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  1. Article ; Online: Douglas D. Thomas named next Editor-in-Chief of

    Brüne, Bernhard

    Biological chemistry

    2020  Volume 402, Issue 1, Page(s) 3–4

    MeSH term(s) Biochemistry/history ; History, 20th Century ; History, 21st Century ; Humans ; Periodicals as Topic/history
    Language English
    Publishing date 2020-11-25
    Publishing country Germany
    Document type Biography ; Editorial ; Historical Article ; Portrait
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2020-0357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Rapid glycolytic activation accompanying innate immune responses: mechanisms and function.

    Namgaladze, Dmitry / Brüne, Bernhard

    Frontiers in immunology

    2023  Volume 14, Page(s) 1180488

    Abstract: Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines ... ...

    Abstract Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines and other effector molecules. Innate immune cells also rapidly rewire their metabolism. The most prominent metabolic alteration following innate immune activation is rapid up-regulation of glycolysis. In this mini-review, we summarize recent advances regarding the mechanisms of rapid glycolytic activation in innate immune cells, highlighting the relevant signaling components. We also discuss the impact of glycolytic activation on inflammatory responses, including the recently elucidated links of metabolism and epigenetics. Finally, we highlight unresolved mechanistic details of glycolytic activation and possible avenues of future research in this area.
    MeSH term(s) Immunity, Innate ; Signal Transduction ; Receptors, Pattern Recognition/metabolism ; Cytokines/metabolism ; Glycolysis
    Chemical Substances Receptors, Pattern Recognition ; Cytokines
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1180488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Happy Birthday: Biological Chemistry is celebrating its 400th volume.

    Brüne, Bernhard

    Biological chemistry

    2019  Volume 401, Issue 1, Page(s) 1

    MeSH term(s) Biochemistry/history ; History, 20th Century ; History, 21st Century ; Humans ; Peer Review, Research
    Language English
    Publishing date 2019-11-06
    Publishing country Germany
    Document type Editorial ; Historical Article
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2019-0389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Murine Alox8 versus the human ALOX15B ortholog: differences and similarities.

    Palmer, Megan A / Benatzy, Yvonne / Brüne, Bernhard

    Pflugers Archiv : European journal of physiology

    2024  

    Abstract: Human arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S- ... ...

    Abstract Human arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S-chirality with singular reaction specificity, although they generate a different product pattern. Furthermore, while both enzymes utilize both esterified fatty acids and fatty acid hydro(pero)xides as substrates, they differ with respect to the orientation of the fatty acid in their substrate-binding pocket. While ALOX15B accepts the fatty acid "tail-first," Alox8 oxygenates the free fatty acid with its "head-first." These differences in substrate orientation and thus in regio- and stereospecificity are thought to be determined by distinct amino acid residues. Towards their biological function, both enzymes share a commonality in regulating cholesterol homeostasis in macrophages, and Alox8 knockdown is associated with reduced atherosclerosis in mice. Additional roles have been linked to lung inflammation along with tumor suppressor activity. This review focuses on the current knowledge of the enzymatic activity of human ALOX15B and murine Alox8, along with their association with diseases.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02961-w
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  5. Article ; Online: A graphical journey through iron metabolism, microRNAs, and hypoxia in ferroptosis.

    Fuhrmann, Dominik C / Brüne, Bernhard

    Redox biology

    2022  Volume 54, Page(s) 102365

    Abstract: Ferroptosis is an iron-dependent form of cell death, which is triggered by disturbed membrane integrity due to an overproduction of lipid peroxides. Induction of ferroptosis comprises several alterations, i.e. altered iron metabolism, response to ... ...

    Abstract Ferroptosis is an iron-dependent form of cell death, which is triggered by disturbed membrane integrity due to an overproduction of lipid peroxides. Induction of ferroptosis comprises several alterations, i.e. altered iron metabolism, response to oxidative stress, or lipid peroxide production. At the physiological level transcription, translation, and microRNAs add to the appearance and/or activity of building blocks that negatively or positively balance ferroptosis. Ferroptosis contributes to tissue damage in the case of, e.g., brain and heart injury but may be desirable to overcome chemotherapy resistance. For a more complete picture, it is crucial to also consider the cellular microenvironment, which during inflammation and in the tumor context is dominated by hypoxia. This graphical review visualizes basic mechanisms of ferroptosis, categorizes general inducers and inhibitors of ferroptosis, and puts a focus on microRNAs, iron homeostasis, and hypoxia as regulatory components.
    MeSH term(s) Ferroptosis/genetics ; Humans ; Hypoxia/genetics ; Iron/metabolism ; Lipid Peroxidation ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemical Substances MicroRNAs ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-06-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2022.102365
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  6. Article ; Online: Exosomal and Non-Exosomal MicroRNAs: New Kids on the Block for Cancer Therapy.

    Syed, Shahzad Nawaz / Brüne, Bernhard

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional ... ...

    Abstract MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional gene regulation, their utility in RNA therapeutics mostly relies on their biochemical nature and their assembly with other macromolecules. Release of extracellular miRs is broadly categorized into two different compositions, namely exosomal (extracellular vesicles) and non-exosomal. This nature of miRs not only affects the uptake into target cells but also poses a challenge and opportunity for RNA therapeutics in cancer. By virtue of their ability to act as mediators of intercellular communication in the tumor microenvironment, extracellular miRs perform both, depending upon the target cell and target landscape, pro- and anti-tumor functions. Tumor-derived miRs mostly perform pro-tumor functions, whereas host cell- or stroma-derived miRs are involved in anti-tumor activities. This review deals with the recent understanding of exosomal and non-exosomal miRs in the tumor microenvironment, as a tool for pro- and anti-tumor activity and prospective exploit options for cancer therapy.
    MeSH term(s) Exosomes/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Neoplasms/genetics ; Neoplasms/therapy ; Tumor Microenvironment/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094493
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  7. Article ; Online: miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages.

    Fuhrmann, Dominik C / Brüne, Bernhard

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 2, Page(s) 89

    Abstract: Human macrophages infiltrating hypoxic regions alter their metabolism, because oxygen becomes limited. Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha ...

    Abstract Human macrophages infiltrating hypoxic regions alter their metabolism, because oxygen becomes limited. Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha serine/threonine-protein kinase (Akt) signaling, which gets activated under reduced oxygen content. We noticed that micro RNA (miR)-193a-3p enhances Akt phosphorylation at threonine 308 under hypoxia. In detail, miR-193a-3p suppresses the protein abundance of phosphatase PTC7 homolog (PPTC7), which in turn increases Akt phosphorylation. Lowering PPTC7 expression by siRNA or overexpressing miR-193a-3p increases Akt phosphorylation. Vice versa, inhibition of miR-193a-3p attenuates Akt activation and prevents a subsequent increase of glycolysis under hypoxia. Excluding effects of miR-193a-3p and Akt on HIF expression, stabilization, and function, we noticed phosphorylation of 6 phosphofructo-2-kinase/fructose 2,6-bisphosphatase PFKFB3 in response to the PI3K/Akt/mTOR signaling cascade. Inhibition of PFKFB3 blocked an increased glycolytic flux under hypoxia. Apparently, miR-193a-3p balances Akt phosphorylation and dephosphorylation by affecting PPTC7 protein amount. Suppression of PPTC7 increases Akt activation and phosphorylation of PFKFB3, which culminates in higher rates of glycolysis under hypoxia.
    MeSH term(s) Cell Proliferation ; Glycolysis ; Humans ; Hypoxia/physiopathology ; Macrophages/metabolism ; Macrophages/pathology ; MicroRNAs/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphofructokinase-2/genetics ; Phosphofructokinase-2/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
    Chemical Substances MIRN193 microRNA, human ; MicroRNAs ; PFKFB3 protein, human (EC 2.7.1.105) ; Phosphofructokinase-2 (EC 2.7.1.105) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04146-z
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  8. Article: Cholesterol metabolism in the regulation of inflammatory responses.

    Bauer, Rebekka / Brüne, Bernhard / Schmid, Tobias

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1121819

    Abstract: The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving mediators, in the regulation of inflammation is well established. While the relevance of cholesterol in the context of atherosclerosis ...

    Abstract The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving mediators, in the regulation of inflammation is well established. While the relevance of cholesterol in the context of atherosclerosis is also widely accepted, the role of cholesterol and its biosynthetic precursors on inflammatory processes is less comprehensively described. In the present mini-review, we summarize the current understanding of the inflammation-regulatory properties of cholesterol and relevant biosynthetic intermediates taking into account the implications of different subcellular distributions. Finally, we discuss the inflammation-regulatory effect of cholesterol homeostasis in the context of SARS-CoV-2 infections.
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1121819
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  9. Book ; Online ; Thesis: Changes in RNA dynamics in the course of hypoxia in myeloid cells

    Bauer, Rebekka [Verfasser] / Brüne, Bernhard Akademischer Betreuer] / [Schmid, Tobias [Akademischer Betreuer] / Brüne, Bernhard Gutachter] / [Grösch, Sabine [Gutachter] / Boon, Reinier [Gutachter]

    2024  

    Author's details Rebekka Bauer ; Gutachter: Bernhard Brüne, Sabine Grösch, Reinier Boon ; Bernhard Brüne, Tobias Schmid
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article: Editorial: Resolution of inflammation: Mechanisms, mediators and biomarkers: Volume II.

    Patrignani, Paola / Brüne, Bernhard / Steinhilber, Dieter

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1100420

    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1100420
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