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Article ; Online: Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes.

Sharma, Basista Rabina / Jaiswal, Swarna / Ravindra, P V

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 152, Page(s) 113148

Abstract: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/prevention & control ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Prebiotics ; Probiotics/therapeutic use
Chemical Substances	Prebiotics
Language	English
Publishing date	2022-06-02
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113148
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Article ; Online: Effect of Integrated Survivorship Model on Physical Health for Breast Cancer Survivors in Rural Area.

Shinde, Sandeep B / Kulkarni, Ketaki Yogesh / Patil, Sanjaykumar / Gudur, Anand / Shinde, Ravindra V / Bhende, Radha P

Asian Pacific journal of cancer prevention : APJCP

2024 Volume 25, Issue 2, Page(s) 401–408

Abstract: ... showed extremely significant results in the intervention group with a p-value of less than 0.0001 ...

Abstract	Objective: The objective of this study was to evaluate the effect of the integrated survivorship model on the physical health of breast cancer survivors in rural areas. Methods: Ninety-two patients who were breast cancer survivors were selected as per inclusion criteria and divided into two groups (control group and intervention group). The participants were randomly allotted to two groups of 46 each. A 12-minute walk test, assessment of quality of life, and difficulty in return to work were used as outcome measures. The integrated survivorship model was implemented in one group for 3 months while the other group was a supporting group and was involved in household activities only. Pre-assessment and post-assessment were taken to evaluate the effect of the integrated survivorship model. All the statistical analysis was done using SPSS statistical Software (version 23.0 for Windows; SPSS, Inc., Chicago, USA) and the results were obtained. Results: The results revealed that the assessment of the 12-minute walk test, physical well-being, social/family well-being, functional well-being, and difficulty in returning to work showed extremely significant results in the intervention group with a p-value of less than 0.0001. Similarly, emotional well-being and additional concern domains showed significant results in the intervention group. Hence, the findings of this study revealed significance in post-assessment in all the outcome measures of the experimental group. Conclusion: The study showed that all the outcome measures such as the 12-minute walk test, assessment of quality of life, and difficulty in return to work were impaired in both groups before the study. The effect of the model showed a significant improvement in the intervention group after implementing the intervention.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/therapy ; Breast Neoplasms/psychology ; Cancer Survivors/psychology ; Quality of Life/psychology ; Survivors/psychology ; Survivorship ; Random Allocation
Language	English
Publishing date	2024-02-01
Publishing country	Thailand
Document type	Clinical Study ; Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2024.25.2.401
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Article ; Online: Identification of prominent airborne pollen in a city situated in foot-hills of Himalayas, Chandigarh, India

Ravindra, Khaiwal / Goyal, Akshi / Mor, Suman

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 6 p.15775-15788

2023

Abstract: Pollen allergy is considered one of the important critical thrust areas, as 20–30% of the world population suffers from allergic rhinitis. The increase in global surface temperature directly affects pollen physiological (e.g., pollen production) and ... ...

Abstract	Pollen allergy is considered one of the important critical thrust areas, as 20–30% of the world population suffers from allergic rhinitis. The increase in global surface temperature directly affects pollen physiological (e.g., pollen production) and morphological parameters and indirectly affects the distribution pattern, the allergenic potential of pollen, and plant species. Therefore, periodic sampling and pollen studies of a region have become necessary to assess the status of change in species and its morphological characteristics of different taxa. The current study is conducted to identify the airborne pollen based on studying their unique and distinctive morphological characters to serve as a reference pollen guide for future research. The airborne pollens were trapped using the Burkard volumetric sampler at three different locations in Chandigarh from 2018 to 2020 and analyzed under Leica DM5500B-Automated Upright Microscope System. The study investigated various pollen features such as shape, size, aperture type, and exine/surface pattern for taxonomic classification of plant groups. The majority of LM-analyzed pollen grains were prolate-spheroidal or oblate, whereas the aperture types were 3-zonocolporate, 3-colpate, and 3-zonocolporate. Exine patterns were predominantly psilate, reticulate, and straite and were easily discernible. Nonetheless, the vast majority of airborne pollen belonging to both arboreal and non-arboreal was quite small and fall into small pollen size classes, i.e., 10–24 μm. The exine pattern was readily apparent and were predominantly psilate, reticulate, and straight. The current study improved the knowledge on airborne pollen biodiversity, which will help to understand the regional distribution, long-range transport, and construct the current status of morphological features of species/taxa.
Keywords	allergenicity ; biodiversity ; exine ; hay fever ; pollen ; pollen productivity ; pollen size ; surface temperature ; Himalayan region ; India
Language	English
Dates of publication	2023-02
Size	p. 15775-15788.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23050-4
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Article: Combination of peripheral nerve stimulator and ultrasound guidance may improve the efficacy of glossopharyngeal nerve block.

Punj, Jyotsna / Jain, Dhruv / Singh, Longjam D / Thakur, Jay P / Pandey, Ravindra K / Darlong, V

Journal of anaesthesiology, clinical pharmacology

2023 Volume 39, Issue 2, Page(s) 318–319

Language	English
Publishing date	2023-04-11
Publishing country	India
Document type	Journal Article
ZDB-ID	1401760-x
ISSN	0970-9185
ISSN	0970-9185
DOI	10.4103/joacp.joacp_293_21
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Article ; Online: Genomic Determinants of Entomopathogenic Fungi and Their Involvement in Pathogenesis

Vidhate, Ravindra P. / Dawkar, Vishal V. / Punekar, Sachin A. / Giri, Ashok P.

Microb Ecol. 2023 Jan., v. 85, no. 1 p.49-60

2023

Abstract: Entomopathogenic fungi offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. The evolutionary history of selected entomopathogenic fungi indicates their ancestral relationship with plant endophytes. During ... ...

Abstract	Entomopathogenic fungi offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. The evolutionary history of selected entomopathogenic fungi indicates their ancestral relationship with plant endophytes. During this host shifting, entomopathogenic fungi must have acquired multiple mechanisms, including a combination of various biomolecules that make them distinguishable from other fungi. In this review, we focus on understanding various biochemical and molecular mechanisms involved in entomopathogenesis. In particular, we attempt to explain the indispensable role of enlarged gene families of various virulent factors, viz. chitinases, proteases, lipases, specialized metabolites, and cytochrome P450, in entomopathogenesis. Our analysis suggests that entomopathogenic fungi recruit a different set of gene products during the progression of pathogenesis. Knowledge of these bio-molecular interactions between fungi and insect hosts will allow researchers to execute pointed efforts towards the development of improved entomopathogenic fungal strains.
Keywords	biological control ; carboxylic ester hydrolases ; chitinase ; cytochrome P-450 ; endophytes ; fungi ; genes ; genomics ; insects ; metabolites ; pathogenesis ; proteinases ; virulence
Language	English
Dates of publication	2023-01
Size	p. 49-60.
Publishing place	Springer US
Document type	Article ; Online
Note	Review
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-021-01936-z
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Article ; Online: Protein-Mediated Changes in Membrane Fluidity and Ordering: Insights into the Molecular Mechanism and Implications for Cellular Function.

Gunwant, Vineet / Gahtori, Preeti / Varanasi, Srinivasa Rao / Pandey, Ravindra

The journal of physical chemistry letters

2024 Volume 15, Issue 16, Page(s) 4408–4415

Abstract: Probing protein-membrane interactions is vital for understanding biological functionality for various applications such as drug development, targeted drug delivery, and creation of functional biomaterials for medical and industrial purposes. In this ... ...

Abstract	Probing protein-membrane interactions is vital for understanding biological functionality for various applications such as drug development, targeted drug delivery, and creation of functional biomaterials for medical and industrial purposes. In this study, we have investigated interaction of Human Serum Albumin (HSA) with two different lipids, dipalmitoylphosphatidylglycerol (dDPPG) and dipalmitoylphosphatidylcholine (dDPPC), using Vibrational Sum Frequency Generation spectroscopy at different membrane fluidity values. In the liquid-expanded (LE) state of the lipid, HSA (at pH 3.5) deeply intercalated lipid chains through a combination of electrostatic and hydrophobic interactions, which resulted in more ordering of the lipid chains. However, in the liquid-condensed (LC) state, protein intercalation is decreased due to tighter lipid packing. Moreover, our findings revealed distinct differences in HSA's interaction with dDPPG and dDPPC lipids. The interaction with dDPPC remained relatively weak compared to dDPPG. These results shed light on the significance of protein mediated changes in lipid characteristics, which hold considerable implications for understanding membrane protein behavior, lipid-mediated cellular processes, and lipid-based biomaterial design.
MeSH term(s)	Humans ; Phosphatidylglycerols/chemistry ; Phosphatidylglycerols/metabolism ; Membrane Fluidity ; 1,2-Dipalmitoylphosphatidylcholine/chemistry ; Hydrophobic and Hydrophilic Interactions ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/metabolism ; Static Electricity
Chemical Substances	Phosphatidylglycerols ; 1,2-Dipalmitoylphosphatidylcholine (2644-64-6) ; 1,2-dipalmitoylphosphatidylglycerol (VA9U6BR3SB) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03627
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Article ; Online: Nutritional interventions for improving the endurance performance in athletes.

Ravindra, P V / Janhavi, P / Divyashree, S / Muthukumar, S P

Archives of physiology and biochemistry

2020 Volume 128, Issue 4, Page(s) 851–858

Abstract: Endurance refers to the ability of skeletal muscles to perform continuously withstanding the hardships of exercise. Endurance exercises have three phases: pre-, during-, and post-workout phase. The nutritional requirements that drive these phases vary on ...

Abstract	Endurance refers to the ability of skeletal muscles to perform continuously withstanding the hardships of exercise. Endurance exercises have three phases: pre-, during-, and post-workout phase. The nutritional requirements that drive these phases vary on intensity, type of workout, individual's body composition, training, weather conditions, etc. Generally, the pre-workout phase requires glycogen synthesis and spare glycogen breakdown. While workout phase, requires rapid absorption of exogenous glucose, insulin release to transport glucose into muscle cells, replenish the loss of electrolytes, promote fluid retention, etc. However, post-workout phase requires quick amino acid absorption, muscle protein synthesis, repair of damaged muscle fibres and tendon, ameliorate inflammation, oxidative stress, etc. Therefore, nutritional sources that can help these metabolic requirements is recommended. In this review, various dietary interventions including timing and amount of nutrient consumption that can promote the above metabolic requirements that in turn support in improving the endurance potential in athletes are discussed.HIGHLIGHTSReview article describes nutritional requirements of endurance exercises.It also describes nutritional interventions to enhance the endurance potential in athletes.
MeSH term(s)	Athletes ; Dietary Supplements ; Glucose ; Glycogen/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Physical Endurance/physiology
Chemical Substances	Glycogen (9005-79-2) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-03-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1238320-x
ISSN	1744-4160 ; 1381-3455
ISSN (online)	1744-4160
ISSN	1381-3455
DOI	10.1080/13813455.2020.1733025
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Article ; Online: Genomic Determinants of Entomopathogenic Fungi and Their Involvement in Pathogenesis.

Vidhate, Ravindra P / Dawkar, Vishal V / Punekar, Sachin A / Giri, Ashok P

Microbial ecology

2022 Volume 85, Issue 1, Page(s) 49–60

Abstract	Entomopathogenic fungi offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. The evolutionary history of selected entomopathogenic fungi indicates their ancestral relationship with plant endophytes. During this host shifting, entomopathogenic fungi must have acquired multiple mechanisms, including a combination of various biomolecules that make them distinguishable from other fungi. In this review, we focus on understanding various biochemical and molecular mechanisms involved in entomopathogenesis. In particular, we attempt to explain the indispensable role of enlarged gene families of various virulent factors, viz. chitinases, proteases, lipases, specialized metabolites, and cytochrome P450, in entomopathogenesis. Our analysis suggests that entomopathogenic fungi recruit a different set of gene products during the progression of pathogenesis. Knowledge of these bio-molecular interactions between fungi and insect hosts will allow researchers to execute pointed efforts towards the development of improved entomopathogenic fungal strains.
MeSH term(s)	Animals ; Fungi/genetics ; Insecta/microbiology ; Plants/microbiology ; Genomics ; Endophytes
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-021-01936-z
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Article ; Online: Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19.

Mrityunjaya, M / Pavithra, V / Neelam, R / Janhavi, P / Halami, P M / Ravindra, P V

Frontiers in immunology

2020 Volume 11, Page(s) 570122

Abstract: The COVID-19 is an acute and contagious disease characterized by pneumonia and ARDS. The disease is caused by SARS-CoV-2, which belongs to the family ... ...

Abstract	The COVID-19 is an acute and contagious disease characterized by pneumonia and ARDS. The disease is caused by SARS-CoV-2, which belongs to the family of
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/diet therapy ; Coronavirus Infections/drug therapy ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/diet therapy ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Dietary Supplements ; Drug Repositioning/methods ; Humans ; Inflammation/drug therapy ; Oxidative Stress/physiology ; Pandemics ; Phytochemicals/therapeutic use ; Pneumonia, Viral/diet therapy ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; Probiotics/therapeutic use ; SARS-CoV-2
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Antiviral Agents ; Cytokines ; Phytochemicals
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.570122
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Article ; Online: How Does pH Affect the Adsorption of Human Serum Protein in the Presence of Hydrophobic and Hydrophilic Nanoparticles at Air-Water and Lipid-Water Interfaces?

Gahtori, Preeti / Gunwant, Vineet / Pandey, Ravindra

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 44, Page(s) 15487–15498

Abstract: This study investigates interaction between hydrophilic (11-mercaptoundecanoic acid (MUA)) and hydrophobic (1-undecanethiol (UDT)) gold nanoparticles (GNPs) with human serum albumin (HSA) protein on air-water and lipid-water interfaces at pH 3 and 7. ... ...

Abstract	This study investigates interaction between hydrophilic (11-mercaptoundecanoic acid (MUA)) and hydrophobic (1-undecanethiol (UDT)) gold nanoparticles (GNPs) with human serum albumin (HSA) protein on air-water and lipid-water interfaces at pH 3 and 7. Vibrational sum frequency generation (VSFG) spectroscopy is used to analyze changes in the intensity of interfacial water molecules and the C-H group of the protein. At the air-water interface, the hydrophobic interaction between the HSA protein and hydrophobic GNPs at pH 3 leads to their accumulation at the interface, resulting in an increased C-H intensity of the protein with a slight decrease in water intensity. Whereas, at pH 7, where the negative charge of the protein results in the reduced surface activity of the HSA compared to pH 3, the interaction between alkyl chain of the hydrophobic GNPs and alkyl group of the protein results in the adsorption of the protein-capped GNPs at the interface. This leads to an increased intensity of the C-H group of protein and water molecules. However, negatively charged hydrophilic GNPs do not induce significant changes in the interfacial water structure or the C-H group of the protein due to the electrostatic force of repulsion with the negatively charged HSA at pH 7. In contrast, at the lipid-water interface, both hydrophobic and hydrophilic GNPs interact with HSA protein, causing disordering of interfacial water molecules at pH 3 and ordering at pH 7. Interestingly, similar behavior of the protein with both types of GNPs results in comparable ordering/disordering at the interface depending on the pH of solution. Furthermore, the VSFG results obtained with the deuterated lipid suggest that changes in ordering and disorder occur due to increased protein adsorption in the presence of GNPs, causing alterations in the membrane structure. These findings give a better understanding of the mechanisms that govern protein-nanoparticle interaction and their consequential effects on the structure, function, and behavior of molecules at the biological membrane interface, which is crucial for developing safe and effective nanoparticle-based therapeutics.
MeSH term(s)	Humans ; Water/chemistry ; Adsorption ; Gold/chemistry ; Metal Nanoparticles ; Blood Proteins ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Lipids/chemistry
Chemical Substances	Water (059QF0KO0R) ; Gold (7440-57-5) ; Blood Proteins ; Lipids
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c01755
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