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  1. Article ; Online: Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?

    Bauer, Lisa / van Riel, Debby

    mBio

    2023  Volume 14, Issue 1, Page(s) e0292022

    Abstract: Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 ... ...

    Abstract Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10.1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Central Nervous System ; Brain ; Nervous System Diseases/pathology
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02920-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts.

    Begeman, Lineke / van Riel, Debby / Koopmans, Marion P G / Kuiken, Thijs

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1151524

    Abstract: Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease. However, ... ...

    Abstract Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease. However, infections in reservoir hosts are often neglected. Therefore, we compared the pathogenesis of rabies virus, macacine alphaherpesvirus, West Nile virus, Puumala orthohantavirus, monkeypox virus, Lassa mammarenavirus, H5N1 highly pathogenic avian influenza, Marburg virus, Nipah virus, Middle East respiratory syndrome, and simian/human immunodeficiency viruses in both humans and reservoir hosts. We showed that most aspects of the pathogeneses were remarkably similar. The remaining differences lead to the identification of tipping points in the pathogeneses that are important for explaining the disease outcome in severe human cases. Further elucidating these tipping points by studying zoonotic viral infections in their reservoir hosts may teach us how to reduce the severity of zoonotic viral diseases in humans.
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1151524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human B cells and dendritic cells are susceptible and permissive to enterovirus D68 infection.

    Laksono, Brigitta M / Sooksawasdi Na Ayudhya, Syriam / Aguilar-Bretones, Muriel / Embregts, Carmen W E / van Nierop, Gijsbert P / van Riel, Debby

    mSphere

    2024  Volume 9, Issue 2, Page(s) e0052623

    Abstract: Enterovirus D68 (EV-D68) is predominantly associated with mild respiratory infections, but can also cause severe respiratory disease and extra-respiratory complications, including acute flaccid myelitis. Systemic dissemination of EV-D68 is crucial for ... ...

    Abstract Enterovirus D68 (EV-D68) is predominantly associated with mild respiratory infections, but can also cause severe respiratory disease and extra-respiratory complications, including acute flaccid myelitis. Systemic dissemination of EV-D68 is crucial for the development of extra-respiratory diseases, but it is currently unclear how EV-D68 spreads systemically (viremia). We hypothesize that immune cells contribute to the systemic dissemination of EV-D68, as this is a mechanism commonly used by other enteroviruses. Therefore, we investigated the susceptibility and permissiveness of human primary immune cells for different EV-D68 isolates. In human peripheral blood mononuclear cells inoculated with EV-D68, only B cells were susceptible but virus replication was limited. However, in B cell-rich cultures, such as Epstein-Barr virus-transformed B-lymphoblastoid cell line (BLCL) and primary lentivirus-transduced B cells, which better represent lymphoid B cells, were productively infected. Subsequently, we showed that dendritic cells (DCs), particularly immature DCs, are susceptible and permissive for EV-D68 infection and that they can spread EV-D68 to autologous BLCL. Altogether, our findings suggest that immune cells, especially B cells and DCs, could play an important role in the pathogenesis of EV-D68 infection. Infection of these cells may contribute to systemic dissemination of EV-D68, which is an essential step toward the development of extra-respiratory complications.IMPORTANCEEnterovirus D68 (EV-D68) is an emerging respiratory virus that has caused outbreaks worldwide since 2014. EV-D68 infects primarily respiratory epithelial cells resulting in mild respiratory diseases. However, EV-D68 infection is also associated with extra-respiratory complications, including polio-like paralysis. It is unclear how EV-D68 spreads systemically and infects other organs. We hypothesized that immune cells could play a role in the extra-respiratory spread of EV-D68. We showed that EV-D68 can infect and replicate in specific immune cells, that is, B cells and dendritic cells (DCs), and that virus could be transferred from DCs to B cells. Our data reveal a potential role of immune cells in the pathogenesis of EV-D68 infection. Intervention strategies that prevent EV-D68 infection of immune cells will therefore potentially prevent systemic spread of virus and thereby severe extra-respiratory complications.
    MeSH term(s) Humans ; Enterovirus D, Human ; Epstein-Barr Virus Infections ; Leukocytes, Mononuclear ; Herpesvirus 4, Human ; Enterovirus Infections ; Respiratory Tract Infections ; Dendritic Cells
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00526-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Next-generation vaccine platforms for COVID-19.

    van Riel, Debby / de Wit, Emmie

    Nature materials

    2020  Volume 19, Issue 8, Page(s) 810–812

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Viral Vaccines/immunology ; Viral Vaccines/therapeutic use
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-020-0746-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The pathogenesis and virulence of enterovirus-D68 infection.

    Sooksawasdi Na Ayudhya, Syriam / Laksono, Brigitta M / van Riel, Debby

    Virulence

    2021  Volume 12, Issue 1, Page(s) 2060–2072

    Abstract: In 2014, enterovirus D68 (EV-D68) emerged causing outbreaks of severe respiratory disease in children worldwide. In a subset of patients, EV-D68 infection was associated with the development of central nervous system (CNS) complications, including acute ... ...

    Abstract In 2014, enterovirus D68 (EV-D68) emerged causing outbreaks of severe respiratory disease in children worldwide. In a subset of patients, EV-D68 infection was associated with the development of central nervous system (CNS) complications, including acute flaccid myelitis (AFM). Since then, the number of reported outbreaks has risen biennially, which emphasizes the need to unravel the systemic pathogenesis in humans. We present here a comprehensive review on the different stages of the pathogenesis of EV-D68 infection - infection in the respiratory tract, systemic dissemination and infection of the CNS - based on observations in humans as well as experimental
    MeSH term(s) Central Nervous System Viral Diseases/epidemiology ; Central Nervous System Viral Diseases/virology ; Disease Outbreaks ; Enterovirus D, Human/pathogenicity ; Enterovirus Infections ; Humans ; Myelitis/epidemiology ; Myelitis/virology ; Neuromuscular Diseases/virology ; Virulence
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2021.1960106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of Endothelial Cells in the Pathogenesis of Influenza in Humans.

    Short, Kirsty R / Kuiken, Thijs / Van Riel, Debby

    The Journal of infectious diseases

    2019  Volume 220, Issue 11, Page(s) 1859–1860

    MeSH term(s) Animals ; Endothelial Cells ; Humans ; Influenza A Virus, H7N9 Subtype ; Influenza in Birds ; Influenza, Human ; Respiratory System ; Risk Assessment ; Tropism
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  8. Article ; Online: The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans.

    Bauer, Lisa / Benavides, Feline F W / Veldhuis Kroeze, Edwin J B / de Wit, Emmie / van Riel, Debby

    Trends in neurosciences

    2023  Volume 46, Issue 11, Page(s) 953–970

    Abstract: Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological ... ...

    Abstract Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
    MeSH term(s) Animals ; Humans ; Influenza in Birds ; Influenza A virus ; Birds ; Mammals
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2023.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 53: Show issues

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  9. Article ; Online: In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection.

    Veldhuis Kroeze, Edwin / Bauer, Lisa / Caliendo, Valentina / van Riel, Debby

    Viruses

    2021  Volume 13, Issue 5

    Abstract: Animal models are an inimitable method to study the systemic pathogenesis of virus-induced disease. Extra-respiratory complications of influenza A virus infections are not extensively studied even though they are often associated with severe disease and ... ...

    Abstract Animal models are an inimitable method to study the systemic pathogenesis of virus-induced disease. Extra-respiratory complications of influenza A virus infections are not extensively studied even though they are often associated with severe disease and mortality. Here we review and recommend mammalian animal models that can be used to study extra-respiratory complications of the central nervous system and cardiovascular system as well as involvement of the eye, placenta, fetus, lacteal gland, liver, pancreas, intestinal tract, and lymphoid tissues during influenza A virus infections.
    MeSH term(s) Animals ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Central Nervous System Diseases/diagnosis ; Central Nervous System Diseases/etiology ; Disease Models, Animal ; Disease Susceptibility ; Humans ; Influenza A virus/physiology ; Influenza, Human/complications ; Influenza, Human/virology ; Organ Specificity
    Language English
    Publishing date 2021-05-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13050848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection.

    Thiele, Swantje / Stanelle-Bertram, Stephanie / Beck, Sebastian / Kouassi, Nancy Mounogou / Zickler, Martin / Müller, Martin / Tuku, Berfin / Resa-Infante, Patricia / van Riel, Debby / Alawi, Malik / Günther, Thomas / Rother, Franziska / Hügel, Stefanie / Reimering, Susanne / McHardy, Alice / Grundhoff, Adam / Brune, Wolfram / Osterhaus, Albert / Bader, Michael /
    Hartmann, Enno / Gabriel, Gülsah

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114023

    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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