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Article: Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes.

Venditti, Noemi / Petronio, Giulio Petronio / Pinti, Melania / Cutolo, Giovanni / Pietrangelo, Laura / Massini, Laura / Magnifico, Irene / Cutuli, Marco Alfio / Petrone, Federica / Papini, Stefano / Di Marco, Roberto / Corbi, Graziamaria

Open medicine (Warsaw, Poland)

2023 Volume 18, Issue 1, Page(s) 20230822

Abstract: The aim of this retrospective cohort study is to understand if and how much the preventive self-isolation approach might have been a valid model to avoid care-related infection, not only from COVID-19 but also from other non-viral infectious diseases. ... ...

Abstract	The aim of this retrospective cohort study is to understand if and how much the preventive self-isolation approach might have been a valid model to avoid care-related infection, not only from COVID-19 but also from other non-viral infectious diseases. From March to May 2020, the healthcare and management staff of the Villa Santa Maria long-term care facilities, located in the village of Montenero di Bisaccia (Campobasso, Molise, Italy), decided to carry out a preventive self-isolation plan to safeguard the residents from SARS-CoV-2. The impact on other infectious diseases was evaluated by analyzing the antibiotic therapies prescription trend among the inpatients. Our data showed that although self-isolation protected residents and caregivers from SARS-CoV-2, it can also be associated with mobility reduction, leading to an increase in bedridden pathologies, namely, pressure ulcers and pressure sores. The simultaneous isolation of residents and caregivers in the same location significantly reduced any outside influence as a cause of possible infections.
Language	English
Publishing date	2023-10-27
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2023-0822
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study.

Sudre, Justine / Venditti, Laura / Ancelet, Claire / Chassin, Olivier / Sarov, Mariana / Smadja, Didier / Chausson, Nicolas / Lun, François / Laine, Olga / Duron, Emmanuelle / Verny, Christiane / Spelle, Laurent / Rouquette, Alexandra / Legris, Nicolas / Denier, Christian

Journal of the American Geriatrics Society

2021 Volume 69, Issue 11, Page(s) 3167–3176

Abstract: ... patients (n = 357) had more baseline comorbidities and lower levels of prestroke independence (modified ... Score [NIHSS] 15 vs. 12; p < 0.001) than younger patients (n = 643). There was no difference ...

Abstract	Background: While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real-life study the differences between older (>80 years old) and younger patients treated for AIS. Methods: Thousand patients treated with thrombolysis and/or EVT were consecutively included in a prospective monocentric database (admitted from December 2015 to May 2019 in our comprehensive stroke center). Demographic data with detailed history, baseline physical examinations and treatments, laboratory and imaging data, prestroke functional status, and outcome 3 months after stroke were analyzed. Results: Older patients (n = 357) had more baseline comorbidities and lower levels of prestroke independence (modified Rankin scale ≤2; 67.2% vs. 96.1%) and more severe strokes (median National Institute of Health Stroke Score [NIHSS] 15 vs. 12; p < 0.001) than younger patients (n = 643). There was no difference in the reperfusion treatments used or treatment timelines. In older patients, good functional status at 3 months was less common (29.7% vs. 61.3%) and mortality was higher (37.1% vs. 11.4%) than in younger patients. Younger age was independently associated with better prognosis (odds ratio [OR] 0.37, 95% confidence interval [CI]: 0.20-0.67; p = 0.001) and lower mortality (OR 4.38, 95% CI: 2.11-9.09; p < 0.001). Among older adults, features associated with good outcome at 3 months were age (OR 0.89, 95% CI: 0.81-0.97; p = 0.01), initial NIHSS (OR 0.89, 95% CI: 0.83-0.94; p < 0.0001), and absence of severe leukoaraiosis, anticoagulant treatment, and symptomatic intracerebral hemorrhage following reperfusion therapy (respectively, OR 0.42, 95% CI: 0.19-0.93; p = 0.03; OR = 0.07, 95% CI: 0.01-0.70; p = 0.02; and OR = 0.07, 95% CI: 0.01-0.61; p = 0.02). Conclusion: Although reperfusion therapy was less successful in older patients, these patients may benefit from acute recanalization despite their age. With an increasing older adult population, high-quality prospective studies are still required to better predict functional outcome and clarify the criteria that would allow better selection of appropriate treatment.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Comorbidity ; Female ; Humans ; Ischemic Stroke/mortality ; Ischemic Stroke/therapy ; Male ; Middle Aged ; Prospective Studies ; Reperfusion ; Severity of Illness Index ; Thrombectomy ; Thrombolytic Therapy ; Treatment Outcome
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.17394
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Article ; Online: Using RE-AIM to examine the potential public health impact of an integrated collaborative care intervention for weight and depression management in primary care: Results from the RAINBOW trial.

Lewis, Megan A / Wagner, Laura K / Rosas, Lisa G / Lv, Nan / Venditti, Elizabeth M / Steinman, Lesley E / Weiner, Bryan J / Goldhaber-Fiebert, Jeremy D / Snowden, Mark B / Ma, Jun

PloS one

2021 Volume 16, Issue 3, Page(s) e0248339

Abstract: ... 24 months (end of follow-up). Semi-structured interviews (n = 142) were conducted with 54 out of 409 ...

Abstract	Background: An integrated collaborative care intervention was used to treat primary care patients with comorbid obesity and depression in a randomized clinical trial. To increase wider uptake and dissemination, information is needed on translational potential. Methods: The trial collected longitudinal, qualitative data at baseline, 6 months (end of intensive treatment), 12 months (end of maintenance treatment), and 24 months (end of follow-up). Semi-structured interviews (n = 142) were conducted with 54 out of 409 randomly selected trial participants and 37 other stakeholders, such as recruitment staff, intervention staff, and clinicians. Using a Framework Analysis approach, we examined themes across time and stakeholder groups according to the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework. Results: At baseline, participants and other stakeholders reported being skeptical of the collaborative care approach related to some RE-AIM dimensions. However, over time they indicated greater confidence regarding the potential for future public health impact. They also provided information on barriers and actionable information to enhance program reach, effectiveness, adoption, implementation, and maintenance. Conclusions: RE-AIM provided a useful framework for understanding how to increase the impact of a collaborative and integrative approach for treating comorbid obesity and depression. It also demonstrates the utility of using the framework as a planning tool early in the evidence-generation pipeline.
MeSH term(s)	Adolescent ; Adult ; Aged ; Depression/psychology ; Depression/therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Obesity/psychology ; Obesity/therapy ; Primary Health Care ; Public Health
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0248339
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Article ; Online: Pre-treatment risk markers for hemorrhagic transformation in posterior circulation acute ischemic stroke treated with reperfusion therapy.

Ancelet, Claire / Neveü, Sophie / Venditti, Laura / Cortese, Jonathan / Chassin, Oliver / Pelissou, Coralie / Berthou, Elsa Talab / Babin, Matthias / Nasser, Ghaidaa / Benoudiba, Farida / Legris, Nicolas / Rivière, Mariana Sarov / Chausson, Nicolas / Spelle, Laurent / Denier, Christian

Journal of neurology

2023 Volume 270, Issue 11, Page(s) 5493–5501

Abstract: Background: Hemorrhagic transformation (HT) is an uncommon complication of posterior circulation acute ischemic stroke (PCS) compared to anterior circulation stroke. Nevertheless, it remains a major concern especially following reperfusion therapy. This ...

Abstract	Background: Hemorrhagic transformation (HT) is an uncommon complication of posterior circulation acute ischemic stroke (PCS) compared to anterior circulation stroke. Nevertheless, it remains a major concern especially following reperfusion therapy. This study aimed at identifying potential predictive factors associated with HT in PCS. Methods: Consecutive patients, from a multicenter cohort, with PCS treated by IVT or EVT or the combination of both, were included from December 2015 to May 2019. The European Cooperative Acute Stroke Study criteria was used to identify HT. Potential risk factors were analyzed using univariate and multivariable testing models. Results: A total of 96 patients were included in our study. Median age was 66 (57-83) years, 54 patients (56%) were male and median baseline NIHSS was 8 (4-14). 77 patients (80%) received IVT and 54 patients (56%) benefited from EVT. HT occurred in 19 patients (20%), while sHT occurred in 3 patients (3%). HT was found to be associated with poor functional status at 3 months in univariate analysis (p = 0.0084). Multivariable analysis confirmed that higher baseline NIHSS (OR 1.1008; 95% CI [1.0216-1.1862]; p = 0.0117) and lobar topography of ischemia (OR 4.4275; 95% CI [1.3732-14.2753]; p = 0.0127) were independent predictors of the occurrence of HT. Discussion: HT is associated with increased morbidity in patients with PCS; higher NIHSS and lobar ischemia were independent predictors of HT in our population. Easy-to-use predictive markers may help to tailor therapeutic management of patients with PCS.
Language	English
Publishing date	2023-07-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11886-w
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Article ; Online: Efficacy and Microbiota Modulation Induced by LimpiAL 2.5%, a New Medical Device for the Inverse Psoriasis Treatment.

Pietrangelo, Laura / Dattola, Annunziata / Magnifico, Irene / Petronio Petronio, Giulio / Cutuli, Marco Alfio / Venditti, Noemi / Guarnieri, Antonio / Wollenberg, Andreas / Pellacani, Giovanni / Di Marco, Roberto

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: 1) Inverse psoriasis (IP), also known as intertriginous, typically affects the groin, armpits, navel, intergluteal fissure, and external genitalia. Skin lesions are erythematous plaques of inflammatory nature, smooth, well-delimited, non-scaly, and non- ... ...

Abstract	(1) Inverse psoriasis (IP), also known as intertriginous, typically affects the groin, armpits, navel, intergluteal fissure, and external genitalia. Skin lesions are erythematous plaques of inflammatory nature, smooth, well-delimited, non-scaly, and non-infiltrated. Lesions may be accompanied by itching, pain, or burning sensation. The aim of this study is both to investigate the modulation of the skin microbiota induced by IP and, on the other hand, to test the effectiveness of the new biotechnological product LimpiAL 2.5%. (2) Patients affected by IP were recruited in a private practice and treated for 4 weeks with LimpiAL 2.5% exclusively. The clinical effects on the lesion skin were evaluated, and the skin microbiotas before and after treatment were compared. (3) The clinical outcomes reveled a significant beneficial effect of the tested product. At the same time, LimpiAL increased the biological diversity of the skin microbiota and exerted a significant decrease of some
MeSH term(s)	Humans ; Psoriasis/drug therapy ; Skin/pathology ; Microbiota ; Erythema/pathology ; Pruritus/pathology
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076339
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Article: A Wall Fragment of

Magnifico, Irene / Perna, Angelica / Cutuli, Marco Alfio / Medoro, Alessandro / Pietrangelo, Laura / Guarnieri, Antonio / Foderà, Emanuele / Passarella, Daniela / Venditti, Noemi / Vergalito, Franca / Petronio Petronio, Giulio / Di Marco, Roberto

Pharmaceutics

2023 Volume 15, Issue 4

Abstract: 1) Background alteration of the skin microbiota, dysbiosis, causes skin barrier impairment resulting in disease development. ...

Abstract	(1) Background alteration of the skin microbiota, dysbiosis, causes skin barrier impairment resulting in disease development.
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15041224
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Article: The new invasive mosquito species

Ganassi, Sonia / De Cristofaro, Antonio / Di Criscio, Dalila / Petrarca, Sonia / Leopardi, Chiara / Guarnieri, Antonio / Pietrangelo, Laura / Venditti, Noemi / Di Marco, Roberto / Petronio Petronio, Giulio

Frontiers in microbiology

2022 Volume 13, Page(s) 931994

Abstract: The increased mobility of goods, people, and animals worldwide has caused the spread of several arthropod vectors, leading to an increased risk of animal and human infections. ...

Abstract	The increased mobility of goods, people, and animals worldwide has caused the spread of several arthropod vectors, leading to an increased risk of animal and human infections.
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.931994
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Article: Emerging Evidence on

Petronio Petronio, Giulio / Pietrangelo, Laura / Cutuli, Marco Alfio / Magnifico, Irene / Venditti, Noemi / Guarnieri, Antonio / Abate, Getnet Atinafu / Yewhalaw, Delenasaw / Davinelli, Sergio / Di Marco, Roberto

Microorganisms

2022 Volume 10, Issue 10

Abstract: In recent years, the scientific community's interest ... ...

Abstract	In recent years, the scientific community's interest in
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10101983
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Article: Potential Mucosal Irritation Discrimination of Surface Disinfectants Employed against SARS-CoV-2 by

Cutuli, Marco Alfio / Guarnieri, Antonio / Pietrangelo, Laura / Magnifico, Irene / Venditti, Noemi / Recchia, Laura / Mangano, Katia / Nicoletti, Ferdinando / Di Marco, Roberto / Petronio Petronio, Giulio

Biomedicines

2021 Volume 9, Issue 4

Abstract: Preventive measures have proven to be the most effective strategy to counteract the spread of the SARS-CoV-2 virus. Among these, disinfection is strongly suggested by international health organizations' official guidelines. As a consequence, the increase ...

Abstract	Preventive measures have proven to be the most effective strategy to counteract the spread of the SARS-CoV-2 virus. Among these, disinfection is strongly suggested by international health organizations' official guidelines. As a consequence, the increase of disinfectants handling is going to expose people to the risk of eyes, mouth, nose, and mucous membranes accidental irritation. To assess mucosal irritation, previous studies employed the snail
Language	English
Publishing date	2021-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9040424
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Article ; Online: LimpiAD foam and the potential control of the pressure ulcers onset.

Pietrangelo, Laura / Magnifico, Irene / Guerrera, Antonella / Cutuli, Marco Alfio / Petronio, Giulio Petronio / Venditti, Noemi / Covelli, Matteo / Buccieri, Nicandro / Garofalo, Silvio / Di Marco, Roberto

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 144, Page(s) 112327

Abstract: Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat ... ...

Abstract	Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat the problem is the adoption of suitable patients' assistance procedures. At the same time, the research focuses on finding medicaments or treatment strategies that could prevent the lesions and/or accelerate their healing. The international market's wide range of cosmetic/pharmaceuticals products is mainly topical preparations based on emollient agents to preserve or restore skin homeostasis. On the other hand, the skin microbiome's implication in the pressure ulcers occurrence is mainly unknown. Based on these assumptions, here we tested an innovative preparation, the LimpiAD foam, as a potential preventive strategy of pressure ulcers onset. The active component of this product is composed of hyaluronic acid conjugated with a bacterial cell wall fragment of C. acnes DSM 28251. For LimpiAD foam, we hypothesised a combined action of the two components on the skin tissue, an emollient effect due to the hyaluronic acid properties together with a modulatory effect on the skin microbiota carried out by the component of bacterial derivation. Our results supported the hypothesis and suggested a potential role of LimpiAD foam in pressure ulcers prevention.
MeSH term(s)	Administration, Cutaneous ; Bacteria/drug effects ; Bacteria/genetics ; Bacteria/growth & development ; Biological Products/administration & dosage ; Biological Products/adverse effects ; Biological Products/pharmacology ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/adverse effects ; Dermatologic Agents/pharmacology ; Drug Compounding ; Dysbiosis ; Humans ; Italy ; Microbiota ; Pilot Projects ; Pressure Ulcer/microbiology ; Pressure Ulcer/pathology ; Pressure Ulcer/prevention & control ; Skin/drug effects ; Skin/microbiology ; Skin/pathology ; Time Factors ; Treatment Outcome
Chemical Substances	Biological Products ; Dermatologic Agents ; LimpiAD foam
Language	English
Publishing date	2021-10-13
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112327
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