LIVIVO - Search results -

Search results

Result 1 - 10 of total 20

Search options

Article ; Online: Molecular pathology of human knee arthrofibrosis defined by RNA sequencing.

Bayram, Banu / Limberg, Afton K / Salib, Christopher G / Bettencourt, Jacob W / Trousdale, William H / Lewallen, Eric A / Reina, Nicolas / Paradise, Christopher R / Thaler, Roman / Morrey, Mark E / Sanchez-Sotelo, Joaquin / Berry, Daniel J / van Wijnen, Andre J / Abdel, Matthew P

Genomics

2020 Volume 112, Issue 4, Page(s) 2703–2712

Abstract: Arthrofibrosis is an abnormal histopathologic response, is debilitating for patients, and poses a substantial unsolved clinical challenge. This study characterizes molecular biomarkers and regulatory pathways associated with arthrofibrosis by comparing ... ...

Abstract	Arthrofibrosis is an abnormal histopathologic response, is debilitating for patients, and poses a substantial unsolved clinical challenge. This study characterizes molecular biomarkers and regulatory pathways associated with arthrofibrosis by comparing fibrotic and non-fibrotic human knee tissue. The fibrotic group encompasses 4 patients undergoing a revision total knee arthroplasty (TKA) for arthrofibrosis (RTKA-A) while the non-fibrotic group includes 4 patients undergoing primary TKA for osteoarthritis (PTKA) and 4 patients undergoing revision TKA for non-arthrofibrotic and non-infectious etiologies (RTKA-NA). RNA-sequencing of posterior capsule specimens revealed differences in gene expression between each patient group by hierarchical clustering, principal component analysis, and correlation analyses. Multiple differentially expressed genes (DEGs) were defined in RTKA-A versus PTKA patients (i.e., 2059 up-regulated and 1795 down-regulated genes) and RTKA-A versus RTKA-NA patients (i.e., 3255 up-regulated and 3683 down-regulated genes). Our findings define molecular and pathological markers of arthrofibrosis, as well as novel potential targets for risk profiling, early diagnosis and pharmacological treatment of patients.
MeSH term(s)	Arthroplasty, Replacement, Knee ; Fibrosis ; Gene Expression Regulation ; Gene Ontology ; Humans ; Knee Joint/metabolism ; Knee Joint/pathology ; Knee Joint/surgery ; RNA-Seq ; Reoperation ; Transcriptome
Language	English
Publishing date	2020-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2020.03.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Photodynamic therapy: occupational hazards and preventative recommendations for clinical administration by healthcare providers.

Breskey, John D / Lacey, Steven E / Vesper, Benjamin J / Paradise, William A / Radosevich, James A / Colvard, Michael D

Photomedicine and laser surgery

2013 Volume 31, Issue 8, Page(s) 398–407

Abstract: Objective: Photodynamic therapy (PDT) as a medical treatment for cancers is an increasing practice in clinical settings, as new photosensitizing chemicals and light source technologies are developed and applied. PDT involves dosing patients with ... ...

Abstract	Objective: Photodynamic therapy (PDT) as a medical treatment for cancers is an increasing practice in clinical settings, as new photosensitizing chemicals and light source technologies are developed and applied. PDT involves dosing patients with photosensitizing drugs, and then exposing them to light using a directed energy device in order to manifest a therapeutic effect. Healthcare professionals providing PDT should be aware of potential occupational health and safety hazards posed by these treatment devices and photosensitizing agents administered to patients. Materials and methods: Here we outline and identify pertinent health and safety considerations to be taken by healthcare staff during PDT procedures. Results: Physical hazards (for example, non-ionizing radiation generated by the light-emitting device, with potential for skin and eye exposure) and chemical hazards (including the photosensitizing agents administered to patients that have the potential for exposure via skin, subcutaneous, ingestion, or inhalation routes) must be considered for safe use of PDT by the healthcare professional. Conclusions: Engineering, administrative, and personal protective equipment controls are recommendations for the safe use and handling of PDT agents and light-emitting technologies.
MeSH term(s)	Aminolevulinic Acid/therapeutic use ; Dihematoporphyrin Ether/therapeutic use ; Hematoporphyrin Photoradiation ; Humans ; Intense Pulsed Light Therapy/instrumentation ; Intense Pulsed Light Therapy/methods ; Lasers ; Occupational Exposure/prevention & control ; Occupational Health ; Photochemotherapy ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/therapeutic use ; Porphyrins/therapeutic use ; Safety Management ; Verteporfin
Chemical Substances	Photosensitizing Agents ; Porphyrins ; Verteporfin (0X9PA28K43) ; Aminolevulinic Acid (88755TAZ87) ; Dihematoporphyrin Ether (97067-70-4)
Language	English
Publishing date	2013-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2158446-1
ISSN	1557-8550 ; 1549-5418
ISSN (online)	1557-8550
ISSN	1549-5418
DOI	10.1089/pho.2013.3496
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1908: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture.

Salib, Christopher G / Reina, Nicolas / Trousdale, William H / Limberg, Afton K / Tibbo, Megan E / Jay, Anthony G / Robin, Joseph X / Turner, Travis W / Jones, Carter R / Paradise, Christopher R / Lewallen, Eric A / Bolon, Brad / Carter, Jodi M / Berry, Daniel J / Morrey, Mark E / Sanchez-Sotelo, Joaquin / van Wijnen, Andre J / Abdel, Matthew P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2019 Volume 37, Issue 12, Page(s) 2609–2620

Abstract: Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around a synovial joint leading to debilitating loss of motion. Treatment options are limited because ... ...

Abstract	Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around a synovial joint leading to debilitating loss of motion. Treatment options are limited because the pathologic mechanisms remain to be characterized. Dysregulation of the inflammatory cascade may lead to communication between myofibroblasts and immune cells triggering tissue metaplasia, and excessive collagen deposition described clinically as arthrofibrosis. We explored the novel use of celecoxib (selective cyclooxygenase-2 [COX-2] inhibitor) to disrupt the downstream effects of the post-traumatic inflammatory cascade and inhibit scar tissue formation in a validated rabbit model of arthrofibrosis combined with new parameters for quantifying the stiffness of the posterior capsule. Biomechanical and molecular analyses, of contracted rabbit knee posterior capsule tissue after COX-2 inhibition revealed increased maximal passive extension and down-regulation of collagen messenger RNA compared with controls. Histopathologic examination suggested a trend of decreased quantities of dense fibrous connective tissue with COX-2 inhibition. These data may suggest that inhibiting the inflammatory cascade could potentially reduce pathologic myofibroblast activation, thereby reducing scar tissue formation and increasing the range of motion in arthrofibrotic joints. Implementing a multi-modal pharmacologic approach may simultaneously target numerous cellular components contributing to the complex process of arthrofibrogenesis. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2609-2620, 2019.
MeSH term(s)	Animals ; Arthroplasty, Replacement, Knee/adverse effects ; Biomechanical Phenomena ; Celecoxib/pharmacology ; Collagen/metabolism ; Contracture/prevention & control ; Cyclooxygenase 2 Inhibitors/pharmacology ; Disease Models, Animal ; Female ; Fibrosis ; Joints/pathology ; Myofibroblasts/physiology ; Rabbits
Chemical Substances	Cyclooxygenase 2 Inhibitors ; Collagen (9007-34-5) ; Celecoxib (JCX84Q7J1L)
Language	English
Publishing date	2019-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.24441
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1879: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Insect species interactions and resource effects in treeholes: are helodid beetles bottom-up facilitators of midge populations?

Paradise, C J / Dunson, William A

Oecologia

1997 Volume 109, Issue 2, Page(s) 303–312

Abstract: The insect community living in central Pennsylvania treeholes in autumn consists primarily of larvae of two species of helodid beetles, Prionocyphon discoideus and Helodes pulchella, and larvae of one species of ceratopogonid midge,Culicoides guttipennis. ...

Abstract	The insect community living in central Pennsylvania treeholes in autumn consists primarily of larvae of two species of helodid beetles, Prionocyphon discoideus and Helodes pulchella, and larvae of one species of ceratopogonid midge,Culicoides guttipennis. We manipulated treehole volume and the densities of these insects in laboratory microcosms. We hypothesized that: (1) helodid beetle larvae, which are shredders, would enhance growth and survival of ceratopogonid midge larvae (deposit feeders) in a processing chain commensalism, and (2) the quantity of resources expressed as water volume plus leaf litter would affect helodids and protozoans directly. Intraspecific competition was not found in midges, nor was interspecific competition between the two helodid species. Protozoan population densities decreased or grew slower in the presence of insects and in smaller microcosms. Development time and adult wing length of the midge (C. guttipennis) were affected by both total microcosm volume and insect species combination. Under resource limitation, midges grew larger in the presence of helodids, and in general, midges were larger in treatments with higher ratios of helodids to midges. Water chemistry in the microcosms was affected both temporally and by insect presence. Hydrogen ion levels decreased over time, and microcosms with no insects had lower hydrogen ion levels. Specific conductance increased in all treatments over time, and microcosms with no insects had lower conductivity than most treatments. Helodid larvae have a positive effect on midges, possibly due to a processing chain facilitation. If helodids are keystone decomposers in this system, their presence could affect resource availability and affect other organisms in the community. Similar processing chain commensalisms occur in other phytotelmata. These types of interactions may therefore be important in the structure and function of detritus-based communities.
Language	English
Publishing date	1997-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s004420050088
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 70/109: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq.

Salib, Christopher G / Lewallen, Eric A / Paradise, Christopher R / Tibbo, Meagan E / Robin, Joseph X / Trousdale, William H / Morrey, Logan M / Xiao, Jason / Turner, Travis W / Limberg, Afton K / Jay, Anthony G / Thaler, Roman / Dudakovic, Amel / Sanchez-Sotelo, Joaquin / Morrey, Mark E / Berry, Daniel J / Lewallen, David G / van Wijnen, Andre J / Abdel, Matthew P

Genomics

2018 Volume 111, Issue 6, Page(s) 1404–1411

Abstract: Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue ... ...

Abstract	Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Case-Control Studies ; Female ; Foreign-Body Reaction/etiology ; Foreign-Body Reaction/metabolism ; Foreign-Body Reaction/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Metal-on-Metal Joint Prostheses/adverse effects ; Middle Aged ; Osteoarthritis/pathology ; Osteoarthritis/surgery ; Pathology, Molecular ; Prosthesis Failure/etiology ; Reoperation ; Synoviocytes/metabolism ; Synoviocytes/pathology ; Transcriptome
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2018.09.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nitric oxide: perspectives and emerging studies of a well known cytotoxin.

Paradise, William A / Vesper, Benjamin J / Goel, Ajay / Waltonen, Joshua D / Altman, Kenneth W / Haines, G Kenneth / Radosevich, James A

International journal of molecular sciences

2010 Volume 11, Issue 7, Page(s) 2715–2745

Abstract: The free radical nitric oxide (NO(*)) is known to play a dual role in human physiology and pathophysiology. At low levels, NO(*) can protect cells; however, at higher levels, NO(*) is a known cytotoxin, having been implicated in tumor angiogenesis and ... ...

Abstract	The free radical nitric oxide (NO()) is known to play a dual role in human physiology and pathophysiology. At low levels, NO() can protect cells; however, at higher levels, NO() is a known cytotoxin, having been implicated in tumor angiogenesis and progression. While the majority of research devoted to understanding the role of NO() in cancer has to date been tissue-specific, we herein review underlying commonalities of NO() which may well exist among tumors arising from a variety of different sites. We also discuss the role of NO() in human physiology and pathophysiology, including the very important relationship between NO() and the glutathione-transferases, a class of protective enzymes involved in cellular protection. The emerging role of NO() in three main areas of epigenetics-DNA methylation, microRNAs, and histone modifications-is then discussed. Finally, we describe the recent development of a model cell line system in which human tumor cell lines were adapted to high NO() (HNO) levels. We anticipate that these HNO cell lines will serve as a useful tool in the ongoing efforts to better understand the role of NO() in cancer.
MeSH term(s)	Animals ; Cytotoxins/metabolism ; Cytotoxins/pharmacology ; Epigenesis, Genetic ; Glutathione S-Transferase pi/metabolism ; Humans ; Models, Biological ; Neoplasms/genetics ; Neoplasms/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide/pharmacology ; Reactive Nitrogen Species/metabolism
Chemical Substances	Cytotoxins ; Reactive Nitrogen Species ; Nitric Oxide (31C4KY9ESH) ; Glutathione S-Transferase pi (EC 2.5.1.18)
Language	English
Publishing date	2010-07-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms11072715
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Application of immunohistochemical staining to detect antigen destruction as a measure of tissue damage.

Onul, Abdullah / Colvard, Michael D / Paradise, William A / Elseth, Kim M / Vesper, Benjamin J / Gouvas, Eftychia / Deliu, Zane / Garcia, Kelly D / Pestle, William J / Radosevich, James A

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2012 Volume 60, Issue 9, Page(s) 683–693

Abstract: Electrocautery and directed energy devices (DEDs) such as lasers, which are used in surgery, result in tissue damage that cannot be readily detected by traditional histological methods, such as hematoxylin and eosin staining. Alternative staining methods, ...

Abstract	Electrocautery and directed energy devices (DEDs) such as lasers, which are used in surgery, result in tissue damage that cannot be readily detected by traditional histological methods, such as hematoxylin and eosin staining. Alternative staining methods, including 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to stain live tissue, have been reported. Despite providing superior detection of damaged tissue relative to the hematoxylin and eosin (H&E) method, the MTT method possesses a number of drawbacks, most notably that it must be carried out on live tissue samples. Herein, we report the development of a novel staining method, "antigen destruction immunohistochemistry" (ADI), which can be carried out on paraffin-embedded tissue. The ADI method takes advantage of epitope loss to define the area of tissue damage and provides many of the benefits of live tissue MTT staining without the drawbacks inherent to that method. In addition, the authors provide data to support the use of antibodies directed at a number of gene products for use in animal tissue for which there are no species-specific antibodies commercially available, as well as an example of a species-specific direct antibody. Data are provided that support the use of this method in many tissue models, as well as evidence that ADI is comparable to the live tissue MTT method.
MeSH term(s)	Animals ; Antibodies ; Antibody Specificity ; Antigens/analysis ; Antigens/immunology ; Coloring Agents ; Cross Reactions ; Eosine Yellowish-(YS) ; Fixatives ; Formaldehyde ; Hematoxylin ; Hot Temperature ; Immunohistochemistry/methods ; Paraffin Embedding ; Protein Denaturation ; Protein Folding ; Receptor, ErbB-2/analysis ; Receptor, ErbB-2/immunology ; Staining and Labeling/methods ; Swine ; Tetrazolium Salts ; Thiazoles ; Tyrosine/analogs & derivatives ; Tyrosine/analysis ; Tyrosine/immunology
Chemical Substances	Antibodies ; Antigens ; Coloring Agents ; Fixatives ; Tetrazolium Salts ; Thiazoles ; Formaldehyde (1HG84L3525) ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U) ; Receptor, ErbB-2 (EC 2.7.10.1) ; thiazolyl blue (EUY85H477I) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
Keywords	covid19
Language	English
Publishing date	2012-06-21
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/0022155412452146
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.321: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Part I. Development of a model system for studying nitric oxide in tumors: high nitric oxide-adapted head and neck squamous cell carcinoma cell lines.

Yarmolyuk, Yaroslav R / Vesper, Benjamin J / Paradise, William A / Elseth, Kim M / Tarjan, Gabor / Haines, G Kenneth / Radosevich, James A

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

2010 Volume 32, Issue 1, Page(s) 77–85

Abstract: The free radical nitric oxide (NO) is over-expressed in many tumors, including head and neck squamous cell carcinomas (HNSCC); however, the role NO plays in tumor pathophysiology is still not well understood. We, herein, report the development of an in ... ...

Abstract	The free radical nitric oxide (NO) is over-expressed in many tumors, including head and neck squamous cell carcinomas (HNSCC); however, the role NO plays in tumor pathophysiology is still not well understood. We, herein, report the development of an in vitro model system which can be used to probe the role of NO in the carcinogenesis of HNSCC. Five HNSCC cell lines were adapted to a high NO (HNO) environment by gradually introducing increasing concentrations of DETA-NONOate, a nitrogen-based NO donor, to cell media. The adaptation process was carried out until a sufficiently high enough donor concentration was reached which enabled the HNO cells to survive and grow, but which was lethal to the original, unadapted ("parent") cells. The adapted HNO cells exhibited analogous morphology to the parent cells, but grew better than their corresponding parent cells in normal media, on soft agar, and in the presence of hydrogen peroxide, an oxygen-based free radical donor. These results indicate that the HNO cell lines are unique and possess biologically different properties than the parent cell lines from which they originated. The HNO/parent cell lines developed herein may be used as a model system to better understand the role NO plays in HNSCC carcinogenesis.
MeSH term(s)	Adaptation, Physiological/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Hydrogen Peroxide/pharmacology ; Models, Biological ; Nitric Oxide/metabolism ; Nitric Oxide Donors/pharmacology ; Nitroso Compounds/pharmacology ; Oxidants/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Nitric Oxide Donors ; Nitroso Compounds ; Oxidants ; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine (146724-94-9) ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2010-10-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	605825-5
ISSN	1423-0380 ; 0289-5447 ; 1010-4283
ISSN (online)	1423-0380
ISSN	0289-5447 ; 1010-4283
DOI	10.1007/s13277-010-0101-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1598: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq

Genomics. 2019 Dec., v. 111, no. 6

2019

Abstract	Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular synovial tissues of patients with MoM THA failure undergoing revision THA compared to patients undergoing primary THA for routine osteoarthritis (OA). Analysis of tissue biopsies by RNA-sequencing (RNA-seq) revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling. Thus, interplay between local tissue inflammation and ECM degradation may account for the pathology and compromised clinical outcomes in select patients with MoM implants. We conclude that adverse responses of host tissues to implant materials result in transcriptomic modifications in patients with MoM implants that permit consideration of strategies that could mitigate ECM damage.
Keywords	biopsy ; extracellular matrix ; gene expression ; genes ; hips ; immune response ; inflammation ; osteoarthritis ; pain ; patients ; sequence analysis ; survival rate ; transcriptomics
Language	English
Dates of publication	2019-12
Size	p. 1404-1411.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2018.09.013
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 2367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Journal: Relationship of Atmospheric Deposition to the Water Chemistry and Biota of Treehole Habitats

Paradise, Christopher J. / Dunson, William A.

Environmental Toxicology and Chemistry

1998 Volume 17, Page(s) 362–368

Abstract: Es wurde die Wasserchemie von Regen und Stammablaufwasser an Baeumen in Zusammenhang mit der Invertebratenfauna in Baumhoehlen in Pennsylvania (USA) untersucht. Im Gebiet des suedwestlichen Plateaus wurden signifikant hoehere SO4-Konzentrationen und ... ...

Abstract	Es wurde die Wasserchemie von Regen und Stammablaufwasser an Baeumen in Zusammenhang mit der Invertebratenfauna in Baumhoehlen in Pennsylvania (USA) untersucht. Im Gebiet des suedwestlichen Plateaus wurden signifikant hoehere SO4-Konzentrationen und niedrigere pH-Werte gemessen als in der zentralen Talregion und in der oestlichen Bergkette. Diese Ergebnisse korrelierten mit hoeherem SO4-Gehalt im Regen in der Plateauregion. Ausserdem liess die hoehere Konzentration von SO4 im Stammablaufwasser als im Regen auf einen deutlichen Einfluss von trockener Ablagerung an Bauemen auf die Wasserchemie der Baumhoehlen schliessen. Auch andere chemische Parameter im Regen und Stammablaufwasser korrelierten mit der Wasserchemie der Baumhoehlen. Es konnten keine regionalen Unterschiede in der Zusammensetzung der Baumhoehlenfauna festgestellt werden, jedoch korrelierte die Dichte der Insekten und der Artenreichtum mit dem Wasservolumen und dem Gehalt an SO4, Na und geloestem organischem Kohlenstoff.
Keywords	Insekt ; Ablagerung ; pH-Wert ; Kenngroesse ; Diversitaet ; Regionale Differenzierung ; Gesamter organischer Kohlenstoff ; Habitat ; Wald ; Wassergehalt ; Regen ; Hydrochemie ; Niederschlagswasser ; Baumstamm ; Sulfat ; Schadstoffdeposition ; Magnesium ; Kalium ; Immissionsbelastung ; Monitoring ; Jahreszeitabhaengigkeit ; Populationsdichte ; Kausalzusammenhang ; Oekotoxikologische Bewertung
Language	English
Document type	Journal
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED