Result 1 - 10 of total 179
ZEMO
| Keywords | covid19 |
|---|---|
| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1007/s42048-020-00079-z |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2021
| Author's details | Tim Grünebaum ; Gutachter: Tessa Flatten ; Betreuer: Kornelius Kraft |
|---|---|
| Keywords | Wirtschaft ; Economics |
| Subject code | sg330 |
| Language | English |
| Publisher | Universitätsbibliothek Dortmund |
| Publishing place | Dortmund |
| Document type | Book ; Online ; Thesis |
| Database | Digital theses on the web |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
examining manufacturers' replacement strategies for a substance of concern
2017 Volume 26, Issue 9, Page(s) 1646–1662
| Author's details | Tim Kraft, Gal Raz |
|---|---|
| Keywords | collaboration ; competition ; environmental regulations ; substances of concern ; game theory |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publishing place | Hoboken, NJ |
| Document type | Article |
| ZDB-ID | 1108460-1 ; 2151364-8 |
| ISSN | 1937-5956 ; 1059-1478 |
| ISSN (online) | 1937-5956 |
| ISSN | 1059-1478 |
| Database | ECONomics Information System |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Biosensors & bioelectronics. 2022 Feb. 01, v. 197
2022
Abstract: Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic ...
| Abstract | Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic solid-state distributed feedback laser with a highly sensitive optical waveguide Mach-Zehnder interferometer on a silicon nitride photonic platform. This organic-hybrid laser allows for optical pumping with a laser diode in an alignment tolerant manner, which facilitates applications in point-of-care diagnostics. The sensitivity to bulk refractive index changes and the concentration dependent binding of streptavidin on a polyethyleneimine-biotin functionalized surface was studied to demonstrate the practicability of this cost-efficient coherent light source for optical waveguide biosensors. |
|---|---|
| Keywords | biosensors ; cost effectiveness ; diagnostic techniques ; diodes ; interferometers ; lab-on-a-chip technology ; photons ; point-of-care systems ; refractive index ; silicon nitride ; streptavidin |
| Language | English |
| Dates of publication | 2022-0201 |
| Publishing place | Elsevier B.V. |
| Document type | Article |
| ZDB-ID | 1011023-9 |
| ISSN | 1873-4235 ; 0956-5663 |
| ISSN (online) | 1873-4235 |
| ISSN | 0956-5663 |
| DOI | 10.1016/j.bios.2021.113816 |
| Database | NAL-Catalogue (AGRICOLA) |
| Zs.A 2275: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2021 Volume 197, Page(s) 113816
Abstract: Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic ...
| Abstract | Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic solid-state distributed feedback laser with a highly sensitive optical waveguide Mach-Zehnder interferometer on a silicon nitride photonic platform. This organic-hybrid laser allows for optical pumping with a laser diode in an alignment tolerant manner, which facilitates applications in point-of-care diagnostics. The sensitivity to bulk refractive index changes and the concentration dependent binding of streptavidin on a polyethyleneimine-biotin functionalized surface was studied to demonstrate the practicability of this cost-efficient coherent light source for optical waveguide biosensors. |
|---|---|
| MeSH term(s) | Biosensing Techniques ; Interferometry ; Lasers, Solid-State ; Silicon Compounds |
| Chemical Substances | Silicon Compounds ; silicon nitride (QHB8T06IDK) |
| Language | English |
| Publishing date | 2021-11-18 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1011023-9 |
| ISSN | 1873-4235 ; 0956-5663 |
| ISSN (online) | 1873-4235 |
| ISSN | 0956-5663 |
| DOI | 10.1016/j.bios.2021.113816 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2275: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Zeitschrift für Gastroenterologie
2024 Volume 62, Issue 01
| Event/congress | 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26 |
|---|---|
| Language | German |
| Publishing date | 2024-01-01 |
| Publisher | Georg Thieme Verlag |
| Publishing place | Stuttgart ; New York |
| Document type | Article ; Conference proceedings |
| ZDB-ID | 201387-3 |
| ISSN | 1439-7803 ; 0044-2771 ; 0172-8504 |
| ISSN (online) | 1439-7803 |
| ISSN | 0044-2771 ; 0172-8504 |
| DOI | 10.1055/s-0043-1777641 |
| Database | Thieme publisher's database |
| Zs.A 111: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.A 111/X: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Physics in medicine and biology
2023 Volume 68, Issue 18
Abstract: Objective. ...
| Abstract | Objective. |
|---|---|
| MeSH term(s) | Animals ; Protons ; Pilot Projects ; Radiometry/methods ; Lasers ; Radiobiology ; Film Dosimetry/methods |
| Chemical Substances | Protons |
| Language | English |
| Publishing date | 2023-09-08 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 208857-5 |
| ISSN | 1361-6560 ; 0031-9155 |
| ISSN (online) | 1361-6560 |
| ISSN | 0031-9155 |
| DOI | 10.1088/1361-6560/acf025 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 199: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 41, Issue 8, Page(s) 111702
Abstract: Disorganization of the basic contractile unit of muscle cells, i.e., the sarcomeres, leads to suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that the nuclear role of SENP7 deSUMOylase is pivotal for sarcomere ... ...
| Abstract | Disorganization of the basic contractile unit of muscle cells, i.e., the sarcomeres, leads to suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that the nuclear role of SENP7 deSUMOylase is pivotal for sarcomere organization. SENP7 expression is temporally upregulated in mature muscle cells and directly regulates transcription of the myosin heavy chain (MyHC-IId) gene. We identify SENP7-dependent deSUMOylation of flightless-1 (Fli-I) as a signal for Fli-I association with scaffold attachment factor b1 (Safb1). SENP7 deficiency leads to higher Fli-I SUMOylation and lower chromatin residency of Safb1, thus generating transcriptionally incompetent chromatin conformation on MyHC-IId. Consequently, lower expression of MyHC-IId causes sarcomere disorganization and disrupted muscle cell contraction. Remarkably, cachexia signaling impedes the SENP7-governed transcriptional program, leading to muscle atrophy, with profound loss of motor protein MyHC-IId. We propose a SENP7-driven distinct transcription program as paramount for muscle cell function, which was found targeted in cachexia. |
|---|---|
| MeSH term(s) | Humans ; Sarcomeres/metabolism ; Cachexia/metabolism ; Muscular Atrophy/genetics ; Muscular Atrophy/complications ; Myosin Heavy Chains/metabolism ; Chromatin ; Endopeptidases/metabolism |
| Chemical Substances | Myosin Heavy Chains (EC 3.6.4.1) ; Chromatin ; SENP7 protein, human (EC 3.4.22.-) ; Endopeptidases (EC 3.4.-) |
| Language | English |
| Publishing date | 2022-11-23 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2649101-1 |
| ISSN | 2211-1247 ; 2211-1247 |
| ISSN (online) | 2211-1247 |
| ISSN | 2211-1247 |
| DOI | 10.1016/j.celrep.2022.111702 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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ACS biomaterials science & engineering
2023 Volume 9, Issue 8, Page(s) 4821–4830
Abstract: Drug loading of polymer micelles can have a profound effect on their particle size and morphology as well as their physicochemical properties. In turn, this influences performance in biological environments. For oral delivery of drugs, the intestinal ... ...
| Abstract | Drug loading of polymer micelles can have a profound effect on their particle size and morphology as well as their physicochemical properties. In turn, this influences performance in biological environments. For oral delivery of drugs, the intestinal environment is key, and consequently, a thorough structural understanding of what happens at this material-biology interface is required to understand in vivo performance and tailor improved delivery vehicles. In this study, we address this interface in vitro through a detailed structural characterization of the colloidal assemblies of polymeric micelles based on poly(2-oxazolines) with three different guest loadings with the natural product curcumin (17-52 wt %) in fed-state simulated intestinal fluids (FeSSIF). For this, we employ NMR spectroscopy, in particular, |
|---|---|
| MeSH term(s) | Micelles ; Curcumin/chemistry ; Antineoplastic Agents ; Polymers/chemistry ; Lipids |
| Chemical Substances | Micelles ; Curcumin (IT942ZTH98) ; Antineoplastic Agents ; poly(2-oxazoline) ; Polymers ; Lipids |
| Language | English |
| Publishing date | 2023-07-13 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2373-9878 |
| ISSN (online) | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.3c00645 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Clinical neurology and neurosurgery
2020 Volume 192, Page(s) 105722
| MeSH term(s) | Bulimia Nervosa/complications ; Bulimia Nervosa/psychology ; Disease Progression ; Female ; Fluid Therapy ; Humans ; Hypokalemia/etiology ; Hypokalemia/therapy ; Hyponatremia/etiology ; Hyponatremia/therapy ; Magnetic Resonance Imaging ; Myelinolysis, Central Pontine/diagnostic imaging ; Myelinolysis, Central Pontine/etiology ; Myelinolysis, Central Pontine/physiopathology ; Young Adult |
|---|---|
| Language | English |
| Publishing date | 2020-02-05 |
| Publishing country | Netherlands |
| Document type | Case Reports ; Journal Article ; Review |
| ZDB-ID | 193107-6 |
| ISSN | 1872-6968 ; 0303-8467 |
| ISSN (online) | 1872-6968 |
| ISSN | 0303-8467 |
| DOI | 10.1016/j.clineuro.2020.105722 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui I Zs.53: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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