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Article ; Online: Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells.

Mukherjee, Tathagata / Tung, Kshyama Subhadarsini / Jena, Parthasarathi / Goswami, Chandan / Chattopadhyay, Subhasis

2024 , Page(s) 1–18

Abstract: TRPV1 and TRPA1, are known to be functionally expressed in T cells, where these two channels differentially regulate effector immune responses. Telmisartan (TM), an anti-hypertension drug, has been recently repurposed to suppress various inflammatory ... ...

Abstract	TRPV1 and TRPA1, are known to be functionally expressed in T cells, where these two channels differentially regulate effector immune responses. Telmisartan (TM), an anti-hypertension drug, has been recently repurposed to suppress various inflammatory responses. However, the possible involvement of TRP channels during TM-driven suppression of T cells responses has not been explored yet. In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2024.2329203
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Article ; Online: Understanding the role of Ca

Kumar, P Sanjai / Radhakrishnan, Anukrishna / Mukherjee, Tathagata / Khamaru, Somlata / Chattopadhyay, Soma / Chattopadhyay, Subhasis

Virus research

2022 Volume 323, Page(s) 198992

Abstract: Transient receptor potential (TRP) channels are a superfamily of cation-specific permeable channels primarily conducting ... ...

Abstract	Transient receptor potential (TRP) channels are a superfamily of cation-specific permeable channels primarily conducting Ca
Language	English
Publishing date	2022-10-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2022.198992
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Article ; Online: TRPA1 activation and Hsp90 inhibition synergistically downregulate macrophage activation and inflammatory responses in vitro.

Radhakrishnan, Anukrishna / Mukherjee, Tathagata / Mahish, Chandan / Kumar, P Sanjai / Goswami, Chandan / Chattopadhyay, Subhasis

BMC immunology

2023 Volume 24, Issue 1, Page(s) 16

Abstract: Background: Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and various immunological responses. Heat shock protein 90 ...

Abstract	Background: Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and various immunological responses. Heat shock protein 90 (Hsp90), a cytoplasmic molecular chaperone, is well-reported for various cellular and physiological processes. Hsp90 inhibition by various molecules has garnered importance for its therapeutic significance in the downregulation of inflammation and are proposed as anti-cancer drugs. However, the possible role of TRPA1 in the Hsp90-associated modulation of immune responses remains scanty. Results: Here, we have investigated the role of TRPA1 in regulating the anti-inflammatory effect of Hsp90 inhibition via 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) in lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) stimulation in RAW 264.7, a mouse macrophage cell lines and PMA differentiated THP-1, a human monocytic cell line similar to macrophages. Activation of TRPA1 with Allyl isothiocyanate (AITC) is observed to execute an anti-inflammatory role via augmenting Hsp90 inhibition-mediated anti-inflammatory responses towards LPS or PMA stimulation in macrophages, whereas inhibition of TRPA1 by 1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7 H-purine-7-acetamide,2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7 H-purin-7-yl)-N-(4-isopropylphenyl)acetamide (HC-030031) downregulates these developments. LPS or PMA-induced macrophage activation was found to be regulated by TRPA1. The same was confirmed by studying the levels of activation markers (major histocompatibility complex II (MHCII), cluster of differentiation (CD) 80 (CD80), and CD86, pro-inflammatory cytokines (tumor necrosis factor (TNF) and interleukin 6 (IL-6)), NO (nitric oxide) production, differential expression of mitogen-activated protein kinase (MAPK) signaling pathways (p-p38 MAPK, phospho-extracellular signal-regulated kinase 1/2 (p-ERK 1/2), and phosphor-stress-activated protein kinase/c-Jun N-terminal kinase (p-SAPK/JNK)), and induction of apoptosis. Additionally, TRPA1 has been found to be an important contributor to intracellular calcium levels toward Hsp90 inhibition in LPS or PMA-stimulated macrophages. Conclusion: This study indicates a significant role of TRPA1 in Hsp90 inhibition-mediated anti-inflammatory developments in LPS or PMA-stimulated macrophages. Activation of TRPA1 and inhibition of Hsp90 has synergistic roles towards regulating inflammatory responses associated with macrophages. The role of TRPA1 in Hsp90 inhibition-mediated modulation of macrophage responses may provide insights towards designing future novel therapeutic approaches to regulate various inflammatory responses.
MeSH term(s)	Animals ; Humans ; Mice ; Acetamides ; Down-Regulation ; Lipopolysaccharides ; Macrophage Activation ; Macrophages ; TRPA1 Cation Channel ; HSP90 Heat-Shock Proteins ; RAW 264.7 Cells
Chemical Substances	Acetamides ; Lipopolysaccharides ; TRPA1 Cation Channel ; TRPA1 protein, human ; HSP90 Heat-Shock Proteins
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041500-X
ISSN	1471-2172 ; 1471-2172
ISSN (online)	1471-2172
ISSN	1471-2172
DOI	10.1186/s12865-023-00549-0
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Book ; Online: Semi-Supervised Cascaded Clustering for Classification of Noisy Label Data

Gupta, Ashit / Deodhar, Anirudh / Mukherjee, Tathagata / Runkana, Venkataramana

2022

Abstract: The performance of supervised classification techniques often deteriorates when the data has noisy labels. Even the semi-supervised classification approaches have largely focused only on the problem of handling missing labels. Most of the approaches ... ...

Abstract	The performance of supervised classification techniques often deteriorates when the data has noisy labels. Even the semi-supervised classification approaches have largely focused only on the problem of handling missing labels. Most of the approaches addressing the noisy label data rely on deep neural networks (DNN) that require huge datasets for classification tasks. This poses a serious challenge especially in process and manufacturing industries, where the data is limited and labels are noisy. We propose a semi-supervised cascaded clustering (SSCC) algorithm to extract patterns and generate a cascaded tree of classes in such datasets. A novel cluster evaluation matrix (CEM) with configurable hyperparameters is introduced to localize and eliminate the noisy labels and invoke a pruning criterion on cascaded clustering. The algorithm reduces the dependency on expensive human expertise for assessing the accuracy of labels. A classifier generated based on SSCC is found to be accurate and consistent even when trained on noisy label datasets. It performed better in comparison with the support vector machines (SVM) when tested on multiple noisy-label datasets, including an industrial dataset. The proposed approach can be effectively used for deriving actionable insights in industrial settings with minimal human expertise. Comment: 11 pages
Keywords	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; I.2.1
Subject code	006
Publishing date	2022-05-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Blood-based DNA methylation in advanced Nasopharyngeal Carcinoma exhibited distinct CpG methylation signature.

Chatterjee, Koustav / Mal, Sudipa / Ghosh, Monalisha / Chattopadhyay, Nabanita Roy / Roy, Sankar Deb / Chakraborty, Koushik / Mukherjee, Syamantak / Aier, Moatoshi / Choudhuri, Tathagata

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22086

Abstract: The TNM staging system is currently used to detect cancer stages. Regardless, a small proportion of cancer patients recur even after therapy, suggesting more specific molecular tools are required to justify the stage-specific detection and prompt cancer ... ...

Abstract	The TNM staging system is currently used to detect cancer stages. Regardless, a small proportion of cancer patients recur even after therapy, suggesting more specific molecular tools are required to justify the stage-specific detection and prompt cancer diagnosis. Thus, we aimed to explore the blood-based DNA methylation signature of metastatic nasopharyngeal carcinoma (NPC) to establish a holistic methylation biomarker panel. For the identification of methylation signature, the EPIC BeadChip-based array was performed. Comparative analysis for identifying unique probes, validation, and functional studies was investigated by analyzing GEO and TCGA datasets. We observed 4093 differentially methylated probes (DMPs), 1232 hydroxymethylated probes, and 25 CpG islands. Gene expression study revealed both upregulated and downregulated genes. Correlation analysis suggested a positive (with a positive r, p ≤ 0.05) and negative (with a negative r, p ≤ 0.05) association with different cancers. TFBS analysis exhibited the binding site for many TFs. Furthermore, gene enrichment analysis indicated the involvement of those identified genes in biological pathways. However, blood-based DNA methylation data uncovered a distinct DNA methylation pattern, which might have an additive role in NPC progression by altering the TFs binding. Moreover, based on tissue-specificity, a variation of correlation between methylation and gene expression was noted in different cancers.
MeSH term(s)	Humans ; DNA Methylation ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/pathology ; Neoplasm Recurrence, Local/genetics ; CpG Islands/genetics ; Nasopharyngeal Neoplasms/pathology ; Epigenesis, Genetic
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45001-w
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Article ; Online: Blood-based DNA methylation in advanced Nasopharyngeal Carcinoma exhibited distinct CpG methylation signature

Koustav Chatterjee / Sudipa Mal / Monalisha Ghosh / Nabanita Roy Chattopadhyay / Sankar Deb Roy / Koushik Chakraborty / Syamantak Mukherjee / Moatoshi Aier / Tathagata Choudhuri

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 16

Abstract: Abstract The TNM staging system is currently used to detect cancer stages. Regardless, a small proportion of cancer patients recur even after therapy, suggesting more specific molecular tools are required to justify the stage-specific detection and ... ...

Abstract	Abstract The TNM staging system is currently used to detect cancer stages. Regardless, a small proportion of cancer patients recur even after therapy, suggesting more specific molecular tools are required to justify the stage-specific detection and prompt cancer diagnosis. Thus, we aimed to explore the blood-based DNA methylation signature of metastatic nasopharyngeal carcinoma (NPC) to establish a holistic methylation biomarker panel. For the identification of methylation signature, the EPIC BeadChip-based array was performed. Comparative analysis for identifying unique probes, validation, and functional studies was investigated by analyzing GEO and TCGA datasets. We observed 4093 differentially methylated probes (DMPs), 1232 hydroxymethylated probes, and 25 CpG islands. Gene expression study revealed both upregulated and downregulated genes. Correlation analysis suggested a positive (with a positive r, p ≤ 0.05) and negative (with a negative r, p ≤ 0.05) association with different cancers. TFBS analysis exhibited the binding site for many TFs. Furthermore, gene enrichment analysis indicated the involvement of those identified genes in biological pathways. However, blood-based DNA methylation data uncovered a distinct DNA methylation pattern, which might have an additive role in NPC progression by altering the TFs binding. Moreover, based on tissue-specificity, a variation of correlation between methylation and gene expression was noted in different cancers.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation.

Dash, Rudra Narayan / Ray, Amrita / Mamidi, Prabhudutta / De, Saikat / Mohapatra, Tapas K / Moharana, Alok K / Mukherjee, Tathagata / Ghosh, Soumyajit / Chattopadhyay, Subhasis / Subudhi, Bharat B / Chattopadhyay, Soma

ACS omega

2023 Volume 9, Issue 1, Page(s) 146–156

Abstract: There is no approved antiviral for the management of the Chikungunya virus (CHIKV). To develop an antiviral drug that can manage both CHIKV and arthritis induced by it, an ester conjugate of telmisartan (TM) and salicylic acid (SA) was synthesized ( ... ...

Abstract	There is no approved antiviral for the management of the Chikungunya virus (CHIKV). To develop an antiviral drug that can manage both CHIKV and arthritis induced by it, an ester conjugate of telmisartan (TM) and salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00763
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Article ; Online: Elevation of TRPV1 expression on T-cells during experimental immunosuppression.

Kumar, P Sanjai / Mukherjee, Tathagata / Khamaru, Somlata / Radhakrishnan, Anukrishna / Nanda-Kishore, Dalai Jupiter / Chawla, Saurabh / Sahoo, Subhransu Sekhar / Chattopadhyay, Subhasis

Journal of biosciences

2022 Volume 47

Abstract: The transient receptor potential vanilloid 1 (TRPV1) channel is a thermo-sensitive, polymodal cation channel. An increase in intracellular calcium ( ... ...

Abstract	The transient receptor potential vanilloid 1 (TRPV1) channel is a thermo-sensitive, polymodal cation channel. An increase in intracellular calcium (Ca
MeSH term(s)	Mice ; Animals ; T-Lymphocytes ; Tacrolimus/pharmacology ; Calcium ; Immunosuppression Therapy ; Antineoplastic Agents ; TRPV Cation Channels/genetics
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Calcium (SY7Q814VUP) ; Antineoplastic Agents ; iodoresiniferatoxin ; TRPV1 protein, mouse ; TRPV Cation Channels
Language	English
Publishing date	2022-11-28
Publishing country	India
Document type	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
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Article ; Online: Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome

Soumyasil Das / Linkon Biswas / Tathagata Mukherjee / Koustav Biswas / Subrata Kumar Pal

Asian Journal of Medical Sciences, Vol 13, Iss 8, Pp 133-

2022 Volume 139

Abstract: Background: Framingham risk score (FRS) is a widely recognized tool used by clinicians worldwide to determine and estimate the 10-year risk of manifesting clinical cardiovascular disease (CVD) of an individual and classify them into different risk ... ...

Abstract	Background: Framingham risk score (FRS) is a widely recognized tool used by clinicians worldwide to determine and estimate the 10-year risk of manifesting clinical cardiovascular disease (CVD) of an individual and classify them into different risk categories on the basis of which necessary intervention can be taken. However, there is certain evidence questioning its predictive ability for risk stratification among ethnic Indian and Asian population. Aims and Objectives: In this study, we wanted to determine the predictive ability of FRS in the Indian population and to assess how the risk score is associated with certain variables which are not included in original FRS. Materials and Methods: It was a single institutional, retrospective, and observational study in patients with evidence (by ECG or Cardiac biomarker test -Preferably Troponin T) of diagnosis of acute myocardial infarction for first time. Eligible patients were assessed for their previous clinical records to calculate risk score as per FSR-coronary heart disease 2002. Predictive ability of FRS and association with different risk factors was tested for statistical significance. Results: The most of the study participants (63.8%) had low risk and only 4.8% of study population had high risk for developing CVD. Patients in the low risk group had significantly better high-density lipoprotein profile than other risk groups (P=0.001). Mean systolic blood pressure was significantly higher in high-risk population (155 vs. 131 vs. 138 mm of Hg; P=0.005). The left ventricular ejection fraction was significantly lower in high-risk group (39.2% vs. 53% vs. 52%, P=0.008). Serum creatinine level was also significantly higher in high-risk group (P=0.03). Conclusion: This clearly showed underestimation of FRS in prediction of CVDs in our study. Perhaps FRS needs a calibration and modified form with inclusion of other risk factors and parameters to determine and predict the future risk of development of CVD more accurately in Indian population.
Keywords	acute coronary syndrome ; framingham risk score ; indian population ; predictive ability ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
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Article ; Online: Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation

Rudra Narayan Dash / Amrita Ray / Prabhudutta Mamidi / Saikat De / Tapas K Mohapatra / Alok K Moharana / Tathagata Mukherjee / Soumyajit Ghosh / Subhasis Chattopadhyay / Bharat B Subudhi / Soma Chattopadhyay

ACS Omega, Vol 9, Iss 1, Pp 146-

2023 Volume 156

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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