LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 90

Search options

  1. Article: Maintaining essential health services during a pandemic: lessons from Costa Rica's COVID-19 response.

    Mora-García, Claudio A / Pearson, Andy A / Prado, Andrea M

    BMJ global health

    2024  Volume 8, Issue Suppl 6

    Abstract: Studies on COVID-19 usually focus on health system responses to decrease the rate of COVID-19 infection and death, but patients with other diseases also require access to health services during the pandemic. This paper describes the structures and ... ...

    Abstract Studies on COVID-19 usually focus on health system responses to decrease the rate of COVID-19 infection and death, but patients with other diseases also require access to health services during the pandemic. This paper describes the structures and processes by which the Costa Rican Social Security Fund (CCSS) changed in response to the COVID-19 pandemic, which helped to sustain essential health services (EHSs). We conducted a desk review of the local literature and semistructured qualitative interviews with key informants from the CCSS. We found that the CCSS implemented changes in structure, such as creating a specialised COVID-19 centre and hiring additional interim health workers. The CCSS also implemented changes in processes, including leveraging its integrated network to optimise its resources and support alternative care modalities. These changes generated changes in outputs and outcomes that helped sustain EHSs for non-COVID-19 patients. These interventions were possible primarily due to Costa Rica's underlying health system, particularly its integrated nature with a single institution in charge of healthcare provision financed through mandatory health insurance, a unique digital medical record system and a contingency fund.
    MeSH term(s) Humans ; Costa Rica ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Delivery of Health Care/organization & administration ; Health Services Accessibility ; Social Security
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2023-014143
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: The puzzle of COVID-19 in Central America and Panama.

    Pearson, Andy A / Prado, Andrea M / Colburn, Forrest D

    Journal of global health

    2021  Volume 11, Page(s) 3077

    MeSH term(s) COVID-19/epidemiology ; Central America/epidemiology ; Humans ; Incidence ; Panama/epidemiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-05
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.11.03077
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Nicaragua's surprising response to COVID-19.

    Pearson, Andy A / Prado, Andrea M / Colburn, Forrest D

    Journal of global health

    2020  Volume 10, Issue 1, Page(s) 10371

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Government ; Humans ; Nicaragua/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2978
    ISSN (online) 2047-2986
    ISSN 2047-2978
    DOI 10.7189/jogh.10.010371
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Collagen IV differentially regulates planarian stem cell potency and lineage progression.

    Chan, Andy / Ma, Sophia / Pearson, Bret J / Chan, Danny

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 16

    Abstract: The extracellular matrix (ECM) provides a precise physical and molecular environment for cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the nature and organization of the ECM niche is not well understood. The adult ... ...

    Abstract The extracellular matrix (ECM) provides a precise physical and molecular environment for cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the nature and organization of the ECM niche is not well understood. The adult freshwater planarian
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Homeostasis ; Non-Fibrillar Collagens/metabolism ; Planarians/genetics ; Planarians/metabolism ; Regeneration ; Signal Transduction ; Stem Cells/cytology ; Stem Cells/metabolism
    Chemical Substances Collagen Type IV ; Non-Fibrillar Collagens
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2021251118
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: What the geological past can tell us about the future of the ocean's twilight zone.

    Crichton, Katherine A / Wilson, Jamie D / Ridgwell, Andy / Boscolo-Galazzo, Flavia / John, Eleanor H / Wade, Bridget S / Pearson, Paul N

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2376

    Abstract: Paleontological reconstructions of plankton community structure during warm periods of the Cenozoic (last 66 million years) reveal that deep-dwelling 'twilight zone' (200-1000 m) plankton were less abundant and diverse, and lived much closer to the ... ...

    Abstract Paleontological reconstructions of plankton community structure during warm periods of the Cenozoic (last 66 million years) reveal that deep-dwelling 'twilight zone' (200-1000 m) plankton were less abundant and diverse, and lived much closer to the surface, than in colder, more recent climates. We suggest that this is a consequence of temperature's role in controlling the rate that sinking organic matter is broken down and metabolized by bacteria, a process that occurs faster at warmer temperatures. In a warmer ocean, a smaller fraction of organic matter reaches the ocean interior, affecting food supply and dissolved oxygen availability at depth. Using an Earth system model that has been evaluated against paleo observations, we illustrate how anthropogenic warming may impact future carbon cycling and twilight zone ecology. Our findings suggest that significant changes are already underway, and without strong emissions mitigation, widespread ecological disruption in the twilight zone is likely by 2100, with effects spanning millennia thereafter.
    MeSH term(s) Seawater/chemistry ; Plankton ; Carbon Cycle ; Temperature ; Oceans and Seas
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37781-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: New refrigerants and system configurations for vapor-compression refrigeration.

    McLinden, Mark O / Seeton, Christopher J / Pearson, Andy

    Science (New York, N.Y.)

    2020  Volume 370, Issue 6518, Page(s) 791–796

    Abstract: The high global warming potential of current refrigerants in cooling equipment based on the vapor-compression cycle has triggered a major effort to find and implement more environmentally benign alternatives. Here, we review the basics of the vapor- ... ...

    Abstract The high global warming potential of current refrigerants in cooling equipment based on the vapor-compression cycle has triggered a major effort to find and implement more environmentally benign alternatives. Here, we review the basics of the vapor-compression cycle together with the safety, environmental, and thermodynamic constraints that have led to the current and next generation of refrigerants. The development of new fluids has focused on fluorinated olefins, known as hydrofluoroolefins (HFOs), and blends that contain HFOs. Many of these are slightly flammable, presenting trade-offs between safety and environmental considerations. Engineers also have options with a resurgence of the "natural refrigerants" (ammonia, carbon dioxide, propane, and isobutane). Innovative system designs that reduce the required quantity of refrigerant may allow a wider choice of refrigerants.
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe3692
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment.

    Lindsay-Mosher, Nicole / Chan, Andy / Pearson, Bret J

    PLoS genetics

    2020  Volume 16, Issue 2, Page(s) e1008613

    Abstract: The extracellular matrix (ECM) is important for maintaining the boundaries between tissues. This role is particularly critical in the stem cell niche, as pre-neoplastic or cancerous stem cells must pass these boundaries in order to invade into the ... ...

    Abstract The extracellular matrix (ECM) is important for maintaining the boundaries between tissues. This role is particularly critical in the stem cell niche, as pre-neoplastic or cancerous stem cells must pass these boundaries in order to invade into the surrounding tissue. Here, we examine the role of the ECM as a regulator of the stem cell compartment in the planarian Schmidtea mediterranea, a highly regenerative, long-lived organism with a large population of adult stem cells. We identify two EGF repeat-containing genes, megf6 and hemicentin, with identical knockdown phenotypes. We find that megf6 and hemicentin are needed to maintain the structure of the basal lamina, and in the absence of either gene, pluripotent stem cells migrate ectopically outside of their compartment and hyper-proliferate, causing lesions in the body wall muscle. These muscle lesions and ectopic stem cells are also associated with ectopic gut branches, which protrude from the normal gut towards the dorsal side of the animal. Interestingly, both megf6 and hemicentin knockdown worms are capable of regenerating tissue free of both muscle lesions and ectopic cells, indicating that these genes are dispensable for regeneration. These results provide insight into the role of planarian ECM in restricting the stem cell compartment, and suggest that signals within the compartment may act to suppress stem cell hyperproliferation.
    MeSH term(s) Adult Stem Cells/physiology ; Animals ; Animals, Genetically Modified ; Cell Movement/genetics ; Extracellular Matrix/metabolism ; Gene Knockdown Techniques ; Genes, Helminth/physiology ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; Platyhelminths/cytology ; Platyhelminths/physiology ; Pluripotent Stem Cells/physiology ; Regeneration/genetics ; Stem Cell Niche/genetics
    Chemical Substances Helminth Proteins
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1008613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Connecting healthcare professionals in Central America through management and leadership development: a social network analysis.

    Prado, Andrea M / Pearson, Andy A / Bertelsen, Nathan S / Pagán, José A

    Globalization and health

    2020  Volume 16, Issue 1, Page(s) 34

    Abstract: Background: Leadership and management training has become increasingly important in the education of health care professionals. Previous research has shown the benefits that a network provides to its members, such as access to resources and information, ...

    Abstract Background: Leadership and management training has become increasingly important in the education of health care professionals. Previous research has shown the benefits that a network provides to its members, such as access to resources and information, but ideas for creating these networks vary. This study used social network analysis to explore the interactions among Central American Healthcare Initiative (CAHI) Fellowship alumni and learn more about information sharing, mentoring, and project development activities among alumni. The CAHI Fellowship provides leadership and management training for multidisciplinary healthcare professionals to reduce health inequities in the region. Access to a network was previously reported as one of the top benefits of the program.
    Results: Information shared from the work of 100 CAHI fellows from six countries, especially within the same country, was analyzed. Mentoring relationships clustered around professions and project types, and networks of joint projects clustered by country. Mentorship, which CAHI management promoted, and joint project networks, in which members voluntarily engaged, had similar inclusiveness ratios.
    Conclusion: Social networks are strategic tools for health care leadership development programs to increase their impact by promoting interactions among participants. These programs can amplify intergenerational and intercountry ties by organizing events, provide opportunities for alumni to meet, assign mentors, and support collaborative action groups. Collaborative networks have great value to potentiate health professionals' leadership and management capabilities in a resource-constrained setting, such as the Global South.
    MeSH term(s) Adult ; Aged ; Central America ; Fellowships and Scholarships/trends ; Female ; Global Health ; Health Personnel/education ; Health Personnel/psychology ; Health Personnel/trends ; Humans ; Leadership ; Male ; Middle Aged ; Social Networking
    Language English
    Publishing date 2020-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1744-8603
    ISSN (online) 1744-8603
    DOI 10.1186/s12992-020-00557-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Impact of Interleukin-6 Receptor Blockade With Tocilizumab on Cardiac Injury in Patients With COVID-19: A Retrospective Cohort Study.

    Weber, Brittany N / Zhou, Guohai / Kim, Andy / Pearson, Jeffrey C / Stone, John / DiCarli, Marcelo / Nikiforow, Sarah / Woolley, Ann

    Open forum infectious diseases

    2021  Volume 8, Issue 2, Page(s) ofab012

    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top