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  1. Article: Fibrillarin binds directly and specifically to U16 box C/D snoRNA.

    Fatica, A / Galardi, S / Altieri, F / Bozzoni, I

    RNA (New York, N.Y.)

    1999  Volume 6, Issue 1, Page(s) 88–95

    Abstract: Eukaryotic nucleoli contain a large family of box C/D small nucleolar ribonucleoprotein complexes ... been reported to be common factors of box C/D snoRNPs in lower and higher eukaryotes; nevertheless none ... by means of UV crosslinking in vivo, two proteins associated with box C/D snoRNAs, fibrillarin and p68 ...

    Abstract Eukaryotic nucleoli contain a large family of box C/D small nucleolar ribonucleoprotein complexes (snoRNPs) that are involved in processing and site-specific methylation of pre-rRNA. Several proteins have been reported to be common factors of box C/D snoRNPs in lower and higher eukaryotes; nevertheless none of them has been clearly shown to directly interact with RNA. We previously identified in Xenopus laevis, by means of UV crosslinking in vivo, two proteins associated with box C/D snoRNAs, fibrillarin and p68. Here we show that fibrillarin interacts directly and specifically with the U16 box C/D snoRNA in a X. laevis oocyte nuclear extract and that it does not require p68 for binding. Specific binding is also obtained with a recombinant fibrillarin demonstrating that the protein is able to bind directly and specifically to U16 snoRNA by itself.
    MeSH term(s) Animals ; Cell Extracts ; Chromosomal Proteins, Non-Histone/metabolism ; Cross-Linking Reagents ; DEAD-box RNA Helicases ; In Vitro Techniques ; Oocytes/metabolism ; Oocytes/radiation effects ; Oocytes/ultrastructure ; Protein Binding ; Protein Kinases/metabolism ; RNA Helicases ; RNA, Small Nucleolar/metabolism ; Ribonucleoproteins/metabolism ; Ultraviolet Rays ; Xenopus laevis
    Chemical Substances Cell Extracts ; Chromosomal Proteins, Non-Histone ; Cross-Linking Reagents ; RNA, Small Nucleolar ; Ribonucleoproteins ; fibrillarin ; Protein Kinases (EC 2.7.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) ; RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 1999-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1241540-6
    ISSN 1355-8382
    ISSN 1355-8382
    DOI 10.1017/s1355838200991623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4777: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: A framework for evaluating clinical artificial intelligence systems without ground-truth annotations.

    Kiyasseh, Dani / Cohen, Aaron / Jiang, Chengsheng / Altieri, Nicholas

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1808

    Abstract: A clinical artificial intelligence (AI) system is often validated on data withheld during its development. This provides an estimate of its performance upon future deployment on data in the wild; those currently unseen but are expected to be encountered ... ...

    Abstract A clinical artificial intelligence (AI) system is often validated on data withheld during its development. This provides an estimate of its performance upon future deployment on data in the wild; those currently unseen but are expected to be encountered in a clinical setting. However, estimating performance on data in the wild is complicated by distribution shift between data in the wild and withheld data and the absence of ground-truth annotations. Here, we introduce SUDO, a framework for evaluating AI systems on data in the wild. Through experiments on AI systems developed for dermatology images, histopathology patches, and clinical notes, we show that SUDO can identify unreliable predictions, inform the selection of models, and allow for the previously out-of-reach assessment of algorithmic bias for data in the wild without ground-truth annotations. These capabilities can contribute to the deployment of trustworthy and ethical AI systems in medicine.
    MeSH term(s) Artificial Intelligence ; Medicine
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46000-9
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  3. Article ; Online: Dead foundation species drive ecosystem dynamics.

    Saldaña, Patrick H / Angelini, Christine / Bertness, Mark D / Altieri, Andrew H

    Trends in ecology & evolution

    2023  Volume 39, Issue 3, Page(s) 294–305

    Abstract: Foundation species facilitate communities, modulate energy flow, and define ecosystems, but their ecological roles after death are frequently overlooked. Here, we reveal the widespread importance of their dead structures as unique, interacting components ...

    Abstract Foundation species facilitate communities, modulate energy flow, and define ecosystems, but their ecological roles after death are frequently overlooked. Here, we reveal the widespread importance of their dead structures as unique, interacting components of ecosystems that are vulnerable to global change. Key metabolic activity, mobility, and morphology traits of foundation species either change or persist after death with important consequences for ecosystem functions, biodiversity, and subsidy dynamics. Dead foundation species frequently mediate ecosystem stability, resilience, and transitions, often through feedbacks, and harnessing their structural and trophic roles can improve restoration outcomes. Enhanced recognition of dead foundation species and their incorporation into habitat monitoring, ecological theory, and ecosystem forecasting can help solve the escalating conservation challenges of the Anthropocene.
    MeSH term(s) Ecosystem ; Biodiversity ; Forecasting
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 284965-3
    ISSN 1872-8383 ; 0169-5347
    ISSN (online) 1872-8383
    ISSN 0169-5347
    DOI 10.1016/j.tree.2023.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Zs Bio TEE: Show issues
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  4. Article: How Refined Surgical Technical Solutions Can Make Bentall Operation a Low-Risk Procedure: 20-Year Personal Experience at the "Root" of the Aortic Diseases-It Is Time to Change Surgical Guidelines.

    Ruvolo, Giovanni / Altieri, Claudia / Bassano, Carlo / Buioni, Dario / Nardi, Paolo / Pisano, Calogera

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: 1) Objective: Twenty years' experience of Bentall-De Bono operations by one surgeon. (2) Methods: From January 2003 to September 2023, four-hundred-and-two patients aged 65.9 ± 15 years underwent a Bentall operation. The EuroScore-2 was 5.0% ± 3.8%. ... ...

    Abstract (1) Objective: Twenty years' experience of Bentall-De Bono operations by one surgeon. (2) Methods: From January 2003 to September 2023, four-hundred-and-two patients aged 65.9 ± 15 years underwent a Bentall operation. The EuroScore-2 was 5.0% ± 3.8%. Associated procedures were performed on 113 patients (28.1%). Results: Operative mortality was 1.2% (
    Language English
    Publishing date 2023-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237330
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  5. Article ; Online: Beyond acute appendicitis: a single-institution experience of unexpected pathology findings after 989 consecutive emergency appendectomy.

    Fransvea, Pietro / Puccioni, Caterina / Altieri, Gaia / D'Agostino, Luca / Costa, Gianluca / Tropeano, Giuseppe / La Greca, Antonio / Brisinda, Giuseppe / Sganga, Gabriele

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 87

    Abstract: Introduction: Appendiceal neoplasms (ANs) are rare, with an estimated incidence of around 1%: neuroendocrine tumours (NETs) and low-grade appendiceal mucinous neoplasms (LAMNs) comprise most cases. Most tumours are cured by appendectomy alone, although ... ...

    Abstract Introduction: Appendiceal neoplasms (ANs) are rare, with an estimated incidence of around 1%: neuroendocrine tumours (NETs) and low-grade appendiceal mucinous neoplasms (LAMNs) comprise most cases. Most tumours are cured by appendectomy alone, although some require right hemicolectomy and intra-operative chemotherapy. The aim of the present study is to evaluate our institution's experience in terms of the prevalence of AN, their histological types, treatment and outcomes in adult patients undergoing emergency appendectomy.
    Material and methods: Single-centre retrospective cohort analysis of patients treated for acute appendicitis at a large academic medical centre. Patients with a diagnosis of acute appendicitis (AA) where further compared with patients with acute appendicitis and a histologically confirmed diagnosis of appendiceal neoplasm (AN).
    Results: A diagnosis of acute appendicitis was made in 1200 patients. Of these, 989 patients underwent emergency appendectomy. The overall incidence of appendiceal neoplasm was 9.3% (92 patients). AN rate increased with increasing age. Patients under the age of 30 had a 3.8% (14/367 patients) rate of occult neoplasm, whereas patients between 40 and 89 years and older had a 13.0% rate of neoplasm. No difference was found in clinical presentations and type of approach while we found a lower complicated appendicitis rate in the AN group.
    Conclusion: ANs are less rare with respect to the literature; however, clinically, there are no specific signs of suspicious and simple appendicectomy appears to be curative in most cases. However, age plays an important role; older patients are at higher risk for AN. ANs still challenge the non-operative management concept introduced into the surgical literature.
    MeSH term(s) Adult ; Humans ; Appendicitis/epidemiology ; Appendicitis/surgery ; Appendiceal Neoplasms/epidemiology ; Appendiceal Neoplasms/surgery ; Appendectomy ; Retrospective Studies ; Acute Disease
    Language English
    Publishing date 2024-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03277-0
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.10: Show issues Location:
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  6. Article ; Online: Indoxyl sulphate-initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor-erythroid-2-related factor 2.

    Barisione, Chiara / Verzola, Daniela / Garibaldi, Silvano / Altieri, Paola / Furfaro, Anna Lisa / Nitti, Mariapaola / Pratesi, Giovanni / Palombo, Domenico / Ameri, Pietro

    Journal of cellular and molecular medicine

    2024  Volume 28, Issue 7, Page(s) e18192

    Abstract: In the last decade, extensive attention has been paid to the uremic toxin indoxyl sulphate (IS) as an inducer of cardiac fibroblast (cFib) activation and cardiac fibrosis in chronic kidney disease. At cellular level, IS engages aryl hydrocarbon receptor ( ...

    Abstract In the last decade, extensive attention has been paid to the uremic toxin indoxyl sulphate (IS) as an inducer of cardiac fibroblast (cFib) activation and cardiac fibrosis in chronic kidney disease. At cellular level, IS engages aryl hydrocarbon receptor (AhR) and regulates many biological functions. We analysed how AhR inhibition by CH-223191 (CH) and overexpression of non-functional (dominant negative, DN) nuclear factor-erythroid-2-related factor 2 (NRF2), a transcription factor recruited by AhR, modulate the response of neonatal mouse (nm) cFib to IS. We also evaluated nm-cardiomyocytes after incubation with the conditioned medium (CM) of IS±CH-treated nm-cFib. IS induced activation, collagen synthesis, TLR4 and-downstream-MCP-1, and the genes encoding angiotensinogen, angiotensin-converting enzyme, angiotensin type 1 receptor (AT1r) and neprilysin (Nepr) in nm-cFib. CH antagonized IS-initiated nm-cFib activation, but did not affect or even magnified the other features. IS promoted NRF2 nuclear translocation and expression the NRF2 target Nqo1. Both pre-incubation with CH and transfection of DN-NRF2 resulted in loss of NRF2 nuclear localization. Moreover, DN-NRF2 overexpression led to greater TLR4 and MCP-1 levels following exposure to IS. The CM of IS-primed nm-cFib and to a larger extent the CM of IS+CH-treated nm-cFib upregulated AT1r, Nepr and TNFα and myostatin genes in nm-cardiomyocytes. Hence, IS triggers pro-inflammatory activation of nm-cFib partly via AhR, and AhR-NRF2 counteract it. Strategies other than AhR inhibition are needed to target IS detrimental actions on cardiac cells.
    MeSH term(s) Mice ; Animals ; Indican/pharmacology ; Indican/metabolism ; Signal Transduction ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Toll-Like Receptor 4/genetics ; Fibroblasts/metabolism
    Chemical Substances Indican (N187WK1Y1J) ; Receptors, Aryl Hydrocarbon ; NF-E2-Related Factor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18192
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
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  7. Article: Minimal Inhibitory Concentrations of Thymol and Carvacrol: Toward a Unified Statistical Approach to Find Common Trends.

    Speranza, Barbara / Bevilacqua, Antonio / Campaniello, Daniela / Altieri, Clelia / Corbo, Maria Rosaria / Sinigaglia, Milena

    Microorganisms

    2023  Volume 11, Issue 7

    Abstract: Thymol and carvacrol are some of the most important and used components of Essential oils (EOs); they are widely studied, and there are much data available in the literature. Their Minimal Inhibitory Concentration (MIC) values found in the literature ... ...

    Abstract Thymol and carvacrol are some of the most important and used components of Essential oils (EOs); they are widely studied, and there are much data available in the literature. Their Minimal Inhibitory Concentration (MIC) values found in the literature from 2005 to present were used to assess the bioactivity toward yeasts, molds, Gram-positive bacteria, and Gram-negative bacteria, as well as on some bacterial species/serotypes (
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11071774
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  8. Article ; Online: Right ventricular inflow obstruction related to late Candida albicans infection of implantable cardioverter-defibrillator leads.

    Buioni, Dario / Pisano, Calogera / Altieri, Claudia / Ruvolo, Giovanni

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2020  Volume 58, Issue 5, Page(s) 1101

    MeSH term(s) Candida albicans ; Candidiasis/diagnosis ; Cardiac Resynchronization Therapy ; Defibrillators, Implantable/adverse effects ; Heart Ventricles/diagnostic imaging ; Humans
    Language English
    Publishing date 2020-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezaa209
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
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  9. Article: A rare localization of papillary fibroelastoma.

    Trombetti, Daniele / Nardi, Paolo / Asta, Laura / Pisano, Calogera / Altieri, Claudia / Ruvolo, Giovanni

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2022  Volume 19, Issue 2, Page(s) 103–104

    Language English
    Publishing date 2022-06-29
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2022.117501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Treating Mitroflow dysfunction by means of an open valve-in-valve Perceval implantation.

    Trombetti, Daniele / Pisano, Calogera / Altieri, Claudia / Nardi, Paolo / Ferrante, Sabrina Maria / Asta, Laura / Buioni, Dario / Ruvolo, Giovanni

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2023  Volume 20, Issue 1, Page(s) 65–66

    Language English
    Publishing date 2023-04-03
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2023.126105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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