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  1. Article ; Online: Updated Clinical Review: Perioperative Use of Tranexamic Acid in Orthopedics and Other Surgeries.

    Pai B H, Poonam / Patel, Shivani / Lai, Yan H

    Advances in anesthesia

    2023  Volume 41, Issue 1, Page(s) 1–15

    Abstract: Tranexamic acid is a well-known antifibrinolytic that has numerous clinical indications, and it is efficacious and safe in many perioperative scenarios including patients with some thrombotic risks. However, further studies that characterize clinical ... ...

    Abstract Tranexamic acid is a well-known antifibrinolytic that has numerous clinical indications, and it is efficacious and safe in many perioperative scenarios including patients with some thrombotic risks. However, further studies that characterize clinical outcomes concerning dosing, timing, and routes in combination are needed in ultra high-risk populations.
    MeSH term(s) Humans ; Tranexamic Acid/therapeutic use ; Orthopedic Procedures/adverse effects ; Orthopedics ; Antifibrinolytic Agents/therapeutic use
    Chemical Substances Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632613-4
    ISSN 1878-0415 ; 0737-6146
    ISSN (online) 1878-0415
    ISSN 0737-6146
    DOI 10.1016/j.aan.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perioperative pain management for spine surgeries.

    Sikachi, Rutuja / Oliver, Lori-Ann / Oliver, Jodi-Ann / Pai B H, Poonam

    International anesthesiology clinics

    2023  Volume 62, Issue 1, Page(s) 28–34

    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 210757-0
    ISSN 1537-1913 ; 0020-5907
    ISSN (online) 1537-1913
    ISSN 0020-5907
    DOI 10.1097/AIA.0000000000000427
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    Zs.B 243: Show issues Location:
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  3. Article: Efficacy Of Quadratus Lumborum Blocks (QLBs) in Robotic Nephrectomy: A Retrospective Study.

    Pai B H, Poonam / Onayemi, Abimbola / Lai, Yan H

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36244

    Abstract: Introduction: Abdominal blocks such as quadratus lumborum block (QLB) have been used as an effective analgesic in abdominal surgeries. However, their efficacy in kidney surgery remains unknown. To the best of our knowledge, there are no clinical studies ...

    Abstract Introduction: Abdominal blocks such as quadratus lumborum block (QLB) have been used as an effective analgesic in abdominal surgeries. However, their efficacy in kidney surgery remains unknown. To the best of our knowledge, there are no clinical studies exploring the relationship between QLBs and post-operative opioid consumption in robotic laparoscopic nephrectomy.
    Objectives: To assess the analgesic efficacy of QLB and its impact on perioperative opioid consumption in robotic laparoscopic nephrectomy.
    Materials and methods: A retrospective chart review was conducted by querying the electronic medical record system of a 2,200-bed tertiary academic hospital center in New York City. The primary measured outcome was postoperative morphine milligram equivalents (MME) consumption for the first 24 hours. Secondary outcomes include intra-operative MME as well as postoperative pain scores measured on a visual analogue scale (VAS) scale at 2, 6, 12, 18, and 24 hours postoperatively.
    Results: The mean total postoperative MME in the posterior QLB (pQLB) group was 11 in the QLB group (interquartile range (IQR) 4, 18) and 15 in the control group (IQR 5.6, 28) . There was a significant reduction in intraoperative MME in the QLB group in comparison to the control group. This reduction was not seen in postoperative MME. There was no significant difference in pain scores at any of the measured time points up to 24 hours postoperatively.
    Conclusion: Our study provides compelling support that ultrasound guided QLB significantly decreased intraoperative opioid requirements but did not have the same effect on postoperative opioid requirements following robotic kidney surgeries in the context of an enhanced recovery after surgery (ERAS) pathway.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36244
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  4. Article ; Online: Feasibility and Efficacy of Low Thoracic Ultrasound-Guided Erector Spinae Plane Blocks in Patients Undergoing Radical Total Mastectomy With Deep Inferior Epigastric Perforator Flap Reconstruction.

    Pai B H, Poonam / Lai, Yan H

    Annals of plastic surgery

    2022  Volume 89, Issue 6, Page(s) 656–659

    Abstract: Abstract: The analgesic efficacy of bilateral low thoracic erector spinae blocks for combined major breast and abdominal surgery has not been reported. The aim of this case series was to assess the feasibility and efficacy of T8 thoracic preincisional ... ...

    Abstract Abstract: The analgesic efficacy of bilateral low thoracic erector spinae blocks for combined major breast and abdominal surgery has not been reported. The aim of this case series was to assess the feasibility and efficacy of T8 thoracic preincisional erector spinae blocks in patients undergoing total radical mastectomies with axillary lymph node dissections in addition to reconstruction with abdominal deep inferior epigastric flaps. The aim was to supply dermatomal coverage to provide analgesia for T2-L1 that formed the basis for an opioid-sparing multimodal technique in the context of our early recovery after breast surgery with deep inferior epigastric flap program.
    MeSH term(s) Humans ; Female ; Perforator Flap ; Mastectomy, Simple ; Mastectomy ; Breast Neoplasms/surgery ; Feasibility Studies ; Mastectomy, Radical ; Nerve Block/methods ; Ultrasonography, Interventional
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000003290
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    Zs.A 1419: Show issues Location:
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  5. Article ; Online: Regional anesthesia and pain medicine.

    Pai B H, Poonam / Lai, Yan H

    Regional anesthesia and pain medicine

    2021  Volume 47, Issue 2, Page(s) 144–145

    MeSH term(s) Analgesics/therapeutic use ; Anesthesia, Conduction/adverse effects ; Humans ; Pain/drug therapy
    Chemical Substances Analgesics
    Language English
    Publishing date 2021-07-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2021-102939
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    Zs.B 2399: Show issues Location:
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  6. Article ; Online: Successful management of subglottic stenosis in pregnancy.

    Fang, Shenghao / Pai B H, Poonam

    BMJ case reports

    2021  Volume 14, Issue 3

    Abstract: Evaluation and management of subglottic stenosis in pregnancy is challenging. It often is not only a multidisciplinary approach between obstetricians, otolaryngologists (ENT surgeons) and anesthesiologists, but also requires a thorough understanding of ... ...

    Abstract Evaluation and management of subglottic stenosis in pregnancy is challenging. It often is not only a multidisciplinary approach between obstetricians, otolaryngologists (ENT surgeons) and anesthesiologists, but also requires a thorough understanding of possible foreseen complications by the patient as well. Hence, whenever we are presented with a challenging case requiring multidisciplinary approach involving team of physicians from different specialties, it is routine practice to huddle regarding the preoperative, intraoperative and postoperative management and care. We present a case of a 37-year-old woman with a known history of idiopathic subglottic stenosis, 16 weeks' pregnant, G4P1, with a surgical history significant for two previous subglottic dilations in the past and who now presented with an audible stridor and shortness of breath on activity. We highlighted the unique challenges encountered and the corresponding management adopted. This is a case of successful management of symptomatic worsening of subglottic stenosis managed during pregnancy.
    MeSH term(s) Adult ; Constriction, Pathologic ; Dilatation ; Female ; Humans ; Laryngostenosis/diagnosis ; Laryngostenosis/surgery ; Pregnancy ; Respiratory Sounds
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236466
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  7. Article ; Online: Endo tracheal tube exchange in a COVID positive patient.

    Onayemi, Abimbola / Pai B H, Poonam

    Journal of clinical anesthesia

    2020  Volume 66, Page(s) 109941

    MeSH term(s) COVID-19 ; Humans ; Intubation, Intratracheal/adverse effects ; Respiration ; Respiration, Artificial ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2020.109941
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    Zs.A 2622: Show issues Location:
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  8. Article: Cross-sectional study on utilisation of social media by regional anaesthesia and acute pain medicine fellowship programs in the United States.

    Hong, Janet / Siddique, Usama / Echevarria, Ghislaine / Patel, Alopi / Lai, Yan H / Pai, B H Poonam

    Journal of anaesthesiology, clinical pharmacology

    2023  Volume 39, Issue 4, Page(s) 571–576

    Abstract: Background and aims: Social media provides a platform for physicians helping them change the practice in anaesthesiology as it promotes both personal and professional growth. In this cross-sectional study, we identify social media presence and ... ...

    Abstract Background and aims: Social media provides a platform for physicians helping them change the practice in anaesthesiology as it promotes both personal and professional growth. In this cross-sectional study, we identify social media presence and engagement of Accreditation Council for Graduate Medical Education (ACGME)-accredited Regional Anesthesia and Acute Pain Medicine (RAAPM) fellowship programs, specifically on Twitter (Twitter Inc., San Francisco, CA) and Instagram (Meta Platforms Inc., Menlo Park, CA). This article presents current evidence about social media presence and engagement of ACGME-accredited RAAPM fellowship programs on Twitter and Instagram. These findings could potentially help cultivate greater social media engagement in the RAAPM community and improve recruitment of prospective applicants.
    Material and methods: The list of ACGME-accredited RAAPM fellowship programs for the academic year 2020-2021 was obtained from the ACGME website. Accounts were searched by reviewing each program's website for profile links and by querying for the name of the program directly on Twitter and Instagram. Department of Anesthesiology, Perioperative and Pain Medicine accounts were analysed for posts pertaining to RAAPM elements, and RAAPM fellowship-specific accounts were investigated. Accounts that were solely focused on an anaesthesiology residency were excluded. All posts over the academic year period of 1 July 2020 to 30 June 2021 were analyzed.
    Results: While many programs had active departmental social media accounts during our study, there was a dearth of RAAPM-related output (3.4% of tweets and 2.7% Instagram posts). Furthermore, only 10% of programs had RAAPM fellowship-specific Twitter accounts, of which only 5% of programs were active. Finally, there were no RAAPM fellowship-specific Instagram accounts.
    Conclusions: While there is robust use of social media by departmental accounts, there is a paucity of RAAPM-related content and RAAPM fellowship-specific social media accounts. The current gap provides valuable opportunities for future investigations into the cyber footprint and innovative engagement strategies for the RAAPM community.
    Language English
    Publishing date 2023-12-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 1401760-x
    ISSN 0970-9185
    ISSN 0970-9185
    DOI 10.4103/joacp.joacp_149_23
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    Zs.A 4830: Show issues Location:
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  10. Article ; Online: Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19.

    Poonam, Pai B H / Koscik, Rebecca / Nguyen, Trong / Rikhi, Shefali / Lin, Hung-Mo

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0270646

    Abstract: Objective: To compare the efficacy and outcomes with inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO) in patients with refractory hypoxemia due to COVID-19.: Design: Retrospective Cohort Study.: Setting: Single health system multicenter ... ...

    Abstract Objective: To compare the efficacy and outcomes with inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO) in patients with refractory hypoxemia due to COVID-19.
    Design: Retrospective Cohort Study.
    Setting: Single health system multicenter academic teaching hospitals.
    Patients or subjects: Age group of 18-80 years admitted to the medical ICU.
    Interventions: Mechanically ventilated patients with COVID-19 infection, who received either iNO or iEPO between March 1st, 2020, and June 30th, 2020.
    Measurements and main results: The primary outcome was the change in the PaO2/FiO2 (P/F) ratio 1 hour after initiation of pulmonary vasodilator therapy. Secondary outcomes include P/F ratios on days 1-3 after initiation, positive response in P/F ratio (increase of at least 20% in PaO2), total days of treatment, rebound hypoxemia (if there was a drop in oxygen saturation after treatment was stopped), ventilator free days (if any patient was extubated), days in ICU, days to extubation, days to tracheostomy, mortality days after intubation, 30-day survival and mortality. 183 patients were excluded, as they received both iNO and iEPO. Of the remaining 103 patients, 62 received iEPO and 41 received iNO. The severity of ARDS was similar in both groups. Change in P/F ratio at one hour was 116 (70.3) with iNO and 107 (57.6) with iEPO (Mean/SD). Twenty-two (53.7%) patients in the iNO group and 25 (40.3%) in the iEPO group were responders to pulmonary vasodilators n(%)(p = 0.152) (more than 20% increase in partial pressure of oxygen, Pao2), and 18 (43.9%) and 31 (50%) patients in the iNO and iEPO group (p = 0.685), respectively, had rebound hypoxemia. Only 7 patients in the cohort achieved ventilator free days (3 in the iEPO group and 4 in iNO group).
    Conclusions: We found no significant difference between iNO and iEPO in terms of change in P/F ratio, duration of mechanical ventilation, ICU, in-hospital mortality in this cohort of mechanically ventilated patients with COVID-19. Larger, prospective studies are necessary to validate these results.
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/drug therapy ; Epoprostenol/therapeutic use ; Humans ; Hypoxia/drug therapy ; Middle Aged ; Nitric Oxide/therapeutic use ; Oxygen/therapeutic use ; Prospective Studies ; Retrospective Studies ; Vasodilator Agents/therapeutic use ; Young Adult
    Chemical Substances Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Epoprostenol (DCR9Z582X0) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270646
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