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  1. Article ; Online: Extranodal Lymphoma of the Breast.

    Nicholson, Brandi T / Bhatti, Rahat M / Glassman, Leonard

    Radiologic clinics of North America

    2016  Volume 54, Issue 4, Page(s) 711–726

    Abstract: Extranodal lymphoma represents fewer than 0.5% of all breast malignancies. Secondary involvement of the breast with lymphoma is more common than primary breast lymphoma. The most common primary breast lymphoma is B-cell lymphoma. The initial imaging ... ...

    Abstract Extranodal lymphoma represents fewer than 0.5% of all breast malignancies. Secondary involvement of the breast with lymphoma is more common than primary breast lymphoma. The most common primary breast lymphoma is B-cell lymphoma. The initial imaging study of choice for a woman with a new breast mass is a diagnostic mammogram. In younger women ultrasound is more commonly the first imaging modality performed. Diagnosis is made from image-guided or physical examination-directed needle biopsy. Treatment is different from that for breast cancer, in that surgery is not the mainstay. Patients with breast lymphoma are treated primarily with chemotherapy and radiation.
    MeSH term(s) Chemoradiotherapy/methods ; Diagnosis, Differential ; Evidence-Based Medicine ; Female ; Humans ; Lymphoma/diagnostic imaging ; Lymphoma/pathology ; Lymphoma/therapy ; Mammography/methods ; Palpation/methods
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2016.03.005
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  2. Article ; Online: Reply: To PMID 22733923.

    Nguyen, Jonathan / Nicholson, Brandi T / Harvey, Jennifer A

    AJR. American journal of roentgenology

    2013  Volume 200, Issue 4, Page(s) W401

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Female ; Humans ; Incidental Findings ; Magnetic Resonance Imaging/statistics & numerical data ; Mass Screening/statistics & numerical data ; Pleural Effusion/diagnosis ; Pleural Effusion/epidemiology
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.12.9980
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  3. Article ; Online: 3D-MR Ductography and Contrast-Enhanced MR Mammography in Patients with Suspicious Nipple Discharge; a Feasibility Study.

    Nicholson, Brandi T / Harvey, Jennifer A / Patrie, James T / Mugler, John P

    The breast journal

    2015  Volume 21, Issue 4, Page(s) 352–362

    Abstract: We evaluated contrast-enhanced magnetic resonance (ce-MR) imaging and an indirect MR galactogram (MRG) sequence against conventional galactography (CG) in women with suspicious nipple discharge who underwent histologic diagnosis. This study was ... ...

    Abstract We evaluated contrast-enhanced magnetic resonance (ce-MR) imaging and an indirect MR galactogram (MRG) sequence against conventional galactography (CG) in women with suspicious nipple discharge who underwent histologic diagnosis. This study was Institutional Review Board approved and HIPAA compliant. Women with suspicious nipple discharge recommended for CG were recruited for our study. Patients underwent both a ce-MR as well as MRG (MRG-1 and MRG-2, variations in isotropic spatial resolution) followed by CG within 60 days. The ce-MR and MRG studies were interpreted together by a single radiologist separately from CG. Pathology was used as our gold standard and was obtained via image-guided core needle biopsy or surgery with papilloma, atypia, and malignancy considered positive. Of the 21 patients recruited for the study, 20 patients had known histology results for 26 lesions; 18 patients (90.0%) had successful CG, 20 (100.0%) ce-MRI, 20 (100.0%) MRG-1, and 19 (95.0%) MRG-2. Histology showed 5 cancers (4 women), 15 papillomas (2 with atypia) (11 women), and 6 additional benign lesions (6 women). Five patients (25.0%) had additional lesions detected by ce-MR that influenced surgical management. Sensitivity, specificity, positive (PPV), and negative predicted values (NPV) for CG, ce-MRI, MRG-1 were 65.0, 33.3, 76.5, and 22.2; 95.0, 66.7, 90.5, and 80.8; 55.0, 66.7, 84.6, and 30.8, respectively. ce-MR had the highest sensitivity, PPV, and NPV compared with CG or MRG. Our MRG protocols show promise, but were not as sensitive as ce-MRI for women with suspicious nipple discharge.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/pathology ; Exudates and Transudates ; Feasibility Studies ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging ; Middle Aged ; Nipples/pathology ; Nipples/secretion ; Radiography ; Retrospective Studies
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.12417
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  4. Article ; Online: Outcome of Architectural Distortion Detected Only at Breast Tomosynthesis versus 2D Mammography.

    Alshafeiy, Taghreed I / Nguyen, Jonathon V / Rochman, Carrie M / Nicholson, Brandi T / Patrie, James T / Harvey, Jennifer A

    Radiology

    2018  Volume 288, Issue 1, Page(s) 38–46

    Abstract: Purpose To compare the outcome of architectural distortion (AD) without associated mass only on digital breast tomosynthesis (DBT) with AD seen at two-dimensional (2D) mammography and to evaluate if the incidence of malignancy is influenced by the ... ...

    Abstract Purpose To compare the outcome of architectural distortion (AD) without associated mass only on digital breast tomosynthesis (DBT) with AD seen at two-dimensional (2D) mammography and to evaluate if the incidence of malignancy is influenced by the presence of a correlate at ultrasonography (US). Materials and Methods This retrospective study had institutional review board approval and was HIPAA compliant. All consecutive cases in which patients with AD were ultimately assigned Breast Imaging Reporting and Data System (BI-RADS) 4 or 5 categories from 2009 to 2016 were reviewed by three readers for visibility (2D vs DBT). The level of suspicion was assigned using a Likert scale. Pathologic results were compared between 2D-detected and DBT-detected AD. Frequencies were compared by using the McNemar and Pearson χ
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Mammography/methods ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Ultrasonography, Mammary/methods
    Language English
    Publishing date 2018-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018171159
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  5. Article ; Online: Radiologist/Educator knowledge of the audience response system and limitations to its use.

    Nicholson, Brandi T / Bassignani, Matthew J

    Academic radiology

    2009  Volume 16, Issue 12, Page(s) 1555–1560

    Abstract: Rationale and objectives: Audience response systems (ARS) have been proven to increase residents' retention in the short and long terms. The purpose of this study was to determine what teaching faculty members know about the ARS at one institution, what ...

    Abstract Rationale and objectives: Audience response systems (ARS) have been proven to increase residents' retention in the short and long terms. The purpose of this study was to determine what teaching faculty members know about the ARS at one institution, what the obstacles are to its use, and ways to increase its use.
    Materials and methods: An anonymous and voluntary survey was sent to teaching faculty members. Fifty-two faculty members received the survey request and were included in the study set. The survey included questions regarding the faculty members' prior use of, understanding of, and ideas about ways to improve the ARS, as well as obstacles to its use.
    Results: Thirty of 52 faculty members (58%) responded. Eight (27%) reported prior use of the ARS. Impediments to using the system more, for infrequent users, included "no need for it again," that it was "a bit tedious to incorporate into lectures," and time limitations. However, most users felt that the system was overall easy to use, and they did so by incorporating it into existing lectures. Perceptions that residents learned more effectively with the ARS motivated faculty members to use it more. They noted that residents seemed to like the ARS lectures more and were more engaged than with other didactic techniques. Faculty members would increase their use of the ARS if more information technology support were available, if training sessions were held, and if they had knowledge that residents preferred this lecture format.
    Conclusions: Faculty members at the authors' academic institution used its ARS infrequently but expressed an overall desire to use it more. They suggested methods that would increase their use of the device and were particularly motivated by residents' satisfaction with their lectures. If their suggestions can be implemented, use of the ARS should increase.
    MeSH term(s) Educational Measurement/methods ; Internship and Residency/methods ; Internship and Residency/organization & administration ; Knowledge of Results (Psychology) ; Professional Competence ; Radiology/education ; Teaching/methods ; United States
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2009.07.014
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  6. Article: Sarcoidosis of the breast: An unusual presentation of a systemic disease.

    Nicholson, Brandi T / Mills, Stacey E

    The breast journal

    2007  Volume 13, Issue 1, Page(s) 99–100

    MeSH term(s) Breast Diseases/diagnosis ; Breast Diseases/diagnostic imaging ; Breast Diseases/pathology ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Radiography ; Sarcoidosis/diagnosis ; Sarcoidosis/diagnostic imaging ; Sarcoidosis/pathology ; Ultrasonography
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1289960-4
    ISSN 1075-122X
    ISSN 1075-122X
    DOI 10.1111/j.1524-4741.2006.00375.x
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  7. Article ; Online: Rim-enhancing breast masses with smooth or spiculated margins on magnetic resonance imaging: histopathology and clinical significance.

    Uematsu, Takayoshi / Kasami, Masako / Nicholson, Brandi T

    Japanese journal of radiology

    2011  Volume 29, Issue 9, Page(s) 609–614

    Abstract: Rim enhancement is defined as enhancement that is more pronounced at the periphery of a mass. It can have varying appearances, ranging from a thin pattern to one that is thicker. This internal enhancement characteristic is an established characteristic ... ...

    Abstract Rim enhancement is defined as enhancement that is more pronounced at the periphery of a mass. It can have varying appearances, ranging from a thin pattern to one that is thicker. This internal enhancement characteristic is an established characteristic of malignant lesions. Additionally, the use of combined descriptors, especially internal enhancement characteristics and the associated margin, can provide a more powerful predictive value than that of individual descriptors. The margin assessment of rim-enhancing masses is important and can vary in appearance from smooth to spiculated. Moreover, rim enhancement may be dynamic in that it changes appearance during the dynamic phases of contrast- enhanced breast magnetic resonance imaging (ce-MRI), and this feature can lead to confusion in the correct application of this lexicon. Rim-enhancing masses on ce-MRI are typically of two morphological types (i.e., a thin rim-enhancing mass with a smooth margin and a thick rim-enhancing mass with a spiculated margin). It is helpful to review and clarify the lexicon of rim enhancement using combined descriptors based on the pathological findings as doing so can help predict the likelihood of malignancy of ce-MRI lesions.
    MeSH term(s) Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Contrast Media ; Female ; Gadolinium DTPA ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods
    Chemical Substances Contrast Media ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2011-09-29
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-011-0612-8
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  8. Article ; Online: Comparison Between Digital and Synthetic 2D Mammograms in Breast Density Interpretation.

    Alshafeiy, Taghreed I / Wadih, Antoine / Nicholson, Brandi T / Rochman, Carrie M / Peppard, Heather R / Patrie, James T / Harvey, Jennifer A

    AJR. American journal of roentgenology

    2017  Volume 209, Issue 1, Page(s) W36–W41

    Abstract: Objective: The purpose of this study was to compare assessments of breast density on synthetic 2D images as compared with digital 2D mammograms.: Materials and methods: This retrospective study included consecutive women undergoing screening with ... ...

    Abstract Objective: The purpose of this study was to compare assessments of breast density on synthetic 2D images as compared with digital 2D mammograms.
    Materials and methods: This retrospective study included consecutive women undergoing screening with digital 2D mammography and tomosynthesis during May 2015 with a negative or benign outcome. In separate reading sessions, three radiologists with 5-25 years of clinical experience and 1 year of experience with synthetic 2D mammography read digital 2D and synthetic 2D images and assigned breast density categories according to the 5th edition of BI-RADS. Inter- and intrareader agreement was assessed for each BI-RADS density assessment and combined dense and nondense categories using percent agreement and Cohen kappa coefficient for consensus and all reads.
    Results: A total of 309 patients met study inclusion criteria. Agreement between consensus BI-RADS density categories assigned for digital and synthetic 2D mammography was 80.3% (95% CI, 75.4-84.5%) with κ = 0.73 (95% CI, 0.66-0.79). For combined dense and nondense categories, agreement reached 91.9% (95% CI, 88.2-94.7%). For consensus readings, similar numbers of patients were shifted between nondense and dense categories (11 and 14, respectively) with the synthetic 2D compared with digital 2D mammography. Interreader differences were apparent; assignment to dense categories was greater with digital 2D mammography for reader 1 (odds ratio [OR], 1.26; p = 0.002), the same for reader 2 (OR, 0.91; p = 0.262), and greater with synthetic 2D mammography for reader 3 (OR, 0.86; p = 0.033).
    Conclusion: Overall, synthetic 2D mammography is comparable with digital 2D mammography in assessment of breast density, though there is some variability by reader. Practices can readily adopt synthetic 2D mammography without concern that it will affect density assessment and subsequent recommendations for supplemental screening.
    MeSH term(s) Adult ; Aged ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Mammography/methods ; Middle Aged ; Radiographic Image Enhancement/methods ; Retrospective Studies
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.16.16966
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  9. Article ; Online: Incidental pleural effusions detected on screening breast MRI.

    Nguyen, Jonathan / Nicholson, Brandi T / Patrie, James T / Harvey, Jennifer A

    AJR. American journal of roentgenology

    2012  Volume 199, Issue 1, Page(s) W142–5

    Abstract: Objective: Pleural effusions are a common complication of malignancy that must be differentiated from physiologic effusions identified on breast MRI. This study aimed to determine the incidence and reference range of physiologic pleural effusions ... ...

    Abstract Objective: Pleural effusions are a common complication of malignancy that must be differentiated from physiologic effusions identified on breast MRI. This study aimed to determine the incidence and reference range of physiologic pleural effusions observed in healthy women undergoing screening breast MRI.
    Materials and methods: A retrospective analysis of 200 consecutive women who underwent screening breast MRI between December 2007 and December 2008 was performed. Medical records were reviewed; patients with abnormal MRI findings resulting in a diagnosis of breast cancer, a prior malignancy, or cardiac or pulmonary disease were excluded. Patient age, the presence of pleural effusions, and, if present, the laterality were recorded. The largest size of effusions was measured at the anterior chest wall. A nonparametric Wilcoxon test was used to compare the sizes of right- and left-sided pleural effusions.
    Results: Of the 200 patients, 174 (87%) had a pleural effusion; 124 (62%) were bilateral and 50 (25%) were unilateral. Compared with the left side, right-sided pleural effusions were more frequent (81.5% vs 67.5%, respectively; p < 0.001) and were slightly larger (mean, 3.3 vs 2.8 mm; p = 0.019). Effusions ranged from 1 to 12 mm on the right and from 1 to 8 mm on the left. The reference range for pleural effusions on breast MRI based on this healthy population is up to 7 mm on the right side and 5 mm on the left side.
    Conclusion: Small pleural effusions are a common physiologic finding in women undergoing screening breast MRI and should not prompt further testing.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Breast Neoplasms/prevention & control ; Comorbidity ; Female ; Humans ; Incidence ; Incidental Findings ; Magnetic Resonance Imaging/statistics & numerical data ; Mass Screening/statistics & numerical data ; Middle Aged ; Neoplasm Staging ; Pleural Effusion/diagnosis ; Pleural Effusion/epidemiology ; Retrospective Studies ; Statistics, Nonparametric
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.11.7868
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  10. Article ; Online: The new radiology residency fourth year under the new curriculum: a survey of current residents' thoughts and suggestions about its design and purpose.

    Nicholson, Brandi T / Sizemore, Alecia W / Gay, Spencer B

    Journal of the American College of Radiology : JACR

    2010  Volume 7, Issue 4, Page(s) 294–298

    Abstract: Rationale and objectives: The ABR announced changes to the board examinations for the resident class entering in 2010. These changes can allow the fourth year to be focused on subspecialization. During the restructuring process at the authors' ... ...

    Abstract Rationale and objectives: The ABR announced changes to the board examinations for the resident class entering in 2010. These changes can allow the fourth year to be focused on subspecialization. During the restructuring process at the authors' institution, residents were queried about fourth-year design. The goal was to create a curriculum that would best meet residents' expectations while balancing clinical and educational needs.
    Materials and methods: Issues from the literature about the fourth-year curriculum were identified. An anonymous and voluntary survey based on these was developed and sent to 36 residents who made up the study group. Answers were reviewed for trends and significant unique responses before curricular development.
    Results: Twenty-two of 36 residents (61%) responded. The most often selected electives were cardiac (91%), body MRI (77%), body interventional procedures (68%), neuroradiologic MRI (59%), musculoskeletal procedures (59%), and musculoskeletal imaging (54%). Fifty percent wanted 6 months in one area. Forty-five percent felt that the length of time in one area (most with a threshold of 9 months) would affect their decisions to pursue fellowships. The majority (73%) planned to use the fourth year to do rotations different from their planned fellowship areas.
    Conclusion: The majority of residents indicate that they would like to have at least half of their fourth year in one area, and most selected similar rotations to one another. The ability to do this extended time on one service may result in a decrease in the number of residents pursuing fellowships. However, most saw the fourth year as a way to broaden their radiologic knowledge.
    MeSH term(s) Curriculum ; Internship and Residency ; Radiology/education ; Surveys and Questionnaires ; United States
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2009.11.023
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