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Article ; Online: Atom- and step-economic 1,3-thiosulfonylation of activated allenes with thiosulfonates to access vinyl sulfones/sulfides.

Xiao, Xiao / Tian, Hong-Yu / Huang, Yin-Qiu / Lu, Yin-Jie / Fang, Jing-Jie / Zhou, Gao-Jie / Chen, Fen-Er

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 47, Page(s) 6765–6768

Abstract: A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, and environmental friendliness. ... ...

Abstract	A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, and environmental friendliness. Moreover, these valuable products can be transformed to vinyl sulfides
MeSH term(s)	Alkadienes ; Sulfides ; Sulfones
Chemical Substances	Alkadienes ; Sulfides ; Sulfones ; propadiene (4AV0LZ8QKB) ; divinyl sulfone (5PFN71LP8M)
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc01731h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD

Xiao, Xiao / Huang, Yin-Qiu / Tian, Hong-Yu / Bai, Jun / Cheng, Fei / Wang, Xu / Ke, Miao-Lin / Chen, Fen-Er

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 18, Page(s) 3015–3018

Abstract: We have established a practical and concise method for the straightforward access of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic ... ...

Abstract	We have established a practical and concise method for the straightforward access of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc07184j
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Article ; Online: Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents.

Zhang, Yin-Qiu / Wu, Jian-Bing / Yin, Wei / Zhang, Yi-Hua / Huang, Zhang-Jian

Chinese journal of natural medicines

2020 Volume 18, Issue 8, Page(s) 633–640

Abstract: To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a-t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet ... ...

Abstract	To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a-t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, 6d, 6g-i, 6o and 6q were more active than TMP. The most active compound 6h exhibited more potent anti-platelet aggregation activity than TMP, RES, as well as positive control ticlopidine (Ticlid) and aspirin (ASP). Furthermore, 6h exerted strong antioxidative activity in a dose-dependent manner in rat pheochromocytoma PC12 cells which were treated with hydrogen peroxide (H
MeSH term(s)	Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Brain Ischemia/drug therapy ; Molecular Structure ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; PC12 Cells ; Platelet Aggregation/drug effects ; Pyrazines/chemistry ; Pyrazines/pharmacology ; Rabbits ; Rats ; Resveratrol/chemistry ; Resveratrol/pharmacology
Chemical Substances	Antioxidants ; Neuroprotective Agents ; Pyrazines ; Resveratrol (Q369O8926L) ; tetramethylpyrazine (V80F4IA5XG)
Language	English
Publishing date	2020-08-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(20)30076-5
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Article: Atom- and step-economic 1,3-thiosulfonylation of activated allenes with thiosulfonates to access vinyl sulfones/sulfides

Xiao, Xiao / Tian, Hong-Yu / Huang, Yin-Qiu / Lu, Yin-Jie / Fang, Jing-Jie / Zhou, Gao-Jie / Chen, Fen-Er

Chemical communications. 2022 June 9, v. 58, no. 47

2022

Abstract	A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, and environmental friendliness. Moreover, these valuable products can be transformed to vinyl sulfides via a base-promoted isomerization. The versatile route can efficiently and rapidly introduce SCD₃ groups with excellent levels of deuterium content (>99% D) by utilizing our newly developed SCD₃ reagents. Gram-scale operations and further transformations are smoothly carried out, providing promising applications for drug discovery.
Keywords	deuterium ; drugs ; isomerization
Language	English
Dates of publication	2022-0609
Size	p. 6765-6768.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc01731h
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Article: Temporal trend of anisometropia incidence in Chinese school-aged children before and during the COVID-19 pandemic.

Huang, Yin / Qiu, Kunliang / Li, Yuancun / Wang, Hongxi / Zhang, Mingzhi

Frontiers in medicine

2024 Volume 11, Page(s) 1322402

Abstract: Objective: To analyze and compare the temporal trends in the incidence of anisometropia among Chinese school-aged children both before and during the COVID-19 pandemic, and to investigate the impact of the pandemic on the incidence of anisometropia.: ... ...

Abstract	Objective: To analyze and compare the temporal trends in the incidence of anisometropia among Chinese school-aged children both before and during the COVID-19 pandemic, and to investigate the impact of the pandemic on the incidence of anisometropia. Methods: We conducted a retrospective study comprising six distinct and independent longitudinal cohorts, each including children aged 6 to 13 years who visited the Joint Shantou International Eye Center between January 2010 and December 2021. Children were grouped into cohorts based on the year of their first eye clinic visit: 2010, 2012, 2014, 2016, 2018, or 2020. Only children without anisometropia at initial visits, followed for 18 ± 6 months, were included. The cumulative incidence and risk factors of anisometropia were analyzed using Kaplan-Meier estimation and Cox proportional hazards regression models. Subgroup analyses were performed based on sex, age groups, initial refractive error status, and initial interocular SE difference. Anisometropic children were further categorized into myopic and non-myopic, with subsequent subgroup analyses conducted. Results: Of 11,235 children were recruited from six cohorts (2010: Conclusion: This study reveals a concerning rise in anisometropia incidence among Chinese school-aged children during the period of the COVID-19 pandemic. These findings highlight the worrisome rise in anisometropia risk during the COVID-19 pandemic and emphasize the importance of early detection and management to safeguard children's visual health.
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1322402
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Article: Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents

ZHANG, Yin-Qiu / WU, Jian-Bing / YIN, Wei / ZHANG, Yi-Hua / HUANG, Zhang-Jian

Chinese journal of natural medicines. 2020 Aug., v. 18, no. 8

2020

Abstract: To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a−t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet ... ...

Abstract	To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a−t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, 6d, 6g−i, 6o and 6q were more active than TMP. The most active compound 6h exhibited more potent anti-platelet aggregation activity than TMP, RES, as well as positive control ticlopidine (Ticlid) and aspirin (ASP). Furthermore, 6h exerted strong antioxidative activity in a dose-dependent manner in rat pheochromocytoma PC12 cells which were treated with hydrogen peroxide (H₂O₂) or hydroxyl radical (·OH). Importantly, 6h significantly protected primary neuronal cells suffered from oxygen-glucose deprivation/reoxygenation (OGD/R) injury, comparable to an anti-ischemic drug edaravone (Eda). Together, our findings suggest that 6h may be a promising candidate warranting further investigation for the intervention of ischemic stroke.
Keywords	adenosine diphosphate ; antioxidant activity ; arachidonic acid ; dose response ; glucose ; hydrogen peroxide ; hydroxyl radicals ; ischemia ; neoplasm cells ; neurons ; neuroprotective effect ; oxidative stress ; oxygen ; platelet aggregation ; pyrazines ; rats ; resveratrol ; stroke
Language	English
Dates of publication	2020-08
Size	p. 633-640.
Publishing place	Elsevier B.V.
Document type	Article
Note	golden set
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(20)30076-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diabetic conditions promote drug coating degradation but prevent endothelial coverage after stenting.

Yin, Jun / Zhao, Chunguang / Huang, Jiabing / Chen, Changqing / Lei, Ting / He, Jiawei / Qiu, Dongxu

Acta biomaterialia

2024 Volume 177, Page(s) 189–202

Abstract: The endothelialization of drug-eluting stents is delayed after implantation in patients with diabetes. Although numerous factors were implicated in hyperglycemia-induced endothelial dysfunction, the effects of stent drug coating degradation on ... ...

Abstract	The endothelialization of drug-eluting stents is delayed after implantation in patients with diabetes. Although numerous factors were implicated in hyperglycemia-induced endothelial dysfunction, the effects of stent drug coating degradation on endothelial dysfunction remains unclear. We hypothesized that diabetic conditions promote drugcoating degradation and enhance antiproliferative agent release, but that the rapid release of these antiproliferative agents inhibits endothelial cell proliferation leading to poor reendothelialization post-stenting. To verify this hypothesis, a dynamic hyperglycemic circulation system was introduced to measure the profile of drugcoating degradation in vitro. Flow cytometry and RNA sequencing were performed to evaluate endothelial cell proliferation. Moreover, a Type 1 diabetic rabbit model was generated and a rescue experiment conducted to evaluate the effects of rapid drugcoating elution on endothelial coverage in vivo. The main findings were as follows: 1) diabetic conditions promoted drugcoating degradation and increased antiproliferative agent release; 2) this increase in antiproliferative agent release inhibited endothelial cell proliferation and delayed endothelial coverage; and 3) strict glycemic control attenuated drugcoating degradation and promoted endothelial coverage post-stenting. This is the first study to illustrate rapid drugcoating degradation and its potential effects on endothelial recovery under diabetic conditions, highlighting the importance of strict glycemic management in patients with diabetes after drug-eluting stent implantation. STATEMENT OF SIGNIFICANCE: Diabetic conditions promote drug coating degradation and increase the release of antiproliferative agents. Rapid drug coating degradation under diabetic conditions inhibits endothelial cell proliferation and delays endothelialization. Strict glycemic control attenuates drug coating degradation and promotes endothelialization.
MeSH term(s)	Animals ; Humans ; Rabbits ; Drug-Eluting Stents ; Stents ; Endothelium ; Diabetes Mellitus ; Antineoplastic Agents
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2024.01.034
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Article ; Online: Influence of Fe

Qiu, Shuxing / Yu, Xiufang / Chen, Yandong / Huang, Xianyou / Yin, Chen / Zhang, Shengfu

ACS omega

2023 Volume 8, Issue 35, Page(s) 31946–31953

Abstract: Iron cokes were produced in an electrical furnace from a coal blend containing varying levels of added ... ...

Abstract	Iron cokes were produced in an electrical furnace from a coal blend containing varying levels of added Fe
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03730
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Article ; Online: Effects of

Huang, Ling / Shui, Xiaomei / Wang, Hanying / Qiu, Haoyu / Tao, Chenzhi / Yin, Heng / Wang, Ping

Biochemistry and biophysics reports

2023 Volume 35, Page(s) 101546

Abstract: The incorporation of probiotics into the diet of large yellow croaker has been demonstrated by several studies to confer partial disease resistance. ...

Abstract	The incorporation of probiotics into the diet of large yellow croaker has been demonstrated by several studies to confer partial disease resistance.
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2023.101546
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Article: Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

Cheng, Fei / Chen, Tao / Huang, Yin-Qiu / Li, Jia-Wei / Zhou, Chen / Xiao, Xiao / Chen, Fen-Er

Organic letters. 2021 Dec. 21, v. 24, no. 1

2021

Abstract: We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up ... ...

Abstract	We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.
Keywords	catalysts ; cross-coupling reactions ; decarboxylation ; ligands ; solvents
Language	English
Dates of publication	2021-1221
Size	p. 115-120.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c03688
Database	NAL-Catalogue (AGRICOLA)

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