LIVIVO - Search results -

Search results

Result 1 - 10 of total 338

Search options

Article ; Online: The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis.

Hu, Yaopeng / Cang, Jiehui / Hiraishi, Keizo / Fujita, Takayuki / Inoue, Ryuji

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation channel that activates in response to increased intracellular ... ...

Abstract	The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation channel that activates in response to increased intracellular Ca
MeSH term(s)	Humans ; Electrophysiologic Techniques, Cardiac ; TRPM Cation Channels/genetics ; Arrhythmias, Cardiac ; Myocytes, Cardiac ; Cardiac Electrophysiology
Chemical Substances	TRPM Cation Channels ; TRPM4 protein, human
Language	English
Publishing date	2023-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411798
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Structure-Activity Relationship Study of Helix-Stabilized Antimicrobial Peptides Containing Nonproteinogenic Amino Acids.

Ito, Takahito / Hashimoto, Wakana / Ohoka, Nobumichi / Misawa, Takashi / Inoue, Takao / Kawano, Ryuji / Demizu, Yosuke

ACS biomaterials science & engineering

2023 Volume 9, Issue 8, Page(s) 4654–4661

Abstract: Helical amphipathic peptides containing cationic and hydrophobic amino acid residues can possess potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. In this study, several amphipathic peptides with enhanced helical ... ...

Abstract	Helical amphipathic peptides containing cationic and hydrophobic amino acid residues can possess potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. In this study, several amphipathic peptides with enhanced helical structures containing nonproteinogenic amino acids were designed, and the relationships between the antimicrobial activity, hemolytic activity, and cytotoxicity were evaluated. In particular, the effect on the antimicrobial activity and cytotoxicity of the number and position of stapling structures introduced into the sequence was investigated. Peptide
MeSH term(s)	Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Peptides ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Amino Acids/pharmacology ; Protein Structure, Secondary ; Gram-Positive Bacteria ; Gram-Negative Bacteria ; Structure-Activity Relationship
Chemical Substances	Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Anti-Bacterial Agents ; Amino Acids
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00759
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline.

Nishimori, Makoto / Hayasaka, Naomi / Otsui, Kazunori / Inoue, Nobutaka / Asakura, Junko / Nagao, Manabu / Toh, Ryuji / Ishida, Tatsuro / Hirata, Ken-Ichi / Furuyashiki, Tomoyuki / Shinohara, Masakazu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4178

Abstract: Stress has garnered significant attention as a prominent risk factor for inflammation-related diseases, particularly cardiovascular diseases (CVDs). However, the precise mechanisms underlying stress-driven CVDs remain elusive, thereby impeding the ... ...

Abstract	Stress has garnered significant attention as a prominent risk factor for inflammation-related diseases, particularly cardiovascular diseases (CVDs). However, the precise mechanisms underlying stress-driven CVDs remain elusive, thereby impeding the development of preventive and therapeutic strategies. To explore the correlation between plasma lipid metabolites and human depressive states, liquid chromatography-mass spectrometry (LC/MS) based analysis of plasma and the self-rating depression (SDS) scale questionnaire were employed. We also used a mouse model with restraint stress to study its effects on plasma lipid metabolites and stenotic vascular remodeling following carotid ligation. In vitro functional and mechanistic studies were performed using macrophages, endothelial cells, and neutrophil cells. We revealed a significant association between depressive state and reduced plasma levels of 4-oxoDHA, a specific omega-3 fatty acid metabolite biosynthesized by 5-lipoxygenase (LO), mainly in neutrophils. In mice, restraint stress decreased plasma 4-oxoDHA levels and exacerbated stenotic vascular remodeling, ameliorated by 4-oxoDHA supplementation. 4-oxoDHA enhanced Nrf2-HO-1 pathways, exerting anti-inflammatory effects on endothelial cells and macrophages. One of the stress hormones, noradrenaline, reduced 4-oxoDHA and the degraded 5-LO in neutrophils through the proteasome system, facilitated by dopamine D2-like receptor activation. Our study proposed circulating 4-oxoDHA levels as a stress biomarker and supplementation of 4-oxoDHA as a novel therapeutic approach for controlling stress-related vascular inflammation.
MeSH term(s)	Humans ; Mice ; Animals ; Fatty Acids, Omega-3/metabolism ; Endothelial Cells/metabolism ; Norepinephrine ; Vascular Remodeling ; Inflammation/drug therapy
Chemical Substances	Fatty Acids, Omega-3 ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54867-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: An oxidative metabolic pathway of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU) from alginate in an alginate-assimilating bacterium.

Nishiyama, Ryuji / Ojima, Takao / Ohnishi, Yuki / Kumaki, Yasuhiro / Aizawa, Tomoyasu / Inoue, Akira

Communications biology

2021 Volume 4, Issue 1, Page(s) 1254

Abstract: Alginate-assimilating bacteria degrade alginate into an unsaturated monosaccharide, which is converted into 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU). DEHU is reduced to 2-keto-3-deoxy-D-gluconate by a DEHU-specific reductase using NAD(P)H. This ...

Abstract	Alginate-assimilating bacteria degrade alginate into an unsaturated monosaccharide, which is converted into 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU). DEHU is reduced to 2-keto-3-deoxy-D-gluconate by a DEHU-specific reductase using NAD(P)H. This is followed by pyruvate production via the Entner-Doudoroff pathway. Previously, we identified FlRed as a DEHU reductase in an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. Here, we showed that FlRed can also catalyze the oxidation of DEHU with NAD
MeSH term(s)	Alginates/metabolism ; Flavobacterium/metabolism ; Metabolic Networks and Pathways ; Oxidation-Reduction ; Uronic Acids/metabolism
Chemical Substances	Alginates ; Uronic Acids
Language	English
Publishing date	2021-11-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-021-02786-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: An oxidative metabolic pathway of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU) from alginate in an alginate-assimilating bacterium

Ryuji Nishiyama / Takao Ojima / Yuki Ohnishi / Yasuhiro Kumaki / Tomoyasu Aizawa / Akira Inoue

Communications Biology, Vol 4, Iss 1, Pp 1-

2021 Volume 13

Abstract: Nishiyama et al. report the biochemical pathway for the conversion of DEHU to α-ketoglutarate in the alginate-assimilating marine bacterium Flavobacterium sp. strain UMI-01. They show that a parallel oxidative pathway besides the reductive route is ... ...

Abstract	Nishiyama et al. report the biochemical pathway for the conversion of DEHU to α-ketoglutarate in the alginate-assimilating marine bacterium Flavobacterium sp. strain UMI-01. They show that a parallel oxidative pathway besides the reductive route is possible, and provide evidence that this pathway might be conserved in other alginate-degrading bacteria.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Endoscopic Biliary Intervention Using Traction Devices for Periampullary Diverticulum.

Inoue, Ryuji / Kawakami, Hiroshi / Kubota, Yoshimasa / Ban, Tessin

Internal medicine (Tokyo, Japan)

2019 Volume 58, Issue 19, Page(s) 2797–2801

Abstract: We describe the case a 92-year-old woman who was admitted to our hospital with choledocholithiasis and periampullary diverticulum (PAD). Due to PAD, clear visualization of the ampulla of Vater could not be obtained. Although selective bile duct ... ...

Abstract	We describe the case a 92-year-old woman who was admitted to our hospital with choledocholithiasis and periampullary diverticulum (PAD). Due to PAD, clear visualization of the ampulla of Vater could not be obtained. Although selective bile duct cannulation was difficult, a 7-Fr plastic stent was placed during the first session. Fifteen days later, endoscopic retrograde cholangiopancreatography was retried using traction devices, and the papilla became visible. Endoscopic sphincterotomy and stone extraction were performed without any complications. The application of traction devices in endoscopic submucosal dissection may be a promising technique in cases in which endoscopic biliary intervention is difficult due to PAD.
MeSH term(s)	Aged, 80 and over ; Ampulla of Vater/diagnostic imaging ; Ampulla of Vater/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Choledocholithiasis/complications ; Choledocholithiasis/diagnosis ; Choledocholithiasis/surgery ; Diverticulum/complications ; Diverticulum/diagnosis ; Diverticulum/surgery ; Duodenal Diseases/complications ; Duodenal Diseases/diagnosis ; Duodenal Diseases/surgery ; Female ; Humans ; Sphincterotomy, Endoscopic/instrumentation ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-06-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2804-19
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block.

Hu, Yaopeng / Li, Qin / Shen, Yanghua / Fujita, Takayuki / Zhu, Xin / Inoue, Ryuji

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, 'E7K', was identified in its distal N-terminus to cause conduction disorder because of enhanced cell-surface expression. It remains, however, ... ...

Abstract	In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, 'E7K', was identified in its distal N-terminus to cause conduction disorder because of enhanced cell-surface expression. It remains, however, unclear how this expression increase leads to conduction failure rather than abnormally enhanced cardiac excitability. To address this issue theoretically, we mathematically formulated the gating kinetics of the E7K-mutant TRPM4 channel by a combined use of voltage jump analysis and ionomycin-perforated cell-attached recording technique and incorporated the resultant rate constants of opening and closing into a human Purkinje fiber single-cell action potential (AP) model (Trovato model) to perform 1D-cable simulations. The results from TRPM4 expressing HEK293 cells showed that as compared with the wild-type, the open state is much preferred in the E7K mutant with increased voltage-and Ca
MeSH term(s)	Gain of Function Mutation ; HEK293 Cells ; Humans ; Membrane Potentials ; Models, Biological ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism
Chemical Substances	TRPM Cation Channels ; TRPM4 protein, human
Language	English
Publishing date	2021-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168513
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Bilateral Nephrectomy for Resistant Hypertension and Secondary Aldosteronism in a Hemodialysis Patient: A Case Report.

Nishihama, Kota / Inoue, Chisa / Nishikawa, Kohei / Okano, Yuko / Takeshita, Atsuro / Uemura, Mei / Yasuma, Taro / Suzuki, Toshinari / Okamoto, Ryuji / D'Alessandro-Gabazza, Corina N / Gabazza, Esteban C / Yano, Yutaka

Internal medicine (Tokyo, Japan)

2023

Abstract: A 42-year-old Japanese woman with end-stage renal failure due to hypertension presented with a systolic blood pressure of 160-200 mmHg despite treatment with 4 different antihypertensive agents. The plasma aldosterone concentration (PAC) and plasma renin ...

Abstract	A 42-year-old Japanese woman with end-stage renal failure due to hypertension presented with a systolic blood pressure of 160-200 mmHg despite treatment with 4 different antihypertensive agents. The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were elevated. Adrenal vein sampling suggested bilateral excessive aldosterone secretion, whereas adrenocortical scintigraphy showed right-dominant accumulation. Open bilateral nephrectomy and right adrenalectomy improved the systolic blood pressure, PAC, and PRA. A pathological examination revealed zona glomerulosa hyperplasia but not microaldosteronoma. This report shows that bilateral nephrectomy, not unilateral adrenalectomy, is a potentially effective treatment option for resistant hypertension with an elevated renin-angiotensin-aldosterone system in hemodialysis patients.
Language	English
Publishing date	2023-10-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2613-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: TRP channels in cardiac and intestinal fibrosis.

Inoue, Ryuji / Kurahara, Lin-Hai / Hiraishi, Keizo

Seminars in cell & developmental biology

2018 Volume 94, Page(s) 40–49

Abstract: It is now widely accepted that advanced fibrosis underlies many chronic inflammatory disorders and is the main cause of morbidity and mortality of the modern world. The pathogenic mechanism of advanced fibrosis involves diverse and intricate interplays ... ...

Abstract	It is now widely accepted that advanced fibrosis underlies many chronic inflammatory disorders and is the main cause of morbidity and mortality of the modern world. The pathogenic mechanism of advanced fibrosis involves diverse and intricate interplays between numerous extracellular and intracellular signaling molecules, among which the non-trivial roles of a stress-responsive Ca
MeSH term(s)	Animals ; Fibrosis/metabolism ; Fibrosis/pathology ; Humans ; Intestinal Diseases/metabolism ; Intestinal Diseases/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Transient Receptor Potential Channels/metabolism
Chemical Substances	Transient Receptor Potential Channels
Language	English
Publishing date	2018-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2018.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2918: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block

Yaopeng Hu / Qin Li / Yanghua Shen / Takayuki Fujita / Xin Zhu / Ryuji Inoue

International Journal of Molecular Sciences, Vol 22, Iss 8513, p

2021 Volume 8513

Abstract: In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, ‘E7K’, was identified in its distal N-terminus to cause conduction disorder because of enhanced cell-surface expression. It remains, however, ... ...

Abstract	In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, ‘E7K’, was identified in its distal N-terminus to cause conduction disorder because of enhanced cell-surface expression. It remains, however, unclear how this expression increase leads to conduction failure rather than abnormally enhanced cardiac excitability. To address this issue theoretically, we mathematically formulated the gating kinetics of the E7K-mutant TRPM4 channel by a combined use of voltage jump analysis and ionomycin-perforated cell-attached recording technique and incorporated the resultant rate constants of opening and closing into a human Purkinje fiber single-cell action potential (AP) model (Trovato model) to perform 1D-cable simulations. The results from TRPM4 expressing HEK293 cells showed that as compared with the wild-type, the open state is much preferred in the E7K mutant with increased voltage-and Ca 2+ -sensitivities. These theoretical predictions were confirmed by power spectrum and single channel analyses of expressed wild-type and E7K-mutant TRPM4 channels. In our modified Trovato model, the facilitated opening of the E7K mutant channel markedly prolonged AP duration with concomitant depolarizing shifts of the resting membrane potential in a manner dependent on the channel density (or maximal activity). This was, however, little evident in the wild-type TRPM4 channel. Moreover, 1D-cable simulations with the modified Trovato model revealed that increasing the density of E7K (but not of wild-type) TRPM4 channels progressively reduced AP conduction velocity eventually culminating in complete conduction block. These results clearly suggest the brady-arrhythmogenicity of the E7K mutant channel which likely results from its pathologically enhanced activity.
Keywords	transient receptor potential melastatin subfamily ; inherent cardiac arrhythmia ; conduction block ; gating analysis ; numerical simulation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED