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  1. Article: Professor William I. Higuchi: teacher and scientist.

    Ho, Norman

    Journal of pharmaceutical sciences

    2008  Volume 97, Issue 1, Page(s) 1–8

    MeSH term(s) Chemistry, Pharmaceutical/history ; History, 20th Century ; History, 21st Century ; Pharmacy/history ; United States
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1002/jps.21213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Treatment of heart failure according to William Stokes: the enchanted mercury.

    Ventura, H O / Mehra, M R / Young, J B

    Journal of cardiac failure

    2001  Volume 7, Issue 3, Page(s) 277–282

    Abstract: ... for the treatment of dropsy without clear guidelines. In this article we describe William Stokes' insights ... of the Liver and Pulmonary Disease" in William Stokes' famous treatise The Diseases of the Heart and the Aorta ...

    Abstract Background: It was not until 1919 that the diuretic properties of mercury were observed in patients with syphilis; in the same year the beneficial effects of mercurial diuretics were shown in a patient with severe rheumatic heart disease and anasarca. However, mercury had been used much earlier for the treatment of dropsy without clear guidelines. In this article we describe William Stokes' insights into the treatment of heart failure, focusing on the beneficial diuretic properties of mercury.
    Methods: We reviewed the chapter "Treatment of the Weak and Probably Dilated Heart in Connexion With Enlargement of the Liver and Pulmonary Disease" in William Stokes' famous treatise The Diseases of the Heart and the Aorta.
    Conclusions: Stokes makes several important clinical observations. First, he provides precise guidelines on when and how to use mercury in these patients. Second, he realizes the importance of mercury for the treatment of decompensated heart failure. Stokes recognizes the cyclical nature of frequent decompensation in congestive heart failure, the relationship of clinical deterioration and reduced urine output, and the importance of reestablishing urinary flow to ameliorate dyspnea. Third, he attempts to define the mechanism of action "... if any of the characteristic action of mercury can be perceived unless we include diuresis." Finally, he gives interesting guidelines on the dosage and side effects of mercury. These observations on the treatment of "congestive" heart failure are an important contribution to the understanding of heart failure pathophysiology and the design of prescription regimens for this disease.
    MeSH term(s) Heart Failure/drug therapy ; Heart Failure/history ; History, 19th Century ; Humans ; Ireland ; Mercury/therapeutic use ; Organomercury Compounds/history ; Organomercury Compounds/therapeutic use
    Chemical Substances Organomercury Compounds ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2001-09
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1054/jcaf.2001.26564
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  3. Article: William Harvey.

    FOUCAR, H O

    Canadian Medical Association journal

    1951  Volume 64, Issue 5, Page(s) 452–453

    MeSH term(s) History, 16th Century ; History, 17th Century ; Humans
    Language English
    Publishing date 1951-05
    Publishing country Canada
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
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  4. Book ; Audio / Video: William Blackmore

    Brayer, Herbert Oliver

    a case study in the economic development of the West

    1949  

    Institution Denver and Rio Grande Railroad Company
    Author's details by Herbert O. Brayer
    Keywords Land grants
    Language English
    Size 2 v. :, ill., ports., maps ;, 24 cm.
    Publisher Bradford-Robinson
    Publishing place Denver
    Document type Book ; Audio / Video
    Note Title 1 of 4 titles on reel 21.
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Suboptimal usage of hearing aids in adults with hearing loss: Singapore audiologists' perspective and current practice.

    Go, Teck Wah William / Ho, Eu Chin

    Singapore medical journal

    2024  

    Language English
    Publishing date 2024-01-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2022-040
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  6. Article ; Online: Idiopathic Slow Transit Constipation: Pathophysiology, Diagnosis, and Management.

    Vlismas, Luke J / Wu, William / Ho, Vincent

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Slow transit constipation (STC) has an estimated prevalence of 2-4% of the general population, and although it is the least prevalent of the chronic constipation phenotypes, it more commonly causes refractory symptoms and is associated with significant ... ...

    Abstract Slow transit constipation (STC) has an estimated prevalence of 2-4% of the general population, and although it is the least prevalent of the chronic constipation phenotypes, it more commonly causes refractory symptoms and is associated with significant psychosocial stress, poor quality of life, and high healthcare costs. This review provides an overview of the pathophysiology, diagnosis, and management options in STC. STC occurs due to colonic dysmotility and is thought to be a neuromuscular disorder of the colon. Several pathophysiologic features have been observed in STC, including reduced contractions on manometry, delayed emptying on transit studies, reduced numbers of interstitial cells of Cajal on histology, and reduced amounts of excitatory neurotransmitters within myenteric plexuses. The underlying aetiology is uncertain, but autoimmune and hormonal mechanisms have been hypothesised. Diagnosing STC may be challenging, and there is substantial overlap with the other clinical constipation phenotypes. Prior to making a diagnosis of STC, other primary constipation phenotypes and secondary causes of constipation need to be ruled out. An assessment of colonic transit time is required for the diagnosis and can be performed by a number of different methods. There are several different management options for constipation, including lifestyle, dietary, pharmacologic, interventional, and surgical. The effectiveness of the available therapies in STC differs from that of the other constipation phenotypes, and prokinetics often make up the mainstay for those who fail standard laxatives. There are few available management options for patients with medically refractory STC, but patients may respond well to surgical intervention. STC is a common condition associated with a significant burden of disease. It can present a clinical challenge, but a structured approach to the diagnosis and management can be of great value to the clinician. There are many therapeutic options available, with some having more benefits than others.
    MeSH term(s) Humans ; Quality of Life ; Constipation/diagnosis ; Constipation/therapy ; Health Care Costs ; Histological Techniques ; Interstitial Cells of Cajal
    Language English
    Publishing date 2024-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010108
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  7. Article ; Online: Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine.

    Forbes, Thomas P / Gillen, John Greg / Feeney, William / Ho, Johnny

    Molecular pharmaceutics

    2024  

    Abstract: Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine. These capabilities are critical for narrow therapeutic ... ...

    Abstract Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine. These capabilities are critical for narrow therapeutic index drugs and pediatric or geriatric dosing, among other specialized needs. Advanced additive manufacturing, three-dimensional (3D) printing, and drop-on-demand (DoD) dispensing technologies have begun to expand into pharmaceutical production. We employed a quality by design (QbD) approach to identify critical quality attributes (CQAs), critical material attributes (CMAs), and critical process parameters (CPPs) of a POC pharmaceutical manufacturing paradigm. This theoretical framework encompasses the production of active pharmaceutical ingredient (API) "inks" at a centralized facility, which are distributed to POC sites for DoD dispensing into/onto delivery vehicles (
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.4c00032
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  8. Article ; Online: Mapping Conductivity in the TEM with SEEBIC.

    Hubbard, William A / Chan, Ho Leung / Regan, B C

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1851–1852

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.956
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  9. Article ; Online: The Effect of Age and Sex on Early Postoperative Outcomes after Surgical Treatment of Distal Radius Fractures.

    Roberts, Tyler / Sambhariya, Varun / Ly, Colin / Ho, Alison / Pientka, William F

    The journal of hand surgery Asian-Pacific volume

    2024  Volume 29, Issue 2, Page(s) 125–133

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Male ; Humans ; Female ; Aged ; Middle Aged ; Retrospective Studies ; Wrist Fractures ; Treatment Outcome ; Radius Fractures/diagnostic imaging ; Radius Fractures/epidemiology ; Radius Fractures/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Osteoporosis
    Language English
    Publishing date 2024-03-15
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2848651-1
    ISSN 2424-8363 ; 2424-8355
    ISSN (online) 2424-8363
    ISSN 2424-8355
    DOI 10.1142/S2424835524500140
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    Zs.A 5911: Show issues Location:
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  10. Article ; Online: QI Consultation Service: Piloting a Novel Approach to Improving Quality Improvement Initiatives in an Academic Psychiatry Department.

    Ho, Patrick / Finn, Christine / Torrey, William

    American journal of medical quality : the official journal of the American College of Medical Quality

    2023  Volume 38, Issue 5, Page(s) 267–269

    MeSH term(s) Humans ; Quality Improvement ; Referral and Consultation ; Psychiatry
    Language English
    Publishing date 2023-09-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1097/JMQ.0000000000000146
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