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Article ; Online: OTUB1-mediated inhibition of ubiquitination

Miaomiao Wu / Lidong Sun / Tanjing Song

Frontiers in Molecular Biosciences, Vol

a growing list of effectors, multiplex mechanisms, and versatile functions

2024 Volume 10

Abstract: Protein ubiquitination plays a pivotal role in protein homeostasis. Ubiquitination may regulate the stability, activity, protein–protein interaction, and localization of a protein. Ubiquitination is subject to regulation by two groups of counteracting ... ...

Abstract	Protein ubiquitination plays a pivotal role in protein homeostasis. Ubiquitination may regulate the stability, activity, protein–protein interaction, and localization of a protein. Ubiquitination is subject to regulation by two groups of counteracting enzymes, the E3 ubiquitin ligases and deubiquitinases. Consistently, deubiquitinases are involved in essentially all biological processes. OTUB1, an OTU-family deubiquitinase, is a critical regulator of development, cancer, DNA damage response, and immune response. OTUB1 antagonizes the ubiquitination of a wide-spectrum of proteins through at least two different mechanisms. Besides direct deubiquitination, OTUB1 can also inhibit ubiquitination by non-canonically blocking ubiquitin transfer from certain ubiquitin-conjugases (E2). In this review, we start with a general background of protein ubiquitination and deubiquitination. Next, we introduce the basic characteristics of OTUB1 and then elaborate on the updated biological functions of OTUB1. Afterwards, we discuss potential mechanisms underlying the versatility and specificity of OTUB1 functions. In the end, we discuss the perspective that OTUB1 can be a potential therapeutic target for cancer.
Keywords	OTUB1 ; ubiquitination ; deubiquitinase ; degradation ; cancer ; ubiquitin-conjugating enzyme ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: OTUB1-mediated inhibition of ubiquitination: a growing list of effectors, multiplex mechanisms, and versatile functions.

Wu, Miaomiao / Sun, Lidong / Song, Tanjing

Frontiers in molecular biosciences

2024 Volume 10, Page(s) 1261273

Abstract: Protein ubiquitination plays a pivotal role in protein homeostasis. Ubiquitination may regulate the stability, activity, protein-protein interaction, and localization of a protein. Ubiquitination is subject to regulation by two groups of counteracting ... ...

Abstract	Protein ubiquitination plays a pivotal role in protein homeostasis. Ubiquitination may regulate the stability, activity, protein-protein interaction, and localization of a protein. Ubiquitination is subject to regulation by two groups of counteracting enzymes, the E3 ubiquitin ligases and deubiquitinases. Consistently, deubiquitinases are involved in essentially all biological processes. OTUB1, an OTU-family deubiquitinase, is a critical regulator of development, cancer, DNA damage response, and immune response. OTUB1 antagonizes the ubiquitination of a wide-spectrum of proteins through at least two different mechanisms. Besides direct deubiquitination, OTUB1 can also inhibit ubiquitination by non-canonically blocking ubiquitin transfer from certain ubiquitin-conjugases (E2). In this review, we start with a general background of protein ubiquitination and deubiquitination. Next, we introduce the basic characteristics of OTUB1 and then elaborate on the updated biological functions of OTUB1. Afterwards, we discuss potential mechanisms underlying the versatility and specificity of OTUB1 functions. In the end, we discuss the perspective that OTUB1 can be a potential therapeutic target for cancer.
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1261273
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Article ; Online: Enhancing shipyard transportation efficiency through dynamic scheduling using digital twin technology.

Sun, Miaomiao / Liang, Chengji / Chang, Daofang

PloS one

2024 Volume 19, Issue 2, Page(s) e0297069

Abstract: Uncertainties, such as road restrictions at shipyards and the irregular shape of blocks, pose challenges for transporter scheduling. Efficient scheduling of multiple transporters is critical to improving transportation efficiency. The digital twin (DT) ... ...

Abstract	Uncertainties, such as road restrictions at shipyards and the irregular shape of blocks, pose challenges for transporter scheduling. Efficient scheduling of multiple transporters is critical to improving transportation efficiency. The digital twin (DT) technology offers numerous benefits, enabling interactions between the virtual and real worlds, real-time mapping, and dynamic performance evaluation. Based on DT technology, this study proposes a dynamic scheduling approach for cooperative transportation utilizing multiple transporters. The scheduling problem for multiple transporters is addressed and modeled in this study, considering factors such as block size and transporter loading. To solve this problem, a framework of DT-based multiple transporters system is established in a virtual environment. By inputting block information into this system, a solution is generated using transporter scheduling rules and interference detection methods. Experimental comparisons are conducted in this paper, exploring various scenarios with different number of tasks and the application of DT. The results demonstrate that the proposed approach effectively enhances transportation efficiency and improves ship construction efficiency. Hence, this study expands the application of DT technology in dynamic scheduling of transportation in shipyards and provides new ideas for shipbuilding company managers.
MeSH term(s)	Transportation ; Digital Technology ; Membrane Transport Proteins ; Uncertainty
Chemical Substances	Membrane Transport Proteins
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297069
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Article ; Online: Understanding Propofol's Protective Mechanism in Tubular Epithelial Cells: Mitigating Pyroptosis via the miR-143-3p/ATPase Na + /K + Transporting Subunit Alpha 2 Pathway in Renal Ischemia-Reperfusion.

Kan, Hongjun / Zhao, Miaomiao / Wang, Wei / Sun, Baozhong

Molecular biotechnology

2024

Abstract: Propofol (Pro), a prevalent intravenous anesthetic, has recently been recognized for its potential in mitigating ischemia-reperfusion (I/R) injuries. Despite a plethora of evidence suggesting the beneficial effects of low-dose Pro in renal I/R injury (RI/ ...

Abstract	Propofol (Pro), a prevalent intravenous anesthetic, has recently been recognized for its potential in mitigating ischemia-reperfusion (I/R) injuries. Despite a plethora of evidence suggesting the beneficial effects of low-dose Pro in renal I/R injury (RI/R), its role in modulating pyroptosis in renal tubular epithelial cells consequent to RI/R has not been thoroughly elucidated. In our investigation, we explored the therapeutic potential of Pro against pyroptosis in renal tubular epithelial cells under the duress of RI/R, employing both in vivo and in vitro models, while deciphering the intricate molecular pathways involved. Our results demonstrate an elevation in the expression of miR-143-3p, contrasted by a diminution in ATPase Na + /K + Transporting Subunit Alpha 2 (ATP1A2) under RI/R conditions. Pro effectively mitigates apoptosis in renal tubular epithelial cells induced by RI/R, principally characterized by the inhibition of pro-inflammatory cytokines interleukin (IL-)-1β and IL-18, enhancement of cellular viability, reduction in the ratio of pyroptotic cells, and suppression of nucleotide-binding domain and leucine-rich repeat-related family, pyrin domain containing 3 inflammasome activation along with the expression of cleaved caspase-1, and gasdermin D. Both knockdown and overexpression studies of miR-143-3p revealed its pivotal role in modulating RI/R-induced tubular cell pyroptosis. Notably, Pro's capacity to inhibit pyroptosis in renal tubular epithelial cells was found to be reversible following ATP1A2 knockdown. Furthermore, our study unveils miR-143-3p as a targeted regulator of ATP1A2 expression. From a mechanistic standpoint, Pro's therapeutic efficacy is attributed to its regulatory influence on miR-143-3p and ATP1A2 expression levels. In conclusion, our findings pioneer the understanding that Pro can significantly ameliorate pyroptosis in renal tubular epithelial cells in the context of RI/R, predominantly through the modulation of the miR-143-3p/ATP1A2 axis. This novel insight furnishes robust empirical support for the development of targeted therapeutics and clinical strategies in addressing RI/R.
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-024-01116-7
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Article ; Online: Immunogenic profiling of metastatic uveal melanoma discerns a potential signature related to prognosis.

Wang, Jian / Liu, Miaomiao / Sun, Jiaxing / Zhang, Zifeng

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 1, Page(s) 23

Abstract: Background: Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The present study aimed to identify the key genes associated with UM metastasis and established a gene signature to analyze the relationship between the signature and ... ...

Abstract	Background: Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The present study aimed to identify the key genes associated with UM metastasis and established a gene signature to analyze the relationship between the signature and prognosis and immune cell infiltration. Later, a predictive model combined with clinical variables was developed and validated. Methods: Two UM gene expression profile chip datasets were downloaded from TCGA and GEO databases. Immune-related genes (IRGs) were obtained from IMPORT database. First, these mRNAs were intersected with IRGs, and weighted gene co-expression network analysis (WGCNA) was used to identify the co-expression of genes primarily associated with metastasis of UM. Univariate Cox regression analysis screened the genes related to prognosis. LASSO-Cox established a risk score to distinguish high-risk group and low-risk group. Then the GSEA enrichment pathway and immune cell infiltration of the two groups were compared. And combined with clinical variables, a predictive model was constructed. The time-dependent receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) curve were used to verify the stability and accuracy of the final predictive model, and a nomogram was then drawn. Results: The MEblack, MEpurple, and MEblue modules were significantly associated with the metastasis of UM patients (P value < 0.001, = 0.001, = 0.022, respectively). Four genes (UBXN2B, OTUD3, KAT8, LAMTOR2) were obtained by Pearson correlation analysis, weighted gene correlation network analysis (WGCNA), univariate Cox, and LASSO-Cox. And a novel prognostic risk score was established. Immune-related prognostic signature can well classify UM patients into high-risk and low-risk groups. Kaplan-Meier curve showed that the OS of high-risk patients was worse than that of low-risk patients. In addition, the risk score played an important role in evaluating the signaling pathway and immune cell infiltration of UM patients in high-risk and low-risk groups. Both the training set and validation set of the model showed good predictive accuracy in the degree of differentiation and calibration (e.g., 1-year overall survival: AUC = 0.930 (0.857-1.003)). Finally, a nomogram was established to serve in clinical practice. Significance: UM key gene signature and prognosis predictive model might provide insights for further investigation of the pathogenesis and development of UM at the molecular level, and provide theoretical basis for determining new prognostic markers of UM and immunotherapy.
MeSH term(s)	Humans ; Prognosis ; Melanoma/genetics ; Uveal Neoplasms/genetics ; Nomograms ; Neoplasms, Second Primary ; Ubiquitin-Specific Proteases
Chemical Substances	OTUD3 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2024-01-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05542-z
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Article ; Online: Clinical characteristics of infantile haemangioma in twins: a retrospective study.

Sun, Zhengwei / Li, Miaomiao / Dong, Changxian / Mei, Shiwei

BMC pediatrics

2024 Volume 24, Issue 1, Page(s) 111

Abstract: Background: Infantile hemangioma is one of the most common benign soft tissue tumors in infants. The pathogenesis of infantile hemangioma remains unclear and twin studies regarding its incidence may help clarify disease pathogenesis. Thus, this study ... ...

Abstract	Background: Infantile hemangioma is one of the most common benign soft tissue tumors in infants. The pathogenesis of infantile hemangioma remains unclear and twin studies regarding its incidence may help clarify disease pathogenesis. Thus, this study aimed to analyze the clinical characteristics of infantile hemangioma in twin patients and discuss its clinical incidence. Methods: We retrospectively analyzed the data of 83 pairs of twins with infantile hemangioma admitted to the Guangdong Provincial Women and Children Hospital and Henan Provincial People's Hospital between May 2016 and May 2022. Thirty-one pairs of twins among whom both developed infantile hemangioma and 52 pairs of twins among whom only one twin was affected were included. Analysis was performed using the Spearman correlation. Additionally, we analyzed the influence of factors such as sex, twin zygosity, preterm birth, birth weight, and assisted reproduction on the clinical characteristics of twins. Results: We observed that disease occurrence in both twins correlated with assisted reproduction (χ2 = 13. 102, P < 0.05) and preterm birth (χ2 = 36.523, P < 0.05). Twin zygosity (χ2 = 0.716, P > 0.05) and total birth weight of twins (t=-3.369, P > 0.05) were not correlated with infantile hemangioma. However, among twins, the ones with lesser birth weight were more likely to develop infantile hemangioma. Conclusions: The clinical characteristics of infantile hemangioma in twins were consistent with their epidemiological characteristics. Female sex, preterm birth, less birth weight, and assisted reproduction increased the probability of morbidity in both twins. Analysis of the characteristics of infantile hemangioma in twins may assist further research and clinical treatment.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Female ; Retrospective Studies ; Birth Weight ; Premature Birth/epidemiology ; Twins ; Hemangioma, Capillary
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-024-04602-8
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Article ; Online: Exosomal miR-223 promotes ARDS by targeting insulin-like growth factor 1 receptor: A cell communication study.

Li, Miaomiao / Zhuang, Lilei / Jiang, Tao / Sun, Li

Experimental lung research

2024 Volume 50, Issue 1, Page(s) 42–52

Abstract: Background: Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome characterized by hypoxemia and changes in the respiratory system. ARDS is the most common cause of death in COVID-19 deaths was ARDS. In this study, we explored the ...

Abstract	Background: Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome characterized by hypoxemia and changes in the respiratory system. ARDS is the most common cause of death in COVID-19 deaths was ARDS. In this study, we explored the role of miR-223 in exosomes in ARDS. Methods: Exosomes were purified from the supernatants of macrophages. qPCR was used to detect relative mRNA levels. A luciferase reporter assay was performed to verify the miRNA target genes. Western blotting was used to detect the activation of inflammatory pathways. Flow cytometry was performed to assess apoptosis. An LPS-induced ARDS mouse model was used to assess the function of miR-223 in ARDS. Results: Exosomes secreted by macrophages promoted apoptosis in A549 cells. Macrophages and exosomes contain high levels of miR-223. Exogenous miR-223 can decrease the expression of insulin-like growth factor 1 receptor (IGF-1R) in A549 and promote the apoptosis of A549.Transfection of anti-miR223 antisense nucleotides effectively reduced the level of miR-223 in macrophages and exosomes and eliminated the pro-apoptotic effect of A549. Conclusions: Macrophages can secrete exosomes containing miR-223 and promote apoptosis by targeting the IGF-1R/Akt/mTOR signaling pathway in A549 cells and mouse models, suggesting that miR-223 is a potential target for treating COVID-19 induced ARDS.
MeSH term(s)	Animals ; Mice ; Cell Communication ; COVID-19 ; Insulin-Like Peptides ; Lipopolysaccharides ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Respiratory Distress Syndrome/genetics ; Humans
Chemical Substances	IGF1R protein, human ; Igf1r protein, mouse ; Insulin-Like Peptides ; Lipopolysaccharides ; MicroRNAs ; MIRN223 microRNA, human ; MIRN223 microRNA, mouse
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2024.2318561
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Article ; Online: Expectations for employing

Hu, Miaomiao / Zhang, Tao / Miao, Ming / Li, Kewen / Luan, Qingmin / Sun, Guilian

Critical reviews in food science and nutrition

2024 , Page(s) 1–9

Abstract: As a promising probiotic strain, ...

Abstract	As a promising probiotic strain,
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2023.2301416
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Article ; Online: Gastrointestinal stromal tumor of jejunum misdiagnosed as uterine leiomyoma: A case report.

Yu, Min / Sun, Miaomiao / Guo, Shanwei / Nan, Fangfang

Asian journal of surgery

2023 Volume 46, Issue 3, Page(s) 1457–1458

MeSH term(s)	Humans ; Jejunum/pathology ; Gastrointestinal Stromal Tumors/diagnosis ; Gastrointestinal Stromal Tumors/surgery ; Gastrointestinal Stromal Tumors/pathology ; Leiomyoma/diagnostic imaging ; Leiomyoma/surgery ; Abdomen ; Diagnostic Errors
Language	English
Publishing date	2023-01-05
Publishing country	China
Document type	Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.07.159
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Article ; Online: The "Hand as Foot" teaching method in uterus and its adjacent organs.

Guo, Shanwei / He, Miaolong / Sun, Miaomiao / Nan, Fangfang

Asian journal of surgery

2022 Volume 45, Issue 11, Page(s) 2316–2317

MeSH term(s)	Female ; Foot ; Hand ; Humans ; Lower Extremity ; Uterus/surgery
Language	English
Publishing date	2022-06-29
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.05.026
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