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  1. Article ; Online: Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis: the case of GFP.

    Schultheiß, Christoph / Binder, Mascha

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 68

    MeSH term(s) Animals ; Disease Models, Animal ; Mice ; Neoplasms/genetics
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-00929-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Aktionsleitfaden - Zukunftschancen für Freund Baum

    Schultheiß, Helmut / Frobel, Kai / Mühlleitner, Daniel / Busch, Christopher

    mit Basisinformationen, Handlungsempfehlungen und Aktionsvorschlägen für die Erhaltung, Pflege und Neupflanzung von Bäumen im Siedlungsbereich

    2017  

    Title variant Zukunftschancen für Freund Baum
    Institution Bund Naturschutz in Bayern
    Author's details Autor: Helmut Schultheiß; Co-Autoren: Dr. Kai Frobel, Dr. Daniel Mühlleitner, Christopher Busch ; BUND Naturschutz in Bayern e.V
    Keywords Baum ; Baumschutz ; Bayern ; Bund Naturschutz ; Naturschutz
    Language German
    Size 167 Seiten, Illustrationen, 30 cm, 556 g
    Publisher BUND Naturschutz in Bayern e.V
    Publishing place Nürnberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT019841152
    ISBN 978-3-9808986-7-6 ; 3-9808986-7-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    184/386 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis

    Christoph Schultheiß / Mascha Binder

    Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-

    the case of GFP

    2022  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma.

    Brandt, Anna / Thiele, Benjamin / Schultheiß, Christoph / Daetwyler, Eveline / Binder, Mascha

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Tumors shed cell-free DNA (cfDNA) into the plasma. "Liquid biopsies" are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may ... ...

    Abstract Tumors shed cell-free DNA (cfDNA) into the plasma. "Liquid biopsies" are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients with head and neck squamous cell carcinoma (HNSCC) due to genetic tumor heterogeneity and limitations in imaging sensitivity. However, there are technical challenges that need to be overcome for the widespread use of liquid biopsy in the clinical management of these patients. In this review, we discuss our current understanding of HNSCC genetics and the role of cfDNA genomic analyses as an emerging precision diagnostic tool.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: B cells in autoimmune hepatitis: bystanders or central players?

    Schultheiß, Christoph / Steinmann, Silja / Lohse, Ansgar W / Binder, Mascha

    Seminars in immunopathology

    2022  Volume 44, Issue 4, Page(s) 411–427

    Abstract: B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of cellular immunity. These multifaceted features are also reflected in autoimmunity where autoreactive B cells ... ...

    Abstract B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of cellular immunity. These multifaceted features are also reflected in autoimmunity where autoreactive B cells can fuel disease by production of cytotoxic autoantibodies, presentation of autoantigens to autoreactive T cells, and secretion of cytokines and chemokines that either promote detrimental immune activation or impair regulatory T and B cells. The role of B cells and autoantibodies in autoimmune hepatitis (AIH) have been controversially discussed, with typical autoantibodies and hypergammaglobulinemia indicating a key role, while strong HLA class II association suggests T cells as key players. In this review, we summarize current knowledge on B cells in AIH and how different B cell subpopulations may drive AIH progression beyond autoantibodies. We also discuss recent findings of B cell-directed therapies in AIH.
    MeSH term(s) Autoantibodies ; Autoantigens ; Autoimmunity ; B-Lymphocytes ; Hepatitis, Autoimmune/etiology ; Humans
    Chemical Substances Autoantibodies ; Autoantigens
    Language English
    Publishing date 2022-04-29
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-022-00937-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Immune signatures in variant syndromes of primary biliary cholangitis and autoimmune hepatitis.

    Schultheiß, Christoph / Steinmann, Silja / Willscher, Edith / Paschold, Lisa / Lohse, Ansgar W / Binder, Mascha

    Hepatology communications

    2023  Volume 7, Issue 5

    Abstract: Background: Variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share diagnostic features of both entities, but their immunological underpinnings remain largely unexplored.: Methods: We performed blood profiling of ... ...

    Abstract Background: Variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share diagnostic features of both entities, but their immunological underpinnings remain largely unexplored.
    Methods: We performed blood profiling of 23 soluble immune markers and immunogenetics in a cohort of 88 patients with autoimmune liver diseases (29 typical AIH, 31 typical PBC and 28 with clinically PBC/AIH variant syndromes). The association with demographical, serological and clinical features was analyzed.
    Results: While T and B cell receptor repertoires were highly skewed in variant syndromes compared to healthy controls, these biases were not sufficiently discriminated within the spectrum of autoimmune liver diseases. High circulating checkpoint molecules sCD25, sLAG-3, sCD86 and sTim-3 discriminated AIH from PBC on top of classical parameters such as transaminases and immunoglobulin levels. In addition, a second cluster of correlated soluble immune factors encompassing essentially TNF, IFNγ, IL12p70, sCTLA-4, sPD-1 and sPD-L1 appeared characteristic of AIH. Cases with complete biochemical responses to treatment generally showed a lower level of dysregulation. Unsupervised hierarchical clustering of classical and variant syndromes identified two pathological immunotypes consisting predominantly of either AIH or PBC cases. Variant syndromes did not form a separate group, but clustered together with either classical AIH or PBC. Clinically, patient with AIH-like variant syndromes were less likely to be able discontinue immunosuppressive treatment.
    Conclusions: Our analyses suggest that variants of immune mediated liver diseases may represent an immunological spectrum from PBC to AIH-like disease reflected by their pattern of soluble immune checkpoint molecules rather than separate entities.
    MeSH term(s) Humans ; Hepatitis, Autoimmune/diagnosis ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/drug therapy ; Immunosuppressive Agents/therapeutic use ; Liver Diseases ; Biomarkers
    Chemical Substances Immunosuppressive Agents ; Biomarkers
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autoantigen-selected B cells are bystanders in spontaneous T cell-driven experimental autoimmune hepatitis.

    Lübbering, David / Preti, Max / Schlott, Lena / Schultheiß, Christoph / Weidemann, Sören / Lohse, Ansgar W / Binder, Mascha / Carambia, Antonella / Herkel, Johannes

    Immunology

    2023  Volume 170, Issue 2, Page(s) 214–229

    Abstract: Autoreactive B cells are considered pathogenic drivers in many autoimmune diseases; however, it is not clear whether autoimmune B cells are invariably pathogenic or whether they can also arise as bystanders of T cell-driven autoimmune pathology. Here, we ...

    Abstract Autoreactive B cells are considered pathogenic drivers in many autoimmune diseases; however, it is not clear whether autoimmune B cells are invariably pathogenic or whether they can also arise as bystanders of T cell-driven autoimmune pathology. Here, we studied the B cell response in an autoantigen- and CD4
    MeSH term(s) Mice ; Animals ; T-Lymphocytes ; Hepatitis, Autoimmune ; Autoantigens ; Liver ; Inflammation/pathology
    Chemical Substances Autoantigens
    Language English
    Publishing date 2023-05-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Elucidation of the cell-specific regulation of the novel human tumor gene NOT

    Schultheiß, Christoph [Verfasser]

    2016  

    Author's details Christoph Schultheiß
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article: SARS-CoV-2-associated T-cell infiltration in the central nervous system.

    Mohme, Malte / Schultheiß, Christoph / Piffko, Andras / Fitzek, Antonia / Paschold, Lisa / Thiele, Benjamin / Püschel, Klaus / Glatzel, Markus / Westphal, Manfred / Lamszus, Katrin / Matschke, Jakob / Binder, Mascha

    Clinical & translational immunology

    2024  Volume 13, Issue 2, Page(s) e1487

    Abstract: Objectives: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Although an acute SARS-CoV-2 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are ... ...

    Abstract Objectives: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Although an acute SARS-CoV-2 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are increasingly recognised in the long-term treatment of COVID-19 patients. The pathophysiology and the neuropathogenesis behind neurologic complications of COVID-19 remain poorly understood, but mounting evidence points to endothelial dysfunction either directly caused by viral infection or indirectly by inflammatory cytokines, followed by a local immune response that may include virus-specific T cells. However, the type and role of central nervous system-infiltrating T cells in COVID-19 are complex and not fully understood.
    Methods: We analysed distinct anatomical brain regions of patients who had deceased as a result of COVID-19-associated pneumonia or complications thereof and performed T cell receptor Vβ repertoire sequencing. Clonotypes were analysed for SARS-CoV-2 association using public TCR repertoire data.
    Results: Our descriptive study demonstrates that SARS-CoV-2-associated T cells are found in almost all brain areas of patients with fatal COVID-19 courses. The olfactory bulb, medulla and cerebellum were brain regions showing the most SARS-CoV-2 specific sequence patterns. Neuropathological workup demonstrated primary CD8
    Conclusion: Future research is needed to better define the relationship between T-cell infiltration and neurological symptoms and its long-term impact on patients' cognitive and mental health.
    Language English
    Publishing date 2024-01-31
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21

    Paschold, Lisa / Simnica, Donjete / Brito, Ramon Benitez / Zhang, Tianjiao / Schultheiß, Christoph / Dierks, Christine / Binder, Mascha

    Blood cancer journal

    2022  Volume 12, Issue 3, Page(s) 49

    MeSH term(s) Disease Progression ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mutation
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-022-00650-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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