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  1. Article: From predator to protector:

    Han, Jian / Dong, Zhiming / Ji, Wenbo / Lv, Wen / Luo, Ming / Fu, Benzhong

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1378288

    Abstract: Fire blight, caused by the Gram-negative ... ...

    Abstract Fire blight, caused by the Gram-negative bacterium
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1378288
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  2. Article: [Progress in research on mRNA therapeutics for the treatment of genetic diseases].

    Shi, Wenjun / Cheng, Xianshuo / Luo, Pei / Ma, Jilong / Dong, Jian

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2024  Volume 41, Issue 3, Page(s) 368–376

    Abstract: In recent years, mRNA drugs have shown a great potential for the treatment of genetic diseases and attracted the attention of many researchers. This article has reviewed the advance in the research of mRNA drugs for the treatment of genetic diseases over ...

    Abstract In recent years, mRNA drugs have shown a great potential for the treatment of genetic diseases and attracted the attention of many researchers. This article has reviewed the advance in the research of mRNA drugs for the treatment of genetic diseases over the past 30 years, including their mechanisms of action and structure design, with a focus on their advantages as alternative therapies such as high specificity, low dosage, and sustained expression. Meanwhile, challenges for the effective delivery and storage methods for the mRNA drugs are discussed, with an aim to provide guidance for subsequent researches.
    MeSH term(s) Humans ; RNA, Messenger/genetics
    Chemical Substances RNA, Messenger
    Language Chinese
    Publishing date 2024-03-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/cma.j.cn511374-20230203-00051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.

    Luo, Pengren / Yang, Jinhong / Jian, Lipeng / Dong, Jigen / Yin, Shi / Luo, Chao / Zhou, Shuai

    International journal of oncology

    2024  Volume 64, Issue 5

    Abstract: Glioma is the most common type of primary intracranial malignant tumor, and because of its high invasiveness and recurrence, its prognosis remains poor. The present study investigated the biological function of piggyBac transportable element derived 5 ( ... ...

    Abstract Glioma is the most common type of primary intracranial malignant tumor, and because of its high invasiveness and recurrence, its prognosis remains poor. The present study investigated the biological function of piggyBac transportable element derived 5 (PGBD5) in glioma. Glioma and para-cancerous tissues were obtained from five patients. Reverse transcription-quantitative PCR and western blotting were used to detect the expression levels of PGBD5. Transwell assay and flow cytometry were used to evaluate cell migration, invasion, apoptosis and cell cycle distribution. In addition, a nude mouse tumor transplantation model was established to study the downstream pathways of PGBD5 and the molecular mechanism was analyzed using transcriptome sequencing. The mRNA and protein expression levels of PGBD5 were increased in glioma tissues and cells. Notably, knockdown of PGBD5
    MeSH term(s) Animals ; Mice ; Humans ; Peroxisome Proliferator-Activated Receptors/metabolism ; Up-Regulation ; Cell Line, Tumor ; Glioma/pathology ; Transcription Factors/genetics ; Brain Neoplasms/pathology ; Cell Proliferation/genetics ; Apoptosis/genetics ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Transposases/genetics ; Transposases/metabolism
    Chemical Substances Peroxisome Proliferator-Activated Receptors ; Transcription Factors ; PGBD5 protein, human (EC 2.7.7.-) ; Transposases (EC 2.7.7.-)
    Language English
    Publishing date 2024-04-05
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1154403-x
    ISSN 1791-2423 ; 1019-6439
    ISSN (online) 1791-2423
    ISSN 1019-6439
    DOI 10.3892/ijo.2024.5643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3690: Show issues Location:
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  4. Article ; Online: Kinetic Study on the Crystal Transformation of Fe-Doped TiO

    Zhang, Lu / Luo, Xian / Zhang, Jian-Dong / Long, Yong-Fu / Xue, Xin / Xu, Ben-Jun

    ACS omega

    2021  Volume 6, Issue 1, Page(s) 965–975

    Abstract: Titanium dioxide ( ... ...

    Abstract Titanium dioxide (TiO
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c05609
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  5. Article: Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation

    Luo, Zhu-Lin / Sun, Hong-Yu / Wu, Xiao-Bo / Cheng, Long / Ren, Jian-Dong

    Food & function. 2021 June 21, v. 12, no. 12

    2021  

    Abstract: Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has ... ...

    Abstract Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has been reported to offer protection against inflammation-driven tissue damage. Here, we evaluated the protective effects of EGCG against lung injury during acute pancreatitis (AP) and further revealed the detailed mechanism. The results showed that EGCG significantly attenuated l-arginine-induced AP and the consequent pulmonary damage in mice. Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung. In vitro, EGCG considerably reduced the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA) in alveolar macrophages (AMs) challenged with AP-conditioned plasma. Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation. In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO. Altogether, EGCG possesses potent activity to attenuate lung injury during AP progression by inhibiting NLRP3 inflammasome activation. As for the mechanism, the EGCG-conferred restriction of NLRP3 inflammasome activation probably arises from the elimination of mtROS as well as its oxidative product ox-mtDNA, which consequently enables the protection against AP-associated lung injury.
    Keywords antagonism ; beverages ; chemoprevention ; epigallocatechin gallate ; green tea ; health promotion ; inflammasomes ; lungs ; macrophages ; mitochondria ; mitochondrial DNA ; oxidative stress ; pancreatitis ; polyphenols ; reactive oxygen species ; rotenone
    Language English
    Dates of publication 2021-0621
    Size p. 5658-5667.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo01154e
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: TFRC-RNA interactions show the regulation of gene expression and alternative splicing associated with IgAN in human renal tubule mesangial cells.

    Li, Jian-Si / Chen, Xiao / Luo, Ailing / Chen, Dong

    Frontiers in genetics

    2023  Volume 14, Page(s) 1176118

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1176118
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  7. Article ; Online: Structural characterization and anti-oxidative activity for a glycopeptide from Ganoderma lucidum fruiting body.

    Luo, Hong-Jian / Zhang, Yu-Kun / Wang, Sai-Zhen / Lin, Shu-Qian / Wang, Lian-Fu / Lin, Zhan-Xi / Lu, Guo-Dong / Lin, Dong-Mei

    International journal of biological macromolecules

    2024  Volume 261, Issue Pt 2, Page(s) 129793

    Abstract: A water-soluble glycopeptide (named GL- ... ...

    Abstract A water-soluble glycopeptide (named GL-PWQ
    MeSH term(s) Reishi/chemistry ; Spectroscopy, Fourier Transform Infrared ; Polysaccharides/chemistry ; Glucose/analysis ; Molecular Weight ; Water
    Chemical Substances Polysaccharides ; Glucose (IY9XDZ35W2) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129793
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    Zs.B 2374: Show issues Location:
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  8. Article ; Online: Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation.

    Luo, Zhu-Lin / Sun, Hong-Yu / Wu, Xiao-Bo / Cheng, Long / Ren, Jian-Dong

    Food & function

    2021  Volume 12, Issue 12, Page(s) 5658–5667

    Abstract: Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has ... ...

    Abstract Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has been reported to offer protection against inflammation-driven tissue damage. Here, we evaluated the protective effects of EGCG against lung injury during acute pancreatitis (AP) and further revealed the detailed mechanism. The results showed that EGCG significantly attenuated l-arginine-induced AP and the consequent pulmonary damage in mice. Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung. In vitro, EGCG considerably reduced the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA) in alveolar macrophages (AMs) challenged with AP-conditioned plasma. Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation. In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO. Altogether, EGCG possesses potent activity to attenuate lung injury during AP progression by inhibiting NLRP3 inflammasome activation. As for the mechanism, the EGCG-conferred restriction of NLRP3 inflammasome activation probably arises from the elimination of mtROS as well as its oxidative product ox-mtDNA, which consequently enables the protection against AP-associated lung injury.
    MeSH term(s) Acute Lung Injury/metabolism ; Animals ; Antioxidants/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; DNA, Mitochondrial/metabolism ; Disease Models, Animal ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/metabolism ; Lung/pathology ; Lung Injury/drug therapy ; Lung Injury/pathology ; Male ; Mice ; Mitochondria/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pancreatitis/drug therapy ; Reactive Oxygen Species/metabolism ; Tea/chemistry
    Chemical Substances Antioxidants ; DNA, Mitochondrial ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Reactive Oxygen Species ; Tea ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL)
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo01154e
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  9. Article ; Online: Extinction by plasmonic nanoparticles in dispersive and dissipative media.

    Zhang, Shangyu / Dong, Jian / Zhang, Wenjie / Luo, Minggang / Liu, Linhua

    Optics letters

    2023  Volume 47, Issue 21, Page(s) 5577–5580

    Abstract: Extinction of small metallic spheres has been well understood through the classical Mie theory when the host medium is dispersive and transparent. However, the role of host dissipation on the particulate extinction remains a competition between the ... ...

    Abstract Extinction of small metallic spheres has been well understood through the classical Mie theory when the host medium is dispersive and transparent. However, the role of host dissipation on the particulate extinction remains a competition between the enhancing and reducing effects on the localized surface plasmonic resonance (LSPR). Here, using a generalized Mie theory, we elaborate on the specific influence mechanisms of host dissipation on the extinction efficiency factors of a plasmonic nanosphere. To this end, we isolate the dissipative effects by comparing the dispersive and dissipative host with its dissipationless counterpart. As a result, we identify the damping effects of host dissipation on the LSPR including the resonance widening and amplitude reducing. The resonance positions are shifted by host dissipation, which cannot be predicted by the classical Fröhlich condition. Finally, we demonstrate that a wideband extinction enhancement due to host dissipation can be realized away from the positions of the LSPR.
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.474771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.

    Guo, Hui-Hui / Shen, Hao-Ran / Wang, Lu-Lu / Luo, Zhi-Gang / Zhang, Jin-Lan / Zhang, Hong-Juan / Gao, Tian-Le / Han, Yan-Xing / Jiang, Jian-Dong

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 163, Page(s) 114754

    Abstract: Metformin (MTF) and berberine (BBR) share several therapeutic benefits in treating metabolic-related disorders. However, as the two agents have very different chemical structure and bioavailability in oral route, the goal of this study is to learn their ... ...

    Abstract Metformin (MTF) and berberine (BBR) share several therapeutic benefits in treating metabolic-related disorders. However, as the two agents have very different chemical structure and bioavailability in oral route, the goal of this study is to learn their characteristics in treating metabolic disorders. The therapeutic efficacy of BBR and MTF was systemically investigated in the high fat diet feeding hamsters and/or ApoE
    MeSH term(s) Cricetinae ; Mice ; Animals ; Metformin/pharmacology ; Metformin/therapeutic use ; Berberine/pharmacology ; Berberine/therapeutic use ; Obesity/drug therapy ; Hyperlipidemias/drug therapy ; Lipids/therapeutic use
    Chemical Substances Metformin (9100L32L2N) ; Berberine (0I8Y3P32UF) ; Lipids
    Language English
    Publishing date 2023-04-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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