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  1. Book: Treatment of primary glomerulonephritis

    Ponticelli, Claudio / Glassock, Richard J.

    (Oxford clinical nephrology series)

    2019  

    Author's details edited by Claudio Ponticelli and Richard J. Glassock
    Series title Oxford clinical nephrology series
    Keywords Glomerulonephritis ; Glomerulonephritis/Chemotherapy
    Subject code 616.612
    Language English
    Size xiv, 619 Seiten, Illustrationen, 24 cm
    Edition Third edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT020170754
    ISBN 978-0-19-878408-1 ; 0-19-878408-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1238 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Primary membranous nephropathy: an endless story.

    Claudio, Ponticelli

    Journal of nephrology

    2022  Volume 36, Issue 2, Page(s) 563–574

    Abstract: Primary membranous nephropathy (PMN) is an autoimmune disease caused by the attack of autoantibodies against podocyte antigens leading to the in situ production of immune complexes. However, the etiology is unknown and the pathogenesis is still far from ... ...

    Abstract Primary membranous nephropathy (PMN) is an autoimmune disease caused by the attack of autoantibodies against podocyte antigens leading to the in situ production of immune complexes. However, the etiology is unknown and the pathogenesis is still far from being completely elucidated. MN is prevalently idiopathic or primary, but in about 20-30% of cases it is secondary to chronic infections, systemic diseases, exposure to drugs, or malignancy. The differentiation between primary and secondary MN may be difficult, particularly when MN precedes signs and symptoms of the original disease, as in some cases of cancer or systemic lupus erythematosus. The natural course of PMN is variable, but in the long term 40-60% of patients with nephrotic syndrome progress to end-stage renal disease (ESRD) or die from thrombotic or cardiovascular events. PMN is a treatable disease. Patients with asymptomatic proteinuria should receive supportive care. Immunosuppressive treatments should be given to patients with nephrotic syndrome or risk of progression. The most frequently adopted treatments rely on cyclical therapy alternating steroids with a cytotoxic agent every other month, i.e., rituximab at different doses, or calcineurin inhibitors plus low-dose steroids. A good rate of response may be obtained but relapses can occur. Randomized controlled trials, with adequate size, long-term follow-up, and fair definition of endpoints are needed to identify treatment with the best therapeutic index.
    MeSH term(s) Humans ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Nephrotic Syndrome/diagnosis ; Nephrotic Syndrome/drug therapy ; Immunosuppressive Agents/adverse effects ; Rituximab/therapeutic use ; Steroids/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Steroids
    Language English
    Publishing date 2022-10-17
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01461-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: [Inibitori della calcineurina e trapianto renale].

    Ponticelli, Claudio

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2021  Volume 38, Issue Suppl 77

    Language Italian
    Publishing date 2021-09-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4313: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Treatment of primary glomerulonephritis

    Ponticelli, Claudio

    (Oxford clinical nephrology series)

    2009  

    Author's details Claudio Ponticelli
    Series title Oxford clinical nephrology series
    Keywords Glomerulonephritis / therapy ; Glomerulonephritis ; Glomerulonephritis/Chemotherapy
    Subject code 616.612
    Language English
    Size XI, 481 S., [8] Bl. : Ill., graph. Darst., 24cm
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes index. - Previous ed.: 1997
    HBZ-ID HT015943614
    ISBN 978-0-19-955288-7 ; 0-19-955288-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 2248 order for loan Magazin

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  5. Book: Medical complications of kidney transplantation

    Ponticelli, Claudio

    2007  

    Author's details Claudio Ponticelli
    Language English
    Size V, 425 S. : Ill.
    Publisher Informa Healthcare
    Publishing place Abingdon
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014983973
    ISBN 0-415-41715-5 ; 978-0-415-41715-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 2580 order for loan Magazin

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  6. Book: Reducing exposure to cancineurin inhibitors following renal transplantation: clinical experience with everolimus (Certican)

    Ponticelli, Claudio

    (Transplantation ; 79,9, Suppl.)

    2005  

    Author's details guest ed.: Claudio Ponticelli
    Series title Transplantation ; 79,9, Suppl.
    Collection
    Language English
    Size S. S67 - S94 : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT014413572
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 488 -79,9,Suppl.- not available for loan Zeitschriften-Lesesaal

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  7. Article ; Online: Nephrotic syndrome: pathophysiology and consequences.

    Claudio, Ponticelli / Gabriella, Moroni

    Journal of nephrology

    2023  Volume 36, Issue 8, Page(s) 2179–2190

    Abstract: In patients with kidney disease, nephrotic syndrome can lead to several complications including progressive kidney dysfunction. Proteinuria may lead to the formation of cellular or fibrous crescents with reciprocal development of rapidly progressive ... ...

    Abstract In patients with kidney disease, nephrotic syndrome can lead to several complications including progressive kidney dysfunction. Proteinuria may lead to the formation of cellular or fibrous crescents with reciprocal development of rapidly progressive glomerulonephritis or focal glomerulosclerosis. Proteinuria may also cause overload and dysfunction of tubular epithelial cells, eventually resulting in tubular atrophy and interstitial fibrosis. Hypoalbuminemia is usually associated with increased risk of mortality and kidney dysfunction. Dyslipidemia may increase the risk of atherosclerotic complications, cause podocyte dysfunction and contribute to vascular thrombosis. Urinary loss of anticoagulants and overproduction of coagulation factors may facilitate a hypercoagulable state. Edema, hypogammaglobulinemia, loss of complement factors, and immunosuppressive therapy can favor infection. Treatment of these complications may reduce their impact on the severity of NS. Nephrotic syndrome is a kidney disorder that can worsen the quality of life and increase the risk of kidney disease progression.
    MeSH term(s) Humans ; Nephrotic Syndrome/etiology ; Quality of Life ; Kidney ; Proteinuria/complications ; Glomerulosclerosis, Focal Segmental/complications ; Kidney Diseases/complications
    Language English
    Publishing date 2023-07-19
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01697-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: COVID-19 Vaccination in Kidney Transplant Candidates and Recipients.

    Ponticelli, Claudio / Campise, Mariarosaria

    Vaccines

    2022  Volume 10, Issue 11

    Abstract: Kidney transplant candidates and kidney transplant recipients (KTRs) are at particular risk of severe complications of COVID-19 disease. In Western countries, mortality in affected hospitalized KTRs ranges between 19% and 50%. COVID-19 vaccination ... ...

    Abstract Kidney transplant candidates and kidney transplant recipients (KTRs) are at particular risk of severe complications of COVID-19 disease. In Western countries, mortality in affected hospitalized KTRs ranges between 19% and 50%. COVID-19 vaccination remains the most important measure to prevent the severity of infection in candidates and recipients of kidney transplant. However, the uraemic condition may affect the vaccine-induced immunity in patients with advanced chronic kidney disease (CKD) and in KTRs. Retention of uraemic toxins, dysbiosis, dysmetabolism, and dialysis can diminish the normal response to vaccination, leading to dysfunction of inflammatory and immune cells. In KTRs the efficacy of vaccines may be reduced by the immunosuppressive medications, and more than half of kidney transplant recipients are unable to build an immune response even after four administrations of anti-COVID-19 vaccines. The lack of antibody response leaves these patients at high risk for SARS-CoV-2 infection and severe COVID-19 disease. The aim of the present review is to focus on the main reasons for the impaired immunological response among candidates and kidney transplant recipients and to highlight some of the present options available to solve the problem.
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10111808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Non-Immunologic Causes of Late Death-Censored Kidney Graft Failure: A Personalized Approach.

    Ponticelli, Claudio / Citterio, Franco

    Journal of personalized medicine

    2022  Volume 12, Issue 8

    Abstract: Despite continuous advances in surgical and immunosuppressive protocols, the long-term survival of transplanted kidneys is still far from being satisfactory. Antibody-mediated rejection, recurrent autoimmune diseases, and death with functioning graft are ...

    Abstract Despite continuous advances in surgical and immunosuppressive protocols, the long-term survival of transplanted kidneys is still far from being satisfactory. Antibody-mediated rejection, recurrent autoimmune diseases, and death with functioning graft are the most frequent causes of late-kidney allograft failure. However, in addition to these complications, a number of other non-immunologic events may impair the function of transplanted kidneys and directly or indirectly lead to their failure. In this narrative review, we will list and discuss the most important nonimmune causes of late death-censored kidney graft failure, including quality of the donated kidney, adherence to prescriptions, drug toxicities, arterial hypertension, dyslipidemia, new onset diabetes mellitus, hyperuricemia, and lifestyle of the renal transplant recipient. For each of these risk factors, we will report the etiopathogenesis and the potential consequences on graft function, keeping in mind that in many cases, two or more risk factors may negatively interact together.
    Language English
    Publishing date 2022-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12081271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Autosomal Dominant Polycystic Kidney Disease: Is There a Role for Autophagy?

    Ponticelli, Claudio / Moroni, Gabriella / Reggiani, Francesco

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disorder initiated by mutations in ... ...

    Abstract Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disorder initiated by mutations in either
    MeSH term(s) Humans ; Aged ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/genetics ; Epithelial-Mesenchymal Transition ; Kidney ; Autophagy ; Cysts
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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