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  1. Article ; Online: Nitric oxide and COVID-19: Dose, timing and how to administer it might be crucial.

    Frostell, Claes G / Hedenstierna, Göran

    Acta anaesthesiologica Scandinavica

    2021  Volume 65, Issue 5, Page(s) 576–577

    MeSH term(s) Administration, Inhalation ; COVID-19 ; Humans ; Nitric Oxide ; Pulmonary Gas Exchange ; Respiratory Distress Syndrome ; SARS-CoV-2
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-03-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80002-8
    ISSN 1399-6576 ; 0001-5172
    ISSN (online) 1399-6576
    ISSN 0001-5172
    DOI 10.1111/aas.13788
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  2. Article: A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury.

    Stene Hurtsén, Anna / McGreevy, David T / Karlsson, Christina / Frostell, Claes G / Hörer, Tal M / Nilsson, Kristofer F

    Intensive care medicine experimental

    2023  Volume 11, Issue 1, Page(s) 18

    Abstract: Background: The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that are clinically monitored in real ... ...

    Abstract Background: The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that are clinically monitored in real time are lacking. The aim of the study was to test the hypothesis that end-tidal carbon dioxide (ETCO
    Materials and methods: Twenty anesthetized pigs (26-35 kg) were randomized to 45 min of either ETCO
    Results: ETCO
    Conclusions: In a porcine model of hemorrhagic shock, ETCO
    Language English
    Publishing date 2023-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00502-w
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  3. Article ; Online: The Swedish Perioperative Register: Description, validation of data mapping and utility.

    Holmström, Björn / Enlund, Gunnar / Spetz, Peter / Frostell, Claes

    Acta anaesthesiologica Scandinavica

    2022  Volume 67, Issue 2, Page(s) 233–239

    Abstract: Background: Since 2013 surgical units in Sweden have reported procedures to the national Swedish Perioperative Register (SPOR). More than four million cases have been documented. Data consist of patient ID, type of surgery, diagnoses, time stamps during ...

    Abstract Background: Since 2013 surgical units in Sweden have reported procedures to the national Swedish Perioperative Register (SPOR). More than four million cases have been documented. Data consist of patient ID, type of surgery, diagnoses, time stamps during the perioperative process (from the decision to operate to the time of discharge from the postoperative recovery area) and quality measures. This article aims to describe SPOR and validate data mapping. Also, we wished to illustrate the utility of the SPOR in assessing variations in national surgical capacity during the COVID-19 pandemia years 2020-2021.
    Methods: After a detailed description of SPOR, we report on the validation of data performed by comparing data from local databases with data stored in the central SPOR database, assessing missing values and accuracy. Effects of the pandemic on surgical capacity were described by developing an index, based on the number of performed surgical procedures per week during four production weeks in January 2020. Subsequent weeks were then compared with this baseline.
    Results: The validation effort demonstrated nearly 100% data accuracy for the number and type of surgical procedures between local and central data. Missing data was a problem for some parameters. The number of performed surgical procedures decreased dramatically from week 11 in 2020 compared with normal production on a national basis, mainly impairing elective surgery.
    Discussion: Data validation revealed good agreement between local and central databases. The changes in national surgical capacity during the pandemic were illustrated by an index based on the reported surgical production.
    MeSH term(s) Humans ; Sweden/epidemiology ; COVID-19/epidemiology ; Elective Surgical Procedures
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80002-8
    ISSN 1399-6576 ; 0001-5172
    ISSN (online) 1399-6576
    ISSN 0001-5172
    DOI 10.1111/aas.14174
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  4. Article: Reassessment of inhaled nitric oxide in acute lung injury.

    Frostell, Claes G

    Acta pharmacologica Sinica

    2003  Volume 24, Issue 12, Page(s) 1314–1315

    MeSH term(s) Administration, Inhalation ; Humans ; Nitric Oxide/administration & dosage ; Nitric Oxide/therapeutic use ; Respiratory Distress Syndrome, Adult/drug therapy
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2003-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 1671-4083 ; 0253-9756
    ISSN (online) 1745-7254
    ISSN 1671-4083 ; 0253-9756
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  5. Article ; Online: Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints.

    Libert, Claude / Ayala, Alfred / Bauer, Michael / Cavaillon, Jean-Marc / Deutschman, Clifford / Frostell, Claes / Knapp, Sylvia / Kozlov, Andrey V / Wang, Ping / Osuchowski, Marcin F / Remick, Daniel G

    Shock (Augusta, Ga.)

    2018  Volume 51, Issue 1, Page(s) 23–32

    Abstract: Although the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review has not been done for preclinical models. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling reviewed the ... ...

    Abstract Although the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review has not been done for preclinical models. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling reviewed the 260 most highly cited papers between 2003 and 2012 using sepsis models to create a series of recommendations. This Part II report provides recommendations for the types of infections and documentation of organ injury in preclinical sepsis models. Concerning the types of infections, the review showed that the cecal ligation and puncture model was used for 44% of the studies while 40% injected endotoxin. Recommendation #8 (numbered sequentially from Part I): endotoxin injection should not be considered as a model of sepsis; live bacteria or fungal strains derived from clinical isolates are more appropriate. Recommendation #9: microorganisms should replicate those typically found in human sepsis. Sepsis-3 states that sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection, but the review of the papers showed limited attempts to document organ dysfunction. Recommendation #10: organ dysfunction definitions should be used in preclinical models. Recommendation #11: not all activities in an organ/system need to be abnormal to verify organ dysfunction. Recommendation #12: organ dysfunction should be measured in an objective manner using reproducible scoring systems. Recommendation #13: not all experiments must measure all parameters of organ dysfunction, but investigators should attempt to fully capture as much information as possible. These recommendations are proposed as "best practices" for animal models of sepsis.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Infections ; Multiple Organ Failure ; Shock, Septic
    Language English
    Publishing date 2018-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001242
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  6. Article ; Online: Clinical Aspects of Nitric Oxide and Surfactant Replaement

    Frostell, Claes G.

    Neonatology - Fetal and Neonatal Research

    1997  Volume 71, Issue S1, Page(s) 39–43

    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000244453
    Database Karger publisher's database

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  7. Article: Lumbalpunktion vid huvudvärk--undersökningen får inte förvärra.

    Rösblad, P G / Dahlgren, Gunnar / Frostell, Claes

    Lakartidningen

    2004  Volume 101, Issue 12, Page(s) 1121–1122

    Title translation Lumbar puncture and headache--the examination should not make it worse.
    MeSH term(s) Headache/diagnosis ; Headache/etiology ; Humans ; Needles/adverse effects ; Risk Factors ; Spinal Puncture/adverse effects ; Spinal Puncture/instrumentation
    Language Swedish
    Publishing date 2004-03-18
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  8. Article: Postpunktionell huvudvärk vid lumbalpunktion bör så långt möjligt undvikas.

    Rösblad, P G / Dahlgren, Gunnar / Frostell, Claes

    Lakartidningen

    2004  Volume 101, Issue 19, Page(s) 1741

    Title translation Headache after lumbar puncture should be avoided as far as possible.
    MeSH term(s) Blood Patch, Epidural ; Headache/prevention & control ; Humans ; Needles/adverse effects ; Spinal Puncture/adverse effects
    Language Swedish
    Publishing date 2004-05-06
    Publishing country Sweden
    Document type Letter
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  9. Article ; Online: Platelet dysfunction in a large-animal model of endotoxic shock; effects of inhaled nitric oxide and low-dose steroid.

    Adamik, Barbara / Frostell, Claes / Paslawska, Urszula / Dragan, Barbara / Zielinski, Stanislaw / Paslawski, Robert / Janiszewski, Adrian / Zielinska, Marzena / Ryniak, Stanislaw / Ledin, Gustaf / Gozdzik, Waldemar

    Nitric oxide : biology and chemistry

    2021  Volume 108, Page(s) 20–27

    Abstract: Objective: The role of inhaled nitric oxide in the treatment of shock remains controversial and further translational research is needed. Long-term observation studies using a model of endotoxin-induced shock to assess the effect of inhaled nitric oxide ...

    Abstract Objective: The role of inhaled nitric oxide in the treatment of shock remains controversial and further translational research is needed. Long-term observation studies using a model of endotoxin-induced shock to assess the effect of inhaled nitric oxide on platelet aggregation have not yet been reported.
    Approach and results: The tests were carried out in an animal model of shock in two 10-h periods. During the first 10 h, endotoxin was infused and the inhibition of platelet aggregation was evaluated; following the termination of endotoxin infusion, the restoration of platelet aggregation was assessed for 10 h. A total of 30 pigs were used (NO group, N = 14; control, N = 16). In the NO group, nitric oxide inhalation (30 ppm) was started 3 h after endotoxin infusion and continued until the end of the study. Treatment with NO selectively decreased pulmonary artery pressure at 4 (p = 0.002) and 8 h (p = 0.05) of the experiment as compared to the control. Endotoxin significantly reduced platelet aggregation, as indicated by the decreased activity of platelet receptors: ASPI, ADP, collagen, and TRAP during the experiment (p < 0.001). Endotoxin had no significant effect on changes in the response of the receptor after ristocetin stimulation. After stopping endotoxin infusion, a significant restoration of receptor activity was observed for collagen and TRAP, while ASPI and ADP remained partially depressed. Inhaled nitric oxide did not cause additional inhibition of platelet aggregation, either during or after endotoxin challenge.
    Conclusions: A profound reduction in platelet aggregation was observed during endotoxic shock. After stopping endotoxin infusion a restoration of platelet receptor activity was seen. The inhibition of platelet aggregation induced by endotoxin infusion was not intensified by nitric oxide, indicating there was no harmful effect of inhaled nitric oxide on platelet aggregation.
    MeSH term(s) Administration, Inhalation ; Animals ; Blood Platelets/metabolism ; Endotoxins ; Hydrocortisone/therapeutic use ; Nitric Oxide/administration & dosage ; Nitric Oxide/therapeutic use ; Platelet Aggregation/drug effects ; Pulmonary Wedge Pressure/drug effects ; Shock, Septic/chemically induced ; Shock, Septic/drug therapy ; Shock, Septic/metabolism ; Swine ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/therapeutic use
    Chemical Substances Endotoxins ; Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2020.12.008
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    Zs.A 4677: Show issues Location:
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  10. Article ; Online: Evaluation of central venous catheters coated with a noble metal alloy-A randomized clinical pilot study of coating durability, performance and tolerability.

    Björling, Gunilla / Johansson, Dorota / Bergström, Linda / Strekalovsky, Anton / Sanchez, Javier / Frostell, Claes / Kalman, Sigridur

    Journal of biomedical materials research. Part B, Applied biomaterials

    2017  Volume 106, Issue 6, Page(s) 2337–2344

    Abstract: The use of Central Venous Catheters (CVCs) commonly results in complications. Coatings with silver or metal alloys can reduce the risk associated with the use of CVC. We have evaluated the durability of a noble metal coated CVC (the Bactiguard Infectious ...

    Abstract The use of Central Venous Catheters (CVCs) commonly results in complications. Coatings with silver or metal alloys can reduce the risk associated with the use of CVC. We have evaluated the durability of a noble metal coated CVC (the Bactiguard Infectious Protection, BIP CVC) and compared with an uncoated CVC for clinical tolerability (Adverse Events, AEs) and performance, in order to create a baseline for a large future study. Patients undergoing major surgery, randomised at a 2:1 ratio to BIP CVC (n = 22) or standard CVC (n = 12), were catheterized 9 - 12 days, respectively. Adverse events, microbial colonization and metal release were measured.
    Findings: There were no AEs in the BIP CVC-group, but 5 AEs occurred in 4 patients (1 patient had 2 AEs) in the standard CVC-group, p = 0.011 (whereof 3 were catheter related). The BIP CVC showed an initial release of coating metals in blood (gold, silver and palladium), which rapidly decreased and were far below Permitted Paily Exposure (PDE) for chronical use. The levels of silver concentration were far below those needed to develop microbial resistance. The performance was equal, and there was no difference concerning microbial colonization, for the two CVCs.
    Conclusion: In this pilot study the BIP CVC had significantly lower AEs and showed a comparable performance to the standard CVC. The coating was durable throughout the study length (up to 16 days) and toxicological evaluation showed good safety margins. Larger studies are needed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2337-2344, 2018.
    MeSH term(s) Adult ; Alloys/administration & dosage ; Alloys/adverse effects ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/prevention & control ; Central Venous Catheters ; Coated Materials, Biocompatible/administration & dosage ; Coated Materials, Biocompatible/adverse effects ; Female ; Humans ; Male ; Time Factors
    Chemical Substances Alloys ; Coated Materials, Biocompatible
    Language English
    Publishing date 2017-11-06
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.34041
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