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  1. Article ; Online: No added value of the modified NEWS score to predict clinical deterioration in COVID-19 patients.

    Volff, Maxime / Tonon, David / Bourenne, Jeremy / Simeone, Pierre / Velly, Lionel

    Anaesthesia, critical care & pain medicine

    2020  Volume 39, Issue 5, Page(s) 577–578

    MeSH term(s) Adult ; Area Under Curve ; Betacoronavirus ; COVID-19 ; Clinical Deterioration ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Female ; Humans ; Intensive Care Units ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Prognosis ; ROC Curve ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Statistics, Nonparametric
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2020.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: No added value of the modified NEWS score to predict clinical deterioration in COVID-19 patients

    Volff, Maxime / Tonon, David / Bourenne, Jeremy / Simeone, Pierre / Velly, Lionel

    Anaesth Crit Care Pain Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #639767
    Database COVID19

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  3. Article ; Online: No added value of the modified NEWS score to predict clinical deterioration in COVID-19 patients

    Volff, Maxime / Tonon, David / Bourenne, Jeremy / Simeone, Pierre / Velly, Lionel

    Anaesthesia Critical Care & Pain Medicine

    2020  Volume 39, Issue 5, Page(s) 577–578

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-5568
    DOI 10.1016/j.accpm.2020.07.008
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Impact of Dexamethasone and Inhaled Nitric Oxide on Severe Acute Kidney Injury in Critically Ill Patients with COVID-19.

    Bobot, Mickaël / Tonon, David / Peres, Noémie / Guervilly, Christophe / Lefèvre, Flora / Max, Howard / Bommel, Youri / Volff, Maxime / Leone, Marc / Lopez, Alexandre / Simeone, Pierre / Carvelli, Julien / Chopinet, Sophie / Hraiech, Sami / Papazian, Laurent / Velly, Lionel / Bourenne, Jérémy / Forel, Jean-Marie

    Journal of clinical medicine

    2022  Volume 11, Issue 20

    Abstract: Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was ...

    Abstract Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific treatments of COVID-19 and ARDS on the risk of severe AKI in critically ill COVID-19 patients. Methods: In this cohort study, data from consecutive patients older than 18 years admitted to 6 ICUs for COVID-19-related ARDS requiring invasive mechanical ventilation were included. The incidence and severity of AKI, defined according to the 2012 KDIGO definition, were monitored during the entire ICU stay until day 90. Patients older than 18 years admitted to the ICU for COVID-19-related ARDS requiring invasive mechanical ventilation were included. Results: 164 patients were included in the final analysis; 97 (59.1%) displayed AKI, of which 39 (23.8%) had severe stage 3 AKI, and 21 (12.8%) required renal replacement therapy (RRT). In univariate analysis, severe AKI was associated with angiotensin-converting enzyme inhibitors (ACEI) exposure (p = 0.016), arterial hypertension (p = 0.029), APACHE-II score (p = 0.004) and mortality at D28 (p = 0.008), D60 (p < 0.001) and D90 (p < 0.001). In multivariate analysis, the factors associated with the onset of stage 3 AKI were: exposure to ACEI (OR: 4.238 (1.307−13.736), p = 0.016), APACHE II score (without age) (OR: 1.138 (1.044−1.241), p = 0.003) and iNO (OR: 5.694 (1.953−16.606), p = 0.001). Prone positioning (OR: 0.234 (0.057−0.967), p = 0.045) and dexamethasone (OR: 0.194 (0.053−0.713), p = 0.014) were associated with a decreased risk of severe AKI. Conclusions: Dexamethasone was associated with the prevention of the risk of severe AKI and RRT, and iNO was associated with severe AKI and RRT in critically ill patients with COVID-19. iNO should be used with caution in COVID-19-related ARDS.
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contrasting Gene Decay in Subterranean Vertebrates: Insights from Cavefishes and Fossorial Mammals.

    Policarpo, Maxime / Fumey, Julien / Lafargeas, Philippe / Naquin, Delphine / Thermes, Claude / Naville, Magali / Dechaud, Corentin / Volff, Jean-Nicolas / Cabau, Cedric / Klopp, Christophe / Møller, Peter Rask / Bernatchez, Louis / García-Machado, Erik / Rétaux, Sylvie / Casane, Didier

    Molecular biology and evolution

    2020  Volume 38, Issue 2, Page(s) 589–605

    Abstract: Evolution sometimes proceeds by loss, especially when structures and genes become dispensable after an environmental shift relaxes functional constraints. Subterranean vertebrates are outstanding models to analyze this process, and gene decay can serve ... ...

    Abstract Evolution sometimes proceeds by loss, especially when structures and genes become dispensable after an environmental shift relaxes functional constraints. Subterranean vertebrates are outstanding models to analyze this process, and gene decay can serve as a readout. We sought to understand some general principles on the extent and tempo of the decay of genes involved in vision, circadian clock, and pigmentation in cavefishes. The analysis of the genomes of two Cuban species belonging to the genus Lucifuga provided evidence for the largest loss of eye-specific genes and nonvisual opsin genes reported so far in cavefishes. Comparisons with a recently evolved cave population of Astyanax mexicanus and three species belonging to the Chinese tetraploid genus Sinocyclocheilus revealed the combined effects of the level of eye regression, time, and genome ploidy on eye-specific gene pseudogenization. The limited extent of gene decay in all these cavefishes and the very small number of loss-of-function mutations per pseudogene suggest that their eye degeneration may not be very ancient, ranging from early to late Pleistocene. This is in sharp contrast with the identification of several vision genes carrying many loss-of-function mutations in ancient fossorial mammals, further suggesting that blind fishes cannot thrive more than a few million years in cave ecosystems.
    MeSH term(s) Animals ; Caves ; Circadian Clocks/genetics ; Fishes/genetics ; Loss of Function Mutation ; Moles/genetics ; Pigmentation/genetics ; Pseudogenes ; Selection, Genetic ; Vision, Ocular/genetics ; Zebrafish
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msaa249
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Impact of Dexamethasone and Inhaled Nitric Oxide on Severe Acute Kidney Injury in Critically Ill Patients with COVID-19

    Mickaël Bobot / David Tonon / Noémie Peres / Christophe Guervilly / Flora Lefèvre / Howard Max / Youri Bommel / Maxime Volff / Marc Leone / Alexandre Lopez / Pierre Simeone / Julien Carvelli / Sophie Chopinet / Sami Hraiech / Laurent Papazian / Lionel Velly / Jérémy Bourenne / Jean-Marie Forel

    Journal of Clinical Medicine, Vol 11, Iss 20, p

    2022  Volume 6130

    Abstract: Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was ...

    Abstract Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific treatments of COVID-19 and ARDS on the risk of severe AKI in critically ill COVID-19 patients. Methods: In this cohort study, data from consecutive patients older than 18 years admitted to 6 ICUs for COVID-19-related ARDS requiring invasive mechanical ventilation were included. The incidence and severity of AKI, defined according to the 2012 KDIGO definition, were monitored during the entire ICU stay until day 90. Patients older than 18 years admitted to the ICU for COVID-19-related ARDS requiring invasive mechanical ventilation were included. Results: 164 patients were included in the final analysis; 97 (59.1%) displayed AKI, of which 39 (23.8%) had severe stage 3 AKI, and 21 (12.8%) required renal replacement therapy (RRT). In univariate analysis, severe AKI was associated with angiotensin-converting enzyme inhibitors (ACEI) exposure ( p = 0.016), arterial hypertension ( p = 0.029), APACHE-II score ( p = 0.004) and mortality at D28 ( p = 0.008), D60 ( p < 0.001) and D90 ( p < 0.001). In multivariate analysis, the factors associated with the onset of stage 3 AKI were: exposure to ACEI (OR: 4.238 (1.307–13.736), p = 0.016), APACHE II score (without age) (OR: 1.138 (1.044–1.241), p = 0.003) and iNO (OR: 5.694 (1.953–16.606), p = 0.001). Prone positioning (OR: 0.234 (0.057–0.967), p = 0.045) and dexamethasone (OR: 0.194 (0.053–0.713), p = 0.014) were associated with a decreased risk of severe AKI. Conclusions: Dexamethasone was associated with the prevention of the risk of severe AKI and RRT, and iNO was associated with severe AKI and RRT in critically ill patients with COVID-19. iNO should be used with caution in COVID-19-related ARDS.
    Keywords acute kidney injury ; intensive care ; dexamethasone ; inhaled nitric oxide ; COVID-19 ; ARDS ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France.

    Volff, Maxime / Tonon, David / Bommel, Youri / Peres, Noémie / Lagier, David / Agard, Geoffray / Jacquier, Alexis / Bartoli, Axel / Carvelli, Julien / Max, Howard / Simeone, Pierre / Blasco, Valery / Pastene, Bruno / Loundou, Anderson / Boyer, Laurent / Leone, Marc / Velly, Lionel / Bourenne, Jeremy / Boussen, Salah /
    Bobot, Mickaël / Bruder, Nicolas

    Journal of clinical medicine

    2021  Volume 10, Issue 23

    Abstract: Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors.: Methods: This observational ... ...

    Abstract Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors.
    Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission.
    Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9-33) days and 29 (17-46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis.
    Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10235650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France

    Maxime Volff / David Tonon / Youri Bommel / Noémie Peres / David Lagier / Geoffray Agard / Alexis Jacquier / Axel Bartoli / Julien Carvelli / Howard Max / Pierre Simeone / Valery Blasco / Bruno Pastene / Anderson Loundou / Laurent Boyer / Marc Leone / Lionel Velly / Jeremy Bourenne / Salah Boussen /
    Mickaël Bobot / Nicolas Bruder

    Journal of Clinical Medicine, Vol 10, Iss 5650, p

    2021  Volume 5650

    Abstract: Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational ... ...

    Abstract Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.
    Keywords Covid-19 ; SARS-CoV-2 ; intensive care unit ; acute respiratory distress syndrome ; mechanical ventilation ; prognostic factors ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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