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  1. Article ; Online: Myelofibrosis: let's go high!

    Ballen, Karen

    Bone marrow transplantation

    2021  Volume 56, Issue 11, Page(s) 2864–2865

    MeSH term(s) Humans ; Parents ; Primary Myelofibrosis/therapy
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01438-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Measurable residual disease for secondary acute myeloid leukemia prior to allogeneic hematopoietic cell transplantation: does it make a difference?

    El Chaer, Firas / Ballen, Karen K

    Bone marrow transplantation

    2022  Volume 57, Issue 10, Page(s) 1473–1474

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual ; Transplantation Conditioning
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01765-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Allogeneic Transplantation for Myelofibrosis with Novel Graft-versus-Host Disease Prophylaxis.

    Volodin, Leonid / Ballen, Karen K

    Acta haematologica

    2020  Volume 144, Issue 2, Page(s) 124–125

    MeSH term(s) Cyclophosphamide ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Humans ; Pilot Projects ; Primary Myelofibrosis/therapy ; Prospective Studies ; Pyrazoles ; Transplantation, Homologous
    Chemical Substances Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2020-06-22
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000508198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advances in Cellular Therapy for T-Cell Prolymphocytic Leukemia.

    Varadarajan, Indumathy / Ballen, Karen

    Frontiers in oncology

    2022  Volume 12, Page(s) 781479

    Abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive hematologic malignancy with a poor prognosis. Alemtuzumab (Campath) remains the cornerstone for treatment, with an 80% complete response (CR). Hematopoietic stem cell transplant (HSCT) is ... ...

    Abstract T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive hematologic malignancy with a poor prognosis. Alemtuzumab (Campath) remains the cornerstone for treatment, with an 80% complete response (CR). Hematopoietic stem cell transplant (HSCT) is considered the standard of care as consolidative therapy in eligible patients. However, allogeneic stem cell transplant is also complicated by increased rates of infections from chemotherapy, acute graft-versus-host disease (GVHD), and chronic GVHD. This review aims to report the available literature on the efficacy and complications of consolidative HSCT. It also discusses the importance of patient selection and pre- and post-transplant complications including atypical infections and GVHD.
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.781479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neurological Complications after Allogeneic Transplantation - Can We Do Better?

    Dowling, Mark R / Ballen, Karen K

    Acta haematologica

    2019  Volume 142, Issue 4, Page(s) 193–194

    MeSH term(s) Child ; Hematopoietic Stem Cell Transplantation ; Humans ; Nervous System Diseases ; Transplantation, Homologous
    Language English
    Publishing date 2019-07-17
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000501297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Update on umbilical cord blood transplantation.

    Ballen, Karen

    F1000Research

    2017  Volume 6, Page(s) 1556

    Abstract: Allogeneic hematopoietic cell transplant is a curative procedure for many patients with leukemia, lymphoma, myelodysplasia, myeloproliferative neoplasms, and genetic disorders. Umbilical cord blood transplantation is a graft source for patients who do ... ...

    Abstract Allogeneic hematopoietic cell transplant is a curative procedure for many patients with leukemia, lymphoma, myelodysplasia, myeloproliferative neoplasms, and genetic disorders. Umbilical cord blood transplantation is a graft source for patients who do not have a matched donor in their family or in the unrelated registry. It is particularly difficult for Black, Hispanic, and White patients of non-Western European background to find fully matched adult volunteer donors. An estimated 700,000 umbilical cord blood units have been donated for public use, and over 40,000 umbilical cord blood transplantations have been performed. Over 25,000 patients have been cured with this approach.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.11952.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What have we learned from transplanting older patients?

    Varadarajan, Indumathy / Ballen, Karen K

    Best practice & research. Clinical haematology

    2019  Volume 32, Issue 4, Page(s) 101110

    Abstract: Aggressive curative therapies have now been extended to patients older than 65 years, a fast-growing segment of the population. As the number of allogeneic transplants in patients older than age 65 is increasing, attention is now focused on improving ... ...

    Abstract Aggressive curative therapies have now been extended to patients older than 65 years, a fast-growing segment of the population. As the number of allogeneic transplants in patients older than age 65 is increasing, attention is now focused on improving outcomes in this group. This paper discusses important aspects of allogeneic transplant in the older patient, focusing on donor and patient selection, choice of conditioning regimen and graft source, and the importance of timely access to a transplant center.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Patient Selection ; Transplantation Conditioning ; Transplantation, Homologous
    Language English
    Publishing date 2019-10-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2019.101110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of graft-versus-host-disease with neurologic complications: clinical paradigm and future directions.

    Sheikh, Mohammad Abdurrehman / Im, Annie / Ballen, Karen / Hashmi, Shahrukh K

    Bone marrow transplantation

    2021  Volume 56, Issue 6, Page(s) 1471–1473

    MeSH term(s) Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01216-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Is there a best graft source of transplantation in acute myeloid leukemia?

    Ballen, Karen K

    Best practice & research. Clinical haematology

    2015  Volume 28, Issue 2-3, Page(s) 147–154

    Abstract: Only 30% of patients in the US who require an allogeneic hematopoietic cell transplant will have a fully HLA matched sibling donor. The National Marrow Donor Program/Be the Match has grown to over 25 million unrelated donors. However, a fully matched ... ...

    Abstract Only 30% of patients in the US who require an allogeneic hematopoietic cell transplant will have a fully HLA matched sibling donor. The National Marrow Donor Program/Be the Match has grown to over 25 million unrelated donors. However, a fully matched unrelated donor may not be available for many patients, particularly for patients of diverse racial and ethnic backgrounds. Over the last 10 years, considerable progress has been made in alternative donor transplant with improvements in outcomes for umbilical cord blood (UCB), haploidentical (haplo) related donor, and mismatched unrelated donor (MMUD) for patients with acute myeloid leukemia. Retrospective studies indicate comparable survival for these three graft sources. In this chapter, we review the latest results for patients receiving alternative donor transplants, and discuss strategies for choosing the optimal donor for each individual patient.
    MeSH term(s) Cord Blood Stem Cell Transplantation/economics ; Cord Blood Stem Cell Transplantation/methods ; Cord Blood Stem Cell Transplantation/mortality ; HLA Antigens/genetics ; HLA Antigens/immunology ; Haplotypes ; Hematopoietic Stem Cell Transplantation/economics ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Histocompatibility Testing ; Humans ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Myeloablative Agonists/therapeutic use ; Recurrence ; Siblings ; Survival Analysis ; Transplantation Conditioning/methods ; Transplantation, Homologous ; Unrelated Donors
    Chemical Substances HLA Antigens ; Myeloablative Agonists
    Language English
    Publishing date 2015-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2015.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exploring new therapies for children with autism: "Do no harm" does not mean do not try.

    Ballen, Karen / Kurtzberg, Joanne

    Stem cells translational medicine

    2021  Volume 10, Issue 6, Page(s) 823–825

    MeSH term(s) Autism Spectrum Disorder/therapy ; Autistic Disorder/therapy ; Child ; Humans
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Editorial
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1002/sctm.20-0548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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