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Article ; Online: Remodulatory effects of coral fossil on hematobiochemical parameters and histoaccumulation of specific organs in lead intoxicated broilers

Afrina Mustari / Mahabub Alam / Shabuj Kumar Pal / Mohammad Alam Miah / Mahmud Hossain Sumon / Emdadul Haque Chowdhury

Journal of King Saud University: Science, Vol 36, Iss 2, Pp 103071- (2024)

2024

Abstract: Objectives: The research aims to assess the impact of coral fossil (CF) on hematobiochemical parameters, organ’s accumulation, and remodulation in lead (Pb) intoxicated broiler birds. Methods: 45 broilers were used in the experiment, which was divided ... ...

Abstract	Objectives: The research aims to assess the impact of coral fossil (CF) on hematobiochemical parameters, organ’s accumulation, and remodulation in lead (Pb) intoxicated broiler birds. Methods: 45 broilers were used in the experiment, which was divided into 03 groups, each of which contained 15 broilers. The control group was Group A. Pb (280 mg/kg b. w.) was administered orally to the birds in group B. Group C received Pb (280 mg/kg b.w.) and CF (1 gm/kg b.w.) oral supplements. The research was carried out for 30 days. Blood samples were collected, and sera were prepared for biochemical analysis. Pb accumulation concentration was assessed in muscle, liver and kidney. Moreover, samples of the brain, liver, and kidneys were obtained and prepared for histological analysis. Results: Pb affected hematological markers (Total RBC, Hb conc., hematocrit value, differential leukocytes and blood indices), which were restored with CF supplementation. In Pb-treated broilers, hepatic enzymes (AST, ALT), renal biomarkers (creatinine, total protein and albumin) and lipid profile (TC, TG, HDL and LDL) increased substantially (p < 0.05), but dropped significantly (p < 0.05) after CF supplementation. Pb accumulation was higher in liver, kidney and muscle tissue that was reduced by CF treatment. The histopathological study demonstrated that there was accumulation of fluid around in brain, hyperplasia of bile duct and glomerular epithelium in Pb intoxicated broilers and these were restored after CF supplementation. Conclusions: Therefore, it can be concluded that CF supplementation restored the lead induced detrimental effects on broilers. So, CF has remodulatory effects on Pb toxicity.
Keywords	Lead ; Coral fossil ; Hematobiochemical ; Accumulation and histotexture ; Science (General) ; Q1-390
Subject code	630
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reliable Fluorometric Detection of SARS-CoV-2 by Targeting the G-Quadruplex through pH-Triggered Conformational Polymorphism.

Pratihar, Sumon / Agrawal, Ragini / Pal, Virender Kumar / Singh, Amit / Govindaraju, Thimmaiah

ACS sensors

2022 Volume 7, Issue 2, Page(s) 453–459

Abstract: Unravelling unique molecular targets specific to viruses is challenging yet critical for diagnosing emerging viral diseases. Nucleic acids and proteins are the major targets in diagnostic assays of viral pathogens. Identification of novel sequences and ... ...

Abstract	Unravelling unique molecular targets specific to viruses is challenging yet critical for diagnosing emerging viral diseases. Nucleic acids and proteins are the major targets in diagnostic assays of viral pathogens. Identification of novel sequences and conformations of nucleic acids as targets is desirable for developing diagnostic assays specific to a virus of interest. Here, we disclose the identification and characterization of a highly conserved antiparallel G-quadruplex (GQ)-forming DNA sequence present within the SARS-CoV-2 genome. The two-quartet GQ with unique loop compositions formed a distinct recognition motif. Design, synthesis, and fine tuning of structure-activity of a set of small molecules led to the identification of a benzobisthiazole-based fluorogenic probe which unambiguously recognizes the target SARS-CoV-2 GQ DNA. A robust cost-effective assay was developed through thermal cycler PCR-based amplification of the antiparallel GQ-forming ORF1ab region of the SARS-CoV-2 genome and endpoint fluorescence detection with the probe. An exclusive pH window (3.5-4) helped trigger reliable conformational polymorphism (RCP) involving DNA duplex to GQ transformation, which aided the development of a GQ-RCP platform for the diagnosis of SARS-CoV-2 clinical samples. This general strategy can be adapted for the development of specific diagnostic assays targeting different noncanonical nucleic acid sequences.
MeSH term(s)	COVID-19/diagnosis ; G-Quadruplexes ; Humans ; Hydrogen-Ion Concentration ; Nucleic Acid Amplification Techniques ; SARS-CoV-2/genetics
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.1c02113
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential for Improving Intrauterine Device (IUD) Service Delivery Quality: Results from a Secondary Data Analysis.

Gehani, Manish / Pal, Manoj / Arya, Anupama / Singh, Shobhana / S, Kaushik / O'Connell, Kathryn A / Cagatay, Levent / Sengupta, Sumon / Singal, Sunita

Gates open research

2020 Volume 3, Page(s) 1473

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2572-4754
ISSN (online)	2572-4754
DOI	10.12688/gatesopenres.12997.3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential for Improving Intrauterine Device (IUD) Service Delivery Quality

Manish Gehani / Manoj Pal / Anupama Arya / Shobhana Singh / Kaushik S. / Kathryn A. O’Connell / Levent Cagatay / Sumon Sengupta / Sunita Singal

Gates Open Research, Vol

Results from a Secondary Data Analysis [version 3; peer review: 2 approved]

2020 Volume 3

Abstract: Background: To accelerate progress toward Family Planning 2020 (FP2020) goals, the government of India focused on improving the quality of intrauterine device (IUD) services. EngenderHealth, an international sexual and reproductive health and rights ... ...

Abstract	Background: To accelerate progress toward Family Planning 2020 (FP2020) goals, the government of India focused on improving the quality of intrauterine device (IUD) services. EngenderHealth, an international sexual and reproductive health and rights organization, has been supporting the governments of Gujarat and Rajasthan since 2014 through the Expanding Access to IUD Services in India (EAISI) project by building the capacity of service providers, monitoring compliance with standard practices, and strengthening health systems. This study sought to assess whether EAISI-trained providers offer higher quality IUD services than non-EAISI-trained providers, as indicated by a reduction in confirmed IUD complications. Methods: The study team conducted an analytical cross-sectional study of secondary data collected from follow-up registers at 176 intervention facilities (38 in Gujarat and 138 in Rajasthan) during Phase I of the EAISI project. The analysis included follow-up clients who returned to the same facility between April 2018 and March 2019. We performed a multivariate logistic regression to determine factors associated with IUD complications. Results: During the period of assessment, 56,733 clients received IUD insertions, and 10,747 (18.9%) clients returned for follow-up services. Of the returning clients, 49.4% (N=5,305) had received IUDs from EAISI-trained providers, while 50.6% (N=5,442) had received IUDs from non-EAISI-trained providers. A total of 4.0% (N=432) of all returning clients experienced complications (expulsion: 1.3%, missing strings: 1.7%, infection: 1.1%). Clients who received IUDs from non-EAISI-trained providers were 55.5% more likely (95% CI [26.2%, 91.5%], p<0.0005) to have experienced complications than clients who received insertions from EAISI-trained providers. The type of IUD, the timing of the insertion, and the timing of the follow-up visit also affected complication prevalence. Conclusion: Our findings indicate that intensive, practical clinical skills training for IUD insertion can reduce the prevalence of complications.
Keywords	Medicine ; R
Subject code	690
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Could EAISI-trained providers provide better quality of IUD services? Results of a secondary data analysis of complications as a proxy indicator [version 2; peer review

Manish Gehani / Manoj Pal / Anupama Arya / Shobhana Singh / Kaushik S. / Kathryn A. O’Connell / Levent Cagatay / Sumon Sengupta / Sunita Singal

Gates Open Research, Vol

2 approved]

2019 Volume 3

Abstract: Background: For accelerating its progress towards FP2020 goals, the Government of India has focused on improving the quality of intrauterine device (IUD) services. EngenderHealth has supported the Governments of Rajasthan and Gujarat since 2014 through ... ...

Abstract	Background: For accelerating its progress towards FP2020 goals, the Government of India has focused on improving the quality of intrauterine device (IUD) services. EngenderHealth has supported the Governments of Rajasthan and Gujarat since 2014 through its Expanding Access to IUD Services in India (EAISI) project by building the capacity of service providers, monitoring their compliance with standard practices, and strengthening health systems. This study sought to assess whether EAISI trained providers provide a better quality of IUD services as compared to non-EAISI trained providers, as indicated by a reduction in confirmed IUD complications? Methods: This study was an analytical cross-sectional study of secondary data collected from the follow-up registers of 176 intervention facilities (138 in Rajasthan and 38 in Gujarat) during Phase I of EAISI project. The analysis included clients who returned between April 2018 and March 2019 to the same facility for a follow-up visit. Multivariate logistic regression was performed to determine factors associated with IUD complications. Results: A total of 56,733 IUD insertions were conducted, and 10,747 (18.9%) client follow-ups were documented. Of these, 49.4% (N=5,305) clients received IUDs from EAISI-trained providers, while 50.6% (N=5,442) received IUDs from non-EAISI trained providers. A total of 4.0% (N=432) of clients experienced complications (Expulsion: 1.3%, Missing Strings: 1.7%, Infection: 1.1%). Clients who received IUDs from non-EAISI-trained providers were 55.5% more likely [95% CI (26.2%, 91.5%), p<0.0005] to have complications compared to clients who received insertions from EAISI-trained providers. Other significant factors include the type of IUD, timing of the follow-up visit and timing of the insertion. Conclusion: The findings demonstrate that intensive, hands-on training of providers to improve clinical skills for IUD insertions can have a positive impact on the reduction of post-insertion complications.
Keywords	Medicine ; R
Subject code	690
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Red discoloration of urine caused by Serratia rubidae

Simit Kumar / Maitreyi Bandyopadhyay / Mitali Chatterjee / Prabir Mukhopadhyay / Suranjan Pal / Sumon Poddar / Parthajit Banerjee

Avicenna Journal of Medicine, Vol 03, Iss 01, Pp 20-

A rare case

2013 Volume 22

Abstract: There have been only a few reported human cases of infections caused by Serratia rubidae in literature. Among these sparse cases there is only one reported case of urinary tract infection (UTI) due to S. rubidae in literature. The organism is known to ... ...

Abstract	There have been only a few reported human cases of infections caused by Serratia rubidae in literature. Among these sparse cases there is only one reported case of urinary tract infection (UTI) due to S. rubidae in literature. The organism is known to produce a red pigment known as prodigiosin. We report a case of UTI caused by S. rubidae in a diabetic patient who presented with burning micturition and reddish discoloration of urine, which on laboratory diagnosis, was proved to be due to the reddish pigment produced by the organism. This case report highlights that this rare organism might be associated with UTI leading to reddish discoloration of urine.
Keywords	diabetes ; serratia rubidae ; urinary tract infection ; Medicine ; R
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Red discoloration of urine caused by Serratia rubidae: A rare case.

Kumar, Simit / Bandyopadhyay, Maitreyi / Chatterjee, Mitali / Mukhopadhyay, Prabir / Pal, Suranjan / Poddar, Sumon / Banerjee, Parthajit

Avicenna journal of medicine

2012 Volume 3, Issue 1, Page(s) 20–22

Abstract	There have been only a few reported human cases of infections caused by Serratia rubidae in literature. Among these sparse cases there is only one reported case of urinary tract infection (UTI) due to S. rubidae in literature. The organism is known to produce a red pigment known as prodigiosin. We report a case of UTI caused by S. rubidae in a diabetic patient who presented with burning micturition and reddish discoloration of urine, which on laboratory diagnosis, was proved to be due to the reddish pigment produced by the organism. This case report highlights that this rare organism might be associated with UTI leading to reddish discoloration of urine.
Language	English
Publishing date	2012-07-05
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2664414-9
ISSN	2249-4464 ; 2231-0770
ISSN (online)	2249-4464
ISSN	2231-0770
DOI	10.4103/2231-0770.112790
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Optophysiological analysis of associational circuits in the olfactory cortex.

Hagiwara, Akari / Pal, Sumon K / Sato, Tomokazu F / Wienisch, Martin / Murthy, Venkatesh N

Frontiers in neural circuits

2012 Volume 6, Page(s) 18

Abstract: Primary olfactory cortical areas receive direct input from the olfactory bulb, but also have extensive associational connections that have been mainly studied with classical anatomical methods. Here, we shed light on the functional properties of ... ...

Abstract	Primary olfactory cortical areas receive direct input from the olfactory bulb, but also have extensive associational connections that have been mainly studied with classical anatomical methods. Here, we shed light on the functional properties of associational connections in the anterior and posterior piriform cortices (aPC and pPC) using optophysiological methods. We found that the aPC receives dense functional connections from the anterior olfactory nucleus (AON), a major hub in olfactory cortical circuits. The local recurrent connectivity within the aPC, long invoked in cortical autoassociative models, is sparse and weak. By contrast, the pPC receives negligible input from the AON, but has dense connections from the aPC as well as more local recurrent connections than the aPC. Finally, there are negligible functional connections from the pPC to aPC. Our study provides a circuit basis for a more sensory role for the aPC in odor processing and an associative role for the pPC.
Language	English
Publishing date	2012-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452968-0
ISSN	1662-5110 ; 1662-5110
ISSN (online)	1662-5110
ISSN	1662-5110
DOI	10.3389/fncir.2012.00018
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Article: Arylamine N-acetyl Transferase (NAT) in the blue secretion of Telescopium telescopium: xenobiotic metabolizing enzyme as a biomarker for detection of environmental pollution.

Gorain, Bapi / Chakraborty, Sumon / Pal, Murari Mohan / Sarkar, Ratul / Samanta, Samir Kumar / Karmakar, Sanmoy / Sen, Tuhinadri

SpringerPlus

2014 Volume 3, Page(s) 666

Abstract: Telescopium telescopium, a marine mollusc collected from Sundarban mangrove, belongs to the largest mollusca phylum in the world and exudes a blue secretion when stimulated mechanically. The blue secretion was found to metabolize (preferentially) para- ... ...

Abstract	Telescopium telescopium, a marine mollusc collected from Sundarban mangrove, belongs to the largest mollusca phylum in the world and exudes a blue secretion when stimulated mechanically. The blue secretion was found to metabolize (preferentially) para-amino benzoic acid, a substrate for N-acetyl transferase (NAT), thereby indicating acetyl transferase like activity of the secretion. Attempts were also made to characterise bioactive fraction of the blue secretion and to further use this as a biomarker for monitoring of marine pollution. NAT like enzyme from marine mollusc is a potential candidate for detoxification of different harmful chemicals. A partially purified extract of blue secretion was obtained by fractional precipitation with (NH4)2SO4. From different fractions obtained by precipitation, the 0-30% fraction (30S) displayed NAT like activity (using para amino benzoic acid as a substrate with para nitrophenyl phosphate or acetyl coenzyme A as acetyl group donors). Maximum NAT like enzyme activity was attained at 25°C and at a pH of 6. The enzyme activity was found to be inhibited by 5 mM phenyl methyl sulfonyl fluoride. The divalent metal ions reduced NAT like activity of 30S. Moreover, Cu(2+) and Zn(2+) (at concentration of 1 mM) completely inhibited NAT activity. The thermal stability and bench-top stability studies were performed and it was found that the enzyme was stable at room temperature for more than 24 hours. Results from the present study further indicate that heavy metal content in blue secretion gradually decreased from pre-monsoon to post-monsoon season, which also corresponded to the change in NAT like activity. Therefore, this article stresses the importance of biomarker research for monitoring pollution.
Language	English
Publishing date	2014-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661116-8
ISSN	2193-1801
ISSN	2193-1801
DOI	10.1186/2193-1801-3-666
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Article: Red discoloration of urine caused by Serratia rubidae: A rare case

Kumar, Simit / Bandyopadhyay, Maitreyi / Chatterjee, Mitali / Mukhopadhyay, Prabir / Pal, Suranjan / Poddar, Sumon / Banerjee, Parthajit

Avicenna Journal of Medicine

2013 Volume 03, Issue 01, Page(s) 20–22

Abstract	There have been only a few reported human cases of infections caused by Serratia rubidae in literature. Among these sparse cases there is only one reported case of urinary tract infection (UTI) due to S. rubidae in literature. The organism is known to produce a red pigment known as prodigiosin. We report a case of UTI caused by S. rubidae in a diabetic patient who presented with burning micturition and reddish discoloration of urine, which on laboratory diagnosis, was proved to be due to the reddish pigment produced by the organism. This case report highlights that this rare organism might be associated with UTI leading to reddish discoloration of urine.
Keywords	Diabetes ; Serratia rubidae ; urinary tract infection
Language	English
Publishing date	2013-01-01
Publisher	Thieme Medical and Scientific Publishers Private Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2664414-9
ISSN	2249-4464 ; 2231-0770 ; 2249-4464
ISSN (online)	2249-4464
ISSN	2231-0770 ; 2249-4464
DOI	10.4103/2231-0770.112790
Database	Thieme publisher's database

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