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Article: The Mysterious Amurian Grig

Storozhenko, Sergey Yu / Molodtsov, Vladimir V / Sergeev, Michael G

2023 Volume 14, Issue 10

Abstract: New data on distribution, ecology and biology of the rare extant ... ...

Abstract	New data on distribution, ecology and biology of the rare extant species
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14100789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Human biomonitoring without in-person interaction: public health engagements during the COVID-19 pandemic and future implications.

Mattson, Alyssa J / Yu, Jiali / Miller, Elizabeth M / Schueller, Michael / Pentella, Michael / Dai, Susie Y

BMC medical research methodology

2024 Volume 24, Issue 1, Page(s) 53

Abstract: Background: Public health initiatives, including human biomonitoring, have been impacted by unique challenges since the onset of the COVID-19 pandemic, compounding a decades-long trend of declining public participation. To combat low public ... ...

Abstract	Background: Public health initiatives, including human biomonitoring, have been impacted by unique challenges since the onset of the COVID-19 pandemic, compounding a decades-long trend of declining public participation. To combat low public participation rates, public health professionals often employ extensive engagement approaches including in-person interactions related to enrollment and sampling, success of which is an essential component of a statistically defensible study. The onset of the COVID-19 pandemic challenged public health programs to diversify engagement and sampling approaches, limiting direct interactions for the health and safety of the population. This study explores biomonitoring recruitment strategies through non-contact mechanisms and evaluate the application feasibility for population-based studies. Methods: The Iowa Biomonitoring Program at the State Hygienic Laboratory developed a human biomonitoring study that utilized a multifaceted, distance-based approach. Traditional techniques, such as mailed recruitment invitations and phone-based discussions, were coupled with internet-based surveys and self-collected, shipped urine and water samples. Participation rates were evaluated by employing different mailing methods, and the demographics of enrolled participants were examined. Results: This non-human contact approach achieved a nearly 14% participation rate among a rural population, well above our target rates. Our improved mailing strategy for targeting initially unresponsive participants yielded a significantly increase in the participation rates. The respondents were predominantly individuals with educational attainment of at least high school level. Among all the eligible participants, 83% submitted self-collected samples, a rate comparable to the National Health and Nutrition Examination Survey which involved in-person interviews. Conclusions: The practice of engaging a rural population during the COVID-19 pandemic by transitioning from face-to-face interactions to a combination of mailing and internet-based approaches resulted in higher-than-expected participant recruitment and sample collection rates. Given the declining trend in the response rates for population-based survey studies, our results suggest conducting human biomonitoring without direct human interaction is feasible, which provides further opportunity to improve response rates and the relevance and reach of public health initiatives.
MeSH term(s)	Humans ; Biological Monitoring ; Public Health ; Nutrition Surveys ; Pandemics ; COVID-19/epidemiology
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-024-02165-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions.

Zhai, Si-Yue / Kong, Michael G / Xia, Yu-Min

Frontiers in immunology

2022 Volume 13, Page(s) 868386

Abstract: Skin diseases are mainly divided into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The pathogenesis might include microbial infections, autoimmune responses, aberrant cellular proliferation or differentiation, and the ... ...

Abstract	Skin diseases are mainly divided into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The pathogenesis might include microbial infections, autoimmune responses, aberrant cellular proliferation or differentiation, and the overproduction of inflammatory factors. The traditional therapies for skin diseases, such as oral or topical drugs, have still been unsatisfactory, partly due to systematic side effects and reappearance. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has demonstrated its safe and effective functions in dermatology. With its generation of reactive oxygen species and reactive nitrogen species, CAP exhibits significant efficacies in inhibiting bacterial, viral, and fungal infections, facilitating wound healing, restraining the proliferation of cancers, and ameliorating psoriatic or vitiligous lesions. This review summarizes recent advances in CAP therapies for various skin diseases and implicates future strategies for increasing effectiveness or broadening clinical indications.
MeSH term(s)	Humans ; Nitrogen ; Oxygen ; Plasma Gases/pharmacology ; Plasma Gases/therapeutic use ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Skin Diseases/drug therapy
Chemical Substances	Plasma Gases ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Nitrogen (N762921K75) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.868386
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Article ; Online: Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma.

Yu, Seok-Yeong / Luan, Yi / Tang, Siyuan / Abazarikia, Amirhossein / Dong, Rosemary / Caffrey, Thomas C / Hollingsworth, Michael A / Oupicky, David / Kim, So-Youn

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 16, Page(s) e2207010

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic male mice, activin A suppression, which is acquired by tumor-targeted Inhba siRNA using cholesterol-modified polymeric nanoparticles, retards tumor growth/metastasis and cachexia and improves survival when compared to scramble siRNA-treated group. Histologically, activin A suppression coincides with decreased expression of proliferation marker Ki67 but increased accumulation of α-SMA
MeSH term(s)	Male ; Mice ; Animals ; Cachexia/etiology ; Cell Line, Tumor ; Pancreatic Neoplasms ; Carcinoma, Pancreatic Ductal ; RNA, Small Interfering/genetics
Chemical Substances	activin A ; inhibin beta A subunit ; RNA, Small Interfering
Language	English
Publishing date	2023-04-21
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202207010
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Article ; Online: Lanspora dorisauae

Pang, Ka-Lai / Guo, Sheng-Yu / Shaumi, Ami / Suetrong, Satinee / Klaysuban, Anupong / Chiang, Michael W L / Jones, E B Gareth

PeerJ

2023 Volume 11, Page(s) e15958

Abstract: This article reports a new marine fungus, ...

Abstract	This article reports a new marine fungus,
MeSH term(s)	Taiwan ; Phylogeny ; Ascomycota/genetics ; Spores, Fungal
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15958
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Article ; Online: N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial.

Sy, Michael / Newton, Barbara L / Pawling, Judy / Hayama, Ken L / Cordon, Andres / Yu, Zhaoxia / Kuhle, Jens / Dennis, James W / Brandt, Alexander U / Demetriou, Michael

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 209

Abstract: Background: In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T and B ... ...

Abstract	Background: In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T and B cells potently reduces episodic relapses, they act peripherally to allow persistence of chronic-active brain inflammation and progressive neurological dysfunction. N-acetyglucosamine (GlcNAc) is a triple modulator of inflammation, myelination and neurodegeneration. GlcNAc promotes biosynthesis of Asn (N)-linked-glycans, which interact with galectins to co-regulate the clustering/signaling/endocytosis of multiple glycoproteins simultaneously. In mice, GlcNAc crosses the blood brain barrier to raise N-glycan branching, suppress inflammatory demyelination by T and B cells and trigger stem/progenitor cell mediated myelin repair. MS clinical severity, demyelination lesion size and neurodegeneration inversely associate with a marker of endogenous GlcNAc, while in healthy humans, age-associated increases in endogenous GlcNAc promote T cell senescence. Objectives and methods: An open label dose-escalation mechanistic trial of oral GlcNAc at 6 g (n = 18) and 12 g (n = 16) for 4 weeks was performed in MS patients on glatiramer acetate and not in relapse from March 2016 to December 2019 to assess changes in serum GlcNAc, lymphocyte N-glycosylation and inflammatory markers. Post-hoc analysis examined changes in serum neurofilament light chain (sNfL) as well as neurological disability via the Expanded Disability Status Scale (EDSS). Results: Prior to GlcNAc therapy, high serum levels of the inflammatory cytokines IFNγ, IL-17 and IL-6 associated with reduced baseline levels of a marker of endogenous serum GlcNAc. Oral GlcNAc therapy was safe, raised serum levels and modulated N-glycan branching in lymphocytes. Glatiramer acetate reduces T Conclusions: Oral GlcNAc inhibits inflammation and neurodegeneration markers in MS patients despite concurrent immunomodulation by glatiramer acetate. Blinded studies are required to investigate GlcNAc's potential to control residual brain inflammation, myelin repair and neurodegeneration in MS.
MeSH term(s)	Humans ; Animals ; Mice ; Acetylglucosamine/therapeutic use ; Interleukin-17 ; Glatiramer Acetate ; Interleukin-6 ; Multiple Sclerosis/drug therapy ; Inflammation/drug therapy ; Encephalitis ; Cytokines
Chemical Substances	Acetylglucosamine (V956696549) ; Interleukin-17 ; Glatiramer Acetate (5M691HL4BO) ; Interleukin-6 ; Cytokines
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02893-9
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Article ; Online: Trends and Outcomes for Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in New South Wales from 2008 to 2019.

Shawon, Md Shajedur Rahman / Falster, Michael O / Hsu, Benjumin / Yu, Jennifer / Ooi, Sze-Yuan / Jorm, Louisa

The American journal of cardiology

2022 Volume 187, Page(s) 110–118

Abstract: Risk profiles are changing for patients who undergo percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). In Australia, little is known of the nature of these changes in contemporary practice and of the impact on patient ... ...

Abstract	Risk profiles are changing for patients who undergo percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). In Australia, little is known of the nature of these changes in contemporary practice and of the impact on patient outcomes. We identified all CABG (n = 40,805) and PCI (n = 142,399) procedures in patients aged ≥18 years in New South Wales, Australia, during 2008 to 2019. Between 2008 and 2019, the age- and gender-standardized revascularization rate increased by 20% (from 267/100,000 to 320/100,000 population) for all revascularizations. The increase in revascularization was particularly driven by a 35% increase (from 194/100,000 to 261/100,000) in PCI, whereas the rate of CABG decreased by 20% (from 73/100,000 to 59/100,000). Mean age and the prevalence of co-morbidities (especially diabetes and atrial fibrillation) increased for patients with PCI in more recent years but remained consistently lower than for patients with CABG. CABGs performed in patients presenting with a non-ST-segment-elevation acute coronary syndrome halved from 34.3% to 18.7% during the study period, whereas PCIs in this group decreased from 36.5% to 29.6%. Risk-adjusted in-hospital mortality decreased by 7.5 deaths/1,000 procedures per month for CABG but remained unchanged for PCI. Risk-adjusted readmission rates were consistently higher for CABG than for PCI and did not change significantly over time. In conclusion, we observed a dramatic shift over time from CABG to PCI as the revascularization procedure of choice, with the patient base for PCI extending to older and sicker patients. There was a large decrease in mortality after CABG, whereas mortality after PCI remained unchanged.
MeSH term(s)	Humans ; Adolescent ; Adult ; Percutaneous Coronary Intervention/adverse effects ; New South Wales/epidemiology ; Risk Factors ; Treatment Outcome ; Coronary Artery Bypass/adverse effects ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/surgery ; Coronary Artery Disease/etiology
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.10.047
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Article ; Online: NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer.

Hong, Sun Mi / Lee, A-Yeon / Kim, Byeong-Ju / Lee, Jeong-Eun / Seon, Su-Yeon / Ha, Yu-Jin / Ng, Jestlin Tianthing / Yoon, Gyesoon / Lim, Su Bin / Morgan, Michael J / Cha, Jong-Ho / Lee, Dakeun / Kim, You-Sun

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Volume 11, Issue 14, Page(s) e2303177

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its ... ...

Abstract	Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its role in the other cells within the tumor microenvironment (TME) during colorectal cancer (CRC) progression. Using single-cell RNA sequencing (scRNA-seq) data, it is founded that NAMPT is highly expressed in SPP1
MeSH term(s)	Animals ; Humans ; Mice ; Colorectal Neoplasms/pathology ; Macrophages/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; Signal Transduction ; Tumor Microenvironment ; Tumor-Associated Macrophages
Chemical Substances	Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; nicotinamide phosphoribosyltransferase, mouse (EC 2.4.2.12)
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202303177
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Article: The High-Low Arctic boundary: How is it determined and where is it located?

Ermokhina, Ksenia A / Terskaia, Anna I / Ivleva, Tatiana Yu / Dudov, Sergey V / Zemlianskii, Vitalii А / Telyatnikov, Michael Yu / Khitun, Olga V / Troeva, Elena I / Koroleva, Natalia E / Abdulmanova, Svetlana Yu

Ecology and evolution

2023 Volume 13, Issue 10, Page(s) e10545

Abstract: Geobotanical subdivision of landcover is a baseline for many studies. The High-Low Arctic boundary is considered to be of fundamental natural importance. The wide application of different delimitation schemes in various ecological studies and climatic ... ...

Abstract	Geobotanical subdivision of landcover is a baseline for many studies. The High-Low Arctic boundary is considered to be of fundamental natural importance. The wide application of different delimitation schemes in various ecological studies and climatic scenarios raises the following questions: (i) What are the common criteria to define the High and Low Arctic? (ii) Could human impact significantly change the distribution of the delimitation criteria? (iii) Is the widely accepted temperature criterion still relevant given ongoing climate change? and (iv) Could we locate the High-Low Arctic boundary by mapping these criteria derived from modern open remote sensing and climatic data? Researchers rely on common criteria for geobotanical delimitation of the Arctic. Unified circumpolar criteria are based on the structure of vegetation cover and climate, while regional specifics are reflected in the floral composition. However, the published delimitation schemes vary greatly. The disagreement in the location of geobotanical boundaries across the studies manifests in poorly comparable results. While maintaining the common principles of geobotanical subdivision, we derived the boundary between the High and Low Arctic using the most up-to-date field data and modern techniques: species distribution modeling, radar, thermal and optical satellite imagery processing, and climatic data analysis. The position of the High-Low Arctic boundary in Western Siberia was clarified and mapped. The new boundary is located 50-100 km further north compared to all the previously presented ones. Long-term anthropogenic press contributes to a change in the vegetation structure but does not noticeably affect key species ranges. A previously specified climatic criterion for the High-Low Arctic boundary accepted in scientific literature has not coincided with the boundary in Western Siberia for over 70 years. The High-Low Arctic boundary is distinctly reflected in biodiversity distribution. The presented approach is appropriate for accurate mapping of the High-Low Arctic boundary in the circumpolar extent.
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10545
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Article ; Online: Nicolau Syndrome After Glatiramer Acetate Injection in Close Proximity to Administration of SARS-CoV-2 mRNA Vaccine.

Sy, Michael Yu / Fromm, Erin / Doan, Linda / Rojek, Nathan / Brandt, Alexander Ulrich

Neurology(R) neuroimmunology & neuroinflammation

2021 Volume 9, Issue 1

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Female ; Glatiramer Acetate/administration & dosage ; Glatiramer Acetate/adverse effects ; Glatiramer Acetate/therapeutic use ; Humans ; Immunization, Secondary ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Injections/adverse effects ; Injections/methods ; Male ; Middle Aged ; Multiple Sclerosis/therapy ; Nicolau Syndrome/complications ; Nicolau Syndrome/pathology ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Immunosuppressive Agents ; Glatiramer Acetate (5M691HL4BO) ; mRNA-1273 vaccine (EPK39PL4R4) ; BNT162 vaccine (N38TVC63NU)
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000001112
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