,
MeSH term(s)	Humans ; Insulin Resistance/physiology ; Diabetes Mellitus, Type 2/metabolism ; Mitochondria ; Muscle, Skeletal/metabolism ; Obesity/metabolism ; Mitochondria, Muscle/metabolism
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00143.2023
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