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  1. Book ; Thesis: ABC transporter modulation in acute myeloid leukemia

    Raaijmakers, Marc H. G. P.

    studies from the leukemic stem cell perspective

    2006  

    Author's details Marc Hermanus Gerardus Petrus Raaijmaker
    Language English ; Dutch
    Size 189 S. : Ill., graph. Darst.
    Publishing country Niger
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nijmegen, Univ., Diss.,2006
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT014678419
    ISBN 90-9020306-0 ; 978-90-9020306-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 E 576 order for loan Magazin

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  2. Article ; Online: Bone marrow inflammation in haematological malignancies.

    de Jong, Madelon M E / Chen, Lanpeng / Raaijmakers, Marc H G P / Cupedo, Tom

    Nature reviews. Immunology

    2024  

    Abstract: Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour ...

    Abstract Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for haematopoietic progenitor cells and mature immune cells and supports the outgrowth and survival of malignant cells residing in these niche compartments. This Review provides an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using acute myeloid leukaemia and multiple myeloma as examples and highlights unique and shared features of inflammation in niches for progenitor cells and plasma cells. Importantly, inflammation exerts profoundly different effects on normal bone marrow niches in these malignancies, and we provide context for possible drivers of these divergent effects. We explore the role of tumour cells in inflammatory changes, as well as the role of cellular constituents of normal bone marrow niches, including myeloid cells and stromal cells. Integrating knowledge of disease-specific dynamics of malignancy-associated bone marrow inflammation will provide a necessary framework for future targeting of these processes to improve patient outcome.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-024-01003-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Aging of the Hematopoietic Stem Cell Niche: An Unnerving Matter.

    Raaijmakers, Marc H G P

    Cell stem cell

    2019  Volume 25, Issue 3, Page(s) 301–303

    Abstract: The drivers of aging in the hematopoietic system remain incompletely understood. In this issue of Cell Stem Cell, Ho et al. (2019) report that functional switching of β-adrenergic nerve signaling underlies remodeling of stem cell niches, driving age- ... ...

    Abstract The drivers of aging in the hematopoietic system remain incompletely understood. In this issue of Cell Stem Cell, Ho et al. (2019) report that functional switching of β-adrenergic nerve signaling underlies remodeling of stem cell niches, driving age-associated alterations in hematopoiesis.
    MeSH term(s) Bone Marrow ; Hematopoiesis ; Hematopoietic Stem Cells ; Myeloid Cells ; Stem Cell Niche
    Language English
    Publishing date 2019-09-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2019.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Resource: A Cellular Developmental Taxonomy of the Bone Marrow Mesenchymal Stem Cell Population in Mice.

    Pisterzi, Paola / Chen, Lanpeng / van Dijk, Claire / Wevers, Michiel J W / Bindels, Eric J M / Raaijmakers, Marc H G P

    HemaSphere

    2023  Volume 7, Issue 2, Page(s) e823

    Abstract: Mesenchymal stem cells (MSCs) play pivotal roles in tissue (re)generation. In the murine bone marrow, they are thought to reside within the Sca- ... ...

    Abstract Mesenchymal stem cells (MSCs) play pivotal roles in tissue (re)generation. In the murine bone marrow, they are thought to reside within the Sca-1
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of

    Ernst, Martijn P T / Pronk, Eline / van Dijk, Claire / van Strien, Paulina M H / van Tienhoven, Tim V D / Wevers, Michiel J W / Sanders, Mathijs A / Bindels, Eric M J / Speck, Nancy A / Raaijmakers, Marc H G P

    HemaSphere

    2023  Volume 7, Issue 2, Page(s) e824

    Abstract: ... ...

    Abstract RUNX1
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The mesenchymal niche in MDS.

    Pronk, Eline / Raaijmakers, Marc H G P

    Blood

    2019  Volume 133, Issue 10, Page(s) 1031–1038

    Abstract: Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a strong propensity for leukemic evolution. Somatic mutations are critical early drivers of the disorder, but the factors enabling the emergence, selection, and subsequent ... ...

    Abstract Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a strong propensity for leukemic evolution. Somatic mutations are critical early drivers of the disorder, but the factors enabling the emergence, selection, and subsequent leukemic evolution of these "leukemia-poised" clones remain incompletely understood. Emerging data point at the mesenchymal niche as a critical contributor to disease initiation and evolution. Disrupted inflammatory signaling from niche cells may facilitate the occurrence of somatic mutations, their selection, and subsequent clonal expansion. This review summarizes the current concepts about "niche-facilitated" bone marrow failure and leukemic evolution, their underlying molecular mechanisms, and clinical implications for future innovative therapeutic targeting of the niche in MDS.
    MeSH term(s) Disease Progression ; Genetic Predisposition to Disease ; Hematopoietic Stem Cells/cytology ; Humans ; Inflammation ; Leukemia/blood ; Leukemia/etiology ; Mesenchymal Stem Cells/cytology ; Mutation ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Signal Transduction ; Stem Cell Niche
    Language English
    Publishing date 2019-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-10-844639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

    Raaijmakers, Marc H G P

    Cell stem cell

    2014  Volume 14, Issue 6, Page(s) 695–697

    Abstract: Early events driving the initiation and evolution of neoplasms remain poorly defined but involvement of an instructive or permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the ... ...

    Abstract Early events driving the initiation and evolution of neoplasms remain poorly defined but involvement of an instructive or permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the niche in myelodysplastic syndromes, the principle preleukemic disorder of the hematopoietic system.
    MeSH term(s) Animals ; Humans ; Mesenchymal Stromal Cells/metabolism ; Mesenchymal Stromal Cells/pathology ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Stem Cell Niche
    Language English
    Publishing date 2014-06-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2014.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Azacytidine Treatment for VEXAS Syndrome.

    Raaijmakers, Marc H G P / Hermans, Maud / Aalbers, Anna / Rijken, Melissa / Dalm, Virgil A S H / van Daele, Paul / Valk, Peter J M

    HemaSphere

    2021  Volume 5, Issue 12, Page(s) e661

    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: RUNX1 germline variants in RUNX1-mutant AML: how frequent?

    Ernst, Martijn P T / Kavelaars, François G / Löwenberg, Bob / Valk, Peter J M / Raaijmakers, Marc H G P

    Blood

    2020  Volume 137, Issue 10, Page(s) 1428–1431

    MeSH term(s) Adult ; Cohort Studies ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Gene Frequency ; Germ-Line Mutation ; Humans ; Leukemia, Myeloid, Acute/genetics ; Male ; Middle Aged ; Mutation ; Point Mutation
    Chemical Substances Core Binding Factor Alpha 2 Subunit ; RUNX1 protein, human
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis.

    Raaijmakers, Marc H G P

    International journal of hematology

    2012  Volume 95, Issue 1, Page(s) 17–25

    Abstract: Myelodysplastic syndromes are a heterogeneous group of diseases characterized by ineffective hematopoiesis and the propensity to leukemic transformation. Their pathogenesis is complex and likely depends on interplay between aberrant hematopoietic cells ... ...

    Abstract Myelodysplastic syndromes are a heterogeneous group of diseases characterized by ineffective hematopoiesis and the propensity to leukemic transformation. Their pathogenesis is complex and likely depends on interplay between aberrant hematopoietic cells and their microenvironment. How niche cells play a role in disease evolution is poorly defined, but the delineation of the hematopoietic stem cell niche and the ability to interrogate its role in hematopoietic disease in animal models have furthered our insights in recent years. The data support a view in which the microenvironment can play an active role in the evolution of myelodysplasia and myeloproliferative disorders, thus providing further rationale to explore therapeutic targeting of mesenchymal-hematopoietic interactions in these diseases.
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Cell Transformation, Neoplastic/metabolism ; Humans ; Myelodysplastic Syndromes/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2012-01-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-011-1001-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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