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Article ; Online: Long-term outcome of absorbable synthetic mesh in clean ventral hernia repairs.

Yu, Jay F / Goldblatt, Hannah E / Alter-Troilo, Katie / Hetzel, Emily / Goldblatt, Matthew I

2021 Volume 36, Issue 7, Page(s) 5144–5148

Abstract: Background: There are many materials available for the reinforcement of complex abdominal wall reconstruction, including permanent synthetic, biologic, and absorbable synthetic meshes. The recurrence rate of complex hernia repairs beyond 5 years has not ...

Abstract	Background: There are many materials available for the reinforcement of complex abdominal wall reconstruction, including permanent synthetic, biologic, and absorbable synthetic meshes. The recurrence rate of complex hernia repairs beyond 5 years has not been reported. We hypothesized that the use of absorbable synthetic mesh in clean wounds would yield favorable long-term outcomes. Study design: Patients who underwent open complex ventral hernia repair with clean wounds (CDC class 1) using absorbable synthetic mesh (Bio-A, Gore, Flagstaff, AZ) in the retrorectus position were retrospectively reviewed. Chart review and a validated telephone questionnaire to screen for recurrence were utilized to evaluate and document hernia recurrence. Results: A total of 49 patients were included in this study. Patients were followed for recurrences for up to 105 months, with a mean follow-up time of 62.4 months (5.2 years). The total number of midline hernia recurrence was 7 out of the original 49 patients (14%). The mean and median recurrence time are 37.4 and 38.8 months, respectively. Kaplan-Meier survival analysis estimated hernia recurrence rate as 2%, 4.6%, 7.1%, 12%, 15%, and 18% at 12, 24, 36, 48, 60, and 72 months, respectively. Conclusion: The use of absorbable synthetic mesh in clean wound ventral hernia repair resulted in favorable long-term recurrence rates. The recurrence rate of absorbable synthetic mesh is similar to that of permanent synthetic mesh, which gives a viable option for patients in whom permanent synthetic mesh is not an option.
MeSH term(s)	Hernia, Ventral/etiology ; Hernia, Ventral/surgery ; Herniorrhaphy/methods ; Humans ; Recurrence ; Retrospective Studies ; Surgical Mesh/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-12-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08885-1
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Article: The Effect of Ocean Salinity on Climate and Its Implications for Earth's Habitability.

Olson, Stephanie / Jansen, Malte F / Abbot, Dorian S / Halevy, Itay / Goldblatt, Colin

Geophysical research letters

2022 Volume 49, Issue 10, Page(s) e2021GL095748

Abstract: The influence of atmospheric composition on the climates of present-day and early Earth has been studied extensively, but the role of ocean composition has received less attention. We use the ROCKE-3D ocean-atmosphere general circulation model to ... ...

Abstract	The influence of atmospheric composition on the climates of present-day and early Earth has been studied extensively, but the role of ocean composition has received less attention. We use the ROCKE-3D ocean-atmosphere general circulation model to investigate the response of Earth's present-day and Archean climate system to low versus high ocean salinity. We find that saltier oceans yield warmer climates in large part due to changes in ocean dynamics. Increasing ocean salinity from 20 to 50 g/kg results in a 71% reduction in sea ice cover in our present-day Earth scenario. This same salinity change also halves the
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	7403-2
ISSN	0094-8276
ISSN	0094-8276
DOI	10.1029/2021GL095748
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Article: Impact of Sports Participation on Achievement of Clinically Relevant Outcomes 2 Years After ACL Reconstruction.

Kuhns, Benjamin D / Sholtis, Connor D / Reuter, John M / Goldblatt, John / Bronstein, Robert / Baumhauer, Judith F / Maloney, Michael D / Mannava, Sandeep

Orthopaedic journal of sports medicine

2023 Volume 11, Issue 8, Page(s) 23259671231187327

Abstract: Background: Clinically relevant threshold values associated with patient-reported outcome measures after orthopaedic procedures such as anterior cruciate ligament reconstruction (ACLR) are important for relating these scores to meaningful postoperative ... ...

Abstract	Background: Clinically relevant threshold values associated with patient-reported outcome measures after orthopaedic procedures such as anterior cruciate ligament reconstruction (ACLR) are important for relating these scores to meaningful postoperative improvement. Purpose/hypothesis: The purpose of this study was to determine the Patient Acceptable Symptom State (PASS) for the Patient-Reported Outcomes Measurement Information System Computer Adaptive Test (PROMIS-CAT) after ACLR. It was hypothesized that preoperative sport participation would have an impact on PASS achievement. Study design: Case series; Level of evidence, 4. Methods: Included were consecutive patients who underwent primary assisted ACLR between January 4 and August 1, 2016. Patients were administered the PROMIS-CAT Physical Function (PF) and Pain Interference domains preoperatively and at a minimum 2 years postoperatively, with external anchor questions used to determine the PASS. Receiver operating characteristic (ROC) curves were constructed for the entire study population as well as separately for athletes and nonathletes to determine PROMIS PASS thresholds for each population. A previously published PROMIS-PF minimal clinically important difference was used to evaluate postoperative improvement. A post hoc multivariate nominal logistic multivariate analysis was constructed to assess the effects of preoperative patient characteristics on the likelihood of attaining both the minimal clinically important difference and PASS. Results: In total, 112 patients were included in the study, with 79 (71%) having recreational or higher levels of athletic participation. The PASS for the study population was 56.0 (area under the ROC curve, 0.86) and was unaffected by baseline PROMIS-PF scores but was affected by preoperative athletic participation (56.0 for athletes, 49.0 for nonathletes). A post hoc analysis found 57 patients (51%) achieved the PASS for the PROMIS-PF (cutoff, 56.0), but when the athlete and nonathlete thresholds were applied to their respective patient groups, 66% of athletes and 64% of nonathletes achieved the PASS postoperatively. The multivariate analysis found that sport participation (odds ratio, 6.2; Conclusion: Preoperative athletic participation significantly affected the ability to achieve PASS.
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671231187327
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Article ; Online: Management of abdominal wall hernias in patients with severe obesity.

Ghanem, Omar M / Orenstein, Sean / Lloyd, S Julie-Ann / Andalib, Amin / Race, Alice / Burt, Holly Ann / Husain, Farah / Goldblatt, Matthew / Kroh, Matthew

Surgical endoscopy

2023 Volume 37, Issue 9, Page(s) 6619–6626

Abstract: Obesity is a risk factor for abdominal wall hernia development and hernia recurrence. The management of these two pathologies is complex and often entwined. Bariatric and ventral hernia surgery require careful consideration of physiologic and technical ... ...

Abstract	Obesity is a risk factor for abdominal wall hernia development and hernia recurrence. The management of these two pathologies is complex and often entwined. Bariatric and ventral hernia surgery require careful consideration of physiologic and technical components for optimal outcomes. In this review, a multidisciplinary group of Society of American Gastrointestinal and Endoscopic Surgeons' bariatric and hernia surgeons present the various weight loss modalities available for the pre-operative optimization of patients with severe obesity and concurrent hernias. The group also details the technical aspects of managing abdominal wall defects during weight loss procedures and suggests the optimal timing of definitive hernia repair after bariatric surgery. Since level one evidence is not available on some of the topics covered by this review, expert opinion was implemented in some instances. Additional high-quality research in this area will allow for better recommendations and therefore treatment strategies for these complex patients.
MeSH term(s)	Humans ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Hernia, Ventral/etiology ; Hernia, Ventral/surgery ; Obesity/surgery ; Bariatric Surgery/methods ; Herniorrhaphy/methods ; Abdominal Wall/surgery ; Surgical Mesh
Language	English
Publishing date	2023-07-24
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10312-6
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Article: Airway Epithelial Innate Immunity.

Johnston, Sebastian L / Goldblatt, David L / Evans, Scott E / Tuvim, Michael J / Dickey, Burton F

Frontiers in physiology

2021 Volume 12, Page(s) 749077

Abstract: Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen classes. It occurs in the ... ...

Abstract	Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen classes. It occurs in the context of numerous interactions with leukocytes, but here we focus on intrinsic epithelial mechanisms. Type 1 immune responses are directed primarily at intracellular pathogens, particularly viruses. Prominent stimuli include microbial nucleic acids and interferons released from neighboring epithelial cells. Epithelial responses revolve around changes in the expression of interferon-sensitive genes (ISGs) that interfere with viral replication, as well as the further induction of interferons that signal in autocrine and paracrine manners. Type 2 immune responses are directed primarily at helminths and fungi. Prominent pathogen stimuli include proteases and chitin, and important responses include mucin hypersecretion and chitinase release. Type 3 immune responses are directed primarily at extracellular microbial pathogens, including bacteria and fungi, as well as viruses during their extracellular phase of infection. Prominent microbial stimuli include bacterial wall components, such as lipopeptides and endotoxin, as well as microbial nucleic acids. Key responses are the release of reactive oxygen species (ROS) and antimicrobial peptides (AMPs). For all three types of response, paracrine signaling to neighboring epithelial cells induces resistance to infection over a wide field. Often, the epithelial effector molecules themselves also have signaling properties, in addition to the release of inflammatory cytokines that boost local innate immunity. Together, these epithelial mechanisms provide a powerful first line of pathogen defense, recruit leukocytes, and instruct adaptive immune responses.
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.749077
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Article: Adult longevity of workers of the bumble bees Bombus fervidus (F.) and Bombus pennsylvanicus (De Geer) (Hymenoptera: Apidae)

Goldblatt, J.W / Fell, R.D

Canadian journal of zoology = Journal canadien de zoologie. Oct 1987. v. 65 (10)

1987

Keywords	Bombus ; longevity ; mortality
Language	English
Dates of publication	1987-10
Size	p. 2349-2353.
Document type	Article
Note	Summary in French.
ZDB-ID	241716-9
ISSN	1480-3283 ; 0008-4301
ISSN (online)	1480-3283
ISSN	0008-4301
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci.

Croucher, Nicholas J / Campo, Joseph J / Le, Timothy Q / Pablo, Jozelyn V / Hung, Christopher / Teng, Andy A / Turner, Claudia / Nosten, François / Bentley, Stephen D / Liang, Xiaowu / Turner, Paul / Goldblatt, David

Nature communications

2024 Volume 15, Issue 1, Page(s) 355

Abstract: Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire recognising pneumococci from birth to 24 months old (mo) in a prospectively-sampled cohort of ... ...

Abstract	Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire recognising pneumococci from birth to 24 months old (mo) in a prospectively-sampled cohort of 63 children using a panproteome array. IgG levels are highest at birth, due to transplacental transmission of maternal antibodies. The subsequent emergence of responses to individual antigens exhibit distinct kinetics across the cohort. Stable differences in the strength of individuals' responses, correlating with maternal IgG concentrations, are established by 6 mo. By 12 mo, children develop unique antibody profiles that are boosted by re-exposure. However, some proteins only stimulate substantial responses in adults. Integrating genomic data on nasopharyngeal colonisation demonstrates rare pneumococcal antigens can elicit strong IgG levels post-exposure. Quantifying such responses to the diverse core loci (DCL) proteins is complicated by cross-immunity between variants. In particular, the conserved N terminus of DCL protein zinc metalloprotease B provokes the strongest early IgG responses. DCL proteins' ability to inhibit mucosal immunity likely explains continued pneumococcal carriage despite hosts' polyvalent antibody repertoire. Yet higher IgG levels are associated with reduced incidence, and severity, of pneumonia, demonstrating the importance of the heterogeneity in response strength and kinetics across antigens and individuals.
MeSH term(s)	Adult ; Infant, Newborn ; Child ; Infant ; Humans ; Child, Preschool ; Streptococcus pneumoniae/genetics ; Genomics ; Immunoglobulin G ; Immunity, Mucosal ; Antigens, Bacterial
Chemical Substances	Immunoglobulin G ; Antigens, Bacterial
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44584-2
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Article ; Book ; Online: PILOT-PLANT BACTERIAL FILM OXIDATION (BACFOX PROCESS) OF RECYCLED ACIDIFIED URANIUM PLANT FERROUS SULPHATE LEACH SOLUTION

Livesey-Goldblatt, E. / Tunley, T. H. / Nagy, I. F.

2020

Abstract: Laboratory tests have established that a rapid oxidation of an acidified solution of ferrous sulphate to ferric can be achieved by passage of an air saturated solution over a film of Thiobacillus ferro-oxidans, Pilot-plant units of various types were ... ...

Abstract	Laboratory tests have established that a rapid oxidation of an acidified solution of ferrous sulphate to ferric can be achieved by passage of an air saturated solution over a film of Thiobacillus ferro-oxidans, Pilot-plant units of various types were constructed and operated to assess their oxidising efficiency using ferrous solutions ranging from 3,5 to 12 gram Fe II/litre and 3,1 to 10,5 gram H280,/litre. The best results were obtained with a plastic corrugated packing media to support the film of bacteria submerged in the iron sulphate solution thoroughly air saturated by forced aeration. The maximum specific rate of oxidation of Fe II to Fe III achieved was 7,5 gram per square metre of bacterial surface per hour.
Language	English
Publishing country	de
Document type	Article ; Book ; Online
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Article: Aristea (Iridaceae, Aristeoideae), a Subgeneric Classification

Goldblatt, Peter

Novon. 2013 Oct. 18, v. 22, no. 4

2013

Abstract: ... A. spiralis (L. f.) Ker Gawl., is designated for Aristea sect. Pseudaristea Pax [â¡ Aristea subg ... Eucapsulares (Goldblatt) Goldblatt [â¡ Aristea sect. Eucapsulares Goldblatt] (ca. 30 species), and Aristea ... subg. Pseudaristea (Pax) Goldblatt [â¡ Aristea sect. Pseudoaristea Pax] (nine species). This replaces ...

Abstract	A novel classification here of the sub-Saharan and Madagascan genus Aristea Aiton (Iridaceae), with ca. 57 species, recognizes three subgenera, Aristea subg. Aristea (18 species), Aristea subg. Eucapsulares (Goldblatt) Goldblatt [â¡ Aristea sect. Eucapsulares Goldblatt] (ca. 30 species), and Aristea subg. Pseudaristea (Pax) Goldblatt [â¡ Aristea sect. Pseudoaristea Pax] (nine species). This replaces a 1940 classification by Henning Weimarck, which included eight sections. In this updated classification, Aristea subg. Aristea includes three sections, and Aristea subg. Eucapsulares, two sections. A lectotype, A. spiralis (L. f.) Ker Gawl., is designated for Aristea sect. Pseudaristea Pax [â¡ Aristea subg. Pseudoaristea (Pax) Goldblatt].
Keywords	Iridaceae ; lectotypes ; new subgenus ; vascular plants
Language	English
Dates of publication	2013-1018
Size	p. 415-417.
Publishing place	the Missouri Botanical Garden
Document type	Article
ZDB-ID	2239681-0
ISSN	1055-3177
ISSN	1055-3177
DOI	10.3417%2F2011119
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: The Effect of Ocean Salinity on Climate and Its Implications for Earth's Habitability

Olson, Stephanie L. / Jansen, Malte F. / Abbot, Dorian S. / Halevy, Itay / Goldblatt, Colin

2022

Abstract	The influence of atmospheric composition on the climates of present-day and early Earth has been studied extensively, but the role of ocean composition has received less attention. We use the ROCKE-3D ocean-atmosphere general circulation model to investigate the response of Earth's present-day and Archean climate system to low vs. high ocean salinity. We find that saltier oceans yield warmer climates in large part due to changes in ocean dynamics. Increasing ocean salinity from 20 g/kg to 50 g/kg results in a 71% reduction in sea ice cover in our present-day Earth scenario. This same salinity change also halves the pCO$_2$ threshold at which Snowball glaciation occurs in our Archean scenarios. In combination with higher levels of greenhouse gases such as CO$_2$ and CH$_4$, a saltier ocean may allow for a warm Archean Earth with only seasonal ice at the poles despite receiving 20% less energy from the Sun. Comment: Accepted for publication in Geophysical Research Letters 04/19/22
Keywords	Astrophysics - Earth and Planetary Astrophysics ; Physics - Atmospheric and Oceanic Physics ; Physics - Geophysics
Subject code	551
Publishing date	2022-05-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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