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  1. Article ; Online: Phenotype overlap in the natural history of asthma.

    Ricciardolo, Fabio L M / Guida, Giuseppe / Bertolini, Francesca / Di Stefano, Antonino / Carriero, Vitina

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 168

    Abstract: The heterogeneity of asthma makes it challenging to unravel the pathophysiologic mechanisms of the disease. Despite the wealth of research identifying diverse phenotypes, many gaps still remain in our knowledge of the disease's complexity. A crucial ... ...

    Abstract The heterogeneity of asthma makes it challenging to unravel the pathophysiologic mechanisms of the disease. Despite the wealth of research identifying diverse phenotypes, many gaps still remain in our knowledge of the disease's complexity. A crucial aspect is the impact of airborne factors over a lifetime, which often results in a complex overlap of phenotypes associated with type 2 (T2), non-T2 and mixed inflammation. Evidence now shows overlaps between the phenotypes associated with T2, non-T2 and mixed T2/non-T2 inflammation. These interconnections could be induced by different determinants such as recurrent infections, environmental factors, T-helper plasticity and comorbidities, collectively resulting in a complex network of distinct pathways generally considered as mutually exclusive. In this scenario, we need to abandon the concept of asthma as a disease characterised by distinct traits grouped into static segregated categories. It is now evident that there are multiple interplays between the various physiologic, cellular and molecular features of asthma, and the overlap of phenotypes cannot be ignored.
    MeSH term(s) Humans ; Asthma/diagnosis ; Asthma/genetics ; Phenotype ; Comorbidity ; Inflammation
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0201-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Which Therapy for Non-Type(T)2/T2-Low Asthma.

    Ricciardolo, Fabio L M / Carriero, Vitina / Bertolini, Francesca

    Journal of personalized medicine

    2021  Volume 12, Issue 1

    Abstract: Currently, the asthmatic population is divided into Type 2-high and non-Type 2/Type 2-low asthmatics, with 50% of patients belonging to one of the two groups. Differently from T2-high, T2-low asthma has not been clearly defined yet, and the T2-low ... ...

    Abstract Currently, the asthmatic population is divided into Type 2-high and non-Type 2/Type 2-low asthmatics, with 50% of patients belonging to one of the two groups. Differently from T2-high, T2-low asthma has not been clearly defined yet, and the T2-low patients are identified on the basis of the absence or non-predominant expression of T2-high biomarkers. The information about the molecular mechanisms underpinning T2-low asthma is scarce, but researchers have recognized as T2-low endotypes type 1 and type 3 immune response, and remodeling events occurring without inflammatory processes. In addition, the lack of agreed biomarkers reprents a challenge for the research of an effective therapy. The first-choice medication is represented by inhaled corticosteroids despite a low efficacy is reported for/in T2-low patients. However, macrolides and long-acting anti-muscarinic drugs have been recognized as efficacious. In recent years, clinical trials targeting biomarkers playing key roles in T3 and T1 immune pathways, alarmins, and molecules involved in neutrophil recruitment have provided conflicting results probably misleading (or biased) in patients' selection. However, further studies are warranted to achieve a precise characterization of T2-low asthma with the aim of defining a tailored therapy for each single asthmatic patient.
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12010010
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  3. Article ; Online: MicroRNAs as Biomarkers in Corticosteroid-Resistant/Neutrophilic Asthma: Still a Long Way to Go!

    Ricciardolo, Fabio L M / Carriero, Vitina / Bullone, Michela

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 1, Page(s) 4–6

    MeSH term(s) Adrenal Cortex Hormones ; Asthma ; Biomarkers ; Humans ; Inflammation ; MicroRNAs ; Sputum
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202004-1216ED
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  4. Article ; Online: The Practical Role of FEF

    Cirillo, Ignazio / Schiavetti, Irene / Ricciardolo, Fabio L M / Miraglia Del Giudice, Michele / Tosca, Maria Angela / Ciprandi, Giorgio

    American journal of rhinology & allergy

    2023  Volume 37, Issue 5, Page(s) 571–574

    Abstract: Allergic rhinitis (AR) is a relevant risk factor asthma as it may frequently precede asthma onset. There is evidence that lung function may be early impaired in AR patients. In this regard, the forced expiratory flow at 25%-75% of vital capacity ( ... ...

    Abstract Allergic rhinitis (AR) is a relevant risk factor asthma as it may frequently precede asthma onset. There is evidence that lung function may be early impaired in AR patients. In this regard, the forced expiratory flow at 25%-75% of vital capacity (FEF
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Adult ; Cross-Sectional Studies ; Nitric Oxide ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/epidemiology ; Asthma/diagnosis ; Asthma/epidemiology ; Bronchial Hyperreactivity
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/19458924231182272
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  5. Article ; Online: Which Therapy for Non-Type(T)2/T2-Low Asthma

    Fabio L. M. Ricciardolo / Vitina Carriero / Francesca Bertolini

    Journal of Personalized Medicine, Vol 12, Iss 10, p

    2021  Volume 10

    Abstract: Currently, the asthmatic population is divided into Type 2-high and non-Type 2/Type 2-low asthmatics, with 50% of patients belonging to one of the two groups. Differently from T2-high, T2-low asthma has not been clearly defined yet, and the T2-low ... ...

    Abstract Currently, the asthmatic population is divided into Type 2-high and non-Type 2/Type 2-low asthmatics, with 50% of patients belonging to one of the two groups. Differently from T2-high, T2-low asthma has not been clearly defined yet, and the T2-low patients are identified on the basis of the absence or non-predominant expression of T2-high biomarkers. The information about the molecular mechanisms underpinning T2-low asthma is scarce, but researchers have recognized as T2-low endotypes type 1 and type 3 immune response, and remodeling events occurring without inflammatory processes. In addition, the lack of agreed biomarkers reprents a challenge for the research of an effective therapy. The first-choice medication is represented by inhaled corticosteroids despite a low efficacy is reported for/in T2-low patients. However, macrolides and long-acting anti-muscarinic drugs have been recognized as efficacious. In recent years, clinical trials targeting biomarkers playing key roles in T3 and T1 immune pathways, alarmins, and molecules involved in neutrophil recruitment have provided conflicting results probably misleading (or biased) in patients’ selection. However, further studies are warranted to achieve a precise characterization of T2-low asthma with the aim of defining a tailored therapy for each single asthmatic patient.
    Keywords non-T2 asthma ; endotypes ; therapy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Uncontrolled asthma: A real-life experience.

    Ciprandi, Giorgio / Gallo, Fabio / Ricciardolo, Fabio L M

    Allergy and asthma proceedings

    2017  Volume 38, Issue 1, Page(s) e1–e2

    Language English
    Publishing date 2017-01-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2017.38.4019
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  7. Article ; Online: Uncontrolled asthma: A real-life experience.

    Ciprandi, Giorgio / Gallo, Fabio / Ricciardolo, Fabio L M

    Allergy and asthma proceedings

    2017  Volume 38, Issue 1, Page(s) 1–2

    MeSH term(s) Anti-Asthmatic Agents ; Asthma ; Forced Expiratory Volume ; Humans
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2017--01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2017.38.4019
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  8. Article ; Online: Oxidative and Nitrosative Stress in the Pathogenesis of Obstructive Lung Diseases of Increasing Severity.

    Di Stefano, Antonino / Maniscalco, Mauro / Balbi, Bruno / Ricciardolo, Fabio L M

    Current medicinal chemistry

    2020  Volume 27, Issue 42, Page(s) 7149–7158

    Abstract: The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide ... ...

    Abstract The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide anions (O
    MeSH term(s) Animals ; Antioxidants ; Humans ; Hydrogen Peroxide ; Nitrosative Stress ; Oxidation-Reduction ; Oxidative Stress ; Peroxidase/metabolism ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2020-06-04
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867327666200604165451
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  9. Article ; Online: Revisiting the role of exhaled nitric oxide in asthma.

    Ricciardolo, Fabio L M

    Current opinion in pulmonary medicine

    2014  Volume 20, Issue 1, Page(s) 53–59

    Abstract: Purpose of review: This review focuses on the most recent studies investigating fractional nitric oxide concentration in exhaled breath (FeNO) as a useful biomarker for identifying specific phenotypes in asthma and as a tool for asthma diagnosis, ... ...

    Abstract Purpose of review: This review focuses on the most recent studies investigating fractional nitric oxide concentration in exhaled breath (FeNO) as a useful biomarker for identifying specific phenotypes in asthma and as a tool for asthma diagnosis, monitoring and clinical decision-making.
    Recent findings: On the basis of the current literature, it has been highlighted that FeNO is a clinically relevant marker in various clinical aspects of asthma: FeNO is a predictor for developing asthma in persistent rhinitis or in infants with respiratory symptoms; FeNO contributes to identification of asthma phenotypes in both children and adults, also in relation to severity; FeNO is useful in monitoring the effectiveness of inhaled corticosteroids (including compliance) and biologic treatments like omalizumab; FeNO, in conjunction with symptom registration and lung function measurements, contributes to asthma diagnosis and optimizes asthma management.
    Summary: FeNO provides further information in distinguishing different phenotypes in asthma, allowing a much more appropriate control of the disease, especially in patients with difficult/severe asthma. In the future, it would be interesting to shed light on the hidden biological mechanisms responsible for low or normal FeNO values in symptomatic asthmatic patients.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/metabolism ; Biomarkers/metabolism ; Breath Tests ; Exhalation ; Humans ; Nitric Oxide/metabolism ; Phenotype ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000006
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  10. Article ; Online: A real-life comparison of the Asthma Control Test and Global Initiative for Asthma asthma control grading.

    Ciprandi, Giorgio / Gallo, Fabio / Ricciardolo, Fabio L M

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2016  Volume 117, Issue 6, Page(s) 725–727

    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2016.09.442
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