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  1. Book ; Online: New drugs against intestinal parasitoses / by J. F. Rossignol

    Rossignol, J. F / World Health Organization. Parasitic Diseases Programme

    1986  

    Abstract: ONLINE ... PDP/EC/WP/86.8. Unpublished ... English only ...

    Abstract ONLINE

    PDP/EC/WP/86.8. Unpublished

    English only

    6 p.
    Keywords Antiparasitic agents ; Intestinal diseases ; Parasitic ; prevention and control
    Language English
    Publisher Geneva : World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: New drugs against intestinal parasitoses / by J. F. Rossignol

    Rossignol, J. F / World Health Organization. Parasitic Diseases Programme

    1986  

    Abstract: ONLINE ... PDP/EC/WP/86.8. Unpublished ... 6 p. ...

    Abstract ONLINE

    PDP/EC/WP/86.8. Unpublished

    6 p.
    Keywords Antiparasitic Agents ; Intestinal Diseases ; Parasitic ; prevention and control
    Language English
    Publisher World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Why phylogenetic signal of traits is important in ecosystems: uniformity of a plant trait increases soil fauna, but only in a phylogenetically uniform vegetation.

    Molleman, F / Rossignol, N / Ponge, J F / Peres, G / Cluzeau, D / Ruiz-Camacho, N / Cortet, J / Pernin, C / Villenave, C / Prinzing, A

    Oecologia

    2023  Volume 202, Issue 1, Page(s) 175–191

    Abstract: Phylogenetically closely related plant species often share similar trait states (phylogenetic signal), but local assembly may favor dissimilar relatives and thereby decouple the diversity of a trait from the diversity of phylogenetic lineages. Associated ...

    Abstract Phylogenetically closely related plant species often share similar trait states (phylogenetic signal), but local assembly may favor dissimilar relatives and thereby decouple the diversity of a trait from the diversity of phylogenetic lineages. Associated fauna might either benefit from plant trait diversity, because it provides them complementary resources, or suffer from it due to dilution of preferred resources. We hence hypothesize that decoupling of trait and phylogenetic diversity weakens the relationship between the plant-trait diversity and the abundance and diversity of associated fauna. Studying permanent meadows, we tested for combined effects of plant phylogenetic diversity and diversity of two functional traits (specific leaf area, leaf dry matter content) on major groups of soil fauna (earthworms, mites, springtails, nematodes). We found that only in phylogenetically uniform plant communities, was uniformity in the functional traits associated with (i) high abundance in springtails, and (ii) high abundance of the sub-group that feeds more directly on plant material (in springtails and mites) or those that are more prone to disturbance (in nematodes), and (iii) high diversity in all three groups tested (springtails, earthworms, nematodes). Our results suggest that soil fauna profits from the resource concentration in local plant communities that are uniform in both functional traits and phylogenetic lineages. Soil fauna would hence benefit from co-occurrence of closely related plants that have conserved the same trait values, rather than of distantly related plants that have converged in traits. This might result in faster decomposition and a positive feedback between trait conservatism and ecosystem functioning.
    MeSH term(s) Ecosystem ; Phylogeny ; Soil ; Plants ; Plant Leaves
    Chemical Substances Soil
    Language English
    Publishing date 2023-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123369-5
    ISSN 1432-1939 ; 0029-8549
    ISSN (online) 1432-1939
    ISSN 0029-8549
    DOI 10.1007/s00442-023-05384-z
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  4. Article: Translation and Validation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale for French Paediatric Populations.

    Bel, Michael J Del / Kemp, Laryssa G / Girard, Céline I / Rossignol, Julie / Goulet, Sébastien F / Bourgon, Jean-François / Carsen, Sasha / Benoit, Daniel L

    Physiotherapy Canada. Physiotherapie Canada

    2021  Volume 72, Issue 4, Page(s) 348–354

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-01-12
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639189-8
    ISSN 1708-8313 ; 0300-0508
    ISSN (online) 1708-8313
    ISSN 0300-0508
    DOI 10.3138/ptc-2019-0033
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  5. Article: Nitazoxanide in the treatment of acquired immune deficiency syndrome-related cryptosporidiosis: results of the United States compassionate use program in 365 patients.

    Rossignol, J-F

    Alimentary pharmacology & therapeutics

    2006  Volume 24, Issue 5, Page(s) 887–894

    Abstract: Background: Cryptosporidiosis in patients with acquired immune deficiency syndrome is a serious, life-threatening disease.: Aim: A large compassionate use clinical trial was conducted in the USA to make nitazoxanide available to patients with ... ...

    Abstract Background: Cryptosporidiosis in patients with acquired immune deficiency syndrome is a serious, life-threatening disease.
    Aim: A large compassionate use clinical trial was conducted in the USA to make nitazoxanide available to patients with acquired immune deficiency syndrome-related cryptosporidiosis and to collect data related to safety and effectiveness of the drug in this population.
    Methods: Patients at least 3 years of age with acquired immune deficiency syndrome, diarrhoea (> or =4 stools/day for >2 weeks) and Cryptosporidium-positive stools received 500-1500 mg of nitazoxanide twice daily. Patients were evaluated at weeks 1, 2, 4 and monthly thereafter for drug safety and effectiveness including the stool examinations, review of symptoms and patient diaries. Data analysis for clinical and parasitological response was intention-to-treat.
    Results: Three hundred and sixty-five patients were enrolled at 165 study centres throughout the USA. The duration of treatment ranged from 1 to 1,528 days (median 62 days). Among the 357 patients included in the intent-to-treat analysis, 209 (59%) achieved a sustained clinical response while on treatment. Clinical responses were closely associated with Cryptosporidium-negative stools (P < 0.0001). No safety issues were identified at doses up to 3000 mg/day or for long durations of treatment.
    Conclusions: Nitazoxanide can be considered useful therapy for treatment of with acquired immune deficiency syndrome-related cryptosporidiosis.
    MeSH term(s) AIDS-Related Opportunistic Infections/complications ; AIDS-Related Opportunistic Infections/drug therapy ; AIDS-Related Opportunistic Infections/epidemiology ; Adolescent ; Adult ; Age Distribution ; Aged ; Antiparasitic Agents/adverse effects ; Antiparasitic Agents/therapeutic use ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Cryptosporidiosis/complications ; Cryptosporidiosis/drug therapy ; Diarrhea/complications ; Diarrhea/drug therapy ; Diarrhea/epidemiology ; Feces/parasitology ; Female ; Humans ; Male ; Middle Aged ; Sex Distribution ; Thiazoles/adverse effects ; Thiazoles/therapeutic use ; Time Factors ; Treatment Outcome ; United States/epidemiology
    Chemical Substances Antiparasitic Agents ; Thiazoles ; nitazoxanide (SOA12P041N)
    Language English
    Publishing date 2006-09-01
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/j.1365-2036.2006.03033.x
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  6. Article ; Online: The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease.

    Barrera-Chimal, Jonatan / Gerarduzzi, Casimiro / Rossignol, Patrick / Jaisser, Frédéric

    Clinical science (London, England : 1979)

    2022  Volume 136, Issue 12, Page(s) 1005–1017

    Abstract: Despite strong preclinical data supporting the use of mineralocorticoid receptor antagonists (MRAs) to provide cardiorenal protection in rodent models of diabetes, the clinical evidence of their utility in treating chronic kidney disease (CKD) has been ... ...

    Abstract Despite strong preclinical data supporting the use of mineralocorticoid receptor antagonists (MRAs) to provide cardiorenal protection in rodent models of diabetes, the clinical evidence of their utility in treating chronic kidney disease (CKD) has been limited. Two major clinical trials (FIDELIO-DKD and FIGARO-DKD) including more than 13,000 patients with albuminuric CKD and Type 2 diabetes randomized to placebo or finerenone (MRA) have recently provided exciting results showing a significant risk reduction for kidney and cardiovascular outcomes. In this review, we will summarize the major findings of these trials, together with post-hoc and pooled analyses that have allowed evaluation of the efficacy and safety of finerenone across the spectrum of CKD, revealing significant protective effects of finerenone against kidney failure, new-onset atrial fibrillation or flutter, new-onset heart failure, cardiovascular death, and first and total heart-failure hospitalizations. Moreover, we will discuss the current evidence that supports the combined use of MRAs with sodium-glucose co-transporter-2 inhibitors, either by providing an additive cardiorenal benefit or by decreasing the risk of hyperkalemia. Although the mechanisms of protection by finerenone have only been partially explored in patients, rodent studies have shed light on its anti-inflammatory and anti-fibrotic effects in models of kidney disease, which is one of the main drivers for testing the efficacy of finerenone in non-diabetic CKD patients in the ongoing FIND-CKD trial.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Naphthyridines/pharmacology ; Naphthyridines/therapeutic use ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Naphthyridines ; finerenone
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220212
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    Ua VI Zs.220: Show issues Location:
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  7. Article ; Online: Investigating the perception of soundscapes through acoustic scene simulation.

    Lafay, G / Rossignol, M / Misdariis, N / Lagrange, M / Petiot, J-F

    Behavior research methods

    2018  Volume 51, Issue 2, Page(s) 532–555

    Abstract: This paper introduces a new experimental protocol for studying mental representations of urban soundscapes through a simulation process. Subjects are asked to create a full soundscape by means of a dedicated software tool, coupled with a structured sound ...

    Abstract This paper introduces a new experimental protocol for studying mental representations of urban soundscapes through a simulation process. Subjects are asked to create a full soundscape by means of a dedicated software tool, coupled with a structured sound data set. This paradigm is used to characterize urban sound environment representations by analyzing the sound classes that were used to simulate the auditory scenes. A rating experiment of the soundscape pleasantness using a seven-point bipolar semantic scale is conducted to further refine the analysis of the simulated urban acoustic scenes. Results show that (1) a semantic characterization in terms of presence/absence of sound sources is an effective way to characterize urban soundscape pleasantness, and (2) acoustic pressure levels computed for specific sound sources better characterize the appraisal than the acoustic pressure level computed over the overall soundscape.
    MeSH term(s) Acoustics ; Auditory Perception ; Emotions ; Humans ; Semantics ; Sound
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 231560-9
    ISSN 1554-3528 ; 0743-3808 ; 1554-351X
    ISSN (online) 1554-3528
    ISSN 0743-3808 ; 1554-351X
    DOI 10.3758/s13428-018-1138-0
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  8. Article: Parasitic gut infections.

    Rossignol, J F

    Current opinion in infectious diseases

    2006  Volume 11, Issue 5, Page(s) 597–600

    Abstract: Emerging spore-forming protozoa such as cryptosporidia and microsporidia are becoming major public health problems in developing countries as well as in the developed world. They are a new addition to an already long list of intestinal parasites, but ... ...

    Abstract Emerging spore-forming protozoa such as cryptosporidia and microsporidia are becoming major public health problems in developing countries as well as in the developed world. They are a new addition to an already long list of intestinal parasites, but their diagnosis is much more difficult than for well-known protozoa and helminths. Fortunately, enzyme immunoassay and polymerase chain reaction techniques are becoming available not only for the detection of Cryptosporidium parvum and the microsporidia, but also for Entamoeba histolytica and Giardia lamblia. These assays are not only increasing the sensitivity of detection but are also allowing, for the first time, species differentiation such as Entamoeba histolytica/dispar or Encephalitozoon intestinalis/Enterocytozoon bieneusi.
    Language English
    Publishing date 2006-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645085-4
    ISSN 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/00001432-199810000-00012
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    Zs.A 2462: Show issues Location:
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  9. Article: Morphological, physiological, and transcriptional responses of the freshwater diatom

    Zepernick, Brittany N / Niknejad, David J / Stark, Gwendolyn F / Truchon, Alexander R / Martin, Robbie M / Rossignol, Karen L / Paerl, Hans W / Wilhelm, Steven W

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1044464

    Abstract: Harmful algal blooms (HABs) caused by the toxin-producing ... ...

    Abstract Harmful algal blooms (HABs) caused by the toxin-producing cyanobacteria
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1044464
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  10. Article ; Online: Prevalence and evaluation of oropharyngeal dysphagia in patients with severe acute respiratory syndrome coronavirus 2 infection in the intensive care unit.

    Mallart, R / Rossignol, C / Poppe, J B / Prum, G / Tamion, F / Veber, B / Verin, E

    The Journal of laryngology and otology

    2022  Volume 136, Issue 7, Page(s) 649–653

    Abstract: Objective: The main objective was to assess the prevalence of dysphagia in the intensive care unit in patients with coronavirus disease 2019.: Results: Over 4 months, 58 patients were intubated and ventilated, 43 of whom were evaluated. Screening ... ...

    Abstract Objective: The main objective was to assess the prevalence of dysphagia in the intensive care unit in patients with coronavirus disease 2019.
    Results: Over 4 months, 58 patients were intubated and ventilated, 43 of whom were evaluated. Screening revealed post-extubation dysphagia in 62.7 per cent of patients. In univariate analysis, a significant association was found between the presence of dysphagia and: the severity of the initial pathology, the duration of intubation, the duration of curare use, the degree of muscle weakness and the severity indicated on the initial scan. At the end of intensive care unit treatment, 22 per cent of the dysphagic patients had a normal diet, 56 per cent had an adapted diet and 22 per cent still received exclusive tube feeding.
    Conclusion: Post-extubation dysphagia is frequent and needs to be investigated.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Deglutition Disorders/complications ; Deglutition Disorders/etiology ; Humans ; Intensive Care Units ; Prevalence ; Retrospective Studies
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215121004710
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